ES2099755T3 - Derivados tripeptidicos de trifluorometilcetona. - Google Patents

Derivados tripeptidicos de trifluorometilcetona.

Info

Publication number
ES2099755T3
ES2099755T3 ES92100014T ES92100014T ES2099755T3 ES 2099755 T3 ES2099755 T3 ES 2099755T3 ES 92100014 T ES92100014 T ES 92100014T ES 92100014 T ES92100014 T ES 92100014T ES 2099755 T3 ES2099755 T3 ES 2099755T3
Authority
ES
Spain
Prior art keywords
alkyl
carboxy
phenyl
derivatives
trifluorometilcetone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92100014T
Other languages
English (en)
Inventor
Keiji Hemmi
Ichiro Shima
Keisuke Imai
Hirokazu Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909028231A external-priority patent/GB9028231D0/en
Priority claimed from GB919119713A external-priority patent/GB9119713D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2099755T3 publication Critical patent/ES2099755T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

NUEVOS DERIVADOS DE TRIFLUOROMETILQUETONA DE LA SIGUIENTE FORMULA: EN LA QUE R ELEVADO 1 ES UNA ALQUIL BAJO QUE TIENE UNO O DOS SUBSTITUENDOS SELECCIONADOS DE CARBOXI, CARBOXI ESTERIFICADO Y ALQUILCARBAMOIL DI-BAJO; FENIL (BAJO) ALQUIL, CUYA MITAD FENIL PUEDE TENER HALOGENO O NITRO O AMINO Y CUYA MITAD ALQUIL PUEDE TENER CARBOXI O CARBOXI ESTERIFICADO; HALO-FENIL; MORFOLINO; O MORFOLINO (BAJO) ALQUIL, R (AL CUADRADO) Y R ELEVADO 3 SON CADA UNO ALQUIL BAJO, X ES MACEUTICAMENTE ACEPTABLES DE LOS MISMOS, PROCESOS PARA SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LAS CONTIENEN.
ES92100014T 1990-12-31 1992-01-02 Derivados tripeptidicos de trifluorometilcetona. Expired - Lifetime ES2099755T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909028231A GB9028231D0 (en) 1990-12-31 1990-12-31 Trifluoromethylketone derivatives,processes for preparation thereof and use thereof
GB919119713A GB9119713D0 (en) 1991-09-16 1991-09-16 Trifluoremethylketone derivatives, processes for preparation thereof and use thereof

Publications (1)

Publication Number Publication Date
ES2099755T3 true ES2099755T3 (es) 1997-06-01

Family

ID=26298196

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92100014T Expired - Lifetime ES2099755T3 (es) 1990-12-31 1992-01-02 Derivados tripeptidicos de trifluorometilcetona.

Country Status (19)

