WO1999025327A3 - Small molecule intervention in hiv-1 replication - Google Patents

Small molecule intervention in hiv-1 replication Download PDF

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Publication number
WO1999025327A3
WO1999025327A3 PCT/US1998/019358 US9819358W WO9925327A3 WO 1999025327 A3 WO1999025327 A3 WO 1999025327A3 US 9819358 W US9819358 W US 9819358W WO 9925327 A3 WO9925327 A3 WO 9925327A3
Authority
WO
WIPO (PCT)
Prior art keywords
hiv
replication
small molecule
molecule intervention
intervention
Prior art date
Application number
PCT/US1998/019358
Other languages
French (fr)
Other versions
WO1999025327A2 (en
Inventor
Anthony William Czarnik
David Phillip Mack
Houng-Yau Mei
David Winslow Moreland
Original Assignee
Warner Lambert Co
Anthony William Czarnik
David Phillip Mack
Mei Houng Yau
David Winslow Moreland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co, Anthony William Czarnik, David Phillip Mack, Mei Houng Yau, David Winslow Moreland filed Critical Warner Lambert Co
Priority to AU93182/98A priority Critical patent/AU9318298A/en
Publication of WO1999025327A2 publication Critical patent/WO1999025327A2/en
Publication of WO1999025327A3 publication Critical patent/WO1999025327A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The instant invention is a series of small molecules which are inhibitors of HIV-1 Tat-TAR interaction. The compounds are useful in the treatment of HIV-1 infections.
PCT/US1998/019358 1997-11-14 1998-09-16 Small molecule intervention in hiv-1 replication WO1999025327A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU93182/98A AU9318298A (en) 1997-11-14 1998-09-16 Small molecule intervention in hiv-1 replication

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6555997P 1997-11-14 1997-11-14
US60/065,559 1997-11-14

Publications (2)

Publication Number Publication Date
WO1999025327A2 WO1999025327A2 (en) 1999-05-27
WO1999025327A3 true WO1999025327A3 (en) 1999-09-23

Family

ID=22063554

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/019358 WO1999025327A2 (en) 1997-11-14 1998-09-16 Small molecule intervention in hiv-1 replication

Country Status (2)

Country Link
AU (1) AU9318298A (en)
WO (1) WO1999025327A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002002516A2 (en) * 2000-06-30 2002-01-10 Thomas Jefferson University Inhibitors of hiv integrase
JP4707261B2 (en) * 2001-05-15 2011-06-22 日本エンバイロケミカルズ株式会社 Quinoxaline compound and industrial bactericidal composition
AU2002312927A1 (en) * 2001-05-18 2002-12-03 Axxima Pharmaceuticals Ag Benzo(g)quinoxaline derivatives as effective compounds against infectious diseases

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0657166A1 (en) * 1993-12-09 1995-06-14 Hoechst Aktiengesellschaft Combination containing a quinoxaline and a nucleoside
EP0708093A1 (en) * 1994-10-19 1996-04-24 Hoechst Aktiengesellschaft Quinoxalines, process for their preparation, and their use
WO1996017832A1 (en) * 1994-12-07 1996-06-13 Warner-Lambert Company Novel glutamate receptor antagonists: fused cycloalkylquinoxalinediones
WO1996040759A1 (en) * 1995-06-07 1996-12-19 Novartis Ag Antiviral peptoid compounds
WO1997027179A2 (en) * 1996-01-26 1997-07-31 Novartis Ag Antiretroviral bases

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0657166A1 (en) * 1993-12-09 1995-06-14 Hoechst Aktiengesellschaft Combination containing a quinoxaline and a nucleoside
EP0708093A1 (en) * 1994-10-19 1996-04-24 Hoechst Aktiengesellschaft Quinoxalines, process for their preparation, and their use
WO1996017832A1 (en) * 1994-12-07 1996-06-13 Warner-Lambert Company Novel glutamate receptor antagonists: fused cycloalkylquinoxalinediones
WO1996040759A1 (en) * 1995-06-07 1996-12-19 Novartis Ag Antiviral peptoid compounds
WO1997027179A2 (en) * 1996-01-26 1997-07-31 Novartis Ag Antiretroviral bases

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
H.-Y- MEI ET AL.: "Discovery of Selective, Small-Molecule Inhibitors of RNA Complexes - I. The Tat Protein/TAR RNA Complexes Required for HIV-1 Transcription", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 5, no. 6, 1997, pages 1173 - 1184, XP002096444 *
H.-Y. MEI ET AL.: "INHIBITION OF AN HIV-1 TAT-DERIVED PEPTIDE BINDING TO TAR RNA BY AMINOGLYCOSIDE ANTIBIOTICS", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 5, no. 22, 1995, pages 2755 - 2760, XP004135228 *
H.-Y.MEI ET AL.: "Inhibitors of Protein-RNA Complexation That Target the RNA: Specific Recognition of Human Immunodeficiency Virus Type 1 TAR RNA by Small Organic Molecules", BIOCHEMISTRY, vol. 37, no. 40, 17 September 1998 (1998-09-17), pages 13204 - 14212, XP002096445 *

Also Published As

Publication number Publication date
AU9318298A (en) 1999-06-07
WO1999025327A2 (en) 1999-05-27

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