TNSN88096A1 - Nouveau n-(1-alkyl-3-hydroxy-4-piperidyl) - Google Patents

Nouveau n-(1-alkyl-3-hydroxy-4-piperidyl)

Info

Publication number
TNSN88096A1
TNSN88096A1 TNTNSN88096A TNSN88096A TNSN88096A1 TN SN88096 A1 TNSN88096 A1 TN SN88096A1 TN TNSN88096 A TNTNSN88096 A TN TNSN88096A TN SN88096 A TNSN88096 A TN SN88096A TN SN88096 A1 TNSN88096 A1 TN SN88096A1
Authority
TN
Tunisia
Prior art keywords
hydroxy
alkyl
compounds
piperidyl
new
Prior art date
Application number
TNTNSN88096A
Other languages
English (en)
Inventor
Henri Paul Van Daele Georges
Francois Vlaeminck Freddy
Anna Jozef De Cleyn Michel
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of TNSN88096A1 publication Critical patent/TNSN88096A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Abstract

L'INVENTION CONCERNE DES N-(1-ALKYL-3- HYDROXY-4-PIPERIDYL) BENZAMIDES SUBSTITUES, LES N-OXYDES, LES SELS D'ADDITION D'ACIDES CONVENANT EN PHARMACIE ET LES FORMES ISOMERES STEREOCHIMIQUES CORRESPONDANTS QUI SONT UTILES COMME MEDICAMENTS, NOTAMMENT POUR STIMULER LA MOTILITE DU SYSTEME GASTRO-INTESTINAL, UN PROCEDE POUR LEUR PREPARATION ET UN PROCEDE DE TRAITEMENT D'ANIMAUX A SANG CHAUD ATTEINTS DE TROUBLES DE LA MOTILITE DU SYSTEME GASTRO- INTESTINAL LES UTILISANT
TNTNSN88096A 1987-09-25 1988-09-23 Nouveau n-(1-alkyl-3-hydroxy-4-piperidyl) TNSN88096A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10111587A 1987-09-25 1987-09-25

Publications (1)

Publication Number Publication Date
TNSN88096A1 true TNSN88096A1 (fr) 1990-07-10

Family

ID=22283104

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN88096A TNSN88096A1 (fr) 1987-09-25 1988-09-23 Nouveau n-(1-alkyl-3-hydroxy-4-piperidyl)

Country Status (24)

Country Link
EP (1) EP0309043B1 (fr)
JP (1) JP2830936B2 (fr)
KR (1) KR0124054B1 (fr)
CN (2) CN1021652C (fr)
AT (1) ATE113936T1 (fr)
AU (1) AU610241B2 (fr)
BG (1) BG60560B1 (fr)
CA (1) CA1317940C (fr)
DE (1) DE3852085T2 (fr)
DK (1) DK529888A (fr)
ES (1) ES2066781T3 (fr)
FI (1) FI94129C (fr)
GR (1) GR3014972T3 (fr)
HU (1) HU203724B (fr)
IE (1) IE64980B1 (fr)
IL (1) IL87847A0 (fr)
MA (1) MA21381A1 (fr)
NO (1) NO172580C (fr)
NZ (1) NZ226125A (fr)
PH (1) PH25504A (fr)
PT (1) PT88577B (fr)
SU (1) SU1625331A3 (fr)
TN (1) TNSN88096A1 (fr)
ZA (1) ZA887157B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ225152A (en) * 1987-07-17 1990-04-26 Janssen Pharmaceutica Nv Heterocyclically substituted piperidinyl benzamides as pharmaceuticals
US5019583A (en) * 1989-02-15 1991-05-28 Glaxo Inc. N-phenyl-N-(4-piperidinyl)amides useful as analgesics
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en) 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
US5438064A (en) * 1991-12-23 1995-08-01 American Home Products Corporation Derivatives of 4-anilinoquinoline-3-carboxamide as analgesic agents
TW294595B (fr) * 1992-11-20 1997-01-01 Janssen Pharmaceutica Nv
JP3719612B2 (ja) * 1993-06-14 2005-11-24 塩野義製薬株式会社 ヘテロ環を含有する尿素誘導体
PT784620E (pt) * 1994-09-27 2000-05-31 Janssen Pharmaceutica Nv Derivados de banzoato biciclicos de piperidinilo n-substituido
WO1996010026A1 (fr) * 1994-09-27 1996-04-04 Janssen Pharmaceutica N.V. Derives benzoates bicycliques de phenyl-oxo-alkyl-(4-piperidinyle)
NZ330263A (en) * 1996-02-15 1999-06-29 Janssen Pharmaceutica Nv Esters of 3-hydroxy-piperidinemethanol derivatives to improve gastric emptying
US6096761A (en) * 1996-02-15 2000-08-01 Janssen Pharmaceutica N.V. Esters of 3-hydroxy-piperidinemethanol derivatives
TW402591B (en) * 1997-07-11 2000-08-21 Janssen Pharmaceutica Nv Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
CN1076173C (zh) * 1998-05-29 2001-12-19 孙国文 香身茶剂
TW570920B (en) * 1998-12-22 2004-01-11 Janssen Pharmaceutica Nv 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
JP4584534B2 (ja) * 2000-06-07 2010-11-24 アリックス セラピューティクス 胃食道逆流性疾患の治療のための材料
GB0211230D0 (en) 2002-05-16 2002-06-26 Medinnova Sf Treatment of heart failure
US8138204B2 (en) 2004-01-07 2012-03-20 Aryx Therapeutics, Inc. Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders
US8524736B2 (en) 2004-01-07 2013-09-03 Armetheon, Inc. Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders
DE602005020580D1 (de) * 2004-01-07 2010-05-27 Aryx Therapeutics Stereoisomere verbindungen und verfahren zur behandlung von erkrankungen des magen-darm-trakts und des zentralen nervensystems
MY150958A (en) * 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
CA2620379C (fr) 2005-08-31 2015-02-24 Aryx Therapeutics, Inc. Methodes synthetiques et intermediaires de composes stereoisomeres utiles dans le traitement des troubles gastro-intestinaux et du systeme nerveux central
US20080085915A1 (en) * 2006-06-23 2008-04-10 Cyrus Becker Compounds and methods for the treatment of gastrointestinal and central nervous system disorders
KR100976063B1 (ko) * 2007-03-16 2010-08-17 동아제약주식회사 신규한 벤즈아미드 유도체 화합물 및 그의 제조방법
WO2010114894A1 (fr) 2009-03-31 2010-10-07 Arqule, Inc. Composés hétérocycliques substitués
JP5845263B2 (ja) * 2010-09-01 2016-01-20 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ ５−ｈｔ２ｂ受容体アンタゴニスト

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1183847A (fr) * 1981-10-01 1985-03-12 Georges Van Daele N-(3-hydroxy-4-piperidinyl)benzamide; derives
US4634704A (en) * 1983-10-06 1987-01-06 Janssen Pharmaceutica, N.V. Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
ZW12187A1 (en) * 1986-07-03 1989-02-01 Janssen Pharmaceutica Nv 4-(aroylamino)piperidinebutanamide derivatives
NZ225152A (en) * 1987-07-17 1990-04-26 Janssen Pharmaceutica Nv Heterocyclically substituted piperidinyl benzamides as pharmaceuticals

Also Published As

Publication number Publication date
DK529888D0 (da) 1988-09-23
GR3014972T3 (en) 1995-05-31
HUT48589A (en) 1989-06-28
EP0309043B1 (fr) 1994-11-09
ATE113936T1 (de) 1994-11-15
AU2232288A (en) 1989-04-06
NO884208L (no) 1989-03-28
FI94129C (fi) 1995-07-25
FI884375A0 (fi) 1988-09-23
NO172580B (no) 1993-05-03
MA21381A1 (fr) 1989-04-01
KR890005053A (ko) 1989-05-11
CA1317940C (fr) 1993-05-18
PT88577B (pt) 1992-11-30
CN1067889A (zh) 1993-01-13
EP0309043A3 (en) 1990-08-08
AU610241B2 (en) 1991-05-16
FI884375A (fi) 1989-03-26
DK529888A (da) 1989-03-26
DE3852085D1 (de) 1994-12-15
HU203724B (en) 1991-09-30
KR0124054B1 (ko) 1997-11-27
CN1021652C (zh) 1993-07-21
NZ226125A (en) 1990-05-28
ES2066781T3 (es) 1995-03-16
BG60560B1 (bg) 1995-08-28
NO884208D0 (no) 1988-09-22
NO172580C (no) 1993-08-11
CN1032438A (zh) 1989-04-19
ZA887157B (en) 1990-05-30
EP0309043A2 (fr) 1989-03-29
FI94129B (fi) 1995-04-13
JP2830936B2 (ja) 1998-12-02
PH25504A (en) 1991-07-24
IE64980B1 (en) 1995-09-20
IL87847A0 (en) 1989-03-31
DE3852085T2 (de) 1995-04-06
PT88577A (pt) 1988-10-01
SU1625331A3 (ru) 1991-01-30
JPH01128968A (ja) 1989-05-22
IE882889L (en) 1989-03-25

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Publication Publication Date Title
TNSN88096A1 (fr) Nouveau n-(1-alkyl-3-hydroxy-4-piperidyl)
DK0389037T3 (da) N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran eller dihydrobenzodioxin)-carboxamidderivater
FI823348A0 (fi) Nya n-(3-hydroxy-4-piperidinyl)benzamid-derivat