DE69123124T2 - Dihydro-Isoquinolinderivate - Google Patents

Dihydro-Isoquinolinderivate

Info

Publication number
DE69123124T2
DE69123124T2 DE69123124T DE69123124T DE69123124T2 DE 69123124 T2 DE69123124 T2 DE 69123124T2 DE 69123124 T DE69123124 T DE 69123124T DE 69123124 T DE69123124 T DE 69123124T DE 69123124 T2 DE69123124 T2 DE 69123124T2
Authority
DE
Germany
Prior art keywords
compound
ester
formula
acid addition
addition salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69123124T
Other languages
German (de)
English (en)
Other versions
DE69123124D1 (de
Inventor
Reto Naef
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of DE69123124D1 publication Critical patent/DE69123124D1/de
Application granted granted Critical
Publication of DE69123124T2 publication Critical patent/DE69123124T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
DE69123124T 1990-12-13 1991-12-09 Dihydro-Isoquinolinderivate Expired - Fee Related DE69123124T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909027055A GB9027055D0 (en) 1990-12-13 1990-12-13 Organic compounds

Publications (2)

Publication Number Publication Date
DE69123124D1 DE69123124D1 (de) 1996-12-19
DE69123124T2 true DE69123124T2 (de) 1997-05-15

Family

ID=10686945

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69123124T Expired - Fee Related DE69123124T2 (de) 1990-12-13 1991-12-09 Dihydro-Isoquinolinderivate

Country Status (25)

Country Link
US (1) US5177085A (https=)
EP (1) EP0490823B1 (https=)
JP (1) JPH0764820B2 (https=)
KR (1) KR920012040A (https=)
AT (1) ATE145201T1 (https=)
AU (1) AU643575B2 (https=)
CA (1) CA2057524A1 (https=)
CZ (1) CZ281669B6 (https=)
DE (1) DE69123124T2 (https=)
DK (1) DK0490823T3 (https=)
ES (1) ES2093694T3 (https=)
FI (1) FI915844A7 (https=)
GB (1) GB9027055D0 (https=)
GR (1) GR3022034T3 (https=)
HU (1) HUT61729A (https=)
IE (1) IE914325A1 (https=)
IL (1) IL100328A (https=)
MX (1) MX9102502A (https=)
MY (1) MY129941A (https=)
NZ (1) NZ240936A (https=)
PL (1) PL168329B1 (https=)
PT (1) PT99775B (https=)
RU (1) RU2060992C1 (https=)
TW (1) TW201736B (https=)
ZA (1) ZA919858B (https=)

