DE69109066T2 - Benzoxazinon- und Benzothiazinonderivate mit kardiovaskularer Wirksamkeit. - Google Patents

Benzoxazinon- und Benzothiazinonderivate mit kardiovaskularer Wirksamkeit.

Info

Publication number
DE69109066T2
DE69109066T2 DE69109066T DE69109066T DE69109066T2 DE 69109066 T2 DE69109066 T2 DE 69109066T2 DE 69109066 T DE69109066 T DE 69109066T DE 69109066 T DE69109066 T DE 69109066T DE 69109066 T2 DE69109066 T2 DE 69109066T2
Authority
DE
Germany
Prior art keywords
compound
formula
dihydro
benzoxazin
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69109066T
Other languages
German (de)
English (en)
Other versions
DE69109066D1 (de
Inventor
Francesca Benedini
Roberta Cereda
Soldato Piero Del
Alberto Sala
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Italfarmaco SpA
Original Assignee
Italfarmaco SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italfarmaco SpA filed Critical Italfarmaco SpA
Application granted granted Critical
Publication of DE69109066D1 publication Critical patent/DE69109066D1/de
Publication of DE69109066T2 publication Critical patent/DE69109066T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/08—1,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
DE69109066T 1990-12-14 1991-11-29 Benzoxazinon- und Benzothiazinonderivate mit kardiovaskularer Wirksamkeit. Expired - Fee Related DE69109066T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02239490A IT1244472B (it) 1990-12-14 1990-12-14 Benzossazinoni e benzotiazinoni ad attivita' cardiovascolare

Publications (2)

Publication Number Publication Date
DE69109066D1 DE69109066D1 (de) 1995-05-24
DE69109066T2 true DE69109066T2 (de) 1995-09-21

Family

ID=11195702

Family Applications (2)

Application Number Title Priority Date Filing Date
DE199191120471T Pending DE490183T1 (de) 1990-12-14 1991-11-29 Benzoxazinon- und benzothiazinonderivate mit kardiovaskularer wirksamkeit.
DE69109066T Expired - Fee Related DE69109066T2 (de) 1990-12-14 1991-11-29 Benzoxazinon- und Benzothiazinonderivate mit kardiovaskularer Wirksamkeit.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE199191120471T Pending DE490183T1 (de) 1990-12-14 1991-11-29 Benzoxazinon- und benzothiazinonderivate mit kardiovaskularer wirksamkeit.

Country Status (22)

Country Link
US (1) US5189034A (enExample)
EP (1) EP0490183B1 (enExample)
JP (1) JP2512845B2 (enExample)
KR (1) KR960016124B1 (enExample)
AT (1) ATE121392T1 (enExample)
AU (1) AU644254B2 (enExample)
CA (1) CA2056814C (enExample)
DE (2) DE490183T1 (enExample)
DK (1) DK0490183T3 (enExample)
ES (1) ES2051674T3 (enExample)
FI (1) FI95796C (enExample)
GR (2) GR920300088T1 (enExample)
HU (1) HUT63398A (enExample)
IE (1) IE67625B1 (enExample)
IT (1) IT1244472B (enExample)
LV (1) LV11029B (enExample)
MX (1) MX9102540A (enExample)
NO (1) NO180585C (enExample)
NZ (1) NZ240978A (enExample)
PT (1) PT99790B (enExample)
TW (1) TW233296B (enExample)
ZA (1) ZA919496B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1245351B (it) * 1991-03-19 1994-09-20 Italfarmaco Spa Isoindoli ad attivita' cardiovascolare
IT1254884B (it) * 1992-04-16 1995-10-11 Italfarmaco Spa Benzossazinoni e benzotiazinoni ad attivita' cardiovascolare
IT1256023B (it) * 1992-06-10 1995-11-20 Italfarmaco Spa Derivati benzossazinonici e benzotiazinonici ad attivita' cardiovascolare
CH685700A5 (fr) * 1993-03-16 1995-09-15 Cermol Sa Esters nitriques de 1,2-benzo-isothiazolyl-3(2H)one-1,1-dioxyde, procédé de préparation de ces esters et médicaments contenant ces esters.
IT1264812B1 (it) * 1993-07-28 1996-10-10 Italfarmaco Spa Derivati benzossazinonici e benzotiazinonici terapeuticamente attivi
JP4613082B2 (ja) 2005-03-14 2011-01-12 ヤンマー株式会社 作業車両のボンネット構造
US8148368B2 (en) * 2010-09-07 2012-04-03 Shaikh Riazuddin 7-nitro-2-(3-nitro phenyl)-4H-3,1-benzoxazin-4-one or derivatives thereof for treating or preventing antiviral infections
WO2013060673A1 (en) * 2011-10-24 2013-05-02 Nicox S.A. Quinone based nitric oxide donating compounds
KR102288434B1 (ko) * 2018-10-18 2021-08-12 에이치케이이노엔 주식회사 신규한 (이소프로필-트리아졸릴)피리디닐 치환된 벤조옥사지논 또는 벤조티아지논 유도체 및 이의 용도

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459748A (en) * 1967-04-28 1969-08-05 Squibb & Sons Inc Hydroxyalkylene-substituted benzoxazines and benzothiazines
US3513166A (en) * 1967-05-22 1970-05-19 Robins Co Inc A H 3-(omega-aminoalkyl)-4-substituted-1,3-benzoxazine-2-ones
GB1274553A (en) * 1969-05-06 1972-05-17 Squibb & Sons Inc Hydroxyalkylene-substituted benzoxazines and benzothiazines
JPS6137766A (ja) * 1984-07-31 1986-02-22 Sankyo Co Ltd フタルイミド誘導体およびその製造法
FR2636065B1 (fr) * 1988-09-08 1993-05-07 Fabre Sa Pierre Nouveaux derives de dihydro-2,3 arylacoylaminoalcoyl-3 4h-benzoxazine-1,3 ones-4, leur preparation et leur application en tant que medicaments utiles en therapeutique

Also Published As

Publication number Publication date
ES2051674T1 (es) 1994-07-01
FI95796B (fi) 1995-12-15
FI915875L (fi) 1992-06-15
EP0490183A1 (en) 1992-06-17
KR920012052A (ko) 1992-07-25
LV11029A (lv) 1996-02-20
JP2512845B2 (ja) 1996-07-03
NZ240978A (en) 1993-07-27
ZA919496B (en) 1992-08-26
ATE121392T1 (de) 1995-05-15
PT99790B (pt) 1999-05-31
GR3015901T3 (en) 1995-07-31
ES2051674T3 (es) 1995-06-16
NO914938D0 (no) 1991-12-13
DE69109066D1 (de) 1995-05-24
CA2056814A1 (en) 1992-06-15
IE914343A1 (en) 1992-06-17
US5189034A (en) 1993-02-23
IT9022394A0 (it) 1990-12-14
HUT63398A (en) 1993-08-30
NO914938L (no) 1992-06-15
AU8972291A (en) 1992-06-18
EP0490183B1 (en) 1995-04-19
TW233296B (enExample) 1994-11-01
PT99790A (pt) 1992-12-31
FI915875A0 (fi) 1991-12-13
FI95796C (fi) 1996-03-25
AU644254B2 (en) 1993-12-02
IT9022394A1 (it) 1992-06-14
KR960016124B1 (ko) 1996-12-04
LV11029B (en) 1996-06-20
DK0490183T3 (da) 1995-06-26
NO180585B (no) 1997-02-03
HU913950D0 (en) 1992-02-28
CA2056814C (en) 1997-01-14
DE490183T1 (de) 1992-12-17
MX9102540A (es) 1992-06-01
IT1244472B (it) 1994-07-15
NO180585C (no) 1997-05-14
GR920300088T1 (en) 1992-12-30
IE67625B1 (en) 1996-04-17
JPH0532642A (ja) 1993-02-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee