MX338355B - Sistemas de suministro de farmaco topico para uso oftalmico. - Google Patents

Sistemas de suministro de farmaco topico para uso oftalmico.

Info

Publication number
MX338355B
MX338355B MX2011012969A MX2011012969A MX338355B MX 338355 B MX338355 B MX 338355B MX 2011012969 A MX2011012969 A MX 2011012969A MX 2011012969 A MX2011012969 A MX 2011012969A MX 338355 B MX338355 B MX 338355B
Authority
MX
Mexico
Prior art keywords
drug delivery
delivery systems
topical drug
ophthalmic use
hydrophobic core
Prior art date
Application number
MX2011012969A
Other languages
English (en)
Other versions
MX2011012969A (es
Inventor
Ashim K Mitra
Poonam R Velagaleti
Ulrich M Grau
Original Assignee
Aurinia Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aurinia Pharmaceuticals Inc filed Critical Aurinia Pharmaceuticals Inc
Publication of MX2011012969A publication Critical patent/MX2011012969A/es
Publication of MX338355B publication Critical patent/MX338355B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se describen sistemas de suministro de fármaco tópicos para uso oftálmico incluyendo formulaciones nanomicelares mezcladas de fármacos insolubles en agua y métodos para tratar las enfermedades que afectan los segmentos oculares posteriores. En una modalidad, una solución oftálmica acuosa incluye nanomicelas en una solución amortiguadora fisiológicamente aceptable, que tiene un pH de 5.0 hasta 8.0, en donde el corticosteroide a una concentración desde alrededor de 0.01% p/v hasta alrededor de 1.00 % p/v se solubiliza a través del atrapado en un núcleo hidrofóbico micelar mezclado con una corona compuesta de cadenas hidrofílicas que se extienden desde el núcleo hidrofóbico, en donde las nanomicelas comprende vitamina E TPGS a una concentración en el intervalo desde alrededor de 3.0 % p/v hasta alrededor de 5.0% p/v estabilizada con octoxinol-40 a una concentración en el intervalo desde alrededor de 1.0 % p/v hasta alrededor de 3.0 % p/v.
MX2011012969A 2009-06-09 2010-05-05 Sistemas de suministro de farmaco topico para uso oftalmico. MX338355B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18539609P 2009-06-09 2009-06-09
PCT/US2010/033779 WO2010144194A1 (en) 2009-06-09 2010-05-05 Topical drug delivery systems for ophthalmic use

Publications (2)

Publication Number Publication Date
MX2011012969A MX2011012969A (es) 2012-02-01
MX338355B true MX338355B (es) 2016-04-13

Family

ID=43300918

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011012969A MX338355B (es) 2009-06-09 2010-05-05 Sistemas de suministro de farmaco topico para uso oftalmico.

Country Status (9)

Country Link
US (2) US9017725B2 (es)
EP (1) EP2440185B1 (es)
JP (1) JP2012529509A (es)
CN (1) CN102458370A (es)
AU (1) AU2010259184B2 (es)
CA (1) CA2764635C (es)
ES (1) ES2537385T3 (es)
MX (1) MX338355B (es)
WO (1) WO2010144194A1 (es)

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CA2764635A1 (en) 2010-12-16
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JP2012529509A (ja) 2012-11-22
ES2537385T3 (es) 2015-06-08
US9017725B2 (en) 2015-04-28
US20150202150A1 (en) 2015-07-23
EP2440185B1 (en) 2015-04-08
EP2440185A4 (en) 2012-12-12
CN102458370A (zh) 2012-05-16
EP2440185A1 (en) 2012-04-18
US20100310642A1 (en) 2010-12-09
AU2010259184B2 (en) 2015-08-13
CA2764635C (en) 2018-05-22

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