DE3785684T2 - Pyrrolidinamid-Derivate von Acylaminosäure, pharmazeutische Zusammensetzung und Verwendung. - Google Patents
Pyrrolidinamid-Derivate von Acylaminosäure, pharmazeutische Zusammensetzung und Verwendung.Info
- Publication number
- DE3785684T2 DE3785684T2 DE87101504T DE3785684T DE3785684T2 DE 3785684 T2 DE3785684 T2 DE 3785684T2 DE 87101504 T DE87101504 T DE 87101504T DE 3785684 T DE3785684 T DE 3785684T DE 3785684 T2 DE3785684 T2 DE 3785684T2
- Authority
- DE
- Germany
- Prior art keywords
- pyrrolidinamide
- derivatives
- pharmaceutical composition
- acylamino acid
- acylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP61022756A JPH0696563B2 (ja) | 1986-02-04 | 1986-02-04 | アシルアミノ酸誘導体、その製法並びに用途 |
JP61043821A JPH0730020B2 (ja) | 1986-02-28 | 1986-02-28 | N置換アミノ酸イミド誘導体、製法並びに用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3785684D1 DE3785684D1 (de) | 1993-06-09 |
DE3785684T2 true DE3785684T2 (de) | 1993-10-21 |
Family
ID=26360023
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE87101504T Expired - Fee Related DE3785684T2 (de) | 1986-02-04 | 1987-02-04 | Pyrrolidinamid-Derivate von Acylaminosäure, pharmazeutische Zusammensetzung und Verwendung. |
Country Status (7)
Country | Link |
---|---|
US (1) | US4826870A (de) |
EP (1) | EP0232849B1 (de) |
AU (1) | AU588968B2 (de) |
CA (1) | CA1320734C (de) |
DE (1) | DE3785684T2 (de) |
ES (1) | ES2056791T3 (de) |
GR (1) | GR3007789T3 (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU598750B2 (en) * | 1985-09-27 | 1990-07-05 | Mitsubishi Chemical Corporation | Phenylalanine derivative and proteinase inhibitor |
US5198458A (en) * | 1986-02-04 | 1993-03-30 | Suntory Limited | Pyrrolidineamide derivatives of acylamino acid and pharmaceutical composition containing the same |
DE3742431A1 (de) * | 1987-12-15 | 1989-07-13 | Hoechst Ag | Neue derivate cyclischer aminosaeuren, verfahren zu ihrer herstellung, sie enthaltende mittel und deren verwendung |
JPH01250370A (ja) * | 1987-12-23 | 1989-10-05 | Zeria Pharmaceut Co Ltd | 新規アミノ酸イミド誘導体、製法ならびに用途 |
CA2004028C (en) * | 1988-12-08 | 1998-09-22 | Motoki Torizuka | Condensed benzene derivative |
WO1991005555A2 (en) * | 1989-10-13 | 1991-05-02 | The Salk Institute Biotechnology/Industrial Associates, Inc. | N-acyl peptide metalloendopeptidase inhibitors and methods of using same |
US4999349A (en) * | 1990-03-22 | 1991-03-12 | Bristol-Myers Squibb Co. | BU-4164E - A and B, prolyl endopeptidase inhibitors |
US5073549A (en) * | 1990-03-22 | 1991-12-17 | Bristol-Myers Squibb Company | BU-4164E - A and B, prolyl endopeptidase inhibitors and their methods of use |
JP3810097B2 (ja) * | 1993-01-15 | 2006-08-16 | 明治製菓株式会社 | ピロリジン−2−イルカルボニル複素環式化合物誘導体 |
FR2703050B1 (fr) * | 1993-03-24 | 1995-04-28 | Adir | Nouveaux dérivés bicycliques azotés, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
US5767242A (en) * | 1994-04-20 | 1998-06-16 | Boehringer Ingelheim Int'l Gmbh | Isolated dimeric fibroblast activation protein alpha, and uses thereof |
HUT76640A (en) | 1995-08-17 | 1997-10-28 | Chinoin Gyogyszer Es Vegyeszet | Compounds of pharmaceutical activity cyclic amide derivatives, pharmaceutical compositions containing them, process for producing them and their use |
BR9712023A (pt) * | 1996-09-10 | 1999-08-31 | Thomae Gmbh Dr K | Aminoácidos derivados, medicamentos contendo esses compostos e processos para a sua preparação. |
DE19720011A1 (de) * | 1997-05-14 | 1998-11-19 | Boehringer Ingelheim Pharma | Abgewandelte Aminosäuren, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Hetstellung |
HUP9700442A1 (hu) * | 1997-02-14 | 1999-09-28 | Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. | Gyűrűs amidszármazékok, e vegyületeket tartalmazó gyógyászati készítmények, eljárás előállításukra és alkalmazásuk |
US6313097B1 (en) | 1999-03-02 | 2001-11-06 | Boehringer Ingelheim Pharma Kg | Antagonists of calcitonin gene-related peptide |
US6121311A (en) * | 1999-04-28 | 2000-09-19 | Japan Tobacco Inc. | Method for treating cocainism |
FI20030014A0 (fi) * | 2003-01-03 | 2003-01-03 | Orion Corp | Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä |
DE602004026289D1 (de) | 2003-05-05 | 2010-05-12 | Probiodrug Ag | Glutaminylcyclase-hemmer |
ZA200603165B (en) | 2003-11-03 | 2007-07-25 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
AU2005210004B2 (en) | 2004-02-05 | 2010-10-28 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
EP1760076A1 (de) * | 2005-09-02 | 2007-03-07 | Ferring B.V. | FAP Inhibitoren |
WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
WO2008065141A1 (en) | 2006-11-30 | 2008-06-05 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
ZA200905537B (en) | 2007-03-01 | 2010-10-27 | Probiodrug Ag | New use of glutaminyl cyclase inhibitors |
JP5667440B2 (ja) | 2007-04-18 | 2015-02-12 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体 |
MX2012002993A (es) | 2009-09-11 | 2012-04-19 | Probiodrug Ag | Derivados heterociclicos como inhibidores de ciclasa glutaminilo. |
JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
MX2012010470A (es) | 2010-03-10 | 2012-10-09 | Probiodrug Ag | Inhibidores heterociclicos d ciclasa de glutaminilo (qc, ec .3 2. 5). |
US8541596B2 (en) | 2010-04-21 | 2013-09-24 | Probiodrug Ag | Inhibitors |
WO2012123563A1 (en) | 2011-03-16 | 2012-09-20 | Probiodrug Ag | Benz imidazole derivatives as inhibitors of glutaminyl cyclase |
EP3461819B1 (de) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Hemmer der glutaminylcyclase |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1062206B (it) * | 1974-02-01 | 1983-09-20 | Rotta Research Lab S P A A S | Derivati della tirosina attivi sulla muscolatura liscia |
GB1492640A (en) * | 1975-07-08 | 1977-11-23 | Ucb Sa | L-pyroglutamyl-l-prolinamide |
FR2489319A1 (fr) * | 1980-08-27 | 1982-03-05 | Clin Midy | Derives de l'acide amino-4 butyrique et les medicaments, actifs notamment sur le systeme nerveux central, en contenant |
JPS60172929A (ja) * | 1984-02-17 | 1985-09-06 | Yakult Honsha Co Ltd | 抗健忘症剤 |
JPS60188317A (ja) * | 1984-03-09 | 1985-09-25 | Yakult Honsha Co Ltd | 抗健忘症剤 |
JPS6137764A (ja) * | 1984-07-31 | 1986-02-22 | Suntory Ltd | 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物 |
JPH0623190B2 (ja) * | 1985-04-16 | 1994-03-30 | サントリー株式会社 | インヒビタ−活性を有するn−アシルピロリジン誘導体及びその製法並びに用途 |
JPH0651677B2 (ja) * | 1985-12-23 | 1994-07-06 | サントリー株式会社 | ジペプチド誘導体及びその製法並びに用途 |
DE3684633D1 (de) * | 1985-04-16 | 1992-05-07 | Suntory Ltd | Dipeptid-derivate von fettsaeure, verfahren zu ihrer herstellung, heilmittel, das sie enthaelt und anwendung. |
JPH0764834B2 (ja) * | 1985-11-29 | 1995-07-12 | サントリー株式会社 | プロリルエンドペプチダーゼ阻害活性を有する新規ピロリジンアミド誘導体およびその製法並びに用途 |
GB8618188D0 (en) * | 1986-07-25 | 1986-09-03 | Ici Plc | Diamine compounds |
EP0284632A1 (de) * | 1987-03-30 | 1988-10-05 | Shosuke Okamoto | Phenylalaninabkömmling und Inhibitor von Proteinase |
-
1987
- 1987-01-30 CA CA000528630A patent/CA1320734C/en not_active Expired - Fee Related
- 1987-02-03 AU AU68228/87A patent/AU588968B2/en not_active Ceased
- 1987-02-03 US US07/010,490 patent/US4826870A/en not_active Expired - Lifetime
- 1987-02-04 ES ES87101504T patent/ES2056791T3/es not_active Expired - Lifetime
- 1987-02-04 EP EP87101504A patent/EP0232849B1/de not_active Expired - Lifetime
- 1987-02-04 DE DE87101504T patent/DE3785684T2/de not_active Expired - Fee Related
-
1993
- 1993-05-06 GR GR920403167T patent/GR3007789T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
US4826870A (en) | 1989-05-02 |
CA1320734C (en) | 1993-07-27 |
EP0232849A2 (de) | 1987-08-19 |
AU6822887A (en) | 1987-08-06 |
AU588968B2 (en) | 1989-09-28 |
ES2056791T3 (es) | 1994-10-16 |
DE3785684D1 (de) | 1993-06-09 |
GR3007789T3 (de) | 1993-08-31 |
EP0232849B1 (de) | 1993-05-05 |
EP0232849A3 (en) | 1989-01-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3785684T2 (de) | Pyrrolidinamid-Derivate von Acylaminosäure, pharmazeutische Zusammensetzung und Verwendung. | |
DE3770085D1 (de) | Cyclodextrinclathrate von carbacyclinderivaten und ihre verwendung als arzneimittel. | |
DE3854013D1 (de) | Verwendung von N,N-Dialkylhydroxylaminen und ihre Herstellung. | |
DE3769122D1 (de) | Nitro-derivate von 2-iminoimidazolidinen und 2-iminotetrahydropyrimidinen. | |
DE3876400D1 (de) | Aminosaeure-imid-derivate, ihre verwendung und diese enthaltende medizinische zusammensetzungen. | |
ES2022889B3 (es) | Derivados de tiolactama-n-acido acetico, su produccion y uso. | |
DE3789347D1 (de) | 5-Substituierte Amino-4-hydroxy-pentansäure-Derivate und deren Verwendung. | |
DE3879811T2 (de) | Pharmazeutische Zusammensetzung und ihre Verwendung. | |
ATE68186T1 (de) | Verwendung von podophyllotoxin und dessen derivaten. | |
DK131887D0 (da) | 1,2,3,4-tetrahydro-3-carbamoyl-2-thioxo/oxo-5-pyrimidencarboxylsyre-derivater og deres anvendelse som laegemidler | |
DE3783751D1 (de) | Glyzirrhetinsaeure-derivate und ihre anwendung. | |
DK133587D0 (da) | 2-heterocyclylthio-penemer, deres anvendelse og farmaceutisk komposition indeholdende forbindelserne | |
ATA125688A (de) | 1-amino-2-(phenoxypropylamino)-1-cyclobuten-3,4 dionderivate und ihre verwendung | |
ES2016376B3 (es) | Acido n,n-bis-(4-fluorofenil) carbamoilacetohidroxamico y composicion farmaceutica que lo contiene. | |
ATE89000T1 (de) | Pyrrolidinamid-derivate von acylaminosaeure, pharmazeutische zusammensetzung und verwendung. | |
DE3769332D1 (de) | Derivate von pyrido-menadion-additionsprodukten und verwendungen davon. | |
DE3779211D1 (de) | Verwendung von dihydrobenzopyranderivaten. | |
DE3788888D1 (de) | Perhydrothiazepin- und Perhydroazepinderivate, ihre Herstellung und ihre therapeutische Verwendung. | |
DK37787D0 (da) | 2,3-dioxabicyclooe3,3,0aaoctan-derivater og deres anvendelse som laegemidler | |
DE3781357T2 (de) | 5-fluorouracil-derivate, pharmazeutische zubereitung und verwendung. | |
DE3785272T2 (de) | Derivate von 2,2-dimethylcyclopropancarbonsaeure. | |
ATA264387A (de) | Pharmazeutische verwendung von phenoxypentyloxy-3,4-dihydro-2h-1-benzopyranderivaten | |
ATA263987A (de) | Pharmazeutische verwendung von phenoxypentyloxy-3,4-dihydro-2h-1-benzopyrander vaten | |
ATE102952T1 (de) | 5-substituierte amino-4-hydroxy-pentansaeurederivate und deren verwendung. | |
ATA273988A (de) | Neue verwendung von 11,28-dioxa-4-azatricyclo- (22.3.1.04,9)octacos-18-en-derivaten und sie enthaltende pharmazeutische zubereitungen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |