DE60213810T2 - Benzoylsulfonamide und sulfonylbenzamidine zur verwendung als antitumor-mittel - Google Patents
Benzoylsulfonamide und sulfonylbenzamidine zur verwendung als antitumor-mittel Download PDFInfo
- Publication number
- DE60213810T2 DE60213810T2 DE60213810T DE60213810T DE60213810T2 DE 60213810 T2 DE60213810 T2 DE 60213810T2 DE 60213810 T DE60213810 T DE 60213810T DE 60213810 T DE60213810 T DE 60213810T DE 60213810 T2 DE60213810 T2 DE 60213810T2
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- Prior art keywords
- hydrogen
- alkyl
- halogen
- alkoxy
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 BENZOYL SULPHONAMIDES Chemical class 0.000 title claims description 30
- 239000002246 antineoplastic agent Substances 0.000 title description 6
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- 206010028980 Neoplasm Diseases 0.000 claims description 72
- 239000001257 hydrogen Substances 0.000 claims description 62
- 229910052739 hydrogen Inorganic materials 0.000 claims description 62
- 150000001875 compounds Chemical class 0.000 claims description 61
- 229910052736 halogen Inorganic materials 0.000 claims description 45
- 150000002367 halogens Chemical class 0.000 claims description 45
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 37
- 239000003814 drug Substances 0.000 claims description 33
- 150000002431 hydrogen Chemical class 0.000 claims description 33
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 20
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 18
- 150000003839 salts Chemical class 0.000 claims description 18
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 16
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims description 11
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 11
- 125000002541 furyl group Chemical group 0.000 claims description 11
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- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 8
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- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 description 6
- ATCRIUVQKHMXSH-UHFFFAOYSA-N 2,4-dichlorobenzoic acid Chemical compound OC(=O)C1=CC=C(Cl)C=C1Cl ATCRIUVQKHMXSH-UHFFFAOYSA-N 0.000 description 6
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- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 210000003905 vulva Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/51—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
- C07D213/34—Sulfur atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/18—Radicals substituted by singly bound hetero atoms other than halogen by sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Quinoline Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29635001P | 2001-06-06 | 2001-06-06 | |
| US296350P | 2001-06-06 | ||
| PCT/US2002/015142 WO2002098848A1 (en) | 2001-06-06 | 2002-05-24 | Benzoylsulfonamides and sulfonylbenzamidines for use as antitumour agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60213810D1 DE60213810D1 (de) | 2006-09-21 |
| DE60213810T2 true DE60213810T2 (de) | 2007-02-01 |
Family
ID=23141662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60213810T Expired - Fee Related DE60213810T2 (de) | 2001-06-06 | 2002-05-24 | Benzoylsulfonamide und sulfonylbenzamidine zur verwendung als antitumor-mittel |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US7183320B2 (https=) |
| EP (1) | EP1401806B1 (https=) |
| JP (1) | JP4167173B2 (https=) |
| KR (1) | KR100880760B1 (https=) |
| CN (1) | CN100475787C (https=) |
| AR (1) | AR036079A1 (https=) |
| AT (1) | ATE335722T1 (https=) |
| AU (1) | AU2002259204B2 (https=) |
| BR (1) | BR0210078A (https=) |
