JP2011509996A - ダンコウバイ抽出物を含む心血管系疾患の予防および治療用の組成物 - Google Patents
ダンコウバイ抽出物を含む心血管系疾患の予防および治療用の組成物 Download PDFInfo
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Abstract
Description
江原道地域(Kangwon-do Province)で採取したダンコウバイの枝と葉を水で洗浄して不純物および塩分を除去した後、乾燥し粉砕した。抽出容器に粉砕されたダンコウバイの枝および葉25gずつおよび70重量%のエタノール水溶液を総500mL加え、還流冷却しながら70℃で3時間ずつ3回反復して加熱抽出した。これを濾紙で濾過し、濾液を40℃の水浴中で減圧濃縮し、凍結乾燥した。その結果、ダンコウバイの枝の粗抽出物6.4gおよびダンコウバイの葉の粗抽出物7.0gを得た。
実施例1で得たダンコウバイの葉と枝の粗抽出物5gずつをそれぞれ50mLの精製水に懸濁した。これを50mLのヘキサン、酢酸エチルおよびn−ブタノールの順に順次的に各3回溶媒分画して各溶媒画分を得、これを減圧濃縮した。その結果、ダンコウバイのヘキサン画分、酢酸エチル画分およびn−ブタノール画分を得た。
前記実施例1および実施例2にて製造されたダンコウバイ粗抽出物および画分の、心血管系疾患発症指標酵素であるNAD(P)Hオキシダーゼの活性の阻害効果を測定した。そのために、シロネズミの動脈平滑筋細胞(ラット大動脈平滑筋細胞、RASMC)および子牛血管内皮細胞(ウシ大動脈内皮細胞、BAECs)を使用してNADPHオキシダーゼ活性の変化を比較し、その結果を下記表1に示す。まず、動脈平滑筋細胞および血管内皮細胞をそれぞれMEM(最小必須培地)とDMEM(ダルベッコ最小必須培地)および10%FBS(ウシ胎仔血清)溶液と混合し、細胞を、5%CO2/37℃の条件下、96ウェルプレートで24時間の間培養した。次いで、該細胞を、FBSが除外された培養液で再度24時間インキュベートした。細胞が安定化された後、該細胞をHBSS(ハンクス平衡塩類溶液)で洗浄した。これらの細胞を実施例1で得たダンコウバイの葉抽出物および枝抽出物と一緒に振盪させ、該混合物を15分間反応させた後、HBSSで再度洗浄した。次いで、該反応液に100mMのNAD(P)Hおよび5μMのルシゲニンを添加し、発光読み取り装置(Victor Light、PerkinElmer)を利用してNAD(P)Hオキシダーゼの活性を1時間測定した。試験は3回操作し、各操作を2〜7回繰り返した。その後、対照群の活性と試料処理群の活性を比較し、IC50値を算出した。IC50値は、NADPHオキシダーゼ活性の50%を阻害する試験物質の濃度(μg/ml)である。
実施例1および実施例2により製造されたダンコウバイ粗抽出物および画分の血管弛緩効果を確認した。そのために、ブタ心臓の冠動脈およびマウスの大動脈の弛緩効果を比較し、その結果を図1、図2、表2(冠動脈)および表3(大動脈)に示す。屠殺場で屠殺直後に購入したブタ心臓から冠動脈摘出した。雄性SD(スプラーグドーリー)系シロネズミから大動脈を摘出し、18mMのNaCl、4.7mMのKCl、1.1mMのMgSO4、1.2mMのKH2PO4、1.5mMのCaCl2、25mMのNaHCO3、10mMのグルコースが入っているクレブス液(pH7.4)中に浸漬して結合組織と脂肪を除去した後、約3mmの長さの切片に切断した。
前記実施例1および実施例2により製造されたダンコウバイ粗抽出物の内皮型一酸化窒素合成酵素の活性増強に対する効果を観察した。前記効果はウシ大動脈内皮細胞の内皮型一酸化窒素合成酵素(eNOS)の1177番セリン残基とAktの473セリン残基のリン酸化度をもって比較した。その結果は図3に示される。
実施例2で得たダンコウバイ抽出物が疾患動物における血圧降下効果、血管内酸化ストレス改善効果、内皮細胞機能障害改善効果を発揮することを確認した。そのためにアンギオテンシン2により引き起こされた疾患モデルで効果の程度を比較し、その結果を図4、図5、図6および表4に示す。
実施例1および実施例2により製造されたダンコウバイ粗抽出物の細胞毒性の程度を比較した結果を図6に示す。
試験結果の有意性は、実験結果をスチューデントt−検定および一元分散分析法を通してpが0.05以下である場合に有意な差があると判定した。
ダンコウバイ抽出物粉末 20mg
ラクトース 100mg
タルク 10mg
これらの成分を混合し、シール・パッケージに充填して散剤を製造した。
ダンコウバイ抽出物粉末 10mg
コーンスターチ 100mg
ラクトース 100mg
ステアリン酸マグネシウム 2mg
これらの成分を混合した後、通常の錠剤製造方法に従って打錠して錠剤を製造した。
ダンコウバイ抽出物粉末 10mg
結晶性セルロース 3mg
ラクトース 14.8mg
ステアリン酸マグネシウム 2mg
通常のカプセル剤製造方法に従って、これらの各成分を混合し、ゼラチンカプセルに充填してカプセル剤を製造した。
ダンコウバイ抽出物粉末 10mg
マンニトール 180mg
注射用の滅菌蒸留水 2794mg
Na2HPO4・12H2O 26mg
通常の注射剤製造方法によって、1アンプル(2mL)当たり前記の成分含量にて注射剤を製造した。
ダンコウバイ抽出物粉末 10mg
異性化糖 10g
マンニトール 5g
精製水 適当量
通常の液剤製造方法によって、これらの成分を精製水に加えて溶解させ、レモン香を適量加えた後、成分を混合し、精製水を加えて総量を100mLに調節した。それを茶色の瓶に充填し、滅菌して液剤を製造した。
ダンコウバイ抽出物粉末 10mg
ビタミンC 15g
ビタミンE(粉末) 100g
乳酸鉄 19.75g
酸化亜鉛 3.5g
ニコチン酸アミド 3.5g
ビタミンA 0.2g
ビタミンB1 0.25g
ビタミンB2 0.3g
水 適当量
通常の健康飲料製造方法によって、これらの成分を混合し、85℃で約1時間、撹拌しながら加熱した後、形成された溶液をろ過した。濾液を2リットルの滅菌容器に入れて密封し、滅菌した後、冷蔵保存し、本発明に係る健康飲料組成物の製造に使用した。前記組成比で、嗜好飲料に比較的適した成分を好ましい実施例として混合し、組成したが、消費者階級や消費国、用途など地域的および民族的嗜好に応じてその配合比を適切に変更することができる。
Claims (10)
- ダンコウバイ抽出物を有効成分として含有する、心血管系疾患の予防用および治療用組成物。
- ダンコウバイが、枝、葉およびその混合物からなる群から選択されるものである、請求項1記載の心血管系疾患の予防用および治療用組成物。
- ダンコウバイ抽出物が、水、C1〜C5の低級アルコールおよびその混合物からなる群から選択された溶媒で抽出されたものである、請求項1記載の心血管系疾患の予防用および治療用組成物。
- ダンコウバイ抽出物が、30〜95重量%のエタノール水溶液で抽出されたものである、請求項3記載の心血管系疾患の予防用および治療用組成物。
- ダンコウバイ抽出物が、水、C1〜C3の低級アルコールおよびその混合物からなる群から選択された溶媒で抽出されたものがブタノールで再抽出されたものである、請求項3記載の心血管系疾患の予防用および治療用組成物。
- ダンコウバイ抽出物がNAD(P)Hオキシダーゼ阻害活性を有する、請求項1記載の心血管系疾患の予防用および治療用組成物。
- ダンコウバイ抽出物が血管弛緩効果を有する、請求項1記載の心血管系疾患の予防用および治療用組成物。
- ダンコウバイ抽出物が内皮型一酸化窒素合成酵素の活性の増加効果を有する、請求項1記載の心血管系疾患の予防用および治療用組成物。
- 心血管系疾患が、鬱血性心臓病、冠動脈疾患(心臓発作)、虚血性心臓病(心筋虚血)、高脂血症、動脈硬化、高血圧、低血圧、不整脈、心不全症、血管再狭窄、脳血管疾患(脳卒中、認知症)、末梢血管疾患および代謝性疾患からなる群から選択される、請求項1〜8いずれか1項記載の心血管系疾患の予防用および治療用組成物。
- ダンコウバイ抽出物を有効成分として含有する、心血管系疾患予防用健康機能食品。
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PCT/KR2008/007484 WO2009091120A2 (en) | 2008-01-18 | 2008-12-17 | Composition comprising the extracts of lindera obtusiloba for prevention and treatment of cardiovascular diseases |
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KR101124442B1 (ko) * | 2009-09-14 | 2012-03-21 | 영남대학교 산학협력단 | 생강나무 줄기의 물 추출물을 유효성분으로 함유하는 아토피성 피부염의 예방 및 개선용 화장료 조성물 |
KR101039628B1 (ko) * | 2009-11-20 | 2011-06-08 | 양지화학 주식회사 | 생강나무 추출물을 유효성분으로 함유하는 혈행개선 조성물 |
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KR101549746B1 (ko) * | 2013-08-22 | 2015-09-04 | 충북대학교 산학협력단 | 생강의 용매분획을 유효성분으로 포함하는 기능성 위장장애 및 위장관 운동장애의 예방 및 치료용 약학적 조성물 |
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Also Published As
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WO2009091120A2 (en) | 2009-07-23 |
KR100989093B1 (ko) | 2010-10-25 |
EP2240193A2 (en) | 2010-10-20 |
WO2009091120A3 (en) | 2009-10-15 |
EP2240193A4 (en) | 2011-04-27 |
US8734866B2 (en) | 2014-05-27 |
CN101951934A (zh) | 2011-01-19 |
ES2398371T3 (es) | 2013-03-15 |
US20110045111A1 (en) | 2011-02-24 |
EP2240193B1 (en) | 2012-10-24 |
PL2240193T3 (pl) | 2013-03-29 |
KR20090079584A (ko) | 2009-07-22 |
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