DE69115682T2 - Verfahren zur herstellung von liposomen mit erhöhtem einschlussvermögen bezüglich zu verkapselnder fremdsubstanzen - Google Patents

Verfahren zur herstellung von liposomen mit erhöhtem einschlussvermögen bezüglich zu verkapselnder fremdsubstanzen

Info

Publication number
DE69115682T2
DE69115682T2 DE69115682T DE69115682T DE69115682T2 DE 69115682 T2 DE69115682 T2 DE 69115682T2 DE 69115682 T DE69115682 T DE 69115682T DE 69115682 T DE69115682 T DE 69115682T DE 69115682 T2 DE69115682 T2 DE 69115682T2
Authority
DE
Germany
Prior art keywords
liposomes
lipid
vesicles
lipids
substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69115682T
Other languages
German (de)
English (en)
Other versions
DE69115682D1 (de
Inventor
Christian Guillot
Roland Hyacinthe
Bernard Lamy
Michel Schneider
Herve Tournier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco International BV
Original Assignee
Bracco International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco International BV filed Critical Bracco International BV
Application granted granted Critical
Publication of DE69115682D1 publication Critical patent/DE69115682D1/de
Publication of DE69115682T2 publication Critical patent/DE69115682T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions
    • A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69115682T 1990-12-11 1991-12-09 Verfahren zur herstellung von liposomen mit erhöhtem einschlussvermögen bezüglich zu verkapselnder fremdsubstanzen Expired - Lifetime DE69115682T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP90810969 1990-12-11
PCT/EP1991/002377 WO1992010166A1 (en) 1990-12-11 1991-12-09 Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated

Publications (2)

Publication Number Publication Date
DE69115682D1 DE69115682D1 (de) 1996-02-01
DE69115682T2 true DE69115682T2 (de) 1996-05-15

Family

ID=8205973

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69115682T Expired - Lifetime DE69115682T2 (de) 1990-12-11 1991-12-09 Verfahren zur herstellung von liposomen mit erhöhtem einschlussvermögen bezüglich zu verkapselnder fremdsubstanzen

Country Status (20)

Country Link
US (1) US5393530A (forum.php)
EP (1) EP0514523B1 (forum.php)
JP (1) JP3241720B2 (forum.php)
KR (1) KR0137783B1 (forum.php)
AT (1) ATE131724T1 (forum.php)
AU (1) AU635456B2 (forum.php)
CA (1) CA2072559C (forum.php)
DE (1) DE69115682T2 (forum.php)
DK (1) DK0514523T3 (forum.php)
ES (1) ES2081605T3 (forum.php)
GR (1) GR3018506T3 (forum.php)
HU (1) HUT62458A (forum.php)
IE (1) IE72163B1 (forum.php)
IL (1) IL99835A (forum.php)
IN (1) IN172269B (forum.php)
IS (1) IS1685B (forum.php)
MX (1) MX9102516A (forum.php)
NZ (1) NZ240817A (forum.php)
WO (1) WO1992010166A1 (forum.php)
ZA (1) ZA918489B (forum.php)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10121903A1 (de) * 2001-04-27 2002-10-31 Nimbus Biotechnologie Gmbh System für die Membranpermeationsmessung

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US9644038B2 (en) 2011-12-21 2017-05-09 The Regents Of The University Of California Apolipoprotein nanodiscs with telodendrimer
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CN104244984B (zh) * 2012-01-27 2020-03-31 变异生物技术公司 用于治疗剂的方法和组合物
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10121903A1 (de) * 2001-04-27 2002-10-31 Nimbus Biotechnologie Gmbh System für die Membranpermeationsmessung

Also Published As

Publication number Publication date
CA2072559A1 (en) 1992-06-12
US5393530A (en) 1995-02-28
IE72163B1 (en) 1997-03-26
ES2081605T3 (es) 1996-03-16
WO1992010166A1 (en) 1992-06-25
JP3241720B2 (ja) 2001-12-25
IE914289A1 (en) 1992-06-17
ATE131724T1 (de) 1996-01-15
ZA918489B (en) 1992-07-29
HUT62458A (en) 1993-05-28
JPH05504150A (ja) 1993-07-01
IL99835A (en) 1995-11-27
IS1685B (is) 1998-02-24
IS3773A7 (is) 1992-06-12
KR920703014A (ko) 1992-12-17
KR0137783B1 (ko) 1998-05-15
DE69115682D1 (de) 1996-02-01
IN172269B (forum.php) 1993-05-29
EP0514523B1 (en) 1995-12-20
AU635456B2 (en) 1993-03-18
GR3018506T3 (en) 1996-03-31
EP0514523A1 (en) 1992-11-25
DK0514523T3 (da) 1996-01-29
NZ240817A (en) 1993-01-27
CA2072559C (en) 1997-03-18
IL99835A0 (en) 1992-08-18
MX9102516A (es) 1992-06-01
AU9062991A (en) 1992-07-08

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