DE60213211T2 - Verfahren zur gewinnung von dekokten aus schalen von vitis labrusca und vitis vinifera - Google Patents
Verfahren zur gewinnung von dekokten aus schalen von vitis labrusca und vitis vinifera Download PDFInfo
- Publication number
- DE60213211T2 DE60213211T2 DE60213211T DE60213211T DE60213211T2 DE 60213211 T2 DE60213211 T2 DE 60213211T2 DE 60213211 T DE60213211 T DE 60213211T DE 60213211 T DE60213211 T DE 60213211T DE 60213211 T2 DE60213211 T2 DE 60213211T2
- Authority
- DE
- Germany
- Prior art keywords
- decoction
- vitis
- hydro
- liquid phase
- alcoholic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims abstract description 56
- 235000004282 Vitis labrusca Nutrition 0.000 title claims abstract description 36
- 235000014787 Vitis vinifera Nutrition 0.000 title claims description 43
- 244000070384 Vitis labrusca Species 0.000 title claims description 37
- 240000006365 Vitis vinifera Species 0.000 title claims description 30
- 235000002532 grape seed extract Nutrition 0.000 title claims description 29
- XEKOWRVHYACXOJ-UHFFFAOYSA-N ethyl acetate Substances CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims abstract description 28
- 208000037849 arterial hypertension Diseases 0.000 claims abstract description 18
- 238000011282 treatment Methods 0.000 claims abstract description 14
- 239000000825 pharmaceutical preparation Substances 0.000 claims abstract description 8
- 230000002265 prevention Effects 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 36
- 239000007791 liquid phase Substances 0.000 claims description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 24
- 235000020679 tap water Nutrition 0.000 claims description 17
- 239000008399 tap water Substances 0.000 claims description 17
- 235000013399 edible fruits Nutrition 0.000 claims description 16
- 239000000399 hydroalcoholic extract Substances 0.000 claims description 16
- 239000002024 ethyl acetate extract Substances 0.000 claims description 13
- 239000011148 porous material Substances 0.000 claims description 11
- 238000000605 extraction Methods 0.000 claims description 9
- 230000003285 pharmacodynamic effect Effects 0.000 claims description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 6
- 230000000144 pharmacologic effect Effects 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 5
- 239000008119 colloidal silica Substances 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 3
- 238000002803 maceration Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 200000000007 Arterial disease Diseases 0.000 claims description 2
- 240000008042 Zea mays Species 0.000 claims 3
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims 3
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims 3
- 150000001408 amides Chemical class 0.000 claims 3
- 235000005822 corn Nutrition 0.000 claims 3
- 238000009835 boiling Methods 0.000 claims 1
- 239000012141 concentrate Substances 0.000 claims 1
- 230000004872 arterial blood pressure Effects 0.000 abstract description 28
- 241000700159 Rattus Species 0.000 abstract description 24
- 239000000284 extract Substances 0.000 abstract description 24
- 206010020772 Hypertension Diseases 0.000 abstract description 16
- 241000219095 Vitis Species 0.000 abstract description 15
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 abstract description 14
- 239000002775 capsule Substances 0.000 abstract description 9
- 230000008569 process Effects 0.000 abstract description 9
- 230000005764 inhibitory process Effects 0.000 abstract description 7
- 230000015572 biosynthetic process Effects 0.000 abstract description 6
- 238000003786 synthesis reaction Methods 0.000 abstract description 6
- 230000009467 reduction Effects 0.000 abstract description 3
- 230000002269 spontaneous effect Effects 0.000 abstract description 3
- 230000001225 therapeutic effect Effects 0.000 abstract description 3
- 208000024172 Cardiovascular disease Diseases 0.000 abstract description 2
- 238000002360 preparation method Methods 0.000 abstract description 2
- 235000009392 Vitis Nutrition 0.000 abstract 1
- 241001512058 Vitis labrusca x Vitis vinifera Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 description 23
- KCWZGJVSDFYRIX-YFKPBYRVSA-N N(gamma)-nitro-L-arginine methyl ester Chemical compound COC(=O)[C@@H](N)CCCN=C(N)N[N+]([O-])=O KCWZGJVSDFYRIX-YFKPBYRVSA-N 0.000 description 15
- 235000009754 Vitis X bourquina Nutrition 0.000 description 14
- 235000012333 Vitis X labruscana Nutrition 0.000 description 14
- 239000000203 mixture Substances 0.000 description 13
- 230000000694 effects Effects 0.000 description 11
- 230000003276 anti-hypertensive effect Effects 0.000 description 10
- 235000020188 drinking water Nutrition 0.000 description 10
- 239000003651 drinking water Substances 0.000 description 10
- 238000010411 cooking Methods 0.000 description 9
- 241000700157 Rattus norvegicus Species 0.000 description 7
- 238000001914 filtration Methods 0.000 description 7
- 230000006978 adaptation Effects 0.000 description 6
- 230000037396 body weight Effects 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 235000013305 food Nutrition 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- VPGRYOFKCNULNK-ACXQXYJUSA-N Deoxycorticosterone acetate Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)COC(=O)C)[C@@]1(C)CC2 VPGRYOFKCNULNK-ACXQXYJUSA-N 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 4
- 230000036772 blood pressure Effects 0.000 description 4
- 208000029078 coronary artery disease Diseases 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 230000007935 neutral effect Effects 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 239000007790 solid phase Substances 0.000 description 4
- 229910001220 stainless steel Inorganic materials 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 229920002261 Corn starch Polymers 0.000 description 2
- 241000885980 Vitacea Species 0.000 description 2
- 238000009530 blood pressure measurement Methods 0.000 description 2
- 230000000747 cardiac effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 description 2
- 230000002526 effect on cardiovascular system Effects 0.000 description 2
- 230000001631 hypertensive effect Effects 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- VZUGBLTVBZJZOE-KRWDZBQOSA-N n-[3-[(4s)-2-amino-1,4-dimethyl-6-oxo-5h-pyrimidin-4-yl]phenyl]-5-chloropyrimidine-2-carboxamide Chemical compound N1=C(N)N(C)C(=O)C[C@@]1(C)C1=CC=CC(NC(=O)C=2N=CC(Cl)=CN=2)=C1 VZUGBLTVBZJZOE-KRWDZBQOSA-N 0.000 description 2
- 238000011458 pharmacological treatment Methods 0.000 description 2
- 235000020095 red wine Nutrition 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000011699 spontaneously hypertensive rat Methods 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- -1 For example Substances 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 102000008299 Nitric Oxide Synthase Human genes 0.000 description 1
- 108010021487 Nitric Oxide Synthase Proteins 0.000 description 1
- 206010062237 Renal impairment Diseases 0.000 description 1
- 235000009233 Stachytarpheta cayennensis Nutrition 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 235000013334 alcoholic beverage Nutrition 0.000 description 1
