DE69218977T2 - Trifluoromethylketon-Tripeptidderivate - Google Patents

Trifluoromethylketon-Tripeptidderivate

Info

Publication number
DE69218977T2
DE69218977T2 DE69218977T DE69218977T DE69218977T2 DE 69218977 T2 DE69218977 T2 DE 69218977T2 DE 69218977 T DE69218977 T DE 69218977T DE 69218977 T DE69218977 T DE 69218977T DE 69218977 T2 DE69218977 T2 DE 69218977T2
Authority
DE
Germany
Prior art keywords
alkyl
carboxy
phenyl
trifluoromethyl ketone
tripeptide derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69218977T
Other languages
English (en)
Other versions
DE69218977D1 (de
Inventor
Keiji Hemmi
Ichiro Shima
Keisuke Imai
Hirokazu Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909028231A external-priority patent/GB9028231D0/en
Priority claimed from GB919119713A external-priority patent/GB9119713D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69218977D1 publication Critical patent/DE69218977D1/de
Publication of DE69218977T2 publication Critical patent/DE69218977T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Magnetically Actuated Valves (AREA)
  • Control Of Throttle Valves Provided In The Intake System Or In The Exhaust System (AREA)
DE69218977T 1990-12-31 1992-01-02 Trifluoromethylketon-Tripeptidderivate Expired - Lifetime DE69218977T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909028231A GB9028231D0 (en) 1990-12-31 1990-12-31 Trifluoromethylketone derivatives,processes for preparation thereof and use thereof
GB919119713A GB9119713D0 (en) 1991-09-16 1991-09-16 Trifluoremethylketone derivatives, processes for preparation thereof and use thereof

Publications (2)

Publication Number Publication Date
DE69218977D1 DE69218977D1 (de) 1997-05-22
DE69218977T2 true DE69218977T2 (de) 1997-08-07

Family

ID=26298196

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69218977T Expired - Lifetime DE69218977T2 (de) 1990-12-31 1992-01-02 Trifluoromethylketon-Tripeptidderivate

Country Status (19)

Country Link
US (2) US5296591A (de)
EP (1) EP0494071B1 (de)
JP (1) JPH0699378B2 (de)
KR (1) KR100192991B1 (de)
CN (1) CN1040003C (de)
AT (1) ATE151775T1 (de)
AU (1) AU641577B2 (de)
CA (1) CA2058560C (de)
DE (1) DE69218977T2 (de)
DK (1) DK0494071T3 (de)
ES (1) ES2099755T3 (de)
FI (1) FI106379B (de)
GR (1) GR3023719T3 (de)
HU (2) HU210263B (de)
IE (1) IE914360A1 (de)
MX (1) MX9102612A (de)
NO (1) NO309274B1 (de)
RU (1) RU2073684C1 (de)
SG (1) SG50457A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5296591A (en) * 1990-12-31 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Trifluoromethylketone derivatives, processes for preparation thereof and use thereof
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
US5714470A (en) * 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
FR2694295B1 (fr) * 1992-07-28 1994-09-02 Adir Nouveaux peptides dérivés de trifluoromethylcetones, leur procéde de préparation et les compositions pharmaceutiques qui les contiennent.
FR2719589B1 (fr) * 1994-05-05 1996-06-14 Adir Nouveaux peptides dérivés de trifluorométhylcétones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
DE69522940T2 (de) * 1994-06-02 2002-04-04 Merrell Pharma Inc Acylierte enolderivate als vorläufdrogen von elastaseinhibitoren
EP0763055B1 (de) * 1994-06-02 1999-11-03 Merrell Pharmaceuticals Inc. Perfluoroalkyll ketone, inhibitoren von elastase und prozess zur deren herstellung
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
JP2002161051A (ja) * 1996-12-24 2002-06-04 Fujisawa Pharmaceut Co Ltd 脳虚血性疾患等の治療剤
ES2421505T3 (es) * 1998-02-24 2013-09-03 Astellas Pharma Inc Preventivos/remedios contra el envejecimiento de la piel
US20020045231A1 (en) * 1999-02-02 2002-04-18 Napper Andrew D. Catalytic antibodies which hydrolyze primary amides and methods for eliciting such antibodies
CA2387199A1 (en) * 1999-10-12 2001-04-19 Fujisawa Pharmaceutical Co., Ltd. Remedies for intractable wound
IL148924A (en) * 2002-03-26 2015-06-30 Mor Research Applic Ltd Use of substances that inhibit intracellular elastase activity in the preparation of a drug for the treatment and / or prevention of necrosis of cells and related diseases
DE10219464A1 (de) 2002-04-30 2003-11-13 Focke & Co Zigarettenpackung
SE0202462D0 (sv) * 2002-08-14 2002-08-14 Astrazeneca Ab Novel use
RU2419625C2 (ru) * 2006-05-23 2011-05-27 Айрм Ллк Соединения и композиции в качестве ингибиторов протеазы, активирующей каналы
WO2008023446A1 (fr) * 2006-08-25 2008-02-28 Stelic Institute Of Regenerative Medicine, Stelic Institute & Co. Remède pour des bronchopneumopathies chroniques obstructives
CN101534824A (zh) * 2006-11-17 2009-09-16 艾博特公司 作为化学活素受体拮抗剂的氨基吡咯烷
AU2010307006B2 (en) * 2009-10-13 2016-08-11 Ligand Pharmaceuticals Inc. Hematopoietic growth factor mimetic small molecule compounds and their uses
JP6200495B2 (ja) * 2013-05-08 2017-09-20 キッセイ薬品工業株式会社 α−置換グリシンアミド誘導体
CN104650016A (zh) * 2015-01-29 2015-05-27 武汉大学 拟三肽类化合物及其制备方法
WO2017221973A1 (ja) * 2016-06-24 2017-12-28 ポーラ化成工業株式会社 シワ改善用の皮膚外用剤
EP3711746A4 (de) 2017-11-15 2021-08-25 Pola Chemical Industries Inc. Ölbasierte zusammensetzung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
EP0276101A3 (de) * 1987-01-19 1989-11-23 Ici Americas Inc. Substituierte Peptid-Derivate
EP0369391A3 (de) * 1988-11-15 1991-09-25 Boehringer Ingelheim Pharmaceuticals Inc. N-substituierte Amide
US5221665A (en) * 1989-10-27 1993-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. N-substituted amides
US5296591A (en) * 1990-12-31 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Trifluoromethylketone derivatives, processes for preparation thereof and use thereof

Also Published As

Publication number Publication date
EP0494071A3 (en) 1993-05-05
KR920011988A (ko) 1992-07-25
CA2058560A1 (en) 1992-07-01
EP0494071B1 (de) 1997-04-16
MX9102612A (es) 1992-06-01
CA2058560C (en) 2000-12-12
AU641577B2 (en) 1993-09-23
FI915996A (fi) 1992-07-01
GR3023719T3 (en) 1997-09-30
DK0494071T3 (de) 1997-05-12
EP0494071A2 (de) 1992-07-08
IE914360A1 (en) 1992-07-01
JPH04297446A (ja) 1992-10-21
SG50457A1 (en) 1998-07-20
DE69218977D1 (de) 1997-05-22
HU210263B (en) 1995-03-28
FI915996A0 (fi) 1991-12-19
HUT60507A (en) 1992-09-28
US5430025A (en) 1995-07-04
RU2073684C1 (ru) 1997-02-20
CN1040003C (zh) 1998-09-30
AU8985391A (en) 1992-07-02
FI106379B (fi) 2001-01-31
KR100192991B1 (ko) 1999-06-15
NO920035L (no) 1992-07-01
US5296591A (en) 1994-03-22
HU914153D0 (en) 1992-03-30
ATE151775T1 (de) 1997-05-15
CN1063108A (zh) 1992-07-29
HU211943A9 (en) 1996-01-29
JPH0699378B2 (ja) 1994-12-07
NO920035D0 (no) 1992-01-02
NO309274B1 (no) 2001-01-08
ES2099755T3 (es) 1997-06-01

Similar Documents

Publication Publication Date Title
DE69218977T2 (de) Trifluoromethylketon-Tripeptidderivate
DE69604714T2 (de) Stilbenderivate und diese enthaltende pharmazeutische Zusammensetzungen
RU95101048A (ru) Производные пролинамида, фармкомпозиция на их основе
FI953467A (fi) Aminohappojohdannaisia, näitä yhdisteitä sisältävät lääkeaineet ja menetelmä niiden valmistamiseksi
DK245888A (da) 4-aminoquinolinderivater
ES2091359T3 (es) Nuevo compuesto peptidico y un procedimiento para su preparacion.
MA22540A1 (fr) Diaminophtalimides substitues et derives analogues .
ATE165600T1 (de) Diphenylpiperazinderivat und dieses enthaltendes arzneimittel für kreislauforgane
ATE170852T1 (de) Benzolsulfonamid-derivate zur behandlung der blaseninstabilität
FI935800A0 (fi) Antidepressiva och mot Parkisons sjukdom verksamma foereningar
NO905620D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive kinazolin-derivater.
DE69330601D1 (de) Serotoninergische ergolin derivate
FI935798A0 (fi) Alkylsubstituerade heterocykliska foereningar
CA2262791A1 (en) Amino acid ester containing azole antifungals
PT855398E (pt) Derivados sasquiterpeno tendo actividade antiviral
SE9203824L (sv) Bensofuranylimidazol-derivat, foerfarande foer framstaellning daerav och terapeutiska kompositioner innehaallande desamma
FR2781482B1 (fr) Nouveaux derives de 8h-thieno-[2,3-b]pyrrolizine-8-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ASTELLAS PHARMA INC., TOKIO/TOKYO, JP