EA199900436A1 - Очистка нейротрофинов - Google Patents

Очистка нейротрофинов

Info

Publication number
EA199900436A1
EA199900436A1 EA199900436A EA199900436A EA199900436A1 EA 199900436 A1 EA199900436 A1 EA 199900436A1 EA 199900436 A EA199900436 A EA 199900436A EA 199900436 A EA199900436 A EA 199900436A EA 199900436 A1 EA199900436 A1 EA 199900436A1
Authority
EA
Eurasian Patent Office
Prior art keywords
neurotrophins
proposed
methods
neurotrofins
cleaning
Prior art date
Application number
EA199900436A
Other languages
English (en)
Other versions
EA002349B1 (ru
Inventor
Луис Е. Бэртон
Чарлес Х. Шмельцер
Джоан Т. Бек
Original Assignee
Джинентех Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Джинентех Инк. filed Critical Джинентех Инк.
Publication of EA199900436A1 publication Critical patent/EA199900436A1/ru
Publication of EA002349B1 publication Critical patent/EA002349B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/48—Nerve growth factor [NGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Предлагаются способы очистки нейротрофинов, включая зрелый NGF, пригодные для клинического применения в крупном масштабе. Способы предусматривают методы разделения нейротрофинов от других ненужных ошибочно процессированных, ошибочно упорядоченных, другого размера, гликозилированных или заряженных форм. Также предлагаются композиции нейротрофинов, включающие зрелый NGF, практически не содержащие данных вариантов.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900436A 1996-11-15 1997-11-14 Очистка нейротрофинов EA002349B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3083896P 1996-11-15 1996-11-15
US4785597P 1997-05-29 1997-05-29
PCT/US1997/021068 WO1998021234A2 (en) 1996-11-15 1997-11-14 Purification of neurotrophins

Publications (2)

Publication Number Publication Date
EA199900436A1 true EA199900436A1 (ru) 2000-02-28
EA002349B1 EA002349B1 (ru) 2002-04-25

Family

ID=26706516

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900436A EA002349B1 (ru) 1996-11-15 1997-11-14 Очистка нейротрофинов

Country Status (21)

Country Link
US (5) US6005081A (ru)
EP (1) EP0942930B1 (ru)
JP (3) JP4671372B2 (ru)
KR (1) KR100554332B1 (ru)
CN (1) CN1268639C (ru)
AT (1) ATE371670T1 (ru)
AU (1) AU729459B2 (ru)
BR (1) BR9713055A (ru)
CA (1) CA2268747A1 (ru)
CZ (1) CZ300296B6 (ru)
DE (1) DE69738074T2 (ru)
EA (1) EA002349B1 (ru)
ES (1) ES2293662T3 (ru)
HU (1) HU222666B1 (ru)
ID (1) ID26697A (ru)
IL (2) IL129851A0 (ru)
NO (1) NO327149B1 (ru)
NZ (1) NZ335207A (ru)
PL (1) PL191400B1 (ru)
TR (1) TR199901734T2 (ru)
WO (1) WO1998021234A2 (ru)

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CN108239146A (zh) * 2018-03-26 2018-07-03 江苏中新医药有限公司 一种高纯度rhNGF的制备方法
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Also Published As

Publication number Publication date
CA2268747A1 (en) 1998-05-22
DE69738074D1 (de) 2007-10-11
KR20000053297A (ko) 2000-08-25
WO1998021234A3 (en) 1998-07-23
NZ335207A (en) 2000-09-29
CZ300296B6 (cs) 2009-04-15
IL129851A (en) 2006-12-10
PL333460A1 (en) 1999-12-20
JP2001503779A (ja) 2001-03-21
HU222666B1 (hu) 2003-09-29
NO992353D0 (no) 1999-05-14
EP0942930A2 (en) 1999-09-22
US20020137893A1 (en) 2002-09-26
EA002349B1 (ru) 2002-04-25
JP4881234B2 (ja) 2012-02-22
NO327149B1 (no) 2009-05-04
US6423831B1 (en) 2002-07-23
PL191400B1 (pl) 2006-05-31
JP2007302679A (ja) 2007-11-22
JP2009040786A (ja) 2009-02-26
JP4671372B2 (ja) 2011-04-13
US6005081A (en) 1999-12-21
KR100554332B1 (ko) 2006-02-24
EP0942930B1 (en) 2007-08-29
CN1237184A (zh) 1999-12-01
US6812330B2 (en) 2004-11-02
NO992353L (no) 1999-07-09
HUP9903947A3 (en) 2001-03-28
CN1268639C (zh) 2006-08-09
ID26697A (id) 2001-02-01
US20040138431A1 (en) 2004-07-15
TR199901734T2 (xx) 2000-01-21
HUP9903947A2 (hu) 2000-03-28
WO1998021234A2 (en) 1998-05-22
CZ166699A3 (cs) 1999-10-13
AU729459B2 (en) 2001-02-01
US6184360B1 (en) 2001-02-06
US6953844B2 (en) 2005-10-11
BR9713055A (pt) 2000-04-04
DE69738074T2 (de) 2008-05-21
IL129851A0 (en) 2000-02-29
ATE371670T1 (de) 2007-09-15
AU5444898A (en) 1998-06-03
ES2293662T3 (es) 2008-03-16

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