DE60302152T2 - Diaminothiazole und ihre anwendung als cdk4 inhibitoren - Google Patents

Diaminothiazole und ihre anwendung als cdk4 inhibitoren Download PDF

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Publication number
DE60302152T2
DE60302152T2 DE60302152T DE60302152T DE60302152T2 DE 60302152 T2 DE60302152 T2 DE 60302152T2 DE 60302152 T DE60302152 T DE 60302152T DE 60302152 T DE60302152 T DE 60302152T DE 60302152 T2 DE60302152 T2 DE 60302152T2
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DE
Germany
Prior art keywords
amino
thiazol
methanone
phenylamino
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60302152T
Other languages
German (de)
English (en)
Other versions
DE60302152D1 (de
Inventor
Xin-Jie Chu
Qingjie Ding
Nan Jiang
Kyungjin Kim
John Allen LOVEY
William Warren McCOMAS
Guilfoyle John MULLIN
Wright Jefferson TILLEY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE60302152D1 publication Critical patent/DE60302152D1/de
Application granted granted Critical
Publication of DE60302152T2 publication Critical patent/DE60302152T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60302152T 2002-05-17 2003-05-12 Diaminothiazole und ihre anwendung als cdk4 inhibitoren Expired - Fee Related DE60302152T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38151302P 2002-05-17 2002-05-17
US381513P 2002-05-17
PCT/EP2003/004939 WO2003097048A1 (en) 2002-05-17 2003-05-12 Diaminothiazoles

Publications (2)

Publication Number Publication Date
DE60302152D1 DE60302152D1 (de) 2005-12-08
DE60302152T2 true DE60302152T2 (de) 2006-07-13

Family

ID=29550137

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60302152T Expired - Fee Related DE60302152T2 (de) 2002-05-17 2003-05-12 Diaminothiazole und ihre anwendung als cdk4 inhibitoren

Country Status (16)

Country Link
US (1) US6818663B2 (enExample)
EP (1) EP1507530B1 (enExample)
JP (1) JP4308133B2 (enExample)
KR (1) KR100619515B1 (enExample)
CN (1) CN100400041C (enExample)
AR (1) AR040078A1 (enExample)
AT (1) ATE308323T1 (enExample)
AU (1) AU2003232754B2 (enExample)
BR (1) BR0310081A (enExample)
CA (1) CA2485367A1 (enExample)
DE (1) DE60302152T2 (enExample)
ES (1) ES2251697T3 (enExample)
MX (1) MXPA04011372A (enExample)
PL (1) PL374581A1 (enExample)
RU (1) RU2311414C2 (enExample)
WO (1) WO2003097048A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2550891A1 (en) * 2003-12-24 2005-07-14 Bayer Cropscience Gmbh Plant growth regulation
US7211576B2 (en) * 2004-04-20 2007-05-01 Hoffmann-La Roche Inc. Diaminothiazoles
US7405220B2 (en) 2004-06-09 2008-07-29 Hoffmann-La Roche Inc. Pyrazolopyrimidines
US7705009B2 (en) * 2005-11-22 2010-04-27 Hoffman-La Roche Inc. 4-aminopyrimidine-5-thione derivatives
EP2078003B1 (en) 2006-10-31 2017-03-08 Merck Sharp & Dohme Corp. Anilinopiperazine derivatives and methods of use thereof
PE20080928A1 (es) 2006-10-31 2008-08-15 Schering Corp Derivados de anilinopiperazina como inhibidores de proteina quinasa
JP5270758B2 (ja) * 2008-08-12 2013-08-21 エア プロダクツ アンド ケミカルズ インコーポレイテッド パー（フェニルエチニル）アレーン誘導体を含有するポリマー組成物
WO2012027481A1 (en) * 2010-08-24 2012-03-01 Gtx, Inc. Compounds for treatment of cancer
EP2780392B1 (en) 2011-11-18 2016-06-29 Greene, Tweed & Co. Crosslinking compounds for high glass transition temperature polymers
WO2014172479A1 (en) 2013-04-16 2014-10-23 Memorial Sloan-Kettering Cancer Center Companion diagnostic for cdk4 inhibitors
WO2015051525A1 (en) * 2013-10-11 2015-04-16 Rhodia Operations Synthesis of acetal/ketal
WO2017156263A1 (en) 2016-03-09 2017-09-14 Memorial Sloan-Kettering Cancer Center Enigma and cdh18 as companion diagnostics for cdk4 inhibitors
WO2017158147A1 (en) 2016-03-18 2017-09-21 Savira Pharmaceuticals Gmbh Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
WO2018089902A1 (en) * 2016-11-13 2018-05-17 Apogee Biotechnology Corporation Diaminothiazole compounds, compositions and methods of use
CN110950848B (zh) * 2018-09-27 2024-03-26 徐诺药业 新型氨基吡唑类衍生物的合成与应用
JP2022530241A (ja) 2019-04-30 2022-06-28 インスチトゥート デ メディシーナ モリクラール ジョアン ロボ アントゥネス Ｃｄｋ阻害剤と組み合わせたｒａｎｋ経路阻害剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2714059B1 (fr) * 1993-12-21 1996-03-08 Sanofi Elf Dérivés amino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
SI20324A (sl) * 1997-10-27 2001-02-28 Agouron Pharmaceuticals, Inc. Substituirane 4-amino-tiazol-2-il spojine kot cdk inhibitorji
UA71971C2 (en) * 1999-06-04 2005-01-17 Agoron Pharmaceuticals Inc Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases
WO2002012250A2 (en) * 2000-08-09 2002-02-14 Agouron Pharmaceuticals, Inc. Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclin-dependent kinases
US6756374B2 (en) 2001-01-22 2004-06-29 Hoffmann-La Roche Inc. Diaminothiazoles having antiproliferative activity

Also Published As

Publication number Publication date
MXPA04011372A (es) 2005-08-15
ATE308323T1 (de) 2005-11-15
KR100619515B1 (ko) 2006-09-08
PL374581A1 (en) 2005-10-31
RU2004137110A (ru) 2005-08-20
US20040006058A1 (en) 2004-01-08
BR0310081A (pt) 2005-02-15
CA2485367A1 (en) 2003-11-27
AU2003232754A1 (en) 2003-12-02
CN100400041C (zh) 2008-07-09
AR040078A1 (es) 2005-03-16
US6818663B2 (en) 2004-11-16
KR20050006261A (ko) 2005-01-15
EP1507530B1 (en) 2005-11-02
DE60302152D1 (de) 2005-12-08
AU2003232754B2 (en) 2009-03-12
WO2003097048A1 (en) 2003-11-27
ES2251697T3 (es) 2006-05-01
CN1652780A (zh) 2005-08-10
JP2005530783A (ja) 2005-10-13
JP4308133B2 (ja) 2009-08-05
RU2311414C2 (ru) 2007-11-27
EP1507530A1 (en) 2005-02-23

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee