DE69434889D1 - An einer neuen Stelle von Rezeptorabhängigen Kalziumkanälen wirkende Verbindungen zur Behandlung von neurologischen Erkrankungen - Google Patents
An einer neuen Stelle von Rezeptorabhängigen Kalziumkanälen wirkende Verbindungen zur Behandlung von neurologischen ErkrankungenInfo
- Publication number
- DE69434889D1 DE69434889D1 DE69434889T DE69434889T DE69434889D1 DE 69434889 D1 DE69434889 D1 DE 69434889D1 DE 69434889 T DE69434889 T DE 69434889T DE 69434889 T DE69434889 T DE 69434889T DE 69434889 D1 DE69434889 D1 DE 69434889D1
- Authority
- DE
- Germany
- Prior art keywords
- receptor
- compound
- disease
- treatment
- neurological disorders
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 108090000312 Calcium Channels Proteins 0.000 title abstract 3
- 102000003922 Calcium Channels Human genes 0.000 title abstract 3
- 208000012902 Nervous system disease Diseases 0.000 title abstract 3
- 208000025966 Neurological disease Diseases 0.000 title abstract 2
- 230000001419 dependent effect Effects 0.000 title 1
- 102000003678 AMPA Receptors Human genes 0.000 abstract 1
- 108090000078 AMPA Receptors Proteins 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 108010009685 Cholinergic Receptors Proteins 0.000 abstract 1
- 206010019196 Head injury Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 abstract 1
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 102000034337 acetylcholine receptors Human genes 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- -1 analgesic Substances 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 150000003975 aryl alkyl amines Chemical class 0.000 abstract 1
- 229940125904 compound 1 Drugs 0.000 abstract 1
- 229940125782 compound 2 Drugs 0.000 abstract 1
- 229940126214 compound 3 Drugs 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 239000003193 general anesthetic agent Substances 0.000 abstract 1
- 229940005494 general anesthetics Drugs 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000036963 noncompetitive effect Effects 0.000 abstract 1
- 208000020431 spinal cord injury Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4462—Non condensed piperidines, e.g. piperocaine only substituted in position 3
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/22—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19421094A | 1994-02-08 | 1994-02-08 | |
US28866894A | 1994-08-09 | 1994-08-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69434889D1 true DE69434889D1 (de) | 2007-01-11 |
Family
ID=26889793
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69427168T Expired - Fee Related DE69427168T2 (de) | 1994-02-08 | 1994-10-26 | Verbindungen, die an eine neue Stelle auf Rezeptor - funktionierenden Kalziumkanalwirksam sind, zur Behandlung von neurologischen Erkrankungen |
DE69434889T Expired - Lifetime DE69434889D1 (de) | 1994-02-08 | 1994-10-26 | An einer neuen Stelle von Rezeptorabhängigen Kalziumkanälen wirkende Verbindungen zur Behandlung von neurologischen Erkrankungen |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69427168T Expired - Fee Related DE69427168T2 (de) | 1994-02-08 | 1994-10-26 | Verbindungen, die an eine neue Stelle auf Rezeptor - funktionierenden Kalziumkanalwirksam sind, zur Behandlung von neurologischen Erkrankungen |
Country Status (15)
Country | Link |
---|---|
US (1) | US6306912B1 (de) |
EP (3) | EP1749522A3 (de) |
JP (6) | JPH09509484A (de) |
KR (1) | KR100366745B1 (de) |
CN (1) | CN1088585C (de) |
AT (2) | ATE346595T1 (de) |
AU (1) | AU710575B2 (de) |
CA (1) | CA2182680A1 (de) |
DE (2) | DE69427168T2 (de) |
DK (1) | DK0743853T3 (de) |
ES (1) | ES2156162T3 (de) |
GR (1) | GR3036215T3 (de) |
PT (1) | PT743853E (de) |
RU (1) | RU2201224C2 (de) |
WO (1) | WO1995021612A2 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6750244B2 (en) | 1993-02-08 | 2004-06-15 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
US6071970A (en) * | 1993-02-08 | 2000-06-06 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
US7087765B2 (en) | 1995-06-07 | 2006-08-08 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
US6211245B1 (en) | 1993-02-08 | 2001-04-03 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
US6017965A (en) * | 1993-02-08 | 2000-01-25 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
EP1749522A3 (de) * | 1994-02-08 | 2010-10-27 | NPS Pharmaceuticals, Inc. | Verbindungen, die an eine neue Stelle auf Rezeptor - funktionierenden Kalziumkanal wirksam sind, zur Behandlung von neurologischen Erkrankungen |
DE4426245A1 (de) | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
GB9611584D0 (en) * | 1996-06-04 | 1996-08-07 | Univ Edinburgh | Neurotransmitters |
WO1997046511A1 (en) * | 1996-06-07 | 1997-12-11 | Nps Pharmaceuticals, Inc. | Coumpounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
WO1998056752A1 (en) * | 1997-06-11 | 1998-12-17 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
US6646149B1 (en) | 1997-07-15 | 2003-11-11 | Nicolaas M. J. Vermeulin | Polyamine analogues as therapeutic and diagnostic agents |
US7208528B1 (en) | 1997-07-15 | 2007-04-24 | Mediquest Therapeutics, Inc. | Polyamine analogues as therapeutic and diagnostic agents |
US6172261B1 (en) * | 1997-07-15 | 2001-01-09 | Oridigm Corporation | Polyamine analogues as therapeutic and diagnostic agents |
AU2003200048B2 (en) * | 1997-07-15 | 2005-12-15 | Mediquest Therapeutics, Inc. | Novel polyamine analogues as therapeutic and diagnostic agents |
JP2001525390A (ja) * | 1997-12-10 | 2001-12-11 | エヌピーエス ファーマシューティカルズ インコーポレーテッド | 抗痙攣薬および中枢神経系活性ビス(フルオロフェニル)アルキルアミド類 |
EP1640359A3 (de) * | 1997-12-10 | 2006-04-05 | Nps Pharmaceuticals, Inc. | Antikonvulsive und zns-aktive bis-fluoroalkylamide |
US5981168A (en) | 1998-05-15 | 1999-11-09 | The University Of British Columbia | Method and composition for modulating amyloidosis |
DE69935331T2 (de) * | 1998-07-13 | 2007-10-31 | NPS Pharmaceuticals, Inc., Salt Lake City | Verfahren und verbindungen zur behandlung der depression |
JP2002527414A (ja) | 1998-10-14 | 2002-08-27 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | 1,2−ジ置換シクロプロパン |
US6680332B1 (en) | 1999-06-04 | 2004-01-20 | Euro-Celtique S.A. | Substituted 5-oxo-5,6,7,8-tetrahydro-4H-1-benzopyrans and benzothiopyrans and the use thereof as potentiators of AMPA |
AU5318300A (en) * | 1999-06-04 | 2000-12-28 | Sui Xiong Cai | Substituted 5-oxo-5,6,7,8-tetrahydro-4h-1-benzopyrans and benzothiopyrans and the use thereof as potentiators of ampa |
USRE43327E1 (en) | 2001-01-08 | 2012-04-24 | Aminex Therapeutics, Inc. | Hydrophobic polyamine analogs and methods for their use |
CA2477604A1 (en) | 2002-03-13 | 2003-09-25 | Signum Biosciences, Inc. | Modulation of protein methylation and phosphoprotein phosphate |
WO2004093816A2 (en) * | 2003-04-22 | 2004-11-04 | Pharmacia Corporation | Compositions comprising a selective cox-2 inhibitor and a calcium modulating agent |
WO2004093813A2 (en) * | 2003-04-22 | 2004-11-04 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of pain, inflammation or inflammation mediated disorders |
EP1843734A4 (de) | 2005-02-03 | 2008-09-10 | Signum Biosciences Inc | Zusammensetzungen und verfahren zur intensivierung kognitiver funktionen |
US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
CN102014897B (zh) | 2008-04-21 | 2015-08-05 | 西格纳姆生物科学公司 | 化合物、组合物和其制备方法 |
CN101838235B (zh) * | 2009-06-12 | 2013-08-07 | 重庆华邦制药有限公司 | 3-苯基-3'-吡啶基丙烯胺类化合物及其合成方法 |
CN102267922B (zh) * | 2011-04-27 | 2014-11-19 | 中国人民解放军第三军医大学第一附属医院 | 一类多胺化合物及制备方法和用途 |
CN103394759B (zh) * | 2013-06-28 | 2016-09-21 | 南通恒鼎重型机床有限公司 | 一种管子旋槽机 |
US9840323B1 (en) | 2014-06-12 | 2017-12-12 | Kaiser Enterprises, Llc | Drone aircraft |
WO2017109709A2 (en) | 2015-12-22 | 2017-06-29 | Novartis Ag | A high-throughput assay method for identifying allosteric nmda receptor modulators |
HUE052620T2 (hu) | 2016-03-25 | 2021-05-28 | Aminex Therapeutics Inc | Biológiailag hozzáférhetõ poliaminok |
CN107056657B (zh) * | 2017-05-22 | 2019-04-26 | 湖南师范大学 | 一种昆虫特异性多胺类小分子毒素、其纯化方法及其应用 |
CN107311891B (zh) * | 2017-06-08 | 2019-08-06 | 山东一航新材料科技有限公司 | 一种亚胺类除水剂的制备方法 |
KR20220025810A (ko) * | 2019-06-26 | 2022-03-03 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 스미스-마제니스 증후군을 치료하기 위한 방법 및 조성물 |
US11358971B2 (en) | 2019-07-03 | 2022-06-14 | H. Lundbeck A/S | Prodrugs of modulators of the NMDA receptor |
US11466027B2 (en) | 2019-07-03 | 2022-10-11 | H. Lundbeck A/S | Modulators of the NMDA receptor |
CN111100097A (zh) * | 2019-12-04 | 2020-05-05 | 中国科学院高能物理研究所 | 二芳基甲烷类化合物及其制备方法 |
CA3193185A1 (en) | 2020-09-30 | 2022-04-07 | Mark R. Burns | Combination drug substance of polyamine transport inhibitor and dfmo |
WO2022108507A1 (en) * | 2020-11-19 | 2022-05-27 | Weifeng Lin | Chemoselective probes and uses thereof |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL300541A (de) * | ||||
DE33285C (de) | G. HAMBRUCH in Berlin W., Behrenstr. 21 | Neuerungen an Schmiervorrichtungen | ||
GB191515827A (de) * | 1915-11-09 | 1916-10-19 | ||
DE1051281B (de) | 1955-07-05 | 1959-02-26 | Bayer Ag | Verfahren zur Herstellung von Derivaten der 1-Aryl-3-aminopropan-1-ole |
DE1099669B (de) * | 1958-07-31 | 1961-02-16 | Bayer Ag | Verfahren zur Herstellung von sauren Farbstoffen der Anthrachinonreihe |
DD33285A1 (de) * | 1963-02-16 | 1964-12-05 | ||
US3466236A (en) * | 1965-11-09 | 1969-09-09 | Eastman Kodak Co | Irradiation of aminocyclobutanones |
US3372193A (en) | 1966-06-01 | 1968-03-05 | Upjohn Co | 1, 1-diaryl-2-methyl-3-(benzylidene-amino) propan-(1)-ols |
GB1169944A (en) | 1966-08-25 | 1969-11-05 | Geistlich Soehne Ag | Novel 3,3-Diphenylpropylamines and processes for the preparation thereof |
FR2424253A1 (fr) | 1978-04-27 | 1979-11-23 | Brun Lab Sa Le | Nouveaux derives de peptides analogues des enkephalines, leur procede de preparation et leur application therapeutique |
DE3414240A1 (de) * | 1984-04-14 | 1985-10-17 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von polyphenylenethern |
EP0208523A3 (de) * | 1985-07-08 | 1989-04-26 | Peter Norman Russell Usherwood | Glutamatantagonisten |
DK258389D0 (da) | 1989-05-26 | 1989-05-26 | Ferrosan As | Aryloxyphenylpropylaminer, deres fremstilling og anvendelse |
US5037846A (en) * | 1990-01-02 | 1991-08-06 | Pfizer Inc. | Indolyl-3 polyamines and their use as antagonists of excitatory amino acid neurotransmitters |
US5312928A (en) | 1991-02-11 | 1994-05-17 | Cambridge Neuroscience | Calcium channel antagonists and methodology for their identification |
HU9400503D0 (en) * | 1991-08-23 | 1994-05-30 | Pfizer | Synthetic aryl polyamines as excitatory amino acid neurotransmitter antagonists |
US5185369A (en) * | 1991-08-23 | 1993-02-09 | Pfizer Inc. | Synthetic heteroaryl polyamines as excitatory amino acid neurotransmitter antagonists |
WO1993004373A1 (en) * | 1991-08-23 | 1993-03-04 | Nps Pharmaceuticals, Inc. | Calcium receptor active molecules |
DE4239816A1 (de) * | 1992-11-26 | 1994-06-01 | Inst Bioanalytik Ggmbh | Arzneimittel zur Behandlung des zentralen Nervensystems |
EP1749522A3 (de) * | 1994-02-08 | 2010-10-27 | NPS Pharmaceuticals, Inc. | Verbindungen, die an eine neue Stelle auf Rezeptor - funktionierenden Kalziumkanal wirksam sind, zur Behandlung von neurologischen Erkrankungen |
DE4426245A1 (de) * | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
-
1994
- 1994-10-26 EP EP06024225A patent/EP1749522A3/de not_active Ceased
- 1994-10-26 AU AU80923/94A patent/AU710575B2/en not_active Ceased
- 1994-10-26 DE DE69427168T patent/DE69427168T2/de not_active Expired - Fee Related
- 1994-10-26 ES ES94932057T patent/ES2156162T3/es not_active Expired - Lifetime
- 1994-10-26 JP JP7521191A patent/JPH09509484A/ja active Pending
- 1994-10-26 DE DE69434889T patent/DE69434889D1/de not_active Expired - Lifetime
- 1994-10-26 PT PT94932057T patent/PT743853E/pt unknown
- 1994-10-26 WO PCT/US1994/012293 patent/WO1995021612A2/en active IP Right Grant
- 1994-10-26 EP EP00121960A patent/EP1123922B1/de not_active Expired - Lifetime
- 1994-10-26 AT AT00121960T patent/ATE346595T1/de not_active IP Right Cessation
- 1994-10-26 CN CN94195074A patent/CN1088585C/zh not_active Expired - Fee Related
- 1994-10-26 DK DK94932057T patent/DK0743853T3/da active
- 1994-10-26 AT AT94932057T patent/ATE200862T1/de not_active IP Right Cessation
- 1994-10-26 RU RU96118132/14A patent/RU2201224C2/ru not_active IP Right Cessation
- 1994-10-26 KR KR1019960704290A patent/KR100366745B1/ko not_active IP Right Cessation
- 1994-10-26 EP EP94932057A patent/EP0743853B1/de not_active Expired - Lifetime
- 1994-10-26 CA CA002182680A patent/CA2182680A1/en not_active Abandoned
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1995
- 1995-06-07 US US08/483,294 patent/US6306912B1/en not_active Expired - Fee Related
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2001
- 2001-07-13 GR GR20010401066T patent/GR3036215T3/el not_active IP Right Cessation
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2003
- 2003-06-03 JP JP2003158350A patent/JP2004002437A/ja active Pending
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2007
- 2007-07-19 JP JP2007188835A patent/JP2007314556A/ja active Pending
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2008
- 2008-12-25 JP JP2008331256A patent/JP2009143927A/ja active Pending
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2012
- 2012-01-05 JP JP2012000548A patent/JP2012102130A/ja active Pending
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2014
- 2014-01-16 JP JP2014005535A patent/JP2014166987A/ja active Pending
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Publication number | Publication date |
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EP0743853B1 (de) | 2001-05-02 |
EP0743853A1 (de) | 1996-11-27 |
DE69427168T2 (de) | 2002-01-24 |
CN1088585C (zh) | 2002-08-07 |
EP1123922A2 (de) | 2001-08-16 |
US6306912B1 (en) | 2001-10-23 |
DE69427168D1 (de) | 2001-06-07 |
JP2014166987A (ja) | 2014-09-11 |
JP2004002437A (ja) | 2004-01-08 |
ATE200862T1 (de) | 2001-05-15 |
EP1123922A3 (de) | 2004-01-02 |
JP2009143927A (ja) | 2009-07-02 |
JPH09509484A (ja) | 1997-09-22 |
WO1995021612A3 (en) | 1995-09-21 |
EP1749522A2 (de) | 2007-02-07 |
EP1123922B1 (de) | 2006-11-29 |
JP2012102130A (ja) | 2012-05-31 |
GR3036215T3 (en) | 2001-10-31 |
JP2007314556A (ja) | 2007-12-06 |
ATE346595T1 (de) | 2006-12-15 |
EP1749522A3 (de) | 2010-10-27 |
RU2201224C2 (ru) | 2003-03-27 |
ES2156162T3 (es) | 2001-06-16 |
PT743853E (pt) | 2001-10-31 |
CN1148337A (zh) | 1997-04-23 |
WO1995021612A2 (en) | 1995-08-17 |
CA2182680A1 (en) | 1995-08-17 |
AU8092394A (en) | 1995-08-29 |
AU710575B2 (en) | 1999-09-23 |
KR100366745B1 (ko) | 2003-04-18 |
DK0743853T3 (da) | 2001-07-16 |
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