ATE206055T1 - Acylierte enolderivate als vorläufdrogen von elastaseinhibitoren - Google Patents

Acylierte enolderivate als vorläufdrogen von elastaseinhibitoren

Info

Publication number
ATE206055T1
ATE206055T1 AT95921240T AT95921240T ATE206055T1 AT E206055 T1 ATE206055 T1 AT E206055T1 AT 95921240 T AT95921240 T AT 95921240T AT 95921240 T AT95921240 T AT 95921240T AT E206055 T1 ATE206055 T1 AT E206055T1
Authority
AT
Austria
Prior art keywords
elastase inhibitors
enol derivatives
precursor drugs
acylated enol
acylated
Prior art date
Application number
AT95921240T
Other languages
English (en)
Inventor
Norton P Peet
Joseph P Burkhart
Shujaath Mehdi
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of ATE206055T1 publication Critical patent/ATE206055T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT95921240T 1994-06-02 1995-05-08 Acylierte enolderivate als vorläufdrogen von elastaseinhibitoren ATE206055T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25279894A 1994-06-02 1994-06-02
US42085995A 1995-04-19 1995-04-19
PCT/US1995/005879 WO1995033478A1 (en) 1994-06-02 1995-05-08 Acylated enol derivatives as prodrugs of elastase inhibitors

Publications (1)

Publication Number Publication Date
ATE206055T1 true ATE206055T1 (de) 2001-10-15

Family

ID=26942673

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95921240T ATE206055T1 (de) 1994-06-02 1995-05-08 Acylierte enolderivate als vorläufdrogen von elastaseinhibitoren

Country Status (20)

Country Link
US (2) US5698523A (de)
EP (1) EP0762887B1 (de)
JP (1) JP4221059B2 (de)
KR (1) KR100367389B1 (de)
CN (1) CN1149833A (de)
AT (1) ATE206055T1 (de)
AU (1) AU696292B2 (de)
CA (1) CA2191844C (de)
DE (1) DE69522940T2 (de)
DK (1) DK0762887T3 (de)
ES (1) ES2161293T3 (de)
FI (1) FI964749A0 (de)
HU (1) HU221310B1 (de)
IL (1) IL113869A (de)
MX (1) MX9606034A (de)
NO (1) NO317185B1 (de)
NZ (1) NZ287604A (de)
PT (1) PT762887E (de)
TW (1) TW406087B (de)
WO (1) WO1995033478A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100367389B1 (ko) * 1994-06-02 2003-07-18 메렐 파마슈티칼스 인크. 엘라스타제억제제의프로드러그로서아실화에놀유도체
AU690986B2 (en) * 1994-06-02 1998-05-07 Merrell Pharmaceuticals Inc. Perfluoroalkyl ketone inhibitors of elastase and processes for making the same
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
MX2009005252A (es) * 2006-11-17 2009-05-28 Abbott Lab Aminopirrolidinas como antagonistas del receptor de quimiocina.

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4308384A (en) * 1978-09-18 1981-12-29 Glaxo Group Limited Production of triazinones
US4277395A (en) * 1980-06-16 1981-07-07 Richardson-Merrell Inc. Novel enzyme inhibitors
US4518528A (en) * 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
DE3324534A1 (de) * 1983-07-07 1985-01-17 Ciba-Geigy Ag, Basel Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel
CA1267499A (en) * 1983-07-12 1990-04-03 Cedric H. Hassall Peptide amides and aldehydes
US4629724A (en) * 1984-12-03 1986-12-16 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitors
US4643991A (en) * 1984-12-18 1987-02-17 The University Of Kentucky Research Foundation Peptide elastase inhibitors and methods
US5055450A (en) * 1985-01-22 1991-10-08 Ici Americas Inc. Peptide derivatives
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
US5496927A (en) * 1985-02-04 1996-03-05 Merrell Pharmaceuticals Inc. Peptidase inhibitors
AU600226B2 (en) * 1985-02-04 1990-08-09 Merrell Pharmaceuticals Inc. Novel peptidase inhibitors
EP0204571B1 (de) * 1985-06-07 1992-01-22 Ici Americas Inc. Selektionierte Difluorverbindungen
GB8613703D0 (en) * 1986-06-05 1986-07-09 Ici America Inc Difluoro peptide compounds
US4935405A (en) * 1986-10-31 1990-06-19 Pfizer Inc. Nor-statine and nor-cyclostatine polypeptides
US4855303A (en) * 1987-07-01 1989-08-08 Pfizer Inc. Fluorine containing renin inhibitors
EP0318318A1 (de) * 1987-11-27 1989-05-31 Sensititre Limited Urintestverfahren und Testsatz
US5162307A (en) * 1988-09-09 1992-11-10 Board Of Trustees Of The University Of Kentucky Polymer bound elastase inhibitors
EP0371179A1 (de) * 1988-10-28 1990-06-06 Merrell Dow Pharmaceuticals Inc. Analoge von Peptidase-Substraten
EP0369391A3 (de) * 1988-11-15 1991-09-25 Boehringer Ingelheim Pharmaceuticals Inc. N-substituierte Amide
ZA905737B (en) * 1989-07-26 1991-05-29 Merrell Dow Pharma Novel peptidase inhibitors
US5221665A (en) * 1989-10-27 1993-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. N-substituted amides
AU661270B2 (en) * 1990-03-05 1995-07-20 Cephalon, Inc. Chymotrypsin-like proteases and their inhibitors
EP0480044A4 (en) * 1990-03-30 1993-06-09 Japan Tobacco Inc. Novel 4h-3,1-benzoxazin-4-one derivative
WO1992012140A1 (en) * 1990-12-28 1992-07-23 Georgia Tech Research Corporation Peptides ketoamides, ketoacids, and ketoesters
US5296591A (en) * 1990-12-31 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Trifluoromethylketone derivatives, processes for preparation thereof and use thereof
DE69233108T2 (de) * 1991-03-01 2004-04-29 Dyax Corp., Cambridge Hemmstoffe für menschliche neutrophile elastase und menschliches kathepsin g
DK0587799T3 (da) * 1991-05-23 1999-11-22 Merrell Pharma Inc Inhibitorer af cathepsin G og elastase til forebyggelse af bindevævsnedbrydning
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
AU655831B2 (en) * 1991-08-22 1995-01-12 Merrell Pharmaceuticals Inc. Novel orally-active elastase inhibitors
CA2171882C (en) * 1993-10-01 2001-12-04 Barbara Cordell Inhibitors of .beta.-amyloid protein production
KR100367389B1 (ko) * 1994-06-02 2003-07-18 메렐 파마슈티칼스 인크. 엘라스타제억제제의프로드러그로서아실화에놀유도체
AU690986B2 (en) * 1994-06-02 1998-05-07 Merrell Pharmaceuticals Inc. Perfluoroalkyl ketone inhibitors of elastase and processes for making the same
SI0804465T1 (en) * 1994-06-02 2003-12-31 Aventis Pharmaceuticals Inc. Novel elastase inhibitors

Also Published As

Publication number Publication date
NZ287604A (en) 1998-12-23
IL113869A0 (en) 1995-08-31
US5698523A (en) 1997-12-16
JP4221059B2 (ja) 2009-02-12
CA2191844C (en) 2001-07-24
US5972897A (en) 1999-10-26
HU221310B1 (en) 2002-09-28
KR100367389B1 (ko) 2003-07-18
DE69522940T2 (de) 2002-04-04
PT762887E (pt) 2002-01-30
TW406087B (en) 2000-09-21
NO965099L (no) 1997-01-31
HUT76131A (en) 1997-06-30
NO317185B1 (no) 2004-09-13
IL113869A (en) 2000-01-31
CA2191844A1 (en) 1995-12-14
HU9603309D0 (en) 1997-01-28
EP0762887A4 (de) 1999-03-31
DE69522940D1 (de) 2001-10-31
WO1995033478A1 (en) 1995-12-14
AU696292B2 (en) 1998-09-03
JPH10501221A (ja) 1998-02-03
FI964749A (fi) 1996-11-28
NO965099D0 (no) 1996-11-29
MX9606034A (es) 1998-05-31
AU2636695A (en) 1996-01-04
EP0762887B1 (de) 2001-09-26
FI964749A0 (fi) 1996-11-28
CN1149833A (zh) 1997-05-14
ES2161293T3 (es) 2001-12-01
EP0762887A1 (de) 1997-03-19
DK0762887T3 (da) 2002-01-14

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee