DE60236974D1 - Kultiviertes Zellkonstrukt mit Sphäroiden kultivierter Tierzellen und seine Verwendung - Google Patents
Kultiviertes Zellkonstrukt mit Sphäroiden kultivierter Tierzellen und seine VerwendungInfo
- Publication number
- DE60236974D1 DE60236974D1 DE60236974T DE60236974T DE60236974D1 DE 60236974 D1 DE60236974 D1 DE 60236974D1 DE 60236974 T DE60236974 T DE 60236974T DE 60236974 T DE60236974 T DE 60236974T DE 60236974 D1 DE60236974 D1 DE 60236974D1
- Authority
- DE
- Germany
- Prior art keywords
- spheroids
- cultivated
- animal cells
- cell construct
- cultured animal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
- C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/14—Coculture with; Conditioned medium produced by hepatocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/28—Vascular endothelial cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/30—Synthetic polymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/30—Synthetic polymers
- C12N2533/40—Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2535/00—Supports or coatings for cell culture characterised by topography
- C12N2535/10—Patterned coating
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001226293 | 2001-07-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60236974D1 true DE60236974D1 (de) | 2010-08-19 |
Family
ID=19059133
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60228594T Expired - Lifetime DE60228594D1 (de) | 2001-07-26 | 2002-07-25 | Konstrukt aus kultivierten zellen mit spheroiden von kultivierten tierzellen und verwendung davon |
DE60236974T Expired - Lifetime DE60236974D1 (de) | 2001-07-26 | 2002-07-25 | Kultiviertes Zellkonstrukt mit Sphäroiden kultivierter Tierzellen und seine Verwendung |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60228594T Expired - Lifetime DE60228594D1 (de) | 2001-07-26 | 2002-07-25 | Konstrukt aus kultivierten zellen mit spheroiden von kultivierten tierzellen und verwendung davon |
Country Status (9)
Country | Link |
---|---|
US (2) | US7470424B2 (de) |
EP (2) | EP1428871B1 (de) |
JP (1) | JP4111446B2 (de) |
KR (1) | KR100675533B1 (de) |
CN (1) | CN1798832B (de) |
AT (1) | ATE406436T1 (de) |
CA (1) | CA2454807C (de) |
DE (2) | DE60228594D1 (de) |
WO (1) | WO2003010302A1 (de) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060270032A1 (en) * | 2005-05-24 | 2006-11-30 | The Regents Of The University Of California | Microscale micropatterened engineered in vitro tissue |
JP2005506839A (ja) * | 2001-10-02 | 2005-03-10 | ベクトン・ディキンソン・アンド・カンパニー | 細胞外マトリックスおよび他の分子を使用する幹細胞の増殖および分化 |
WO2004069988A1 (ja) * | 2003-02-06 | 2004-08-19 | Cellseed Inc. | 高密度細胞アレイ用基板、製造法、及びその利用方法 |
US8642338B2 (en) * | 2003-02-06 | 2014-02-04 | Cellseed Inc. | Anterior ocular segment related cell sheets, three-dimensional structures, and processes for producing the same |
KR101141985B1 (ko) | 2003-02-06 | 2012-05-17 | 고지 니시다 | 각막 상피 형성용 세포 시트, 그들의 제조 방법 및 그들의이용 방법 |
JP4649935B2 (ja) * | 2004-02-02 | 2011-03-16 | コニカミノルタホールディングス株式会社 | インクジェットプリンタ |
US8241905B2 (en) | 2004-02-24 | 2012-08-14 | The Curators Of The University Of Missouri | Self-assembling cell aggregates and methods of making engineered tissue using the same |
US10533158B2 (en) * | 2005-02-28 | 2020-01-14 | Tokai University Educational System | Cultured cell sheet, production method thereof, and application method thereof |
JPWO2006093153A1 (ja) | 2005-02-28 | 2008-08-07 | 株式会社セルシード | 培養細胞シート、製造方法及びその利用した組織修復方法 |
AU2013202489B2 (en) * | 2005-11-18 | 2016-03-03 | Lifescan, Inc. | A method for creating cell clusters |
ES2605412T3 (es) * | 2005-11-18 | 2017-03-14 | Lifescan, Inc. | Un método para crear grupos de células |
JP5070565B2 (ja) | 2006-05-29 | 2012-11-14 | 大日本印刷株式会社 | 細胞培養用基板 |
US20090203536A1 (en) * | 2006-06-06 | 2009-08-13 | Vermette Patrick | Assay supports comprising a peg support, said support attached from a peg solution in cloud point (theta solvent) conditions |
JP5261920B2 (ja) | 2006-11-10 | 2013-08-14 | 大日本印刷株式会社 | 細胞を用いた試験法および試験用キット |
US8592139B2 (en) | 2006-11-10 | 2013-11-26 | Dai Nippon Printing Co., Ltd. | Test method using cells and test kit therefor |
EP2120546B1 (de) * | 2006-12-18 | 2016-09-28 | Ben Gurion University Of The Negev | Gerüst für die geweberegeneration oder reparatur |
JP5583312B2 (ja) | 2007-02-20 | 2014-09-03 | 富士フイルム株式会社 | 組織体形成用基材、組織体形成キット、それを用いた組織体形成法、及び該組織体形成法により形成された三次元組織体 |
US20100216245A1 (en) * | 2007-10-19 | 2010-08-26 | National Center For Child Health And Development | Frozen cell immobilized product, primary hepatocyte culture tool, and method for producing primary hepatocyte culture tool |
WO2009072590A1 (ja) * | 2007-12-06 | 2009-06-11 | Tokyo University Of Science Educational Foundation Administrative Organization | 分岐ポリアルキレングリコール誘導体、感光性組成物、架橋体及び基板 |
WO2010008905A2 (en) | 2008-06-24 | 2010-01-21 | The Curators Of The University Of Missouri | Self-assembling multicellular bodies and methods of producing a three-dimensional biological structure using the same |
KR101005874B1 (ko) * | 2008-08-27 | 2011-01-06 | 한길토건(주) | 강재 재활용이 가능한 암파쇄 방호시설의 공법 |
US9598668B2 (en) * | 2008-10-14 | 2017-03-21 | Cellseed Inc. | Temperature-responsive cell culture substrate and method for producing the same |
JP5496488B2 (ja) * | 2008-10-22 | 2014-05-21 | 学校法人東京女子医科大学 | 細胞パターン回収ツール |
EP2358860A1 (de) * | 2008-11-21 | 2011-08-24 | Corning Incorporated | Substrate und vorrichtungen mit beabstandeten vorsprüngen für die zellkultur |
US20100166822A1 (en) * | 2008-12-31 | 2010-07-01 | Howmedica Osteonics Corp. | Adhesive cartilage implant |
JP2010233538A (ja) * | 2009-03-31 | 2010-10-21 | Trans Parent:Kk | 基質代謝物の評価方法 |
JP2012523238A (ja) | 2009-04-09 | 2012-10-04 | ジ・アリゾナ・ボード・オブ・リージェンツ・オン・ビハーフ・オブ・ザ・ユニバーシティ・オブ・アリゾナ | 三次元繊維芽細胞構築物の細胞播種および共培養 |
HUP0900819A2 (en) * | 2009-05-05 | 2011-01-28 | Pecsi Tudomanyegyetem | Lung tissue culture |
US8481303B2 (en) | 2009-10-12 | 2013-07-09 | Corning Incorporated | Microfluidic device for cell culture |
WO2011110722A1 (es) * | 2010-03-12 | 2011-09-15 | Fundación Progreso Y Salud | Método para la proliferación "in vitro" de células procedentes de tejidos de origen endodérmico |
CN101955595B (zh) * | 2010-08-11 | 2012-01-04 | 东南大学 | 在多种材料表面制备化学微图案引导细胞定点生长的方法 |
WO2012048170A2 (en) * | 2010-10-06 | 2012-04-12 | Massachusetts Institute Of Technology | Humanized animals via tissue engineering and uses therefor |
EP2737051A1 (de) | 2011-07-25 | 2014-06-04 | Cytoo | Verfahren und vorrichtung zur bildung dreidimensionaler multizellularanordnungen |
CA2878404A1 (en) | 2012-07-10 | 2014-01-16 | The Trustees Of The University Of Pennsylvania | Biomaterials for enhanced implant-host integration |
EP2902496B1 (de) | 2012-09-27 | 2018-04-18 | Kuraray Co., Ltd. | Verfahren zur bewertung des effekts von cytokin auf die stoffwechselaktivität von cytochrom p450 und verfahren zum screening von arzneimitteln |
WO2014131019A2 (en) | 2013-02-25 | 2014-08-28 | Ohio State Innovation Foundation | Her-1, her-3 and igf-1r compositions and uses thereof |
WO2014143998A1 (en) * | 2013-03-15 | 2014-09-18 | The Broad Institute | Systems and methods for culturing epithelial cells |
US9790465B2 (en) | 2013-04-30 | 2017-10-17 | Corning Incorporated | Spheroid cell culture well article and methods thereof |
JP6122817B2 (ja) * | 2014-03-26 | 2017-04-26 | 株式会社Screenホールディングス | スフェロイドの評価方法およびスフェロイド評価装置 |
KR101647793B1 (ko) | 2014-09-02 | 2016-08-12 | 충남대학교산학협력단 | 온도 감응성 글리콜 키토산 유도체를 이용한 스페로이드 형성용 배양 용기 및 이를 이용한 스페로이드 형성 방법 |
KR102470508B1 (ko) | 2014-10-29 | 2022-11-24 | 코닝 인코포레이티드 | 관류 생물반응기 플랫폼 |
CN107109328B (zh) | 2014-10-29 | 2021-02-05 | 康宁股份有限公司 | 细胞培养插入件 |
CN104630148B (zh) * | 2015-01-19 | 2017-06-06 | 西安交通大学 | 一种基于水凝胶微孔板的细胞球原位制备方法 |
CN104894051A (zh) * | 2015-05-27 | 2015-09-09 | 成都易创思生物科技有限公司 | 一种新型的细胞培养方法 |
US11338065B2 (en) | 2015-10-08 | 2022-05-24 | Massachusetts Institute Of Technology | In situ expansion of engineered devices for regeneration |
KR20180104646A (ko) | 2016-01-07 | 2018-09-21 | 비.지. 네게브 테크놀로지즈 앤드 애플리케이션스 리미티드, 엣 벤-구리온 유니버시티 | 면역관용 반응을 구축하기 위한 조성물 및 방법 |
KR102038496B1 (ko) * | 2016-10-07 | 2019-10-30 | 울산과학기술원 | 다공성막을 이용한 현적 세포 배양 기기, 이의 제조 방법, 이를 이용한 현적 세포 배양 방법, 및 현적 세포 배양 자동화 장치 |
WO2019014635A1 (en) | 2017-07-14 | 2019-01-17 | Corning Incorporated | 3D CELL CULTURE CONTAINERS FOR MANUAL OR AUTOMATIC EXCHANGE |
EP3652291B1 (de) | 2017-07-14 | 2021-12-29 | Corning Incorporated | Zellkulturgefäss |
US11857970B2 (en) | 2017-07-14 | 2024-01-02 | Corning Incorporated | Cell culture vessel |
WO2019014610A1 (en) | 2017-07-14 | 2019-01-17 | Corning Incorporated | CELL CULTURE CONTAINER FOR 3D CULTURE AND METHODS OF CULTURING 3D CELLS |
WO2020013845A1 (en) | 2018-07-13 | 2020-01-16 | Corning Incorporated | Cell culture vessels with stabilizer devices |
JP7171696B2 (ja) | 2018-07-13 | 2022-11-15 | コーニング インコーポレイテッド | 相互接続されたウェルを有するマイクロプレートを備えた流体デバイス |
JP7171695B2 (ja) | 2018-07-13 | 2022-11-15 | コーニング インコーポレイテッド | 液体培地送達面を含む側壁を有するマイクロキャビティ皿 |
KR20210070648A (ko) * | 2019-12-05 | 2021-06-15 | 한국화학연구원 | 세포 비접착성 peg 고분자 기판 상에 형성된 심근세포 스페로이드 및 이의 제조방법 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2545100B1 (fr) * | 1983-04-29 | 1985-12-20 | Inst Nat Sante Rech Med | Procede d'obtention de cultures d'hepatocytes humains, les cultures obtenues et leurs applications biologiques et biochimiques |
US5037969A (en) | 1986-07-03 | 1991-08-06 | Takeda Chemical Industries, Ltd. | Glycosyl derivatives and use thereof |
JPH0751061B2 (ja) | 1989-06-03 | 1995-06-05 | 鐘淵化学工業株式会社 | 細胞の配列制御用具の製法 |
DE3938632C1 (en) * | 1989-11-21 | 1991-03-14 | Adelbert Prof. Dr.Dr. 8046 Garching De Bacher | Culturing living animal cells - using natural or synthetic polymer substrate vacuum deposition coated with e.g. nitride of Gp=III element |
EP0529751A1 (de) * | 1991-08-09 | 1993-03-03 | W.R. Grace & Co.-Conn. | Zellkulturträger und -testmaterial |
US5776748A (en) | 1993-10-04 | 1998-07-07 | President And Fellows Of Harvard College | Method of formation of microstamped patterns on plates for adhesion of cells and other biological materials, devices and uses therefor |
JP2609073B2 (ja) | 1994-10-26 | 1997-05-14 | 鐘淵化学工業株式会社 | 細胞の配列制御用具および細胞の配列制御法 |
AU5289096A (en) | 1995-04-14 | 1996-10-30 | Kazunori Kataoka | Polyethylene oxides having saccharide residue at one end and different functional group at another end, and process for producing the same |
CN1085987C (zh) | 1995-04-19 | 2002-06-05 | 片冈一则 | 杂远螯嵌段共聚物及其制备方法 |
JP3711288B2 (ja) | 1995-08-10 | 2005-11-02 | 一則 片岡 | 両末端に官能基を有するブロックポリマー |
JP2002510969A (ja) * | 1997-05-14 | 2002-04-09 | ザ ジェネラル ホスピタル コーポレーション | マイクロパターン化形態における細胞の共培養 |
JP3077628B2 (ja) | 1997-05-27 | 2000-08-14 | 日本電気株式会社 | 細胞毒性試験方法 |
JP2973976B2 (ja) | 1997-06-23 | 1999-11-08 | 日本電気株式会社 | 接着性細胞を用いた毒性試験方法 |
-
2002
- 2002-07-25 US US10/484,839 patent/US7470424B2/en not_active Expired - Fee Related
- 2002-07-25 WO PCT/JP2002/007539 patent/WO2003010302A1/ja active IP Right Grant
- 2002-07-25 JP JP2003515653A patent/JP4111446B2/ja not_active Expired - Fee Related
- 2002-07-25 EP EP02755656A patent/EP1428871B1/de not_active Expired - Lifetime
- 2002-07-25 DE DE60228594T patent/DE60228594D1/de not_active Expired - Lifetime
- 2002-07-25 DE DE60236974T patent/DE60236974D1/de not_active Expired - Lifetime
- 2002-07-25 KR KR1020047000851A patent/KR100675533B1/ko not_active IP Right Cessation
- 2002-07-25 CA CA2454807A patent/CA2454807C/en not_active Expired - Fee Related
- 2002-07-25 CN CN028148428A patent/CN1798832B/zh not_active Expired - Fee Related
- 2002-07-25 EP EP08005978A patent/EP1939280B1/de not_active Expired - Lifetime
- 2002-07-25 AT AT02755656T patent/ATE406436T1/de not_active IP Right Cessation
-
2008
- 2008-09-08 US US12/230,916 patent/US7691369B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1428871A1 (de) | 2004-06-16 |
CN1798832B (zh) | 2010-04-28 |
CN1798832A (zh) | 2006-07-05 |
JPWO2003010302A1 (ja) | 2005-06-02 |
EP1939280A1 (de) | 2008-07-02 |
EP1428871A4 (de) | 2004-11-24 |
WO2003010302A1 (fr) | 2003-02-06 |
US20090011504A1 (en) | 2009-01-08 |
KR100675533B1 (ko) | 2007-01-29 |
EP1428871B1 (de) | 2008-08-27 |
US7470424B2 (en) | 2008-12-30 |
ATE406436T1 (de) | 2008-09-15 |
JP4111446B2 (ja) | 2008-07-02 |
KR20040025700A (ko) | 2004-03-24 |
US7691369B2 (en) | 2010-04-06 |
EP1939280B1 (de) | 2010-07-07 |
DE60228594D1 (de) | 2008-10-09 |
CA2454807C (en) | 2012-09-18 |
CA2454807A1 (en) | 2003-02-06 |
US20040197907A1 (en) | 2004-10-07 |
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