DE60137042D1 - Vorrichtungen zur probenverarbeitung - Google Patents

Vorrichtungen zur probenverarbeitung

Info

Publication number
DE60137042D1
DE60137042D1 DE60137042T DE60137042T DE60137042D1 DE 60137042 D1 DE60137042 D1 DE 60137042D1 DE 60137042 T DE60137042 T DE 60137042T DE 60137042 T DE60137042 T DE 60137042T DE 60137042 D1 DE60137042 D1 DE 60137042D1
Authority
DE
Germany
Prior art keywords
processing devices
sample processing
conduits
carriers
devices
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60137042T
Other languages
German (de)
English (en)
Inventor
William Bedingham
Joel R Dufresne
Michael R Harms
Christopher R Kokaisel
Diane North
Barry W Robole
Kenneth B Wood
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3M Innovative Properties Co
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26909069&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60137042(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Application granted granted Critical
Publication of DE60137042D1 publication Critical patent/DE60137042D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N35/00069—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255—Multi-well filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0642—Filling fluids into wells by specific techniques
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/142—Preventing evaporation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0661—Valves, specific forms thereof with moving parts shape memory polymer valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F27—FURNACES; KILNS; OVENS; RETORTS
    • F27B—FURNACES, KILNS, OVENS OR RETORTS IN GENERAL; OPEN SINTERING OR LIKE APPARATUS
    • F27B9/00—Furnaces through which the charge is moved mechanically, e.g. of tunnel type; Similar furnaces in which the charge moves by gravity
    • F27B9/14—Furnaces through which the charge is moved mechanically, e.g. of tunnel type; Similar furnaces in which the charge moves by gravity characterised by the path of the charge during treatment; characterised by the means by which the charge is moved during treatment
    • F27B9/16—Furnaces through which the charge is moved mechanically, e.g. of tunnel type; Similar furnaces in which the charge moves by gravity characterised by the path of the charge during treatment; characterised by the means by which the charge is moved during treatment the charge moving in a circular or arcuate path
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F27—FURNACES; KILNS; OVENS; RETORTS
    • F27D—DETAILS OR ACCESSORIES OF FURNACES, KILNS, OVENS OR RETORTS, IN SO FAR AS THEY ARE OF KINDS OCCURRING IN MORE THAN ONE KIND OF FURNACE
    • F27D5/00—Supports, screens or the like for the charge within the furnace
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Weting (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Finish Polishing, Edge Sharpening, And Grinding By Specific Grinding Devices (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
DE60137042T 2000-06-28 2001-06-28 Vorrichtungen zur probenverarbeitung Expired - Lifetime DE60137042D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21450800P 2000-06-28 2000-06-28
US09/710,184 US6627159B1 (en) 2000-06-28 2000-11-10 Centrifugal filling of sample processing devices
PCT/US2001/020619 WO2002001180A2 (en) 2000-06-28 2001-06-28 Sample processing devices

Publications (1)

Publication Number Publication Date
DE60137042D1 true DE60137042D1 (de) 2009-01-29

Family

ID=26909069

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60137042T Expired - Lifetime DE60137042D1 (de) 2000-06-28 2001-06-28 Vorrichtungen zur probenverarbeitung

Country Status (8)

Country Link
US (8) US6627159B1 (https=)
EP (4) EP1296765B2 (https=)
JP (2) JP4938198B2 (https=)
AT (1) ATE417667T1 (https=)
AU (4) AU7305501A (https=)
CA (3) CA2411518A1 (https=)
DE (1) DE60137042D1 (https=)
WO (2) WO2002001180A2 (https=)

Families Citing this family (215)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7244622B2 (en) * 1996-04-03 2007-07-17 Applera Corporation Device and method for multiple analyte detection
US8709153B2 (en) 1999-06-28 2014-04-29 California Institute Of Technology Microfludic protein crystallography techniques
US7052545B2 (en) * 2001-04-06 2006-05-30 California Institute Of Technology High throughput screening of crystallization of materials
US7195670B2 (en) * 2000-06-27 2007-03-27 California Institute Of Technology High throughput screening of crystallization of materials
US7951612B2 (en) * 1999-07-08 2011-05-31 Lee H. Angros In situ heat induced antigen recovery and staining apparatus and method
US8298485B2 (en) * 1999-07-08 2012-10-30 Lee H. Angros In situ heat induced antigen recovery and staining apparatus and method
US6534008B1 (en) * 1999-07-08 2003-03-18 Lee Angros In situ heat induced antigen recovery and staining apparatus and method
JP2001281233A (ja) * 2000-03-28 2001-10-10 Inst Of Physical & Chemical Res 水性分配用マイクロチップおよびそれを用いた水性分配方法
US7867763B2 (en) * 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
US7062418B2 (en) * 2000-06-27 2006-06-13 Fluidigm Corporation Computer aided design method and system for developing a microfluidic system
US6734401B2 (en) 2000-06-28 2004-05-11 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
US6720187B2 (en) 2000-06-28 2004-04-13 3M Innovative Properties Company Multi-format sample processing devices
US6627159B1 (en) * 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
EP1336097A4 (en) * 2000-10-13 2006-02-01 Fluidigm Corp SAMPLE INJECTION SYSTEM BASED ON A MICROFLUIDIC EQUIPMENT FOR ANALYTICAL EQUIPMENT
US8097471B2 (en) 2000-11-10 2012-01-17 3M Innovative Properties Company Sample processing devices
US6875403B2 (en) * 2001-02-09 2005-04-05 Microchem Solutions Method and apparatus for reproducible sample injection on microfabricated devices
DE10108892B4 (de) * 2001-02-23 2005-08-18 Graffinity Pharmaceuticals Ag Synthesevorrichtung und Verfahren zu deren Herstellung
US6743632B2 (en) * 2001-03-14 2004-06-01 Universities Space Research Association Directional acceleration vector-driven displacement of fluids (DAVD-DOF)
EP1384022A4 (en) 2001-04-06 2004-08-04 California Inst Of Techn NUCLEIC ACID AMPLIFICATION USING MICROFLUID DEVICES
US20030118804A1 (en) * 2001-05-02 2003-06-26 3M Innovative Properties Company Sample processing device with resealable process chamber
US6514750B2 (en) 2001-07-03 2003-02-04 Pe Corporation (Ny) PCR sample handling device
US7128876B2 (en) * 2001-07-17 2006-10-31 Agilent Technologies, Inc. Microdevice and method for component separation in a fluid
EP1438385A1 (en) * 2001-10-25 2004-07-21 Bar-Ilan University Interactive transparent individual cells biochip processor
US8440093B1 (en) 2001-10-26 2013-05-14 Fuidigm Corporation Methods and devices for electronic and magnetic sensing of the contents of microfluidic flow channels
GB0128350D0 (en) * 2001-11-27 2002-01-16 Lab901 Ltd Non-rigid apparatus for microfluidic applications
US7691333B2 (en) * 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
US7347976B2 (en) * 2001-12-20 2008-03-25 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using a hydrophilic solid support in a hydrophobic matrix
US7192560B2 (en) * 2001-12-20 2007-03-20 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using anion exchange
US6889468B2 (en) 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
US6532997B1 (en) 2001-12-28 2003-03-18 3M Innovative Properties Company Sample processing device with integral electrophoresis channels
