DE69408550T2 - Enantioselektieve Synthese von Thieno 2,3-b thiopyran-7,7-dioxid-Derivaten - Google Patents

Enantioselektieve Synthese von Thieno 2,3-b thiopyran-7,7-dioxid-Derivaten

Info

Publication number
DE69408550T2
DE69408550T2 DE69408550T DE69408550T DE69408550T2 DE 69408550 T2 DE69408550 T2 DE 69408550T2 DE 69408550 T DE69408550 T DE 69408550T DE 69408550 T DE69408550 T DE 69408550T DE 69408550 T2 DE69408550 T2 DE 69408550T2
Authority
DE
Germany
Prior art keywords
compound
acid
mixture
treating
cake
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69408550T
Other languages
German (de)
English (en)
Other versions
DE69408550D1 (de
Inventor
Thomas J. Clark Nj 07066 Blacklock
David J. Skillman Nj 08558 Mathre
Paul Warren Nj 07060 Sohar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE69408550D1 publication Critical patent/DE69408550D1/de
Application granted granted Critical
Publication of DE69408550T2 publication Critical patent/DE69408550T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Seasonings (AREA)
DE69408550T 1993-03-22 1994-03-17 Enantioselektieve Synthese von Thieno 2,3-b thiopyran-7,7-dioxid-Derivaten Expired - Lifetime DE69408550T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3552393A 1993-03-22 1993-03-22
US19588694A 1994-02-10 1994-02-10

Publications (2)

Publication Number Publication Date
DE69408550D1 DE69408550D1 (de) 1998-03-26
DE69408550T2 true DE69408550T2 (de) 1998-08-27

Family

ID=26712200

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69408550T Expired - Lifetime DE69408550T2 (de) 1993-03-22 1994-03-17 Enantioselektieve Synthese von Thieno 2,3-b thiopyran-7,7-dioxid-Derivaten

Country Status (28)

Country Link
US (1) US5688968A (enExample)
EP (1) EP0617037B1 (enExample)
JP (1) JP3273096B2 (enExample)
KR (1) KR0157162B1 (enExample)
CN (1) CN1046732C (enExample)
AT (1) ATE163291T1 (enExample)
AU (1) AU673409B2 (enExample)
BR (1) BR9406017A (enExample)
CA (1) CA2119218C (enExample)
CY (1) CY2108B1 (enExample)
CZ (1) CZ281390B6 (enExample)
DE (1) DE69408550T2 (enExample)
DK (1) DK0617037T3 (enExample)
ES (1) ES2112482T3 (enExample)
FI (1) FI107384B (enExample)
GR (1) GR3026178T3 (enExample)
HR (1) HRP940182B1 (enExample)
HU (1) HU217363B (enExample)
NO (1) NO313240B1 (enExample)
NZ (1) NZ263092A (enExample)
PL (1) PL176373B1 (enExample)
RO (1) RO115264B1 (enExample)
SI (1) SI9420016B (enExample)
SK (1) SK280831B6 (enExample)
TW (1) TW265343B (enExample)
UA (1) UA41921C2 (enExample)
WO (1) WO1994021645A1 (enExample)
YU (1) YU48951B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760249A (en) * 1995-08-29 1998-06-02 Merck & Co., Inc. Synthesis of hydroxysulfone and related compounds
ES2177415B1 (es) * 2000-09-04 2004-10-16 Ragactives, S.L. Procedimiento para la obtencion de 4-alquilamino-5, 6-dihidro-4h-tieno-(2,3b)-tiopiran-2-sulfonamida-7-dioxidos, e intermedios.
ES2204306B1 (es) * 2002-08-16 2005-08-01 Ragactives, S.L. Formas polimorficas de clorhidrato de dorzolamida, su obtencion y composiciones farmaceuticas que las contienen.
AU2003242982A1 (en) * 2003-04-07 2004-11-01 Hetero Drugs Limited A novel crystalline form of dorzolamide hydrochloride
AU2005290855B2 (en) * 2004-07-09 2010-08-19 Fdc Ltd An improved process for the preparation of 5,6 -dihydro -4H-4(S)-ethylamino-6(S)-methylthieno[2,3-b] thiopyran-2-sulfonamide- 7,7 -dioxide and its salt
ES2253112B1 (es) * 2004-11-05 2007-03-16 Ragactives, S.L. Procedimiento para la obtencion de derivados de 4-(n-alquilamino)-5, 6-dihidro-4h-tieno-(2,3-b)-tiopirano.
US7109353B2 (en) 2004-12-28 2006-09-19 Council Of Scientific And Industrial Research Process for preparing 5,6-dihydro-4-(S)-(ethylamino)-6-(S) methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide HCl
WO2006070387A1 (en) * 2004-12-28 2006-07-06 Council Of Scientific And Industrial Research PROCESS FOR PREPARING 5,6-DIHYDRO-4-(S)-(ETHYLAMINO)-6-(S) METHYL-4H-THIENO[2,3b]THIOPYRAN-2-SULPHONAMIDE-7,7-DIOXIDE HCI
EP1753769A2 (en) * 2005-01-06 2007-02-21 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method of making dorzolamide hydrochloride
US20060173068A1 (en) * 2005-01-18 2006-08-03 Judith Aronhime Amorphous and crystalline forms of dorzolamide hydrochloride and processes of making same
CA2685413A1 (en) * 2007-05-07 2008-11-13 Cipla Limited Process for preparing dorzolamide
BR112013023130B1 (pt) 2011-03-10 2020-02-18 F.I.S. - Fabbrica Italiana Sintetici S.P.A. Processo de redução assimétrica
ITMI20121165A1 (it) * 2012-07-03 2014-01-04 Zach System Spa Processo di riduzione asimmetrica
JP2016536295A (ja) * 2013-10-17 2016-11-24 ダウ アグロサイエンシィズ エルエルシー 有害生物防除性化合物の製造方法
US9102655B2 (en) * 2013-10-17 2015-08-11 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
CN103497202B (zh) * 2013-10-23 2015-12-02 武汉武药科技有限公司 盐酸多佐胺中间体的合成方法
CN108822127B (zh) * 2018-05-30 2020-05-15 沈阳药科大学 4-羟亚胺基噻吩并[2,3-b]噻喃-2-甲酰胺类化合物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863922A (en) * 1984-12-12 1989-09-05 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use
US4797413A (en) * 1986-05-14 1989-01-10 Merck & Co., Inc. Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use
US4968814A (en) * 1990-04-18 1990-11-06 Merck & Co., Inc. (S)-Alkyl 3-(thien-2-ylthio)butyrate and analogs and synthesis thereof
US5091409A (en) * 1990-05-17 1992-02-25 Merck & Co., Inc. 4-alkylamino-6-(C3-5 -hydrocarbyl)thieno[2,3-B]thiopyran-2-sulfonamide-7,7-dioxides

Also Published As

Publication number Publication date
PL176373B1 (pl) 1999-05-31
CN1046732C (zh) 1999-11-24
SK116995A3 (en) 1997-06-04
YU48951B (sh) 2003-01-31
HRP940182B1 (en) 2000-02-29
SI9420016A (en) 1996-06-30
NZ263092A (en) 1997-12-19
HU217363B (hu) 2000-01-28
CY2108B1 (en) 2002-04-26
HK1009063A1 (en) 1999-05-21
RO115264B1 (ro) 1999-12-30
HRP940182A2 (en) 1996-08-31
NO953733L (no) 1995-09-21
SI9420016B (sl) 2002-12-31
ES2112482T3 (es) 1998-04-01
EP0617037B1 (en) 1998-02-18
DE69408550D1 (de) 1998-03-26
WO1994021645A1 (en) 1994-09-29
NO313240B1 (no) 2002-09-02
UA41921C2 (uk) 2001-10-15
US5688968A (en) 1997-11-18
FI107384B (fi) 2001-07-31
YU13194A (sh) 1997-01-08
JPH06298767A (ja) 1994-10-25
DK0617037T3 (da) 1998-03-16
PL310633A1 (en) 1995-12-27
AU5787194A (en) 1994-09-29
AU673409B2 (en) 1996-11-07
HU9502772D0 (en) 1995-11-28
CZ281390B6 (cs) 1996-09-11
FI954438L (fi) 1995-09-20
EP0617037A1 (en) 1994-09-28
CA2119218A1 (en) 1994-09-23
SK280831B6 (sk) 2000-08-14
NO953733D0 (no) 1995-09-21
HUT72676A (en) 1996-05-28
CZ241895A3 (en) 1996-01-17
CA2119218C (en) 2000-02-15
GR3026178T3 (en) 1998-05-29
BR9406017A (pt) 1995-12-19
KR0157162B1 (ko) 1998-11-16
CN1119866A (zh) 1996-04-03
JP3273096B2 (ja) 2002-04-08
ATE163291T1 (de) 1998-03-15
FI954438A0 (fi) 1995-09-20
TW265343B (enExample) 1995-12-11

