HU214028B - Process for producing cyclosporin derivatives and pharmaceutical compositions containing them - Google Patents
Process for producing cyclosporin derivatives and pharmaceutical compositions containing them Download PDFInfo
- Publication number
- HU214028B HU214028B HU9300418A HU9300418A HU214028B HU 214028 B HU214028 B HU 214028B HU 9300418 A HU9300418 A HU 9300418A HU 9300418 A HU9300418 A HU 9300418A HU 214028 B HU214028 B HU 214028B
- Authority
- HU
- Hungary
- Prior art keywords
- formula
- cyclosporins
- cyclosporin
- group
- alphaabu
- Prior art date
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- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title claims abstract description 47
- 238000000034 method Methods 0.000 title claims abstract description 37
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- 229930182912 cyclosporin Natural products 0.000 claims description 97
- 108010036941 Cyclosporins Proteins 0.000 claims description 71
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- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
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- 150000004820 halides Chemical class 0.000 description 1
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- 238000007654 immersion Methods 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
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- 208000028774 intestinal disease Diseases 0.000 description 1
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- 201000010659 intrinsic asthma Diseases 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
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- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 229910001425 magnesium ion Inorganic materials 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- XMJHPCRAQCTCFT-UHFFFAOYSA-N methyl chloroformate Chemical compound COC(Cl)=O XMJHPCRAQCTCFT-UHFFFAOYSA-N 0.000 description 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- 238000005065 mining Methods 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 239000007923 nasal drop Substances 0.000 description 1
- 229940100662 nasal drops Drugs 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000009826 neoplastic cell growth Effects 0.000 description 1
- 230000000414 obstructive effect Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
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- 239000003960 organic solvent Substances 0.000 description 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
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- 230000000144 pharmacologic effect Effects 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
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- 108090000765 processed proteins & peptides Proteins 0.000 description 1
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- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
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- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
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- 210000003437 trachea Anatomy 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Gasification And Melting Of Waste (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929204466A GB9204466D0 (en) | 1992-03-02 | 1992-03-02 | Improvements in or relating to organic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9300418D0 HU9300418D0 (en) | 1993-05-28 |
| HUT64567A HUT64567A (en) | 1994-01-28 |
| HU214028B true HU214028B (en) | 1997-12-29 |
Family
ID=10711333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9300418A HU214028B (en) | 1992-03-02 | 1993-02-16 | Process for producing cyclosporin derivatives and pharmaceutical compositions containing them |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5643870A (OSRAM) |
| EP (1) | EP0577544B1 (OSRAM) |
| JP (1) | JP3382656B2 (OSRAM) |
| KR (1) | KR100256988B1 (OSRAM) |
| CN (1) | CN1037104C (OSRAM) |
| AT (1) | ATE146484T1 (OSRAM) |
| AU (1) | AU667072B2 (OSRAM) |
| CA (1) | CA2090634C (OSRAM) |
| CZ (1) | CZ285421B6 (OSRAM) |
| DE (1) | DE69306670T2 (OSRAM) |