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US5786354A (en) * 1994-06-21 1998-07-28 Celltech Therapeutics, Limited Tri-substituted phenyl derivatives and processes for their preparation
US6245774B1 (en) 1994-06-21 2001-06-12 Celltech Therapeutics Limited Tri-substituted phenyl or pyridine derivatives
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US5922751A (en) * 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
RU2161967C2 (ru) * 1994-08-18 2001-01-20 Дзе Проктер Энд Гэмбл Компани Соединения 7-(2-имидазолиниламино) хинолина, пригодные в качестве агонистов альфа-2-адренорецептора
US5948820A (en) 1994-08-22 1999-09-07 Yoshitomi Pharmaceutical Industries, Ltd. Benzene compound and pharmaceutical use thereof
EP0778263B1 (en) * 1994-08-22 2002-01-09 Welfide Corporation Benzene compound and medicinal use thereof
US6025361A (en) * 1994-12-13 2000-02-15 Euro-Celtique, S.A. Trisubstituted thioxanthines
EP0799040B1 (en) * 1994-12-13 2003-08-20 Euroceltique S.A. Trisubstituted thioxanthines
US6268373B1 (en) * 1995-06-07 2001-07-31 Euro-Celtique S.A. Trisubstituted thioxanthines
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GB9526243D0 (en) * 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Chemical compounds
GB9526246D0 (en) * 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Chemical compounds
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WO1997034473A1 (en) * 1996-03-21 1997-09-25 The Trustees Of Columbia University In The City Of New York Craf1 (traf-3) isoforms and uses thereof
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EP0946523A1 (en) 1996-12-23 1999-10-06 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors
WO1998038168A1 (en) * 1997-02-27 1998-09-03 Tanabe Seiyaku Co., Ltd. Isoquinolinone derivatives, process for preparing the same, and their use as phosphodiesterase inhibitors
GB9705361D0 (en) 1997-03-14 1997-04-30 Celltech Therapeutics Ltd Chemical compounds
GB9713087D0 (en) * 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
PT998460E (pt) 1997-07-25 2004-07-30 Altana Pharma Ag Novos derivados de tetrazole
EP1023269A4 (en) * 1997-09-30 2001-06-27 Molecular Design Int BETA3-ADRENORECEPTOR AGONISTS, AGONIST COMPOSITIONS AND METHODS OF USE
IT1296985B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
IT1302677B1 (it) * 1998-10-15 2000-09-29 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
GB9914258D0 (en) 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
CA2715683A1 (en) 1999-08-21 2001-03-01 Nycomed Gmbh Synergistic combination
GB9924862D0 (en) 1999-10-20 1999-12-22 Celltech Therapeutics Ltd Chemical compounds
DE60125026T2 (de) * 2000-03-23 2007-06-28 Takeda Pharmaceutical Co. Ltd. Fluorisochinolinderivate, verfahren zu ihrer herstellung und ihre anwendung
CZ20031334A3 (cs) 2000-11-14 2003-09-17 Altana Pharma Ag Isochinolinové deriváty a jejich použití jako inhibitory
AU2002224835A1 (en) * 2000-11-14 2002-05-27 Byk Gulden Lomberg Chemische Fabrik G.M.B.H. Dihydroisoquinolines as novel phosphodiesterase inhibitors
US6593341B2 (en) 2001-03-29 2003-07-15 Molecular Design International, Inc. β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same
BR0209774A (pt) * 2001-05-29 2004-06-01 Schering Ag Pirimidinas inibidoras de cdk, sua preparação e aplicação como medicamento
DK1471054T3 (da) * 2002-01-11 2009-11-09 Daiichi Sankyo Co Ltd Aminoalkohol-derivat eller phosphonsyre-derivat og medicinsk sammensætning, der indeholder disse
US7745180B2 (en) * 2002-04-24 2010-06-29 Hitachi Chemical Co., Ltd. Device and method for high-throughput quantification of mRNA from whole blood
RS20050117A (sr) * 2002-08-17 2007-06-04 Altana Pharma Ag., Novi benzonaftiridini
CA2495597A1 (en) * 2002-08-17 2004-03-04 Altana Pharma Ag Novel phenanthridines
ATE353217T1 (de) 2002-08-29 2007-02-15 Altana Pharma Ag 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren
JP4587294B2 (ja) 2002-08-29 2010-11-24 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐｄｅ４インヒビターとしての２−ヒドロキシ−６−フェニルフェナントリジン
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US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US7153824B2 (en) 2003-04-01 2006-12-26 Applied Research Systems Ars Holding N.V. Inhibitors of phosphodiesterases in infertility
RU2355686C2 (ru) * 2003-10-16 2009-05-20 Ф.Хоффманн-Ля Рош Аг Ингибиторы глутаминфруктозо-6-фосфатамидотрансферазы
CA2556086C (en) 2004-02-18 2014-04-01 Altana Pharma Ag Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors
NZ549162A (en) 2004-02-24 2009-12-24 Sankyo Co Amino-pyrrol alcohol compounds
PL2589599T4 (pl) 2004-03-03 2015-06-30 Takeda Gmbh Nowe hydroksy-6-heteroarylofenantrydyny i ich zastosowanie jako inhibitorów PDE4
RU2281100C1 (ru) * 2005-01-11 2006-08-10 Общество с ограниченной ответственностью "Синтез-2000" Спазмолитическое средство
PL1856093T3 (pl) 2005-03-02 2010-05-31 Takeda Gmbh Chlorowodorek (2R,4aR,10bR)-6-(2,6-dimetoksy-pirydyn-3-ylo)-9-etoksy-8-metoksy-1,2,3,4,4a,10b-heksahydrofenantrydyn-2-olu
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
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AU2014305843B2 (en) 2013-08-09 2019-08-29 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
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GB1400425A (en) * 1971-09-22 1975-07-16 Rolland Sa A Substituted 3-hydroxymethyl-isoquinolines and derivatives
PH25651A (en) * 1986-05-21 1991-08-21 Duphar Int Res New di, tetrahydroisoquinoline derivatives
HU196758B (en) * 1986-05-21 1989-01-30 Gyogyszerkutato Intezet Process for production of 3-hidroxi-methil-quinolines and medical compositions containing them
GB8800397D0 (en) * 1988-01-08 1988-02-10 Sandoz Ltd Improvements in/relating to organic compounds

Also Published As

Publication number Publication date
IL100328A (en) 1995-12-08
HU913760D0 (en) 1992-02-28
EP0490823A1 (en) 1992-06-17
IL100328A0 (en) 1992-09-06
DE69123124D1 (de) 1996-12-19
KR920012040A (ko) 1992-07-25
CA2057524A1 (en) 1992-06-14
FI915844A0 (fi) 1991-12-11
FI915844L (fi) 1992-06-14
EP0490823B1 (en) 1996-11-13
JPH04275276A (ja) 1992-09-30
CS375791A3 (en) 1992-06-17
PT99775B (pt) 1999-05-31
RU2060992C1 (ru) 1996-05-27
HUT61729A (en) 1993-03-01
AU643575B2 (en) 1993-11-18
MX9102502A (es) 1992-06-01
TW201736B (https=) 1993-03-11
FI915844A7 (fi) 1992-06-14
ATE145201T1 (de) 1996-11-15
CZ281669B6 (cs) 1996-12-11
IE914325A1 (en) 1992-06-17
MY129941A (en) 2007-05-31
ZA919858B (en) 1993-06-14
JPH0764820B2 (ja) 1995-07-12
DK0490823T3 (https=) 1997-02-17
GR3022034T3 (en) 1997-03-31
PL168329B1 (pl) 1996-02-29
ES2093694T3 (es) 1997-01-01
US5177085A (en) 1993-01-05
PT99775A (pt) 1992-11-30
PL292738A1 (en) 1992-12-14
AU8898591A (en) 1992-06-18
NZ240936A (en) 1993-09-27
GB9027055D0 (en) 1991-02-06

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee