FI930912A0 - Nya cyklosporiner - Google Patents

Nya cyklosporiner

Info

Publication number
FI930912A0
FI930912A0 FI930912A FI930912A FI930912A0 FI 930912 A0 FI930912 A0 FI 930912A0 FI 930912 A FI930912 A FI 930912A FI 930912 A FI930912 A FI 930912A FI 930912 A0 FI930912 A0 FI 930912A0
Authority
FI
Finland
Prior art keywords
cyclosporiner
nya
amino
2alkyl
cyclosporins
Prior art date
Application number
FI930912A
Other languages
English (en)
Other versions
FI111729B (fi
FI930912A (fi
Inventor
Johann Jakob Boelsterli
Marcel Karl Eberle
Reto Naef
Trevor Glyn Payne
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of FI930912A0 publication Critical patent/FI930912A0/fi
Publication of FI930912A publication Critical patent/FI930912A/fi
Application granted granted Critical
Publication of FI111729B publication Critical patent/FI111729B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Gasification And Melting Of Waste (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI930912A 1992-03-02 1993-03-01 Menetelmä terapeuttisesti käyttökeloisen syklosporiinin valmistamiseksi FI111729B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929204466A GB9204466D0 (en) 1992-03-02 1992-03-02 Improvements in or relating to organic compounds
GB9204466 1992-03-02

Publications (3)

Publication Number Publication Date
FI930912A0 true FI930912A0 (fi) 1993-03-01
FI930912A FI930912A (fi) 1993-09-03
FI111729B FI111729B (fi) 2003-09-15

Family

ID=10711333

Family Applications (1)

Application Number Title Priority Date Filing Date
FI930912A FI111729B (fi) 1992-03-02 1993-03-01 Menetelmä terapeuttisesti käyttökeloisen syklosporiinin valmistamiseksi

Country Status (26)

Country Link
US (1) US5643870A (fi)
EP (1) EP0577544B1 (fi)
JP (1) JP3382656B2 (fi)
KR (1) KR100256988B1 (fi)
CN (1) CN1037104C (fi)
AT (1) ATE146484T1 (fi)
AU (1) AU667072B2 (fi)
CA (1) CA2090634C (fi)
CZ (1) CZ285421B6 (fi)
DE (1) DE69306670T2 (fi)
DK (1) DK0577544T3 (fi)
ES (1) ES2096262T3 (fi)
FI (1) FI111729B (fi)
GB (1) GB9204466D0 (fi)
GR (1) GR3022539T3 (fi)
HU (1) HU214028B (fi)
IL (1) IL104891A (fi)
MX (1) MX9301129A (fi)
MY (1) MY106921A (fi)
NO (1) NO310685B1 (fi)
NZ (1) NZ247031A (fi)
PL (1) PL174816B1 (fi)
RU (1) RU2131883C1 (fi)
SK (1) SK279529B6 (fi)
TW (1) TW264472B (fi)
ZA (1) ZA931491B (fi)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639852A (en) * 1994-09-01 1997-06-17 Wisconsin Alumni Research Foundation Immunostimulatory agents
CN1130373C (zh) * 1996-09-13 2003-12-10 诺瓦蒂斯有限公司 [3'－脱氧－3'－氧代－MeBmt]'环孢菌素制备方法
ZA9711732B (en) 1996-12-31 1998-12-28 Quadrant Holdings Cambridge Methods and compositions for improvement bioavailability of bioactive agents for mucosal delivery
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
KR100585348B1 (ko) * 1997-10-08 2006-06-01 이소테크니카 인코포레이티드 중수소화된 시클로스포린 유사체 및 면역조절제로서 그의용도
US6784156B2 (en) 2001-03-05 2004-08-31 Enanta Pharmaceuticals, Inc. Cyclosporins for the treatment of respiratory diseases
US6809077B2 (en) * 2001-10-12 2004-10-26 Enanta Pharmaceuticals, Inc. Cyclosporin analogs for the treatment of autoimmune diseases
US20030087813A1 (en) * 2001-10-12 2003-05-08 Or Yat Sun Cyclosporin analogs for the treatment of lung diseases
NZ531944A (en) * 2001-10-19 2006-03-31 Isotechnika Inc Synthesis of cyclosporin analogs
US7012065B2 (en) 2003-02-07 2006-03-14 Enanta Pharmaceuticals, Inc. Cyclosporins for the treatment of immune disorders
AU2004222306A1 (en) * 2003-03-17 2004-09-30 Albany Molecular Research, Inc. Novel cyclosporins
US20040266669A1 (en) * 2003-06-20 2004-12-30 Wu Frank X. H. Cyclosporin derivatives for the treatment of immune disorders
JP2006014722A (ja) 2004-06-02 2006-01-19 Keio Gijuku 遺伝子マーカー及びその利用
US7511013B2 (en) * 2004-09-29 2009-03-31 Amr Technology, Inc. Cyclosporin analogues and their pharmaceutical uses
EP1809656A4 (en) * 2004-09-29 2009-03-25 Amr Technology Inc CYCLOSPORINAL KINANALOGA AND ITS PHARMACEUTICAL APPLICATIONS
WO2006041631A2 (en) * 2004-10-06 2006-04-20 Amr Technology, Inc. Novel cyclosporin alkynes and their utility as pharmaceutical agents
ES2314731T3 (es) * 2004-11-22 2009-03-16 Astellas Pharma Inc. Analogo de ciclosporina.
US7696165B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
AU2008310956B2 (en) * 2007-10-08 2014-08-07 Aurinia Pharmaceuticals Inc. Ophthalmic compositions comprising calcineurin inhibitors or mTOR inhibitors
EP2307446A4 (en) * 2008-07-30 2012-11-07 Isotechnika Pharma Inc NON-IMMUNOSUPPRESSIVE CYCLOSPORINE ANALOGOUS MOLECULES
US9017725B2 (en) 2009-06-09 2015-04-28 Aurinia Pharmaceuticals Inc. Topical drug delivery systems for ophthalmic use
US20130267460A1 (en) * 2010-09-16 2013-10-10 The Johns Hopkins University Methods of Inhibiting Alphavirus Replication and Treating Alphavirus Infection
HUE042490T2 (hu) 2010-12-15 2019-07-29 Contravir Pharmaceuticals Inc 1-es és 3-as aminosav-pozícióban módosított ciklosporin analóg molekulák
CN105076117B (zh) * 2014-10-31 2017-08-25 北京林业大学 一种种子抗老化剂及其制备方法
KR20170000243U (ko) 2015-07-09 2017-01-18 (주)하나피앤씨 배관연결용 플랜지 기구
US9981041B2 (en) * 2016-08-23 2018-05-29 Ira Jason Salzman Ophthalmic lubricating spray
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2819094A1 (de) * 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
EP0194972B1 (en) * 1985-03-11 1992-07-29 Sandoz Ag Novel cyclosporins
US4649047A (en) * 1985-03-19 1987-03-10 University Of Georgia Research Foundation, Inc. Ophthalmic treatment by topical administration of cyclosporin
US4764503A (en) * 1986-11-19 1988-08-16 Sandoz Ltd. Novel cyclosporins
EP0283801A3 (en) * 1987-03-27 1990-05-30 Abbott Laboratories Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies
US4798823A (en) * 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
ES2059558T3 (es) * 1987-06-17 1994-11-16 Sandoz Ag Ciclosporins y su uso como productos farmaceuticos.
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
JPH04502328A (ja) * 1988-12-05 1992-04-23 ザ・トラステイーズ・オブ・コロンビア・ユニヴアーシテイ・イン・ザ・シテイ・オブ・ニユー・ヨーク シクロスポリンａの新規誘導体、それに対する抗体及びその使用
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
GB8916901D0 (en) * 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US5202310A (en) * 1990-06-06 1993-04-13 Levy Gary A Cyclosporine metabolites
FI111730B (fi) * 1990-11-02 2003-09-15 Novartis Ag Menetelmä ei-immunosuppressiivisen syklosporiinin valmistamiseksi

Also Published As

Publication number Publication date
SK14093A3 (en) 1993-10-06
MX9301129A (es) 1994-07-29
EP0577544B1 (en) 1996-12-18
IL104891A (en) 1997-04-15
FI111729B (fi) 2003-09-15
HUT64567A (en) 1994-01-28
NO930738L (no) 1993-09-03
IL104891A0 (en) 1993-07-08
ES2096262T3 (es) 1997-03-01
PL297902A1 (en) 1993-09-06
CZ30393A3 (en) 1994-02-16
HU214028B (en) 1997-12-29
ZA931491B (en) 1994-09-02
MY106921A (en) 1995-08-30
NZ247031A (en) 1995-05-26
JP3382656B2 (ja) 2003-03-04
ATE146484T1 (de) 1997-01-15
GB9204466D0 (en) 1992-04-15
CA2090634A1 (en) 1993-09-03
US5643870A (en) 1997-07-01
KR100256988B1 (ko) 2000-05-15
DE69306670D1 (de) 1997-01-30
AU3387293A (en) 1993-09-09
GR3022539T3 (en) 1997-05-31
DE69306670T2 (de) 1997-07-03
PL174816B1 (pl) 1998-09-30
JPH07252296A (ja) 1995-10-03
FI930912A (fi) 1993-09-03
HU9300418D0 (en) 1993-05-28
RU2131883C1 (ru) 1999-06-20
CA2090634C (en) 2005-12-13
NO310685B1 (no) 2001-08-13
TW264472B (fi) 1995-12-01
CN1037104C (zh) 1998-01-21
EP0577544A1 (en) 1994-01-05
CN1076453A (zh) 1993-09-22
NO930738D0 (no) 1993-03-01
SK279529B6 (sk) 1998-12-02
AU667072B2 (en) 1996-03-07
KR930019692A (ko) 1993-10-18
CZ285421B6 (cs) 1999-08-11
DK0577544T3 (da) 1997-04-01

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Owner name: NOVARTIS AG