DE69005286D1 - Peptide mit tachykininantagonistischer Aktivität, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate. - Google Patents

Peptide mit tachykininantagonistischer Aktivität, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate.

Info

Publication number
DE69005286D1
DE69005286D1 DE90123875T DE69005286T DE69005286D1 DE 69005286 D1 DE69005286 D1 DE 69005286D1 DE 90123875 T DE90123875 T DE 90123875T DE 69005286 T DE69005286 T DE 69005286T DE 69005286 D1 DE69005286 D1 DE 69005286D1
Authority
DE
Germany
Prior art keywords
preparation
peptides
pharmaceutical preparations
preparations containing
antagonistic activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE90123875T
Other languages
English (en)
Other versions
DE69005286T2 (de
Inventor
Matsuo Masaaki
Hagiwara Daijiro
Miyake Hiroshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of DE69005286D1 publication Critical patent/DE69005286D1/de
Application granted granted Critical
Publication of DE69005286T2 publication Critical patent/DE69005286T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE90123875T 1989-12-22 1990-12-12 Peptide mit tachykininantagonistischer Aktivität, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate. Expired - Fee Related DE69005286T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898929070A GB8929070D0 (en) 1989-12-22 1989-12-22 Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same

Publications (2)

Publication Number Publication Date
DE69005286D1 true DE69005286D1 (de) 1994-01-27
DE69005286T2 DE69005286T2 (de) 1994-04-21

Family

ID=10668423

Family Applications (1)

Application Number Title Priority Date Filing Date
DE90123875T Expired - Fee Related DE69005286T2 (de) 1989-12-22 1990-12-12 Peptide mit tachykininantagonistischer Aktivität, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate.

Country Status (21)

Country Link
US (1) US5468731A (de)
EP (1) EP0443132B1 (de)
JP (1) JP2560919B2 (de)
KR (1) KR0180223B1 (de)
CN (2) CN1034869C (de)
AT (1) ATE98651T1 (de)
AU (1) AU640185B2 (de)
CA (1) CA2032864C (de)
DE (1) DE69005286T2 (de)
DK (1) DK0443132T3 (de)
ES (1) ES2060910T3 (de)
FI (1) FI93548C (de)
GB (1) GB8929070D0 (de)
HK (1) HK18696A (de)
HU (2) HUT56581A (de)
IE (1) IE64570B1 (de)
NO (1) NO177535C (de)
PT (1) PT96324B (de)
RU (1) RU2055078C1 (de)
UA (1) UA27254C2 (de)
ZA (1) ZA909901B (de)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
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US5472978A (en) * 1991-07-05 1995-12-05 Merck Sharp & Dohme Ltd. Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
US5654400A (en) * 1991-10-04 1997-08-05 Fujisawa Pharmaceutical Co., Ltd. Process for making peptide compounds having tachykinin antagonistic activity
CA2324959C (en) * 1991-11-12 2002-11-12 Pfizer Limited Phthalimido compounds as intermediates for producing substance p receptor antagonists
GB9200535D0 (en) * 1992-01-10 1992-02-26 Fujisawa Pharmaceutical Co New compound
PT655055E (pt) * 1992-08-13 2001-03-30 Warner Lambert Co Antagonistas de taquiquinina
CZ127694A3 (en) * 1992-09-03 1994-11-16 Boehringer Ingelheim Kg Novel derivatives of amino acids, process of their preparation and pharmaceutical preparations in which they are comprised
DE4243496A1 (de) * 1992-09-03 1994-03-10 Boehringer Ingelheim Kg Neue Dipeptidderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
FR2700472B1 (fr) 1993-01-19 1995-02-17 Rhone Poulenc Rorer Sa Association synergisante ayant un effet antagoniste des récepteurs NK1 et NK2.
WO1994020126A1 (en) * 1993-03-03 1994-09-15 Fujisawa Pharmaceutical Co., Ltd. Use of peptides for the manufacture of a medicament
WO1995000536A1 (en) * 1993-06-22 1995-01-05 Fujisawa Pharmaceutical Co., Ltd. Peptide compounds
KR960703621A (ko) * 1993-08-10 1996-08-31 후지야마 아키라 경피흡수 제제(Percutaneously absorbable preparation)
CA2174737C (en) * 1993-10-29 2008-04-22 Douglas V. Faller Physiologically stable compositions of butyric acid, and butyric acid salts and derivatives as anti-neoplastic agents
US6403577B1 (en) 1993-11-17 2002-06-11 Eli Lilly And Company Hexamethyleneiminyl tachykinin receptor antagonists
ITFI940009A1 (it) * 1994-01-19 1995-07-19 Menarini Farma Ind Antagonisti delle tachichinine, loro preparazione e formulazioni farmaceutiche che li contengono.
DE69519182T2 (de) * 1994-03-17 2001-05-17 Fujirebio Kk Azapeptid-Derivate
FR2719312B1 (fr) * 1994-04-28 1996-06-14 Adir Nouveau pseudopeptides dérivés de neurokinines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
EP0804463A1 (de) * 1994-05-07 1997-11-05 Boehringer Ingelheim Kg Neurokinin (tachykinin)-antagonisten
FR2728166A1 (fr) 1994-12-19 1996-06-21 Oreal Composition topique contenant un antagoniste de substance p
FR2728165A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
FR2728169A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
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FR2741262B1 (fr) 1995-11-20 1999-03-05 Oreal Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
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AU744261B2 (en) * 1997-04-24 2002-02-21 Merck Sharp & Dohme Limited Use of NK-1 receptor antagonists for treating eating disorders
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JP2002512625A (ja) * 1997-05-29 2002-04-23 メルク エンド カンパニー インコーポレーテッド 細胞接着阻害薬としての複素環アミド化合物
CA2298777A1 (en) * 1997-08-04 1999-02-18 Merck Sharp & Dohme Limited Use of nk-1 receptor antagonists for treating mania
CA2298779A1 (en) * 1997-08-04 1999-02-18 Merck Sharp & Dohme Limited Use of nk-1 receptor antagonists for treating aggressive behaviour disorders
GB9716463D0 (en) * 1997-08-04 1997-10-08 Merck Sharp & Dohme Therapeutic agents
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Also Published As

Publication number Publication date
FI93548B (fi) 1995-01-13
KR0180223B1 (ko) 1999-04-01
UA27254C2 (uk) 2000-08-15
HU908443D0 (en) 1991-07-29
EP0443132B1 (de) 1993-12-15
HUT56581A (en) 1991-09-30
DK0443132T3 (da) 1994-01-24
NO177535C (no) 1995-10-04
IE64570B1 (en) 1995-08-23
HU211558A9 (en) 1995-12-28
KR910011891A (ko) 1991-08-07
CA2032864C (en) 2003-05-06
HK18696A (en) 1996-02-09
FI906204A (fi) 1991-06-23
RU2055078C1 (ru) 1996-02-27
US5468731A (en) 1995-11-21
ES2060910T3 (es) 1994-12-01
AU6801090A (en) 1991-06-27
NO905572D0 (no) 1990-12-21
ZA909901B (en) 1991-10-30
EP0443132A1 (de) 1991-08-28
PT96324B (pt) 1998-10-30
FI93548C (fi) 1995-04-25
NO177535B (no) 1995-06-26
ATE98651T1 (de) 1994-01-15
CA2032864A1 (en) 1991-06-23
JPH04210996A (ja) 1992-08-03
CN1064080A (zh) 1992-09-02
DE69005286T2 (de) 1994-04-21
CN1159949A (zh) 1997-09-24
NO905572L (no) 1991-06-24
JP2560919B2 (ja) 1996-12-04
AU640185B2 (en) 1993-08-19
GB8929070D0 (en) 1990-02-28
PT96324A (pt) 1991-09-30
FI906204A0 (fi) 1990-12-17
IE904581A1 (en) 1991-07-03
CN1034869C (zh) 1997-05-14

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