- 239000002876 beta blocker Substances 0.000 description 1
- 229940097320 beta blocking agent Drugs 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 229940030606 diuretics Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 235000009200 high fat diet Nutrition 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000005977 kidney dysfunction Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000013059 nephrectomy Methods 0.000 description 1
- 238000004091 panning Methods 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 230000004224 protection Effects 0.000 description 1
- 230000009979 protective mechanism Effects 0.000 description 1
- 230000036454 renin-angiotensin system Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002889 sympathetic effect Effects 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 235000014101 wine Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Table Devices Or Equipment (AREA)
- Meat, Egg Or Seafood Products (AREA)
- Extraction Or Liquid Replacement (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI0106382-0A BRPI0106382B1 (pt) | 2001-03-13 | 2001-03-13 | Process for obtaining decocts from vitis labrusca and vitis vinifera casts, process for obtaining the hydro-alcoholic extract, process for obtaining the hydro-alcoholic extract-ethyl acetate and pharmaceutical compositions |
| BR0106382 | 2001-03-13 | ||
| PCT/BR2002/000038 WO2002072118A1 (en) | 2001-03-13 | 2002-03-12 | Process for obtention of decoctions of vitis labrusca and vitis vinifera skins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60213211D1 DE60213211D1 (de) | 2006-08-31 |
| DE60213211T2 true DE60213211T2 (de) | 2007-07-19 |
Family
ID=36782358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60213211T Expired - Lifetime DE60213211T2 (de) | 2001-03-13 | 2002-03-12 | Verfahren zur gewinnung von dekokten aus schalen von vitis labrusca und vitis vinifera |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20040202737A1 (https=) |
| EP (1) | EP1368045B1 (https=) |
| JP (1) | JP2004525124A (https=) |
| AT (1) | ATE333283T1 (https=) |
| BR (1) | BRPI0106382B1 (https=) |
| CA (1) | CA2440333C (https=) |
| DE (1) | DE60213211T2 (https=) |
| ES (1) | ES2269650T3 (https=) |
| MX (1) | MXPA03008161A (https=) |
| PT (1) | PT1368045E (https=) |
| WO (1) | WO2002072118A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001122791A (ja) | 1999-10-20 | 2001-05-08 | Boehringer Ingelheim Internatl Gmbh | 下肢の慢性静脈不全の軽減および予防のための赤色ブドウ樹葉の水性抽出物よりなる食事補強剤 |
| EP1572221A1 (en) * | 2002-12-20 | 2005-09-14 | Council of Scientific and Industrial Research | Ayurvedic herbal soft drink |
| AU2003298180B2 (en) * | 2002-12-31 | 2010-01-21 | Boehringer Ingelheim International Gmbh | Film coated tablet comprising an extract of red vine leaves |
| JP2007523110A (ja) | 2004-02-19 | 2007-08-16 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 赤ブドウ葉の抽出物および抗炎症剤を含む、慢性静脈疾患を治療するための組成物 |
| BRPI0604281A (pt) * | 2006-07-18 | 2008-03-04 | Roberto Soares De Moura | processo para obtenção de decotos de frutos e caroços de euterpe oleracea (açaì) processo de obtenção de extratos hidro-alcoólicos a partir dos decotos; processo obtenção de liofilizado e/ou spray dryer do extrato hidro-alcoólico; composições farmacêuticas contendo os liofilizados e/ou spray dryer dos ditos extratos e uso terapêutico das composições como vasodilatador no tratamento das sìndromes isquêmicas, vaso-espásticas e da hipertenção arterial |
| JP5892436B2 (ja) * | 2011-08-26 | 2016-03-23 | ビーエイチエヌ株式会社 | 血圧降下剤 |
| KR102155113B1 (ko) * | 2019-10-30 | 2020-09-11 | 유한회사 한풍제약 | 고혈압 치료용 약학적 조성물 및 식품 조성물 |
| JP6953054B1 (ja) * | 2021-03-31 | 2021-10-27 | Ｄｅｌｔａ−Ｆｌｙ Ｐｈａｒｍａ株式会社 | 湿度に敏感な医薬用途物質を安定化する方法及び安定製剤 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2092743A1 (en) * | 1970-06-15 | 1972-01-28 | Aquitaine Invest Pharma | Complete extraction of total flavanol gomers from plats -peripheral - venous activity |
| IT1201151B (it) * | 1987-01-14 | 1989-01-27 | Indena Spa | Complessi fosfolipidici con estratti da vitis vinifera,procedimento per la loro preparazione e composizioni che li cntengono |
| US5484594A (en) * | 1988-06-28 | 1996-01-16 | Tecnofarmaci S.P.A. | Process for preparing grapeseed extracts enriched in procyanidol oligomers |
| IT1255029B (it) * | 1992-05-11 | 1995-10-13 | Paolo Morazzoni | Formulazioni farmaceutiche orali contenenti antocianosidi |
| JP2695585B2 (ja) * | 1992-12-28 | 1997-12-24 | キヤノン株式会社 | 光起電力素子及びその製造方法、並びにそれを用いた発電装置 |
| US5536600A (en) * | 1994-09-23 | 1996-07-16 | Kaun; Thomas D. | Li-alloy electrode for Li-alloy/metal sulfide cells |
| FR2750606B1 (fr) * | 1996-07-03 | 1999-01-29 | Maurel Sante | Complexes organometalliques a base de sitosterols et de diglycerides et compositions pharmaceutiques en contenant |
| US5912363A (en) * | 1997-08-29 | 1999-06-15 | Interhealth Nutraceuticals | Method for extraction of proanthocyanidins from plant material |
| FR2775686B1 (fr) * | 1998-03-09 | 2006-07-28 | Pascal Commenil | Exploitation industrielle et commerciale des lipides cuticulaires de la baie de raisin en pharmacologie et cosmetologie |
| IT1302365B1 (it) * | 1998-10-09 | 2000-09-05 | Sigma Tau Healthscience Spa | Uso di carnitine e resveratrolo per produrre una composizione per laprevenzione o il trattamento terapeutico di alterazioni cerebrali |
| US20020192314A1 (en) * | 2001-03-06 | 2002-12-19 | Cho Suk H. | Dietary supplement compositions |
| US6918946B2 (en) * | 2001-07-02 | 2005-07-19 | Board Of Regents, The University Of Texas System | Applications of light-emitting nanoparticles |
| US20030134198A1 (en) * | 2001-09-28 | 2003-07-17 | Kabushiki Kaisha Toshiba | Negative electrode material, negative electrode, nonaqueous electrolyte battery and method of manufacturing a negative electrode material |
-
2001
- 2001-03-13 BR BRPI0106382-0A patent/BRPI0106382B1/pt not_active IP Right Cessation
-
2002
- 2002-03-12 EP EP02702184A patent/EP1368045B1/en not_active Expired - Lifetime
- 2002-03-12 WO PCT/BR2002/000038 patent/WO2002072118A1/en not_active Ceased
- 2002-03-12 US US10/469,990 patent/US20040202737A1/en not_active Abandoned
- 2002-03-12 PT PT02702184T patent/PT1368045E/pt unknown
- 2002-03-12 MX MXPA03008161A patent/MXPA03008161A/es active IP Right Grant
- 2002-03-12 JP JP2002571077A patent/JP2004525124A/ja active Pending
- 2002-03-12 DE DE60213211T patent/DE60213211T2/de not_active Expired - Lifetime
- 2002-03-12 CA CA002440333A patent/CA2440333C/en not_active Expired - Lifetime
- 2002-03-12 AT AT02702184T patent/ATE333283T1/de not_active IP Right Cessation
- 2002-03-12 ES ES02702184T patent/ES2269650T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002072118A1 (en) | 2002-09-19 |
| DE60213211D1 (de) | 2006-08-31 |
| CA2440333C (en) | 2009-02-24 |
| EP1368045B1 (en) | 2006-07-19 |
| MXPA03008161A (es) | 2004-11-12 |
| US20040202737A1 (en) | 2004-10-14 |
| JP2004525124A (ja) | 2004-08-19 |
| PT1368045E (pt) | 2006-12-29 |
| BRPI0106382B8 (https=) | 2021-05-25 |
| ATE333283T1 (de) | 2006-08-15 |
| BR0106382A (pt) | 2003-09-30 |
| BRPI0106382B1 (pt) | 2017-07-11 |
| EP1368045A1 (en) | 2003-12-10 |
| CA2440333A1 (en) | 2002-09-19 |
| ES2269650T3 (es) | 2007-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |