CN100475787C - 用作抗肿瘤剂的苯甲酰基磺酰胺类化合物和磺酰基苄脒类化合物 - Google Patents
用作抗肿瘤剂的苯甲酰基磺酰胺类化合物和磺酰基苄脒类化合物 Download PDFInfo
- Publication number
- CN100475787C CN100475787C CNB028115104A CN02811510A CN100475787C CN 100475787 C CN100475787 C CN 100475787C CN B028115104 A CNB028115104 A CN B028115104A CN 02811510 A CN02811510 A CN 02811510A CN 100475787 C CN100475787 C CN 100475787C
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- China
- Prior art keywords
- hydrogen
- alkyl
- phenyl
- halogen
- alkoxyl group
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/51—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
- C07D213/34—Sulfur atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/18—Radicals substituted by singly bound hetero atoms other than halogen by sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29635001P | 2001-06-06 | 2001-06-06 | |
| US60/296,350 | 2001-06-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1514824A CN1514824A (zh) | 2004-07-21 |
| CN100475787C true CN100475787C (zh) | 2009-04-08 |
Family
ID=23141662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB028115104A Expired - Fee Related CN100475787C (zh) | 2001-06-06 | 2002-05-24 | 用作抗肿瘤剂的苯甲酰基磺酰胺类化合物和磺酰基苄脒类化合物 |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US7183320B2 (https=) |
| EP (1) | EP1401806B1 (https=) |
| JP (1) | JP4167173B2 (https=) |
| KR (1) | KR100880760B1 (https=) |
| CN (1) | CN100475787C (https=) |
| AR (1) | AR036079A1 (https=) |
| AT (1) | ATE335722T1 (https=) |
| AU (1) | AU2002259204B2 (https=) |
| BR (1) | BR0210078A (https=) |
| CA (1) | CA2446719A1 (https=) |
| CR (1) | CR7182A (https=) |
| CY (1) | CY1105386T1 (https=) |
| CZ (1) | CZ20033296A3 (https=) |
| DE (1) | DE60213810T2 (https=) |
| DK (1) | DK1401806T3 (https=) |
| EA (1) | EA005810B1 (https=) |
| EC (1) | ECSP034874A (https=) |
| EG (1) | EG24356A (https=) |
| ES (1) | ES2269688T3 (https=) |
| HR (1) | HRP20031000A2 (https=) |
| HU (1) | HUP0400114A3 (https=) |
| IL (1) | IL158985A0 (https=) |
| MX (1) | MXPA03011197A (https=) |
| MY (1) | MY136855A (https=) |
| NO (1) | NO20035366L (https=) |
| NZ (1) | NZ529098A (https=) |
| PE (1) | PE20030199A1 (https=) |
| PL (1) | PL367188A1 (https=) |
| PT (1) | PT1401806E (https=) |
| SK (1) | SK14642003A3 (https=) |
| SV (1) | SV2003001076A (https=) |
| TW (1) | TWI266761B (https=) |
| UA (1) | UA74889C2 (https=) |
| WO (1) | WO2002098848A1 (https=) |
| ZA (1) | ZA200308644B (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60316984T2 (de) * | 2002-11-22 | 2008-07-17 | Eli Lilly And Co., Indianapolis | Benzoylsulfonamide als antitumor-mittel |
| US8614318B2 (en) | 2003-11-13 | 2013-12-24 | Abbvie Inc. | Apoptosis promoters |
| US7973161B2 (en) | 2003-11-13 | 2011-07-05 | Abbott Laboratories | Apoptosis promoters |
| US7767684B2 (en) | 2003-11-13 | 2010-08-03 | Abbott Laboratories | Apoptosis promoters |
| WO2005049593A2 (en) * | 2003-11-13 | 2005-06-02 | Abbott Laboratories | N-acylsulfonamide apoptosis promoters |