| DK (1) | DK0577544T3 (OSRAM) |
| ES (1) | ES2096262T3 (OSRAM) |
| FI (1) | FI111729B (OSRAM) |
| GB (1) | GB9204466D0 (OSRAM) |
| GR (1) | GR3022539T3 (OSRAM) |
| HU (1) | HU214028B (OSRAM) |
| IL (1) | IL104891A (OSRAM) |
| MX (1) | MX9301129A (OSRAM) |
| MY (1) | MY106921A (OSRAM) |
| NO (1) | NO310685B1 (OSRAM) |
| NZ (1) | NZ247031A (OSRAM) |
| PL (1) | PL174816B1 (OSRAM) |
| RU (1) | RU2131883C1 (OSRAM) |
| SK (1) | SK279529B6 (OSRAM) |
| TW (1) | TW264472B (OSRAM) |
| ZA (1) | ZA931491B (OSRAM) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639852A (en) * | 1994-09-01 | 1997-06-17 | Wisconsin Alumni Research Foundation | Immunostimulatory agents |
| CN1130373C (zh) * | 1996-09-13 | 2003-12-10 | 诺瓦蒂斯有限公司 | [3'－脱氧－3'－氧代－MeBmt]'环孢菌素制备方法 |
| ZA9711732B (en) | 1996-12-31 | 1998-12-28 | Quadrant Holdings Cambridge | Methods and compositions for improvement bioavailability of bioactive agents for mucosal delivery |
| US20030220234A1 (en) | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
| DE69840586D1 (de) | 1997-10-08 | 2009-04-02 | Isotechnika Inc | Deuterierte Cyclosporin-analoga und ihre Verwendung als immunmodulierende Agenzien |
| RU2235554C2 (ru) * | 1998-03-06 | 2004-09-10 | Новартис Аг | Предварительно приготовленные эмульсионные концентраты, содержащие циклоспорин или макролид |
| US6784156B2 (en) * | 2001-03-05 | 2004-08-31 | Enanta Pharmaceuticals, Inc. | Cyclosporins for the treatment of respiratory diseases |
| US6995139B2 (en) * | 2001-04-20 | 2006-02-07 | Debiopharm S.A. | Cyclic undecapeptide pro-drugs and uses thereof |
| US20030087813A1 (en) * | 2001-10-12 | 2003-05-08 | Or Yat Sun | Cyclosporin analogs for the treatment of lung diseases |
| US6809077B2 (en) * | 2001-10-12 | 2004-10-26 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogs for the treatment of autoimmune diseases |
| RU2321593C9 (ru) | 2001-10-19 | 2008-06-20 | Изотехника Инк. | Синтез аналогов циклоспорина |
| ATE401339T1 (de) * | 2001-10-19 | 2008-08-15 | Isotechnika Inc | Mischungen von cyclosporin-analogen und ihre verwendung als immunmodulatoren |
| US7012065B2 (en) | 2003-02-07 | 2006-03-14 | Enanta Pharmaceuticals, Inc. | Cyclosporins for the treatment of immune disorders |
| JP2006524232A (ja) * | 2003-03-17 | 2006-10-26 | アルバニー モレキュラー リサーチ インコーポレーティッド | 新規サイクロスポリン |
| US20040266669A1 (en) * | 2003-06-20 | 2004-12-30 | Wu Frank X. H. | Cyclosporin derivatives for the treatment of immune disorders |
| JP2006014722A (ja) | 2004-06-02 | 2006-01-19 | Keio Gijuku | 遺伝子マーカー及びその利用 |
| WO2006039164A2 (en) * | 2004-09-29 | 2006-04-13 | Amr Technology, Inc. | Novel cyclosporin analogues and their pharmaceutical uses |
| EP1809656A4 (en) * | 2004-09-29 | 2009-03-25 | Amr Technology Inc | CYCLOSPORINAL KINANALOGA AND ITS PHARMACEUTICAL APPLICATIONS |
| US7361636B2 (en) * | 2004-10-06 | 2008-04-22 | Amr Technology, Inc. | Cyclosporin alkynes and their utility as pharmaceutical agents |
| DE602005010607D1 (de) * | 2004-11-22 | 2008-12-04 | Astellas Pharma Inc | Zyklosporinanalog |
| US7696166B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
| US7696165B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
| JP5668476B2 (ja) | 2007-10-08 | 2015-02-12 | オーリニア・ファーマシューティカルズ・インコーポレイテッドＡｕｒｉｎｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | カルシニューリン阻害剤またはｍＴＯＲ阻害剤を含む眼科用組成物 |
| JP5726733B2 (ja) * | 2008-07-30 | 2015-06-03 | シクロフィリン ファーマシューティカルズ コープ． | 非免疫抑制性シクロスポリン類似体分子 |
| WO2010144194A1 (en) | 2009-06-09 | 2010-12-16 | Lux Biosciences, Inc. | Topical drug delivery systems for ophthalmic use |
| WO2012037485A2 (en) * | 2010-09-16 | 2012-03-22 | 1The Johns Hopkins University | Methods of inhibiting alphavirus replication and treating alphavirus infection |
| HRP20190096T1 (hr) | 2010-12-15 | 2019-02-22 | Contravir Pharmaceuticals, Inc. | Molekule analoga ciklosporina modificirani na amino kiselini 1 i 3 |
| CN105076117B (zh) * | 2014-10-31 | 2017-08-25 | 北京林业大学 | 一种种子抗老化剂及其制备方法 |
| KR20170000243U (ko) | 2015-07-09 | 2017-01-18 | (주)하나피앤씨 | 배관연결용 플랜지 기구 |
| US9981041B2 (en) * | 2016-08-23 | 2018-05-29 | Ira Jason Salzman | Ophthalmic lubricating spray |
