ES8702910A1 - Procedimiento para la obtencion de benzodiazepinas. - Google Patents
Procedimiento para la obtencion de benzodiazepinas.Info
- Publication number
- ES8702910A1 ES8702910A1 ES546378A ES546378A ES8702910A1 ES 8702910 A1 ES8702910 A1 ES 8702910A1 ES 546378 A ES546378 A ES 546378A ES 546378 A ES546378 A ES 546378A ES 8702910 A1 ES8702910 A1 ES 8702910A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- benzodiazepines
- treatment
- disorders
- amnesia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE BENZODIAZEPINAS, DE FORMULA (I). COMPRENDE LA REACCION DE CICLACION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), PARA FORMAR UNA COMPUESTO DE FORMULA (I), EN LA QUE R1 Y R2 FORMAN UN ENLACE, R3 Y R4 REPRESENTAN HIDROGENO, R, R5 Y R6 PUEDEN SER VARIOS RADICALES, Y N VALE 1-3. LA CICLACION SE LLEVA A CABO POR CALENTAMIENTO A UNA TEMPERATURA COMPRENDIDA ENTRE 130JC Y 230JC, EN UN DISOLVENTE INERTE DE ELEVADO PUNTO DE EBULLICION. R3 PUEDE SER TAMBIEN UN GRUPO PROTECTOR Y R1 Y R2 GRUPOS ALQUILO, EN CUYO CASO EL COMPUESTO OBTENIDO SE PUEDE ALQUILAR. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE TRASTORNOS CEREBRALES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843431195 DE3431195A1 (de) | 1984-08-24 | 1984-08-24 | Neue benzodiazepine, verfahren zu ihrer herstellung sowie ihre verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES546378A0 ES546378A0 (es) | 1987-01-16 |
| ES8702910A1 true ES8702910A1 (es) | 1987-01-16 |
Family
ID=6243820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES546378A Expired ES8702910A1 (es) | 1984-08-24 | 1985-08-23 | Procedimiento para la obtencion de benzodiazepinas. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4647560A (es) |
| EP (1) | EP0172526B1 (es) |
| JP (1) | JPS6157582A (es) |
| KR (1) | KR920000763B1 (es) |
| AT (1) | ATE46905T1 (es) |
| AU (1) | AU574216B2 (es) |
| CA (1) | CA1249269A (es) |
| DE (2) | DE3431195A1 (es) |
| DK (1) | DK384585A (es) |
| ES (1) | ES8702910A1 (es) |
| FI (1) | FI79315C (es) |
| GR (1) | GR852035B (es) |
| HU (1) | HU201933B (es) |
| IL (1) | IL76153A0 (es) |
| NO (1) | NO161494C (es) |
| NZ (1) | NZ213186A (es) |
| PH (1) | PH23803A (es) |
| PT (1) | PT81003B (es) |
| ZA (1) | ZA856409B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4957915A (en) * | 1989-02-27 | 1990-09-18 | Biomeasure, Inc. | Benzodiazepine analogs |
| EP0698015A1 (en) * | 1993-05-14 | 1996-02-28 | Genentech, Inc. | Preparation of n-cyanodithioimino-carbonates and 3-mercapto-5-amino-1h-1,2,4-triazole |
| CA2469879A1 (en) * | 2001-12-14 | 2003-06-26 | Merck & Co. Inc. | A novel sordarin derivative isolated from culture fermentations and functions as an antifungal agent |
| WO2004067008A1 (ja) * | 2003-01-28 | 2004-08-12 | Takeda Pharmaceutical Company Limited | 受容体作動薬 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3998811A (en) * | 1971-03-17 | 1976-12-21 | Crc Compagnia Di Recerca Chimica S.A. | Optically active 1,4-benzodiazepines and process for the preparation thereof |
| HU171033B (hu) * | 1974-05-29 | 1977-10-28 | Richter Gedeon Vegyeszet | Sposob poluchenija proizvodnykh benzodiazepina |
| CA1157855A (en) * | 1980-07-31 | 1983-11-29 | Albert E. Fischli | Benzodiazepine derivatives |
| HUT36793A (en) * | 1983-06-27 | 1985-10-28 | Sandoz Ag | Process for producing new spirosuccunimide derivatives and pharmaceutical composition containing them |
-
1984
- 1984-08-24 DE DE19843431195 patent/DE3431195A1/de not_active Withdrawn
-
1985
- 1985-08-05 NO NO853089A patent/NO161494C/no unknown
- 1985-08-08 US US06/763,746 patent/US4647560A/en not_active Expired - Fee Related
- 1985-08-14 DE DE8585110191T patent/DE3573425D1/de not_active Expired
- 1985-08-14 EP EP85110191A patent/EP0172526B1/de not_active Expired
- 1985-08-14 AT AT85110191T patent/ATE46905T1/de not_active IP Right Cessation
- 1985-08-21 PH PH32676A patent/PH23803A/en unknown
- 1985-08-21 IL IL76153A patent/IL76153A0/xx not_active IP Right Cessation
- 1985-08-21 NZ NZ213186A patent/NZ213186A/en unknown
- 1985-08-22 PT PT81003A patent/PT81003B/pt not_active IP Right Cessation
- 1985-08-22 FI FI853229A patent/FI79315C/fi not_active IP Right Cessation
- 1985-08-22 CA CA000489254A patent/CA1249269A/en not_active Expired
- 1985-08-22 GR GR852035A patent/GR852035B/el unknown
- 1985-08-22 AU AU46574/85A patent/AU574216B2/en not_active Ceased
- 1985-08-23 DK DK384585A patent/DK384585A/da not_active Application Discontinuation
- 1985-08-23 HU HU853222A patent/HU201933B/hu not_active IP Right Cessation
- 1985-08-23 JP JP60184317A patent/JPS6157582A/ja active Granted
- 1985-08-23 ZA ZA856409A patent/ZA856409B/xx unknown
- 1985-08-23 KR KR1019850006080A patent/KR920000763B1/ko not_active IP Right Cessation
- 1985-08-23 ES ES546378A patent/ES8702910A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6157582A (ja) | 1986-03-24 |
| DK384585A (da) | 1986-02-25 |
| NZ213186A (en) | 1988-04-29 |
| ZA856409B (en) | 1986-04-30 |
| EP0172526A1 (de) | 1986-02-26 |
| PT81003B (pt) | 1987-12-30 |
| FI853229L (fi) | 1986-02-25 |
| CA1249269A (en) | 1989-01-24 |
| FI79315B (fi) | 1989-08-31 |
| PT81003A (en) | 1985-09-01 |
| ES546378A0 (es) | 1987-01-16 |
| PH23803A (en) | 1989-11-03 |
| JPH0378868B2 (es) | 1991-12-17 |
| KR860001812A (ko) | 1986-03-22 |
| EP0172526B1 (de) | 1989-10-04 |
| FI853229A0 (fi) | 1985-08-22 |
| HU201933B (en) | 1991-01-28 |
| NO161494C (no) | 1989-08-23 |
| DE3431195A1 (de) | 1986-03-06 |
| DK384585D0 (da) | 1985-08-23 |
| FI79315C (fi) | 1989-12-11 |
| HUT39449A (en) | 1986-09-29 |
| US4647560A (en) | 1987-03-03 |
| GR852035B (es) | 1985-12-18 |
| ATE46905T1 (de) | 1989-10-15 |
| IL76153A0 (en) | 1985-12-31 |
| DE3573425D1 (en) | 1989-11-09 |
| NO853089L (no) | 1986-02-25 |
| NO161494B (no) | 1989-05-16 |
| KR920000763B1 (ko) | 1992-01-21 |
| AU574216B2 (en) | 1988-06-30 |
| AU4657485A (en) | 1986-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970401 |