| EP1765778B1 (en) * | 2004-05-26 | 2012-01-25 | Abbott Laboratories | N-sulfonylcarboximidamide apoptosis promoters |
| US8772269B2 (en) | 2004-09-13 | 2014-07-08 | Eisai R&D Management Co., Ltd. | Use of sulfonamide-including compounds in combination with angiogenesis inhibitors |
| EP2364699A1 (en) | 2004-09-13 | 2011-09-14 | Eisai R&D Management Co., Ltd. | Joint use of sulfonamide based compound with angiogenesis inhibitor |
| JP5134247B2 (ja) * | 2004-09-13 | 2013-01-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド含有化合物の血管新生阻害物質との併用 |
| WO2006090927A1 (ja) * | 2005-02-28 | 2006-08-31 | Eisai R & D Management Co., Ltd. | スルホンアミド化合物の摂食亢進作用 |
| JPWO2006090928A1 (ja) * | 2005-02-28 | 2008-07-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド化合物の血管新生阻害物質との新規併用 |
| PL1859793T3 (pl) * | 2005-02-28 | 2011-09-30 | Eisai R&D Man Co Ltd | Nowe połączone zastosowanie związku sulfonamidowego w leczeniu choroby nowotworowej |
| EP1888550B1 (en) | 2005-05-12 | 2014-06-25 | AbbVie Bahamas Ltd. | Apoptosis promoters |
| US8624027B2 (en) | 2005-05-12 | 2014-01-07 | Abbvie Inc. | Combination therapy for treating cancer and diagnostic assays for use therein |
| US7208526B2 (en) | 2005-05-20 | 2007-04-24 | Hoffmann-La Roche Inc. | Styrylsulfonamides |
| US7208506B2 (en) * | 2005-07-07 | 2007-04-24 | Hoffmann-La Roche Inc. | Heteroarylethenyl derivatives, their manufacture and use as pharmaceutical agents |
| US7625896B2 (en) * | 2005-11-25 | 2009-12-01 | Hoffman-La Roche Inc. | Pyridylsulfonamide derivatives |
| US20100291592A1 (en) | 2006-04-20 | 2010-11-18 | Taro Semba | Novel marker for sensitivity against sulfonamide compound |
| CA2662320C (en) | 2006-09-05 | 2014-07-22 | Abbott Laboratories | Bcl inhibitors treating platelet excess |
| US7939532B2 (en) * | 2006-10-26 | 2011-05-10 | Hoffmann-La Roche Inc. | Heterocyclyl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents |
| US7879884B2 (en) | 2007-05-16 | 2011-02-01 | Hoffmann-La Roche Inc. | Aryl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents |
| US8557983B2 (en) | 2008-12-04 | 2013-10-15 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US20100160322A1 (en) | 2008-12-04 | 2010-06-24 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US8563735B2 (en) | 2008-12-05 | 2013-10-22 | Abbvie Inc. | Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
| US8586754B2 (en) | 2008-12-05 | 2013-11-19 | Abbvie Inc. | BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
| CN102282129A (zh) * | 2009-01-19 | 2011-12-14 | 雅培制药有限公司 | 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂 |
| JP2012136435A (ja) * | 2009-03-30 | 2012-07-19 | Eisai R & D Management Co Ltd | 腫瘍組織の感受性を検査する方法 |
| KR200457823Y1 (ko) * | 2009-05-08 | 2012-01-05 | 황정용 | 쭈꾸미 포획용 어구 |
| NZ595708A (en) | 2009-05-26 | 2014-03-28 | Abbvie Bahamas Ltd | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US20220315555A1 (en) | 2009-05-26 | 2022-10-06 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US9034875B2 (en) | 2009-05-26 | 2015-05-19 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US8546399B2 (en) | 2009-05-26 | 2013-10-01 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