| US20190224275A1 (en) | 2017-05-12 | 2019-07-25 | Aurinia Pharmaceuticals Inc. | Protocol for treatment of lupus nephritis |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2819094A1 (de) * | 1977-05-10 | 1978-11-23 | Sandoz Ag | Cyclosporin-derivate, ihre verwendung und herstellung |
| EP0194972B1 (en) * | 1985-03-11 | 1992-07-29 | Sandoz Ag | Novel cyclosporins |
| US4649047A (en) * | 1985-03-19 | 1987-03-10 | University Of Georgia Research Foundation, Inc. | Ophthalmic treatment by topical administration of cyclosporin |
| US4764503A (en) * | 1986-11-19 | 1988-08-16 | Sandoz Ltd. | Novel cyclosporins |
| EP0283801A3 (en) * | 1987-03-27 | 1990-05-30 | Abbott Laboratories | Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies |
| US4798823A (en) * | 1987-06-03 | 1989-01-17 | Merck & Co., Inc. | New cyclosporin analogs with modified "C-9 amino acids" |
| DE3884470T2 (de) * | 1987-06-17 | 1994-03-10 | Sandoz Ag | Cyclosporine und deren Benutzung als Arzneimittel. |
| GB8717300D0 (en) * | 1987-07-22 | 1987-08-26 | Nat Res Dev | Cyclosporins |
| US4839342A (en) * | 1987-09-03 | 1989-06-13 | University Of Georgia Research Foundation, Inc. | Method of increasing tear production by topical administration of cyclosporin |
| DE3840354A1 (de) * | 1988-11-30 | 1990-06-07 | Hoechst Ag | Benzolsulfonamid-derivate und verfahren zu ihrer herstellung |
| AU4958590A (en) * | 1988-12-05 | 1990-07-10 | Trustees Of Columbia University In The City Of New York, The | Novel derivatives of cyclosporine a, antibodies directed thereto and uses thereof |
| US4996193A (en) * | 1989-03-03 | 1991-02-26 | The Regents Of The University Of California | Combined topical and systemic method of administration of cyclosporine |
| GB8916901D0 (en) * | 1989-07-24 | 1989-09-06 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US5202310A (en) * | 1990-06-06 | 1993-04-13 | Levy Gary A | Cyclosporine metabolites |
| DE69124459T3 (de) * | 1990-11-02 | 2001-05-31 | Novartis Ag, Basel | Zyklosporine |
-
1992
- 1992-03-02 GB GB929204466A patent/GB9204466D0/en active Pending
-
1993
- 1993-02-16 HU HU9300418A patent/HU214028B/hu not_active IP Right Cessation
- 1993-02-22 ES ES93810113T patent/ES2096262T3/es not_active Expired - Lifetime
- 1993-02-22 AT AT93810113T patent/ATE146484T1/de not_active IP Right Cessation
- 1993-02-22 EP EP93810113A patent/EP0577544B1/en not_active Expired - Lifetime
- 1993-02-22 DK DK93810113.6T patent/DK0577544T3/da active
- 1993-02-22 DE DE69306670T patent/DE69306670T2/de not_active Expired - Fee Related
- 1993-02-26 US US08/023,525 patent/US5643870A/en not_active Expired - Lifetime
- 1993-02-26 MY MYPI93000352A patent/MY106921A/en unknown
- 1993-02-26 SK SK140-93A patent/SK279529B6/sk not_active IP Right Cessation
- 1993-02-27 KR KR1019930002881A patent/KR100256988B1/ko not_active Expired - Fee Related
- 1993-03-01 CN CN93102101A patent/CN1037104C/zh not_active Expired - Fee Related
- 1993-03-01 CZ CZ93303A patent/CZ285421B6/cs not_active IP Right Cessation
- 1993-03-01 NO NO19930738A patent/NO310685B1/no not_active IP Right Cessation
- 1993-03-01 AU AU33872/93A patent/AU667072B2/en not_active Ceased
- 1993-03-01 CA CA002090634A patent/CA2090634C/en not_active Expired - Fee Related
- 1993-03-01 FI FI930912A patent/FI111729B/fi active
- 1993-03-01 RU RU93004574A patent/RU2131883C1/ru active
- 1993-03-01 MX MX9301129A patent/MX9301129A/es unknown
- 1993-03-01 PL PL93297902A patent/PL174816B1/pl not_active IP Right Cessation
- 1993-03-01 IL IL104891A patent/IL104891A/xx not_active IP Right Cessation
- 1993-03-01 NZ NZ247031A patent/NZ247031A/en not_active IP Right Cessation
- 1993-03-01 JP JP03983793A patent/JP3382656B2/ja not_active Expired - Fee Related
- 1993-03-02 ZA ZA931491A patent/ZA931491B/xx unknown
- 1993-03-03 TW TW082101559A patent/TW264472B/zh active
-
1997
- 1997-02-12 GR GR970400227T patent/GR3022539T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DGB9 | Succession in title of applicant |
Owner name: NOVARTIS AG., CH |
|
| MM4A | Lapse of definitive patent protection due to non-payment of fees |