Country Link
US (2) US5296591A (es)
EP (1) EP0494071B1 (es)
JP (1) JPH0699378B2 (es)
KR (1) KR100192991B1 (es)
CN (1) CN1040003C (es)
AT (1) ATE151775T1 (es)
AU (1) AU641577B2 (es)
CA (1) CA2058560C (es)
DE (1) DE69218977T2 (es)
DK (1) DK0494071T3 (es)
ES (1) ES2099755T3 (es)
FI (1) FI106379B (es)
GR (1) GR3023719T3 (es)
HU (2) HU210263B (es)
IE (1) IE914360A1 (es)
MX (1) MX9102612A (es)
NO (1) NO309274B1 (es)
RU (1) RU2073684C1 (es)
SG (1) SG50457A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5296591A (en) * 1990-12-31 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Trifluoromethylketone derivatives, processes for preparation thereof and use thereof
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
US5714470A (en) * 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
FR2694295B1 (fr) * 1992-07-28 1994-09-02 Adir Nouveaux peptides dérivés de trifluoromethylcetones, leur procéde de préparation et les compositions pharmaceutiques qui les contiennent.
FR2719589B1 (fr) * 1994-05-05 1996-06-14 Adir Nouveaux peptides dérivés de trifluorométhylcétones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
NZ284766A (en) * 1994-06-02 1998-06-26 Merrell Pharma Inc Perfluoro amino ketones; medicaments as elastase inhibitors
ATE206055T1 (de) * 1994-06-02 2001-10-15 Merrell Pharma Inc Acylierte enolderivate als vorläufdrogen von elastaseinhibitoren
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
JP2002161051A (ja) * 1996-12-24 2002-06-04 Fujisawa Pharmaceut Co Ltd 脳虚血性疾患等の治療剤
ES2421505T3 (es) * 1998-02-24 2013-09-03 Astellas Pharma Inc Preventivos/remedios contra el envejecimiento de la piel
US20020045231A1 (en) * 1999-02-02 2002-04-18 Napper Andrew D. Catalytic antibodies which hydrolyze primary amides and methods for eliciting such antibodies
CA2387199A1 (en) * 1999-10-12 2001-04-19 Fujisawa Pharmaceutical Co., Ltd. Remedies for intractable wound
IL148924A (en) * 2002-03-26 2015-06-30 Mor Research Applic Ltd Use of substances that inhibit intracellular elastase activity in the preparation of a drug for the treatment and / or prevention of necrosis of cells and related diseases
DE10219464A1 (de) 2002-04-30 2003-11-13 Focke & Co Zigarettenpackung
SE0202462D0 (sv) * 2002-08-14 2002-08-14 Astrazeneca Ab Novel use
DE602007013387D1 (de) * 2006-05-23 2011-05-05 Irm Llc Verbindungen und zusammensetzungen als kanalaktivierende protease-hemmer
US20090202514A1 (en) * 2006-08-25 2009-08-13 Hiroyuki Yoneyama Agents for improving chronic obstructive pulmonary diseases
US8754107B2 (en) * 2006-11-17 2014-06-17 Abbvie Inc. Aminopyrrolidines as chemokine receptor antagonists
DK2488486T3 (da) * 2009-10-13 2019-11-18 Ligand Pharm Inc Småmolekylære forbindelser der efterligner hæmapoetisk vækstfaktor og anvendelse deraf
SG11201509244XA (en) * 2013-05-08 2015-12-30 Kissei Pharmaceutical Α-substituted glycineamide derivative
CN104650016A (zh) * 2015-01-29 2015-05-27 武汉大学 拟三肽类化合物及其制备方法
TWI734647B (zh) 2016-06-24 2021-07-21 日商寶麗化成工業股份有限公司 皺紋改善用之皮膚外用劑
MX2020004892A (es) 2017-11-15 2020-08-06 Pola Chem Ind Inc Composicion a base de aceite.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
EP0276101A3 (en) * 1987-01-19 1989-11-23 Ici Americas Inc. Substituted peptide derivatives
EP0369391A3 (en) 1988-11-15 1991-09-25 Boehringer Ingelheim Pharmaceuticals Inc. N-substituted amides
US5221665A (en) * 1989-10-27 1993-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. N-substituted amides
US5296591A (en) * 1990-12-31 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Trifluoromethylketone derivatives, processes for preparation thereof and use thereof

Also Published As

Publication number Publication date
DK0494071T3 (es) 1997-05-12
HU211943A9 (en) 1996-01-29
JPH04297446A (ja) 1992-10-21
EP0494071B1 (en) 1997-04-16
DE69218977T2 (de) 1997-08-07
AU641577B2 (en) 1993-09-23
NO920035L (no) 1992-07-01
CN1040003C (zh) 1998-09-30
CN1063108A (zh) 1992-07-29
EP0494071A2 (en) 1992-07-08
HUT60507A (en) 1992-09-28
US5296591A (en) 1994-03-22
KR100192991B1 (ko) 1999-06-15
ATE151775T1 (de) 1997-05-15
NO309274B1 (no) 2001-01-08
AU8985391A (en) 1992-07-02
JPH0699378B2 (ja) 1994-12-07
FI915996A0 (fi) 1991-12-19
HU914153D0 (en) 1992-03-30
EP0494071A3 (en) 1993-05-05
DE69218977D1 (de) 1997-05-22
IE914360A1 (en) 1992-07-01
FI915996A (fi) 1992-07-01
NO920035D0 (no) 1992-01-02
HU210263B (en) 1995-03-28
RU2073684C1 (ru) 1997-02-20
CA2058560C (en) 2000-12-12
KR920011988A (ko) 1992-07-25
FI106379B (fi) 2001-01-31
CA2058560A1 (en) 1992-07-01
SG50457A1 (en) 1998-07-20
US5430025A (en) 1995-07-04
GR3023719T3 (en) 1997-09-30
MX9102612A (es) 1992-06-01

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