Similar Documents

Publication Publication Date Title
DE69408550T2 (de) Enantioselektieve Synthese von Thieno 2,3-b thiopyran-7,7-dioxid-Derivaten
DE3879292T2 (de) Substituierte aromatische sulfonamide als mittel gegen glaukom.
DE69803176T2 (de) Verfahren zur herstellung von einer pharmacologisch aktiven substanz
DE60217062T2 (de) Verfahren zur herstellung von clopidogrel
EP0352613B1 (de) Substituierte Aminomethyltetraline sowie ihre heterocyclischen Analoga
DE3851114T2 (de) Trizyklische Verbindungen.
WO2000035872A1 (de) Verfahren zur herstellung von 3-alkanoyl- und 3-alkylindolen
EP0496238A1 (de) Substituierte Benzoxazepine und Benzthiazepine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln
CH670644A5 (enExample)
DE69126814T2 (de) Substituierte aromatische Sulfonamide als Mittel gegen Glaukom
DE69131657T2 (de) Verfahren zur industriellen Herstellung von 4-Chloro-3-sulfamoyl-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)-Benzamid
DE60316047T2 (de) Verfahren zur Herstellung von Olanzapine und ein Zwischenprodukt dafür
DE69302544T2 (de) 2-amino-1,2,3,4-tetrahydronaphthalen derivate mit wirkung auf das kardiovasculäre system, verfahren zu deren herstellung und deren pharmazeutische zusammensetzungen
AT411996B (de) Verfahren zur herstellung von cefuroxim in der form seines n-butylammoniumsalzes
DE69611303T2 (de) Benzolsulfonamidderivate, ihre herstellung und ihre therapeutische verwendung
CH686672A5 (de) Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure.
DE69100200T2 (de) Verfahren zur industriellen Herstellung von 3-Sulfamoyl-4-chlor-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)-Benzamide ausgehend von 2,3-Dihydro-2-methyl-1H-indol und Hydroxylamine-O-sulfonsäure.
DE69018352T2 (de) N-hydroxy-dibenz[b,e]oxepin-alkylamine und -alkanoische Säureamide, verwandte heterocyclische Analoge, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Medikamenten.
DE69616811T2 (de) Synthese von hydroxysulfonen und verwandten verbindungen
AT391696B (de) Verfahren zur herstellung von s- 3morpholino-4- (3'-tert-butylamino-2'-hydroxypropoxy)-1,2,5thiadiazol
DE60007599T2 (de) Verfahren zur Herstellung von zyklischen Piperidinylaminomethyl-trifluoromethyl-etherderivaten
DE602005003672T2 (de) VERBESSERTES VERFAHREN ZUR HERSTELLUNG VON 5,6 -DIHYDRO -4H-4(S)-ETHYLAMIN-6(S)-METHYLTHIENOÄ2,3-bÜ THIOPYRAN-2-SULFONAMID- 7,7 -DIOXID UND SEINEN SALZEN
RU2114851C1 (ru) Способ получения 7,7-диоксида 5,6-дигидро-(s)-4-(алкиламино)-(s)-6-алкил-4н-тиено(2,3-b)тиопиран-2- сульфонамида и 7,7-диоксида 5,6-дигидро-(s)-4-(ациламидо)-(s)-6-алкил-4н-тиено(2,3-b)тиопирана
AT336602B (de) Verfahren zur herstellung eines optisch aktiven thiolactons
HK1009063B (en) Enantioselective synthesis of thieno(2,3,-b) thiopyran-7,7-dioxide compounds

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MERCK SHARP & DOHME CORP., NEW JERSEY, N.J., US

R081 Change of applicant/patentee

Ref document number: 617037

Country of ref document: EP

Owner name: SCHERING CORPORATION, US

Free format text: FORMER OWNER: MERCK SHARP & DOHME CORP., 07065-0900 RAHWAY, US

Effective date: 20121213

R082 Change of representative

Ref document number: 617037

Country of ref document: EP

Representative=s name: ABITZ & PARTNER, DE

Effective date: 20121213