DE69217711T2 - Auf der gastrointestinale Mukosa klebenden Matrizen oder Überzugmitteln enthaltende pharmazeutische Zubereitung - Google Patents
Auf der gastrointestinale Mukosa klebenden Matrizen oder Überzugmitteln enthaltende pharmazeutische ZubereitungInfo
- Publication number
- DE69217711T2 DE69217711T2 DE69217711T DE69217711T DE69217711T2 DE 69217711 T2 DE69217711 T2 DE 69217711T2 DE 69217711 T DE69217711 T DE 69217711T DE 69217711 T DE69217711 T DE 69217711T DE 69217711 T2 DE69217711 T2 DE 69217711T2
- Authority
- DE
- Germany
- Prior art keywords
- matrix
- fatty acid
- gastrointestinal mucosa
- active ingredient
- glyceride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- 239000008187 granular material Substances 0.000 claims abstract description 113
- -1 fatty acid ester Chemical class 0.000 claims abstract description 96
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 81
- 239000000194 fatty acid Substances 0.000 claims abstract description 81
- 229930195729 fatty acid Natural products 0.000 claims abstract description 81
- 239000004480 active ingredient Substances 0.000 claims abstract description 71
- 229920000223 polyglycerol Polymers 0.000 claims abstract description 71
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 68
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- 238000002360 preparation method Methods 0.000 claims abstract description 24
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- 125000005456 glyceride group Chemical group 0.000 claims description 95
- 238000000034 method Methods 0.000 claims description 57
- 150000003839 salts Chemical class 0.000 claims description 37
- 125000000217 alkyl group Chemical group 0.000 claims description 36
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- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
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- SEEPANYCNGTZFQ-UHFFFAOYSA-N sulfadiazine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CC=N1 SEEPANYCNGTZFQ-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11674591 | 1991-04-19 | ||
| JP22515591 | 1991-08-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69217711D1 DE69217711D1 (de) | 1997-04-10 |
| DE69217711T2 true DE69217711T2 (de) | 1997-07-17 |
Family
ID=26455015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69217711T Expired - Fee Related DE69217711T2 (de) | 1991-04-19 | 1992-04-14 | Auf der gastrointestinale Mukosa klebenden Matrizen oder Überzugmitteln enthaltende pharmazeutische Zubereitung |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US5576025A (enExample) |
| EP (1) | EP0514008B1 (enExample) |
| JP (4) | JP3272029B2 (enExample) |
| KR (1) | KR100217165B1 (enExample) |
| AT (1) | ATE149348T1 (enExample) |
| CA (1) | CA2066384C (enExample) |
| DE (1) | DE69217711T2 (enExample) |
| DK (1) | DK0514008T3 (enExample) |
| ES (1) | ES2098447T3 (enExample) |
| GR (1) | GR3023383T3 (enExample) |
| SG (1) | SG50480A1 (enExample) |
| TW (1) | TW209174B (enExample) |
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| US20020099067A1 (en) * | 1993-07-08 | 2002-07-25 | Ulrich Posanski | Pharmaceutical compositions for sparingly soluble therapeutic agents |
| JPH07112940A (ja) * | 1993-08-26 | 1995-05-02 | Takeda Chem Ind Ltd | 徐放性非経口投与製剤およびその製造方法 |
| TW359614B (en) * | 1993-08-31 | 1999-06-01 | Takeda Chemical Industries Ltd | Composition containing benzimidazole compounds for rectal administration |
| EP0995447A1 (en) * | 1993-09-09 | 2000-04-26 | Takeda Chemical Industries, Ltd. | Formulation comprising antibacterial substance and antiulcer substance |
| US6692766B1 (en) * | 1994-06-15 | 2004-02-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Controlled release oral drug delivery system |
| GB9505032D0 (en) | 1995-03-13 | 1995-05-03 | Westminster Lab Ltd | Improvements in or relating to organic compositions |
| US5965161A (en) * | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
| DE19600324A1 (de) | 1996-01-08 | 1997-07-10 | Basf Ag | Granulate für kosmetische und pharmazeutische Zubereitungen |
| GB9607955D0 (en) * | 1996-04-17 | 1996-06-19 | Tillotts Pharma Ag | Hydrophobic carbomer salt compositions |
| CN1220598A (zh) * | 1996-05-02 | 1999-06-23 | 大正制药株式会社 | 水难溶性酸性药物的悬浮液 |
| FR2754177B1 (fr) * | 1996-10-07 | 1999-08-06 | Sanofi Sa | Microspheres pharmaceutiques d'acide valproique pour administration orale |
| WO1998042323A1 (en) * | 1997-03-25 | 1998-10-01 | Takeda Chemical Industries, Ltd. | Stabilized urease inhibitor |
| US6428813B1 (en) | 1997-03-25 | 2002-08-06 | Takeda Chemical Industries, Ltd. | Gastrointestinal mucosa-adherent pharmaceutical composition |
| ATE364374T1 (de) | 1997-08-11 | 2007-07-15 | Pfizer Prod Inc | Feste pharmazeutische dispersionen mit erhöhter bioverfügbarkeit |
| US6120803A (en) * | 1997-08-11 | 2000-09-19 | Alza Corporation | Prolonged release active agent dosage form adapted for gastric retention |
| WO1999010010A1 (en) * | 1997-08-27 | 1999-03-04 | Takeda Chemical Industries, Ltd. | Sustained-release oral preparation |
| US6607751B1 (en) * | 1997-10-10 | 2003-08-19 | Intellipharamaceutics Corp. | Controlled release delivery device for pharmaceutical agents incorporating microbial polysaccharide gum |
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| BR9908616A (pt) | 1998-03-20 | 2000-10-31 | Kowa Co | Composição farmacêutica adesiva gástrica e/ou duodenal. |
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| HRP20020006A2 (en) | 1999-06-07 | 2003-04-30 | Altana Pharma Ag | Novel preparation and administration form comprising an acid-labile active compound |
| RU2246293C2 (ru) | 1999-06-14 | 2005-02-20 | Космо С.П.А. | Фармацевтические композиции для перорального введения с регулируемым высвобождением активного ингредиента и маскируемым вкусом |
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| ATE366119T1 (de) * | 1999-08-09 | 2007-07-15 | Dainippon Sumitomo Pharma Co | Chitosanpulver enthaltende feste zubereitungen und verfahren zu deren herstellung |
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| JP4632499B2 (ja) * | 1999-08-26 | 2011-02-16 | 武田薬品工業株式会社 | 鼻粘膜付着マトリックス |
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-
1992
- 1992-04-11 TW TW081102828A patent/TW209174B/zh active
- 1992-04-14 SG SG1996002366A patent/SG50480A1/en unknown
- 1992-04-14 ES ES92303357T patent/ES2098447T3/es not_active Expired - Lifetime
- 1992-04-14 DE DE69217711T patent/DE69217711T2/de not_active Expired - Fee Related
- 1992-04-14 AT AT92303357T patent/ATE149348T1/de not_active IP Right Cessation
- 1992-04-14 DK DK92303357.5T patent/DK0514008T3/da active
- 1992-04-14 EP EP92303357A patent/EP0514008B1/en not_active Expired - Lifetime
- 1992-04-15 JP JP12268192A patent/JP3272029B2/ja not_active Expired - Fee Related
- 1992-04-16 CA CA002066384A patent/CA2066384C/en not_active Expired - Fee Related
- 1992-04-18 KR KR1019920006554A patent/KR100217165B1/ko not_active Expired - Fee Related
-
1995
- 1995-03-29 US US08/412,591 patent/US5576025A/en not_active Expired - Lifetime
-
1996
- 1996-08-20 US US08/697,166 patent/US5731006A/en not_active Expired - Fee Related
-
1997
- 1997-05-09 GR GR970401036T patent/GR3023383T3/el unknown
- 1997-12-18 US US08/993,314 patent/US6368635B1/en not_active Expired - Fee Related
-
2001
- 2001-05-11 JP JP2001141179A patent/JP4084000B2/ja not_active Expired - Fee Related
- 2001-05-11 JP JP2001141178A patent/JP2001354593A/ja active Pending
-
2002
- 2002-02-20 US US10/077,896 patent/US20020142041A1/en not_active Abandoned
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2007
- 2007-07-09 JP JP2007179258A patent/JP2007246547A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ATE149348T1 (de) | 1997-03-15 |
| US20020142041A1 (en) | 2002-10-03 |
| JP2001354550A (ja) | 2001-12-25 |
| US5731006A (en) | 1998-03-24 |
| KR100217165B1 (ko) | 1999-09-01 |
| US5576025A (en) | 1996-11-19 |
| CA2066384A1 (en) | 1992-10-20 |
| EP0514008B1 (en) | 1997-03-05 |
| DK0514008T3 (da) | 1997-05-12 |
| CA2066384C (en) | 2007-04-03 |
| GR3023383T3 (en) | 1997-08-29 |
| JP3272029B2 (ja) | 2002-04-08 |
| SG50480A1 (en) | 1998-07-20 |
| JP2001354593A (ja) | 2001-12-25 |
| EP0514008A1 (en) | 1992-11-19 |
| US6368635B1 (en) | 2002-04-09 |
| DE69217711D1 (de) | 1997-04-10 |
| JP4084000B2 (ja) | 2008-04-30 |
| KR920019336A (ko) | 1992-11-19 |
| TW209174B (enExample) | 1993-07-11 |
| JPH05132416A (ja) | 1993-05-28 |
| ES2098447T3 (es) | 1997-05-01 |
| JP2007246547A (ja) | 2007-09-27 |
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