| WO2011119345A2 (en) * | 2010-03-25 | 2011-09-29 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| CA3152557A1 (en) | 2010-10-29 | 2012-05-03 | Abbvie Inc. | Solid dispersions containing an apoptosis-inducing agent |
| UA113500C2 (xx) | 2010-10-29 | 2017-02-10 | Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб | |
| TWI620736B (zh) | 2010-11-23 | 2018-04-11 | 艾伯維巴哈馬有限公司 | 使用選擇性ｂｃｌ-２抑制劑之治療方法 |
| PT2643322T (pt) * | 2010-11-23 | 2017-11-13 | Abbvie Inc | Sais e formas cristalinas de um agente indutor de apoptose |
| CN103159649B (zh) * | 2011-12-19 | 2016-03-09 | 天津市国际生物医药联合研究院 | 磺酰胺类化合物的制备及其应用 |
| CN103159650B (zh) * | 2011-12-19 | 2016-04-20 | 天津市国际生物医药联合研究院 | 芳香杂环磺酰胺类化合物的制备及其应用 |
| US20140275082A1 (en) | 2013-03-14 | 2014-09-18 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| CN105712925B (zh) * | 2014-12-05 | 2019-01-04 | 沈阳中化农药化工研发有限公司 | 一种取代的磺酰胺基(硫代)羰基化合物及其用途 |
| NZ735398A (en) | 2015-02-13 | 2024-07-05 | Oxford Drug Design Ltd | Novel n-acyl-arylsulfonamide derivatives as aminoacyl-trna synthetase inhibitors |
| CN105753748B (zh) * | 2016-02-15 | 2018-05-29 | 南京励合化学新材料有限公司 | 一种医药中间体磺酰类化合物的合成方法 |
| GB201617064D0 (en) | 2016-10-07 | 2016-11-23 | Inhibox Limited And Latvian Institute Of Organic Synthesis The | Compounds and their therapeutic use |
| HUE060310T2 (hu) | 2017-04-18 | 2023-02-28 | Shanghai Fochon Pharmaceutical Co Ltd | Apoptosis-indukáló szerek |
| US11479532B2 (en) * | 2017-06-23 | 2022-10-25 | University Of South Florida | 5-aminolevulinate synthase inhibitors and methods of use thereof |
| TW202402267A (zh) * | 2017-12-29 | 2024-01-16 | 共信醫藥科技股份有限公司 | 苯磺醯胺衍生物及調節脂膜筏之方法 |
| CN114790149B (zh) * | 2021-01-26 | 2024-11-19 | 江苏中旗科技股份有限公司 | 一种以2-氯-4-氟苯胺为原料合成2-氯-4-氟苯甲酸的方法 |
| WO2025031361A1 (zh) * | 2023-08-09 | 2025-02-13 | 上海科技大学 | 磺酰胺类化合物作为制备治疗癌症药物的用途 |
Citations (1)
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| US5110830A (en) * | 1984-06-27 | 1992-05-05 | Eli Lilly And Company | Benzenesulfonamides treatment of tumors susceptible to |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4157257A (en) | 1976-10-01 | 1979-06-05 | Utsunomiya University | Benzenesulfonamide derivatives |
| US4347380A (en) * | 1979-04-20 | 1982-08-31 | Stauffer Chemical Company | N-Acylsulfonamide herbicidal antidotes |
| US4266078A (en) * | 1979-04-20 | 1981-05-05 | Stauffer Chemical Company | N-Acylsulfonamide herbicidal antidotes |
| US4433997A (en) * | 1979-04-20 | 1984-02-28 | Stauffer Chemical Co | N-Acylsulfonamide herbicidal antidotes |
| US4495365A (en) * | 1980-11-21 | 1985-01-22 | Stauffer Chemical Co. | N-Acylsulfonamide herbicidal antidotes |
| US4845128A (en) * | 1984-06-27 | 1989-07-04 | Eli Lilly And Company | N([(4-trifluoromethylphenyl)amino]carbonyl)benzene sulfonamides |
| JP2679498B2 (ja) * | 1991-12-25 | 1997-11-19 | 王子製紙株式会社 | 感熱記録体 |
| CA2110524A1 (en) | 1992-12-10 | 1994-06-11 | Gerald Burr Grindey | Antitumor compositions and methods of treatment |
| JPH0747772A (ja) * | 1993-08-05 | 1995-02-21 | New Oji Paper Co Ltd | 感熱記録体 |
| AU5772196A (en) | 1995-05-19 | 1996-11-29 | Chiroscience Limited | 3,4-disubstituted-phenylsulphonamides and their therapeutic use |
| ES2193615T3 (es) | 1995-10-25 | 2003-11-01 | Senju Pharma Co | .nhibidor de la angiogenesis. |
| US5929097A (en) * | 1996-10-16 | 1999-07-27 | American Cyanamid Company | Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and tace inhibitors |
| JP2002536415A (ja) * | 1999-02-12 | 2002-10-29 | セルパス インコーポレイテッド | 抗腫瘍療法 |
| US6720338B2 (en) | 2000-09-20 | 2004-04-13 | Abbott Laboratories | N-acylsulfonamide apoptosis promoters |
| UY26942A1 (es) | 2000-09-20 | 2002-04-26 | Abbott Lab | N-acilsulfonamidas promotoras de la apoptosis |
| US20020055631A1 (en) | 2000-09-20 | 2002-05-09 | Augeri David J. | N-acylsulfonamide apoptosis promoters |
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2002
- 2002-05-24 CZ CZ20033296A patent/CZ20033296A3/cs unknown
- 2002-05-24 BR BR0210078-9A patent/BR0210078A/pt not_active IP Right Cessation
- 2002-05-24 MX MXPA03011197A patent/MXPA03011197A/es active IP Right Grant
- 2002-05-24 EA EA200400006A patent/EA005810B1/ru not_active IP Right Cessation
- 2002-05-24 CA CA002446719A patent/CA2446719A1/en not_active Abandoned
- 2002-05-24 UA UA20031211105A patent/UA74889C2/uk unknown
- 2002-05-24 KR KR1020037015958A patent/KR100880760B1/ko not_active Expired - Fee Related
- 2002-05-24 PT PT02729196T patent/PT1401806E/pt unknown
- 2002-05-24 HR HR20031000A patent/HRP20031000A2/xx not_active Application Discontinuation
- 2002-05-24 IL IL15898502A patent/IL158985A0/xx unknown
- 2002-05-24 AT AT02729196T patent/ATE335722T1/de not_active IP Right Cessation
- 2002-05-24 PL PL02367188A patent/PL367188A1/xx not_active Application Discontinuation
- 2002-05-24 JP JP2003501838A patent/JP4167173B2/ja not_active Expired - Fee Related
- 2002-05-24 WO PCT/US2002/015142 patent/WO2002098848A1/en not_active Ceased
- 2002-05-24 ES ES02729196T patent/ES2269688T3/es not_active Expired - Lifetime
- 2002-05-24 AU AU2002259204A patent/AU2002259204B2/en not_active Ceased
- 2002-05-24 DK DK02729196T patent/DK1401806T3/da active
- 2002-05-24 SK SK1464-2003A patent/SK14642003A3/sk unknown
- 2002-05-24 US US10/478,389 patent/US7183320B2/en not_active Expired - Fee Related
- 2002-05-24 DE DE60213810T patent/DE60213810T2/de not_active Expired - Fee Related
- 2002-05-24 NZ NZ529098A patent/NZ529098A/en unknown
- 2002-05-24 HU HU0400114A patent/HUP0400114A3/hu unknown
- 2002-05-24 EP EP02729196A patent/EP1401806B1/en not_active Expired - Lifetime
- 2002-05-24 CN CNB028115104A patent/CN100475787C/zh not_active Expired - Fee Related
- 2002-06-03 TW TWPHENYLSULA patent/TWI266761B/zh not_active IP Right Cessation
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5110830A (en) * | 1984-06-27 | 1992-05-05 | Eli Lilly And Company | Benzenesulfonamides treatment of tumors susceptible to |
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