KR100880760B1 - 항종양제로서 사용하기 위한 벤조일술폰아미드 및술포닐벤즈아미딘 - Google Patents

항종양제로서 사용하기 위한 벤조일술폰아미드 및술포닐벤즈아미딘 Download PDF

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KR100880760B1
KR100880760B1 KR1020037015958A KR20037015958A KR100880760B1 KR 100880760 B1 KR100880760 B1 KR 100880760B1 KR 1020037015958 A KR1020037015958 A KR 1020037015958A KR 20037015958 A KR20037015958 A KR 20037015958A KR 100880760 B1 KR100880760 B1 KR 100880760B1
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hydrogen
alkyl
halo
alkoxy
phenyl
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KR20040007656A (ko
Inventor
토마스 휴즈 코르벳
코라 수 그로스만
카렌 린 롭
추안 신
필립 아서 힙스킨드
호-쉔 린
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일라이 릴리 앤드 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/51—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C07D213/34—Sulfur atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/18—Radicals substituted by singly bound hetero atoms other than halogen by sulfur atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Furan Compounds (AREA)
KR1020037015958A 2001-06-06 2002-05-24 항종양제로서 사용하기 위한 벤조일술폰아미드 및술포닐벤즈아미딘 Expired - Fee Related KR100880760B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29635001P 2001-06-06 2001-06-06
US60/296,350 2001-06-06
PCT/US2002/015142 WO2002098848A1 (en) 2001-06-06 2002-05-24 Benzoylsulfonamides and sulfonylbenzamidines for use as antitumour agents

Publications (2)

Publication Number Publication Date
KR20040007656A KR20040007656A (ko) 2004-01-24
KR100880760B1 true KR100880760B1 (ko) 2009-02-02

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KR1020037015958A Expired - Fee Related KR100880760B1 (ko) 2001-06-06 2002-05-24 항종양제로서 사용하기 위한 벤조일술폰아미드 및술포닐벤즈아미딘

Country Status (35)

Country Link
US (1) US7183320B2 (https=)
EP (1) EP1401806B1 (https=)
JP (1) JP4167173B2 (https=)
KR (1) KR100880760B1 (https=)
CN (1) CN100475787C (https=)
AR (1) AR036079A1 (https=)
AT (1) ATE335722T1 (https=)
AU (1) AU2002259204B2 (https=)
BR (1) BR0210078A (https=)
CA (1) CA2446719A1 (https=)
CR (1) CR7182A (https=)
CY (1) CY1105386T1 (https=)
CZ (1) CZ20033296A3 (https=)
DE (1) DE60213810T2 (https=)
DK (1) DK1401806T3 (https=)
EA (1) EA005810B1 (https=)
EC (1) ECSP034874A (https=)
EG (1) EG24356A (https=)
ES (1) ES2269688T3 (https=)
HR (1) HRP20031000A2 (https=)
HU (1) HUP0400114A3 (https=)
IL (1) IL158985A0 (https=)
MX (1) MXPA03011197A (https=)
MY (1) MY136855A (https=)
NO (1) NO20035366L (https=)
NZ (1) NZ529098A (https=)
PE (1) PE20030199A1 (https=)
PL (1) PL367188A1 (https=)
PT (1) PT1401806E (https=)
SK (1) SK14642003A3 (https=)
SV (1) SV2003001076A (https=)
TW (1) TWI266761B (https=)
UA (1) UA74889C2 (https=)
WO (1) WO2002098848A1 (https=)
ZA (1) ZA200308644B (https=)

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US8772269B2 (en) 2004-09-13 2014-07-08 Eisai R&D Management Co., Ltd. Use of sulfonamide-including compounds in combination with angiogenesis inhibitors
EP2364699A1 (en) 2004-09-13 2011-09-14 Eisai R&D Management Co., Ltd. Joint use of sulfonamide based compound with angiogenesis inhibitor
JP5134247B2 (ja) * 2004-09-13 2013-01-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 スルホンアミド含有化合物の血管新生阻害物質との併用
WO2006090927A1 (ja) * 2005-02-28 2006-08-31 Eisai R & D Management Co., Ltd. スルホンアミド化合物の摂食亢進作用
JPWO2006090928A1 (ja) * 2005-02-28 2008-07-24 エーザイ・アール・アンド・ディー・マネジメント株式会社 スルホンアミド化合物の血管新生阻害物質との新規併用
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EP1888550B1 (en) 2005-05-12 2014-06-25 AbbVie Bahamas Ltd. Apoptosis promoters
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CN102282129A (zh) * 2009-01-19 2011-12-14 雅培制药有限公司 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂
JP2012136435A (ja) * 2009-03-30 2012-07-19 Eisai R & D Management Co Ltd 腫瘍組織の感受性を検査する方法
KR200457823Y1 (ko) * 2009-05-08 2012-01-05 황정용 쭈꾸미 포획용 어구
NZ595708A (en) 2009-05-26 2014-03-28 Abbvie Bahamas Ltd Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US20220315555A1 (en) 2009-05-26 2022-10-06 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US9034875B2 (en) 2009-05-26 2015-05-19 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
WO2011119345A2 (en) * 2010-03-25 2011-09-29 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
CA3152557A1 (en) 2010-10-29 2012-05-03 Abbvie Inc. Solid dispersions containing an apoptosis-inducing agent
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
TWI620736B (zh) 2010-11-23 2018-04-11 艾伯維巴哈馬有限公司 使用選擇性ｂｃｌ-２抑制劑之治療方法
PT2643322T (pt) * 2010-11-23 2017-11-13 Abbvie Inc Sais e formas cristalinas de um agente indutor de apoptose
CN103159649B (zh) * 2011-12-19 2016-03-09 天津市国际生物医药联合研究院 磺酰胺类化合物的制备及其应用
CN103159650B (zh) * 2011-12-19 2016-04-20 天津市国际生物医药联合研究院 芳香杂环磺酰胺类化合物的制备及其应用
US20140275082A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
CN105712925B (zh) * 2014-12-05 2019-01-04 沈阳中化农药化工研发有限公司 一种取代的磺酰胺基(硫代)羰基化合物及其用途
NZ735398A (en) 2015-02-13 2024-07-05 Oxford Drug Design Ltd Novel n-acyl-arylsulfonamide derivatives as aminoacyl-trna synthetase inhibitors
CN105753748B (zh) * 2016-02-15 2018-05-29 南京励合化学新材料有限公司 一种医药中间体磺酰类化合物的合成方法
GB201617064D0 (en) 2016-10-07 2016-11-23 Inhibox Limited And Latvian Institute Of Organic Synthesis The Compounds and their therapeutic use
HUE060310T2 (hu) 2017-04-18 2023-02-28 Shanghai Fochon Pharmaceutical Co Ltd Apoptosis-indukáló szerek
US11479532B2 (en) * 2017-06-23 2022-10-25 University Of South Florida 5-aminolevulinate synthase inhibitors and methods of use thereof
TW202402267A (zh) * 2017-12-29 2024-01-16 共信醫藥科技股份有限公司 苯磺醯胺衍生物及調節脂膜筏之方法
CN114790149B (zh) * 2021-01-26 2024-11-19 江苏中旗科技股份有限公司 一种以2-氯-4-氟苯胺为原料合成2-氯-4-氟苯甲酸的方法
WO2025031361A1 (zh) * 2023-08-09 2025-02-13 上海科技大学 磺酰胺类化合物作为制备治疗癌症药物的用途

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JPH05169834A (ja) * 1991-12-25 1993-07-09 Oji Paper Co Ltd 感熱記録体
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US4266078A (en) * 1979-04-20 1981-05-05 Stauffer Chemical Company N-Acylsulfonamide herbicidal antidotes
JPH05169834A (ja) * 1991-12-25 1993-07-09 Oji Paper Co Ltd 感熱記録体
JPH0747772A (ja) * 1993-08-05 1995-02-21 New Oji Paper Co Ltd 感熱記録体
WO1996036611A1 (en) 1995-05-19 1996-11-21 Chiroscience Limited 3,4-disubstituted-phenylsulphonamides and their therapeutic use

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PE20030199A1 (es) 2003-03-12
MXPA03011197A (es) 2004-02-26
EA005810B1 (ru) 2005-06-30
HK1064360A1 (en) 2005-01-28
IL158985A0 (en) 2004-05-12
HUP0400114A2 (hu) 2005-04-28
WO2002098848A1 (en) 2002-12-12
ES2269688T3 (es) 2007-04-01
NZ529098A (en) 2005-08-26
CN1514824A (zh) 2004-07-21
SV2003001076A (es) 2003-07-29
JP4167173B2 (ja) 2008-10-15
ECSP034874A (es) 2004-01-28
SK14642003A3 (sk) 2004-12-01
AR036079A1 (es) 2004-08-11
CR7182A (es) 2004-06-08
JP2004530709A (ja) 2004-10-07
HRP20031000A2 (en) 2004-04-30
NO20035366L (no) 2004-02-06
KR20040007656A (ko) 2004-01-24
US7183320B2 (en) 2007-02-27
TWI266761B (en) 2006-11-21
PT1401806E (pt) 2006-11-30
DE60213810D1 (de) 2006-09-21
EA200400006A1 (ru) 2004-06-24
CN100475787C (zh) 2009-04-08
MY136855A (en) 2008-11-28
HUP0400114A3 (en) 2007-05-02
DK1401806T3 (da) 2006-11-27
UA74889C2 (en) 2006-02-15
NO20035366D0 (no) 2003-12-02
CA2446719A1 (en) 2002-12-12
PL367188A1 (en) 2005-02-21
DE60213810T2 (de) 2007-02-01
CZ20033296A3 (cs) 2004-04-14
BR0210078A (pt) 2004-06-22
ATE335722T1 (de) 2006-09-15
CY1105386T1 (el) 2010-04-28
AU2002259204B2 (en) 2008-01-17
EP1401806A1 (en) 2004-03-31
EG24356A (en) 2009-03-04
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EP1401806B1 (en) 2006-08-09
US20040157741A1 (en) 2004-08-12

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