DE69716896T2 - Substituierte benzylamine-derivate und ihre verwendung zur behandlung von depression - Google Patents

Substituierte benzylamine-derivate und ihre verwendung zur behandlung von depression

Info

Publication number
DE69716896T2
DE69716896T2 DE69716896T DE69716896T DE69716896T2 DE 69716896 T2 DE69716896 T2 DE 69716896T2 DE 69716896 T DE69716896 T DE 69716896T DE 69716896 T DE69716896 T DE 69716896T DE 69716896 T2 DE69716896 T2 DE 69716896T2
Authority
DE
Germany
Prior art keywords
benzisoxazol
formula
solution
hydrogen
benzenemethanamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69716896T
Other languages
German (de)
English (en)
Other versions
DE69716896D1 (de
Inventor
Antonius Dijcks
Simon James Anthony Grove
Casimir Leysen
Theodorus Linders
Duncan Robertson Rae
Stephanus Ruigt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Application granted granted Critical
Publication of DE69716896D1 publication Critical patent/DE69716896D1/de
Publication of DE69716896T2 publication Critical patent/DE69716896T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
DE69716896T 1996-04-19 1997-04-15 Substituierte benzylamine-derivate und ihre verwendung zur behandlung von depression Expired - Lifetime DE69716896T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96201065 1996-04-19
PCT/EP1997/001904 WO1997040027A1 (en) 1996-04-19 1997-04-15 Substituted benzylamines and their use for the treatment of depression

Publications (2)

Publication Number Publication Date
DE69716896D1 DE69716896D1 (de) 2002-12-12
DE69716896T2 true DE69716896T2 (de) 2003-07-24

Family

ID=8223896

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69716896T Expired - Lifetime DE69716896T2 (de) 1996-04-19 1997-04-15 Substituierte benzylamine-derivate und ihre verwendung zur behandlung von depression

Country Status (24)

Country Link
EP (1) EP0898566B1 (enExample)
JP (1) JP4008033B2 (enExample)
CN (1) CN1139580C (enExample)
AR (1) AR006719A1 (enExample)
AT (1) ATE227278T1 (enExample)
AU (1) AU725847B2 (enExample)
BR (1) BR9708790A (enExample)
CA (1) CA2251820C (enExample)
CZ (1) CZ295747B6 (enExample)
DE (1) DE69716896T2 (enExample)
DK (1) DK0898566T3 (enExample)
ES (1) ES2186888T3 (enExample)
HU (1) HU224637B1 (enExample)
ID (1) ID17723A (enExample)
IL (1) IL120669A (enExample)
NO (1) NO311976B1 (enExample)
NZ (1) NZ332334A (enExample)
PL (1) PL192561B1 (enExample)
PT (1) PT898566E (enExample)
RU (1) RU2179553C2 (enExample)
TR (1) TR199802104T2 (enExample)
TW (1) TW498070B (enExample)
WO (1) WO1997040027A1 (enExample)
ZA (1) ZA973209B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6080773A (en) 1997-10-14 2000-06-27 Akzo Nobel, N.V. Benzylamine derivatives which are useful in treating psychiatric disorders
US6342533B1 (en) 1998-12-01 2002-01-29 Sepracor, Inc. Derivatives of (−)-venlafaxine and methods of preparing and using the same
US7253165B2 (en) 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
IL148622A0 (en) * 1999-09-14 2002-09-12 Aventis Pharm Prod Inc Benzisoxazolyl-pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as d4 antagonists
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
ATE421505T1 (de) * 2002-07-19 2009-02-15 Memory Pharmaceutical Corp 4-aminobenzofuranverbindungen als phosphodiesterase-4-inhibitoren
KR100742014B1 (ko) * 2003-08-14 2007-07-23 에프. 호프만-라 로슈 아게 Ｇａｂａ계 조절제
GB0321538D0 (en) 2003-09-13 2003-10-15 Glaxo Group Ltd Therapeutically useful compounds
JP5432526B2 (ja) * 2006-01-06 2014-03-05 サノビオン ファーマシューティカルズ インク モノアミン再取り込み阻害剤としてのシクロアルキルアミン
EP1925305A1 (en) * 2006-10-23 2008-05-28 N.V. Organon Ih channel inhibitors for the promotion of wakefulness
SA109310013B1 (ar) 2008-12-24 2013-07-28 Astrazeneca Ab مركبات إيثان أمين وطرق لتحضيرها
EP2473489B1 (en) 2009-07-07 2013-08-21 Merck Sharp & Dohme B.V. 2-(1,2-benzisoxazol-3-yl)benzylamine derivatives
CN102942464B (zh) * 2012-12-06 2015-04-08 西北师范大学 化合物1-(2-卤苯基)-3-甲基-丁酮-1的合成方法
CN112300061B (zh) * 2020-10-06 2022-02-18 大连理工大学 一种含氮杂环二芳酮化合物的制备方法
GB202103008D0 (en) 2021-03-03 2021-04-14 King S College London Compounds
GB202103012D0 (en) 2021-03-03 2021-04-14 King S College London Compounds
GB202103017D0 (en) 2021-03-03 2021-04-14 King S College London Compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4980365A (en) * 1987-07-13 1990-12-25 Hoechst-Roussel Pharmaceuticals Inc. N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents
FR2680366B1 (fr) * 1991-08-13 1995-01-20 Adir Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
DE69716896D1 (de) 2002-12-12
JP4008033B2 (ja) 2007-11-14
CN1139580C (zh) 2004-02-25
AU2387097A (en) 1997-11-12
ZA973209B (en) 1997-11-20
ES2186888T3 (es) 2003-05-16
NO984836D0 (no) 1998-10-16
RU2179553C2 (ru) 2002-02-20
CZ334998A3 (cs) 1999-06-16
HK1018271A1 (en) 1999-12-17
ID17723A (id) 1998-01-22
EP0898566A1 (en) 1999-03-03
HU224637B1 (hu) 2005-12-28
WO1997040027A1 (en) 1997-10-30
NZ332334A (en) 2000-06-23
NO311976B1 (no) 2002-02-25
CA2251820A1 (en) 1997-10-30
IL120669A0 (en) 1997-08-14
TR199802104T2 (xx) 2000-09-21
NO984836L (no) 1998-12-16
EP0898566B1 (en) 2002-11-06
HUP9901434A3 (en) 2001-11-28
HUP9901434A2 (hu) 1999-08-30
CA2251820C (en) 2007-03-27
PT898566E (pt) 2003-03-31
AU725847B2 (en) 2000-10-19
CZ295747B6 (cs) 2005-10-12
DK0898566T3 (da) 2003-03-03
IL120669A (en) 2001-04-30
JP2000508672A (ja) 2000-07-11
BR9708790A (pt) 1999-08-03
AR006719A1 (es) 1999-09-08
TW498070B (en) 2002-08-11
ATE227278T1 (de) 2002-11-15
CN1219169A (zh) 1999-06-09
PL192561B1 (pl) 2006-11-30
PL329348A1 (en) 1999-03-29

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