| CA (1) | CA2446719A1 (https=) |
| CR (1) | CR7182A (https=) |
| CY (1) | CY1105386T1 (https=) |
| CZ (1) | CZ20033296A3 (https=) |
| DE (1) | DE60213810T2 (https=) |
| DK (1) | DK1401806T3 (https=) |
| EA (1) | EA005810B1 (https=) |
| EC (1) | ECSP034874A (https=) |
| EG (1) | EG24356A (https=) |
| ES (1) | ES2269688T3 (https=) |
| HR (1) | HRP20031000A2 (https=) |
| HU (1) | HUP0400114A3 (https=) |
| IL (1) | IL158985A0 (https=) |
| MX (1) | MXPA03011197A (https=) |
| MY (1) | MY136855A (https=) |
| NO (1) | NO20035366L (https=) |
| NZ (1) | NZ529098A (https=) |
| PE (1) | PE20030199A1 (https=) |
| PL (1) | PL367188A1 (https=) |
| PT (1) | PT1401806E (https=) |
| SK (1) | SK14642003A3 (https=) |
| SV (1) | SV2003001076A (https=) |
| TW (1) | TWI266761B (https=) |
| UA (1) | UA74889C2 (https=) |
| WO (1) | WO2002098848A1 (https=) |
| ZA (1) | ZA200308644B (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60316984T2 (de) * | 2002-11-22 | 2008-07-17 | Eli Lilly And Co., Indianapolis | Benzoylsulfonamide als antitumor-mittel |
| WO2005049593A2 (en) * | 2003-11-13 | 2005-06-02 | Abbott Laboratories | N-acylsulfonamide apoptosis promoters |
| US7767684B2 (en) | 2003-11-13 | 2010-08-03 | Abbott Laboratories | Apoptosis promoters |
| US7973161B2 (en) | 2003-11-13 | 2011-07-05 | Abbott Laboratories | Apoptosis promoters |
| US8614318B2 (en) | 2003-11-13 | 2013-12-24 | Abbvie Inc. | Apoptosis promoters |
| ATE542796T1 (de) * | 2004-05-26 | 2012-02-15 | Abbott Lab | N-sulfonylcarboximidamidverbindungen als apoptosepromotoren |
| JP5134247B2 (ja) * | 2004-09-13 | 2013-01-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド含有化合物の血管新生阻害物質との併用 |
| WO2006030947A1 (ja) * | 2004-09-13 | 2006-03-23 | Eisai R & D Management Co., Ltd. | スルホンアミド含有化合物の血管新生阻害物質との併用 |
| US8772269B2 (en) | 2004-09-13 | 2014-07-08 | Eisai R&D Management Co., Ltd. | Use of sulfonamide-including compounds in combination with angiogenesis inhibitors |
| CA2599301A1 (en) * | 2005-02-28 | 2006-08-31 | Eisai R & D Management Co., Ltd. | Novel use of sulfonamide compound in combination with angiogenesis inhibitor |
| WO2006090932A1 (ja) * | 2005-02-28 | 2006-08-31 | Eisai R & D Managemant Co., Ltd. | スルホンアミド化合物の代理マーカー |
| SI1859793T1 (sl) * | 2005-02-28 | 2011-08-31 | Eisai R&D Man Co Ltd | Nova kombinirana uporaba sulfonamidne spojine za zdravljenje raka |
| PL1888550T3 (pl) | 2005-05-12 | 2014-12-31 | Abbvie Bahamas Ltd | Promotory apoptozy |
| US8624027B2 (en) | 2005-05-12 | 2014-01-07 | Abbvie Inc. | Combination therapy for treating cancer and diagnostic assays for use therein |
| US7208526B2 (en) | 2005-05-20 | 2007-04-24 | Hoffmann-La Roche Inc. | Styrylsulfonamides |
| US7208506B2 (en) * | 2005-07-07 | 2007-04-24 | Hoffmann-La Roche Inc. | Heteroarylethenyl derivatives, their manufacture and use as pharmaceutical agents |
| US7625896B2 (en) * | 2005-11-25 | 2009-12-01 | Hoffman-La Roche Inc. | Pyridylsulfonamide derivatives |
| US20100291592A1 (en) | 2006-04-20 | 2010-11-18 | Taro Semba | Novel marker for sensitivity against sulfonamide compound |
| JP5277168B2 (ja) | 2006-09-05 | 2013-08-28 | アボット・ラボラトリーズ | 血小板過剰を治療するｂｃｌインヒビター |
| US7939532B2 (en) | 2006-10-26 | 2011-05-10 | Hoffmann-La Roche Inc. | Heterocyclyl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents |
| JP2010526844A (ja) * | 2007-05-16 | 2010-08-05 | エフ．ホフマン−ラ ロシュ アーゲー | アリールピリジルスルホンアミド誘導体、それらの製造法及び医薬剤としての使用 |
| US20100160322A1 (en) | 2008-12-04 | 2010-06-24 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US8557983B2 (en) | 2008-12-04 | 2013-10-15 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US8586754B2 (en) | 2008-12-05 | 2013-11-19 | Abbvie Inc. | BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
| US8563735B2 (en) | 2008-12-05 | 2013-10-22 | Abbvie Inc. | Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
| CA2747835A1 (en) * | 2009-01-19 | 2010-07-22 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| JP2012136435A (ja) * | 2009-03-30 | 2012-07-19 | Eisai R & D Management Co Ltd | 腫瘍組織の感受性を検査する方法 |
| KR200457823Y1 (ko) * | 2009-05-08 | 2012-01-05 | 황정용 | 쭈꾸미 포획용 어구 |
| US20220315555A1 (en) | 2009-05-26 | 2022-10-06 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US8546399B2 (en) | 2009-05-26 | 2013-10-01 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
| WO2010138588A2 (en) | 2009-05-26 | 2010-12-02 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US9034875B2 (en) | 2009-05-26 | 2015-05-19 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| RU2015141713A (ru) * | 2010-03-25 | 2018-12-28 | Эббви Инк. | Средства, индуцирующие апоптоз, для лечения рака, иммунных и аутоиммунных заболеваний |
| CA3152557A1 (en) | 2010-10-29 | 2012-05-03 | Abbvie Inc. | Solid dispersions containing an apoptosis-inducing agent |
| UA113500C2 (xx) | 2010-10-29 | 2017-02-10 | Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб | |
| ES2603129T3 (es) | 2010-11-23 | 2017-02-23 | Abbvie Ireland Unlimited Company | Métodos de tratamiento utilizando inhibidores selectivos de Bcl-2 |
| PT2643322T (pt) * | 2010-11-23 | 2017-11-13 | Abbvie Inc | Sais e formas cristalinas de um agente indutor de apoptose |
| CN103159650B (zh) * | 2011-12-19 | 2016-04-20 | 天津市国际生物医药联合研究院 | 芳香杂环磺酰胺类化合物的制备及其应用 |
| CN103159649B (zh) * | 2011-12-19 | 2016-03-09 | 天津市国际生物医药联合研究院 | 磺酰胺类化合物的制备及其应用 |
| US20140275082A1 (en) | 2013-03-14 | 2014-09-18 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| CN105712925B (zh) * | 2014-12-05 | 2019-01-04 | 沈阳中化农药化工研发有限公司 | 一种取代的磺酰胺基(硫代)羰基化合物及其用途 |
| EA036995B1 (ru) | 2015-02-13 | 2021-01-25 | Оксфорд Драг Дизайн Лимитед | НОВЫЕ N-АЦИЛАРИЛСУЛЬФОНАМИДНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ АМИНОАЦИЛ-тРНК СИНТЕТАЗЫ |
| CN105753748B (zh) * | 2016-02-15 | 2018-05-29 | 南京励合化学新材料有限公司 | 一种医药中间体磺酰类化合物的合成方法 |
| GB201617064D0 (en) | 2016-10-07 | 2016-11-23 | Inhibox Limited And Latvian Institute Of Organic Synthesis The | Compounds and their therapeutic use |
| EP3612531B1 (en) | 2017-04-18 | 2022-08-24 | Shanghai Fochon Pharmaceutical Co., Ltd. | Apoptosis-inducing agents |
| US11479532B2 (en) * | 2017-06-23 | 2022-10-25 | University Of South Florida | 5-aminolevulinate synthase inhibitors and methods of use thereof |
| KR20230127355A (ko) * | 2017-12-29 | 2023-08-31 | 공윈 바이오팜 컴퍼니, 리미티드 (타이완) | 벤젠술폰아미드 유도체 및 지질 래프트 조정 방법 |
| CN114790149B (zh) * | 2021-01-26 | 2024-11-19 | 江苏中旗科技股份有限公司 | 一种以2-氯-4-氟苯胺为原料合成2-氯-4-氟苯甲酸的方法 |
| WO2025031360A1 (zh) * | 2023-08-09 | 2025-02-13 | 上海科技大学 | 磺酰胺类化合物及其用途 |
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| US4157257A (en) | 1976-10-01 | 1979-06-05 | Utsunomiya University | Benzenesulfonamide derivatives |
| US4433997A (en) * | 1979-04-20 | 1984-02-28 | Stauffer Chemical Co | N-Acylsulfonamide herbicidal antidotes |
| US4266078A (en) * | 1979-04-20 | 1981-05-05 | Stauffer Chemical Company | N-Acylsulfonamide herbicidal antidotes |
| US4347380A (en) * | 1979-04-20 | 1982-08-31 | Stauffer Chemical Company | N-Acylsulfonamide herbicidal antidotes |
| US4495365A (en) * | 1980-11-21 | 1985-01-22 | Stauffer Chemical Co. | N-Acylsulfonamide herbicidal antidotes |
| US5110830A (en) * | 1984-06-27 | 1992-05-05 | Eli Lilly And Company | Benzenesulfonamides treatment of tumors susceptible to |
| US4845128A (en) * | 1984-06-27 | 1989-07-04 | Eli Lilly And Company | N([(4-trifluoromethylphenyl)amino]carbonyl)benzene sulfonamides |
| JP2679498B2 (ja) * | 1991-12-25 | 1997-11-19 | 王子製紙株式会社 | 感熱記録体 |
| CA2110524A1 (en) | 1992-12-10 | 1994-06-11 | Gerald Burr Grindey | Antitumor compositions and methods of treatment |
| JPH0747772A (ja) * | 1993-08-05 | 1995-02-21 | New Oji Paper Co Ltd | 感熱記録体 |
| AU5772196A (en) | 1995-05-19 | 1996-11-29 | Chiroscience Limited | 3,4-disubstituted-phenylsulphonamides and their therapeutic use |
| DE69625622T2 (de) | 1995-10-25 | 2003-08-14 | Senju Pharmaceutical Co., Ltd. | Angiogenese Inhibitoren |
| US5929097A (en) * | 1996-10-16 | 1999-07-27 | American Cyanamid Company | Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and tace inhibitors |
| JP2002536415A (ja) * | 1999-02-12 | 2002-10-29 | セルパス インコーポレイテッド | 抗腫瘍療法 |
| AR031130A1 (es) | 2000-09-20 | 2003-09-10 | Abbott Lab | N-acilsulfonamidas promotoras de la apoptosis |
| US6720338B2 (en) | 2000-09-20 | 2004-04-13 | Abbott Laboratories | N-acylsulfonamide apoptosis promoters |
| US20020055631A1 (en) | 2000-09-20 | 2002-05-09 | Augeri David J. | N-acylsulfonamide apoptosis promoters |
-
2002
- 2002-05-24 US US10/478,389 patent/US7183320B2/en not_active Expired - Fee Related
- 2002-05-24 WO PCT/US2002/015142 patent/WO2002098848A1/en not_active Ceased
- 2002-05-24 KR KR1020037015958A patent/KR100880760B1/ko not_active Expired - Fee Related
- 2002-05-24 JP JP2003501838A patent/JP4167173B2/ja not_active Expired - Fee Related
- 2002-05-24 DE DE60213810T patent/DE60213810T2/de not_active Expired - Fee Related
- 2002-05-24 UA UA20031211105A patent/UA74889C2/uk unknown
- 2002-05-24 SK SK1464-2003A patent/SK14642003A3/sk unknown
- 2002-05-24 MX MXPA03011197A patent/MXPA03011197A/es active IP Right Grant
- 2002-05-24 CN CNB028115104A patent/CN100475787C/zh not_active Expired - Fee Related
- 2002-05-24 CZ CZ20033296A patent/CZ20033296A3/cs unknown
- 2002-05-24 EP EP02729196A patent/EP1401806B1/en not_active Expired - Lifetime
- 2002-05-24 CA CA002446719A patent/CA2446719A1/en not_active Abandoned
- 2002-05-24 HR HR20031000A patent/HRP20031000A2/xx not_active Application Discontinuation
- 2002-05-24 PL PL02367188A patent/PL367188A1/xx not_active Application Discontinuation
- 2002-05-24 NZ NZ529098A patent/NZ529098A/en unknown
- 2002-05-24 EA EA200400006A patent/EA005810B1/ru not_active IP Right Cessation
- 2002-05-24 PT PT02729196T patent/PT1401806E/pt unknown
- 2002-05-24 DK DK02729196T patent/DK1401806T3/da active
- 2002-05-24 IL IL15898502A patent/IL158985A0/xx unknown
- 2002-05-24 HU HU0400114A patent/HUP0400114A3/hu unknown
- 2002-05-24 ES ES02729196T patent/ES2269688T3/es not_active Expired - Lifetime
- 2002-05-24 AT AT02729196T patent/ATE335722T1/de not_active IP Right Cessation
- 2002-05-24 BR BR0210078-9A patent/BR0210078A/pt not_active IP Right Cessation
- 2002-05-24 AU AU2002259204A patent/AU2002259204B2/en not_active Ceased
- 2002-06-03 TW TWPHENYLSULA patent/TWI266761B/zh not_active IP Right Cessation
- 2002-06-04 EG EG2002060594A patent/EG24356A/xx active
- 2002-06-04 AR ARP020102075A patent/AR036079A1/es unknown
- 2002-06-05 SV SV2002001076A patent/SV2003001076A/es not_active Application Discontinuation
- 2002-06-05 MY MYPI20022075A patent/MY136855A/en unknown
- 2002-06-07 PE PE2002000494A patent/PE20030199A1/es not_active Application Discontinuation
-
2003
- 2003-11-05 ZA ZA200308644A patent/ZA200308644B/en unknown
- 2003-12-02 NO NO20035366A patent/NO20035366L/no not_active Application Discontinuation
- 2003-12-02 EC EC2003004874A patent/ECSP034874A/es unknown
- 2003-12-05 CR CR7182A patent/CR7182A/es unknown
-
2006
- 2006-09-27 CY CY20061101396T patent/CY1105386T1/el unknown
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