DE69306670T2 - Neue Cyclosporine mit Modifikationen in Position 1 - Google Patents

Neue Cyclosporine mit Modifikationen in Position 1

Info

Publication number
DE69306670T2
DE69306670T2 DE69306670T DE69306670T DE69306670T2 DE 69306670 T2 DE69306670 T2 DE 69306670T2 DE 69306670 T DE69306670 T DE 69306670T DE 69306670 T DE69306670 T DE 69306670T DE 69306670 T2 DE69306670 T2 DE 69306670T2
Authority
DE
Germany
Prior art keywords
cyclosporin
formula
ser
residue
cyclosporins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69306670T
Other languages
German (de)
English (en)
Other versions
DE69306670D1 (de
Inventor
Johann Jakob Boelsterli
Marcel Karl Eberle
Reto Naef
Trevor Glyn Payne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of DE69306670D1 publication Critical patent/DE69306670D1/de
Application granted granted Critical
Publication of DE69306670T2 publication Critical patent/DE69306670T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Gasification And Melting Of Waste (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69306670T 1992-03-02 1993-02-22 Neue Cyclosporine mit Modifikationen in Position 1 Expired - Fee Related DE69306670T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929204466A GB9204466D0 (en) 1992-03-02 1992-03-02 Improvements in or relating to organic compounds

Publications (2)

Publication Number Publication Date
DE69306670D1 DE69306670D1 (de) 1997-01-30
DE69306670T2 true DE69306670T2 (de) 1997-07-03

Family

ID=10711333

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69306670T Expired - Fee Related DE69306670T2 (de) 1992-03-02 1993-02-22 Neue Cyclosporine mit Modifikationen in Position 1

Country Status (26)

Country Link
US (1) US5643870A (OSRAM)
EP (1) EP0577544B1 (OSRAM)
JP (1) JP3382656B2 (OSRAM)
KR (1) KR100256988B1 (OSRAM)
CN (1) CN1037104C (OSRAM)
AT (1) ATE146484T1 (OSRAM)
AU (1) AU667072B2 (OSRAM)
CA (1) CA2090634C (OSRAM)
CZ (1) CZ285421B6 (OSRAM)
DE (1) DE69306670T2 (OSRAM)
DK (1) DK0577544T3 (OSRAM)
ES (1) ES2096262T3 (OSRAM)
FI (1) FI111729B (OSRAM)
GB (1) GB9204466D0 (OSRAM)
GR (1) GR3022539T3 (OSRAM)
HU (1) HU214028B (OSRAM)
IL (1) IL104891A (OSRAM)
MX (1) MX9301129A (OSRAM)
MY (1) MY106921A (OSRAM)
NO (1) NO310685B1 (OSRAM)
NZ (1) NZ247031A (OSRAM)
PL (1) PL174816B1 (OSRAM)
RU (1) RU2131883C1 (OSRAM)
SK (1) SK279529B6 (OSRAM)
TW (1) TW264472B (OSRAM)
ZA (1) ZA931491B (OSRAM)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639852A (en) * 1994-09-01 1997-06-17 Wisconsin Alumni Research Foundation Immunostimulatory agents
CN1130373C (zh) * 1996-09-13 2003-12-10 诺瓦蒂斯有限公司 [3'－脱氧－3'－氧代－MeBmt]'环孢菌素制备方法
ZA9711732B (en) 1996-12-31 1998-12-28 Quadrant Holdings Cambridge Methods and compositions for improvement bioavailability of bioactive agents for mucosal delivery
US20030220234A1 (en) 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
DE69840586D1 (de) 1997-10-08 2009-04-02 Isotechnika Inc Deuterierte Cyclosporin-analoga und ihre Verwendung als immunmodulierende Agenzien
RU2235554C2 (ru) * 1998-03-06 2004-09-10 Новартис Аг Предварительно приготовленные эмульсионные концентраты, содержащие циклоспорин или макролид
US6784156B2 (en) * 2001-03-05 2004-08-31 Enanta Pharmaceuticals, Inc. Cyclosporins for the treatment of respiratory diseases
US6995139B2 (en) * 2001-04-20 2006-02-07 Debiopharm S.A. Cyclic undecapeptide pro-drugs and uses thereof
US20030087813A1 (en) * 2001-10-12 2003-05-08 Or Yat Sun Cyclosporin analogs for the treatment of lung diseases
US6809077B2 (en) * 2001-10-12 2004-10-26 Enanta Pharmaceuticals, Inc. Cyclosporin analogs for the treatment of autoimmune diseases
RU2321593C9 (ru) 2001-10-19 2008-06-20 Изотехника Инк. Синтез аналогов циклоспорина
ATE401339T1 (de) * 2001-10-19 2008-08-15 Isotechnika Inc Mischungen von cyclosporin-analogen und ihre verwendung als immunmodulatoren
US7012065B2 (en) 2003-02-07 2006-03-14 Enanta Pharmaceuticals, Inc. Cyclosporins for the treatment of immune disorders
JP2006524232A (ja) * 2003-03-17 2006-10-26 アルバニー モレキュラー リサーチ インコーポレーティッド 新規サイクロスポリン
US20040266669A1 (en) * 2003-06-20 2004-12-30 Wu Frank X. H. Cyclosporin derivatives for the treatment of immune disorders
JP2006014722A (ja) 2004-06-02 2006-01-19 Keio Gijuku 遺伝子マーカー及びその利用
WO2006039164A2 (en) * 2004-09-29 2006-04-13 Amr Technology, Inc. Novel cyclosporin analogues and their pharmaceutical uses
EP1809656A4 (en) * 2004-09-29 2009-03-25 Amr Technology Inc CYCLOSPORINAL KINANALOGA AND ITS PHARMACEUTICAL APPLICATIONS
US7361636B2 (en) * 2004-10-06 2008-04-22 Amr Technology, Inc. Cyclosporin alkynes and their utility as pharmaceutical agents
DE602005010607D1 (de) * 2004-11-22 2008-12-04 Astellas Pharma Inc Zyklosporinanalog
US7696166B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
JP5668476B2 (ja) 2007-10-08 2015-02-12 オーリニア・ファーマシューティカルズ・インコーポレイテッドＡｕｒｉｎｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． カルシニューリン阻害剤またはｍＴＯＲ阻害剤を含む眼科用組成物
JP5726733B2 (ja) * 2008-07-30 2015-06-03 シクロフィリン ファーマシューティカルズ コープ． 非免疫抑制性シクロスポリン類似体分子
WO2010144194A1 (en) 2009-06-09 2010-12-16 Lux Biosciences, Inc. Topical drug delivery systems for ophthalmic use
WO2012037485A2 (en) * 2010-09-16 2012-03-22 1The Johns Hopkins University Methods of inhibiting alphavirus replication and treating alphavirus infection
HRP20190096T1 (hr) 2010-12-15 2019-02-22 Contravir Pharmaceuticals, Inc. Molekule analoga ciklosporina modificirani na amino kiselini 1 i 3
CN105076117B (zh) * 2014-10-31 2017-08-25 北京林业大学 一种种子抗老化剂及其制备方法
KR20170000243U (ko) 2015-07-09 2017-01-18 (주)하나피앤씨 배관연결용 플랜지 기구
US9981041B2 (en) * 2016-08-23 2018-05-29 Ira Jason Salzman Ophthalmic lubricating spray
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2819094A1 (de) * 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
EP0194972B1 (en) * 1985-03-11 1992-07-29 Sandoz Ag Novel cyclosporins
US4649047A (en) * 1985-03-19 1987-03-10 University Of Georgia Research Foundation, Inc. Ophthalmic treatment by topical administration of cyclosporin
US4764503A (en) * 1986-11-19 1988-08-16 Sandoz Ltd. Novel cyclosporins
EP0283801A3 (en) * 1987-03-27 1990-05-30 Abbott Laboratories Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies
US4798823A (en) * 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
DE3884470T2 (de) * 1987-06-17 1994-03-10 Sandoz Ag Cyclosporine und deren Benutzung als Arzneimittel.
GB8717300D0 (en) * 1987-07-22 1987-08-26 Nat Res Dev Cyclosporins
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
DE3840354A1 (de) * 1988-11-30 1990-06-07 Hoechst Ag Benzolsulfonamid-derivate und verfahren zu ihrer herstellung
AU4958590A (en) * 1988-12-05 1990-07-10 Trustees Of Columbia University In The City Of New York, The Novel derivatives of cyclosporine a, antibodies directed thereto and uses thereof
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
GB8916901D0 (en) * 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US5202310A (en) * 1990-06-06 1993-04-13 Levy Gary A Cyclosporine metabolites
DE69124459T3 (de) * 1990-11-02 2001-05-31 Novartis Ag, Basel Zyklosporine

Also Published As

Publication number Publication date
HUT64567A (en) 1994-01-28
GB9204466D0 (en) 1992-04-15
NO310685B1 (no) 2001-08-13
TW264472B (OSRAM) 1995-12-01
CZ30393A3 (en) 1994-02-16
GR3022539T3 (en) 1997-05-31
FI930912L (fi) 1993-09-03
DE69306670D1 (de) 1997-01-30
ES2096262T3 (es) 1997-03-01
EP0577544B1 (en) 1996-12-18
CA2090634A1 (en) 1993-09-03
CN1037104C (zh) 1998-01-21
RU2131883C1 (ru) 1999-06-20
US5643870A (en) 1997-07-01
ATE146484T1 (de) 1997-01-15
NO930738L (no) 1993-09-03
EP0577544A1 (en) 1994-01-05
KR930019692A (ko) 1993-10-18
PL297902A1 (en) 1993-09-06
CN1076453A (zh) 1993-09-22
MX9301129A (es) 1994-07-29
FI111729B (fi) 2003-09-15
FI930912A0 (fi) 1993-03-01
PL174816B1 (pl) 1998-09-30
HU9300418D0 (en) 1993-05-28
JPH07252296A (ja) 1995-10-03
SK279529B6 (sk) 1998-12-02
ZA931491B (en) 1994-09-02
IL104891A0 (en) 1993-07-08
DK0577544T3 (da) 1997-04-01
HU214028B (en) 1997-12-29
IL104891A (en) 1997-04-15
SK14093A3 (en) 1993-10-06
NO930738D0 (no) 1993-03-01
KR100256988B1 (ko) 2000-05-15
CA2090634C (en) 2005-12-13
MY106921A (en) 1995-08-30
JP3382656B2 (ja) 2003-03-04
NZ247031A (en) 1995-05-26
AU3387293A (en) 1993-09-09
AU667072B2 (en) 1996-03-07
CZ285421B6 (cs) 1999-08-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NOVARTIS AG, BASEL, CH

8328 Change in the person/name/address of the agent

Free format text: SPOTT WEINMILLER & PARTNER, 80336 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: DERZEIT KEIN VERTRETER BESTELLT

8339 Ceased/non-payment of the annual fee