AU2003224817B2 (en) 2002-04-01 2008-11-06 Fluidigm Corporation Microfluidic particle-analysis systems
US7312085B2 (en) * 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
JP4743165B2 (ja) * 2002-04-25 2011-08-10 東ソー株式会社 微小流路構造体
US7083974B2 (en) * 2002-07-12 2006-08-01 Applera Corporation Rotatable sample disk and method of loading a sample disk
EP1385006A3 (en) * 2002-07-24 2004-09-01 F. Hoffmann-La Roche Ag System and cartridge for processing a biological sample
US7201881B2 (en) * 2002-07-26 2007-04-10 Applera Corporation Actuator for deformable valves in a microfluidic device, and method
US7452509B2 (en) * 2002-07-26 2008-11-18 Applied Biosystems Inc. Microfluidic device including displaceable material trap, and system
US7135147B2 (en) * 2002-07-26 2006-11-14 Applera Corporation Closing blade for deformable valve in a microfluidic device and method
US7041258B2 (en) * 2002-07-26 2006-05-09 Applera Corporation Micro-channel design features that facilitate centripetal fluid transfer
CA2493700A1 (en) * 2002-07-26 2004-02-05 Applera Corporation Micro-channel design features that facilitate centripetal fluid transfer
US7198759B2 (en) * 2002-07-26 2007-04-03 Applera Corporation Microfluidic devices, methods, and systems
CA2492538A1 (en) * 2002-07-26 2004-02-05 Applera Corporation Valve assembly for microfluidic devices, and method for opening and closing same
US7214348B2 (en) * 2002-07-26 2007-05-08 Applera Corporation Microfluidic size-exclusion devices, systems, and methods
CA2492613A1 (en) * 2002-07-26 2004-02-05 Applera Corporation Microfluidic size-exclusion devices, systems, and methods
US7452712B2 (en) 2002-07-30 2008-11-18 Applied Biosystems Inc. Sample block apparatus and method of maintaining a microcard on a sample block
JP2006501056A (ja) 2002-09-25 2006-01-12 カリフォルニア インスティテュート オブ テクノロジー ミクロ流体大規模集積
WO2004040001A2 (en) 2002-10-02 2004-05-13 California Institute Of Technology Microfluidic nucleic acid analysis
EP1419818B1 (de) * 2002-11-14 2013-10-30 Boehringer Ingelheim microParts GmbH Vorrichtung zum schrittweisen Transport von Flüssigkeit unter Ausnutzung von Kapillarkräften
US7169602B2 (en) * 2002-12-04 2007-01-30 Applera Corporation Sample substrate for use in biological testing and method for filling a sample substrate
US7507376B2 (en) * 2002-12-19 2009-03-24 3M Innovative Properties Company Integrated sample processing devices
US20040129676A1 (en) * 2003-01-07 2004-07-08 Tan Roy H. Apparatus for transfer of an array of liquids and methods for manufacturing same
US7332129B2 (en) * 2003-01-09 2008-02-19 3M Innovative Properties Company Sample processing device having process chambers with bypass slots
US20040157343A1 (en) * 2003-02-06 2004-08-12 Applera Corporation Devices and methods for biological sample preparation
IL154677A0 (en) * 2003-02-27 2003-09-17 Univ Bar Ilan A method and apparatus for manipulating an individual cell
US7332348B2 (en) 2003-02-28 2008-02-19 Applera Corporation Sample substrate having a divided sample chamber and method of loading thereof
US7476363B2 (en) * 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
US20050145496A1 (en) 2003-04-03 2005-07-07 Federico Goodsaid Thermal reaction device and method for using the same
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
CA2521171C (en) * 2003-04-03 2013-05-28 Fluidigm Corp. Microfluidic devices and methods of using same
US8828663B2 (en) 2005-03-18 2014-09-09 Fluidigm Corporation Thermal reaction device and method for using the same
US7981600B2 (en) * 2003-04-17 2011-07-19 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using an anion exchange material that includes a polyoxyalkylene
JP2004325185A (ja) * 2003-04-23 2004-11-18 Arkray Inc 二段式検体分析用具
JP2005037368A (ja) * 2003-05-12 2005-02-10 Yokogawa Electric Corp 化学反応用カートリッジおよびその作製方法および化学反応用カートリッジ駆動システム
US20040258563A1 (en) 2003-06-23 2004-12-23 Applera Corporation Caps for sample wells and microcards for biological materials
US9200245B2 (en) 2003-06-26 2015-12-01 Seng Enterprises Ltd. Multiwell plate
EP1654347B1 (en) * 2003-06-26 2014-06-04 Seng Enterprises Limited Improved materials for constructing cell-chips, cell-chip covers, cell-chip coats, processed cell-chips and uses thereof
US8597597B2 (en) * 2003-06-26 2013-12-03 Seng Enterprises Ltd. Picoliter well holding device and method of making the same
US7888110B2 (en) * 2003-06-26 2011-02-15 Seng Enterprises Ltd. Pico liter well holding device and method of making the same
US7238269B2 (en) * 2003-07-01 2007-07-03 3M Innovative Properties Company Sample processing device with unvented channel
US7413712B2 (en) * 2003-08-11 2008-08-19 California Institute Of Technology Microfluidic rotary flow reactor matrix
US20070099290A1 (en) * 2003-09-02 2007-05-03 Kazuhiro Iida Customizable chip and method of manufacturing the same
US20050047967A1 (en) * 2003-09-03 2005-03-03 Industrial Technology Research Institute Microfluidic component providing multi-directional fluid movement
WO2005029041A2 (en) * 2003-09-19 2005-03-31 Applera Corporation High density sequence detection methods and apparatus
US7407630B2 (en) 2003-09-19 2008-08-05 Applera Corporation High density plate filler
US20050069462A1 (en) * 2003-09-30 2005-03-31 International Business Machines Corporation Microfluidics Packaging
US20050069949A1 (en) * 2003-09-30 2005-03-31 International Business Machines Corporation Microfabricated Fluidic Structures
US7718133B2 (en) * 2003-10-09 2010-05-18 3M Innovative Properties Company Multilayer processing devices and methods
WO2005038041A2 (en) * 2003-10-16 2005-04-28 Third Wave Technologies, Inc. Direct nucleic acid detection in bodily fluids
USD513075S1 (en) * 2003-10-20 2005-12-20 3M Innovative Properties Company Sample processing device
US7837947B2 (en) * 2003-12-12 2010-11-23 3M Innovative Properties Company Sample mixing on a microfluidic device
US7322254B2 (en) * 2003-12-12 2008-01-29 3M Innovative Properties Company Variable valve apparatus and methods
US20050130177A1 (en) * 2003-12-12 2005-06-16 3M Innovative Properties Company Variable valve apparatus and methods
US7939249B2 (en) 2003-12-24 2011-05-10 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and concentration step
US20050142570A1 (en) * 2003-12-24 2005-06-30 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and sedimenting reagent
US20050142571A1 (en) * 2003-12-24 2005-06-30 3M Innovative Properties Company Methods for nucleic acid isolation and kits using solid phase material
US7727710B2 (en) * 2003-12-24 2010-06-01 3M Innovative Properties Company Materials, methods, and kits for reducing nonspecific binding of molecules to a surface
SG10201405756WA (en) * 2004-01-25 2014-11-27 Fluidigm Corp Crystal forming devices and systems and methods for making and using the same
SG2013006333A (en) * 2004-05-02 2014-08-28 Fluidigm Corp Thermal reaction device and method for using the same
EP1796824A4 (en) * 2004-05-02 2016-10-19 Fluidigm Corp DEVICE FOR THERMAL REACTIONS AND METHOD FOR THEIR USE
JP2008505346A (ja) * 2004-06-07 2008-02-21 アイキューム， インク． サンプルマルチ処理
US7932090B2 (en) * 2004-08-05 2011-04-26 3M Innovative Properties Company Sample processing device positioning apparatus and methods
US20080009051A1 (en) * 2004-08-25 2008-01-10 Seng Enterprises Ltd. Method and Device for Isolating Cells
US7832429B2 (en) 2004-10-13 2010-11-16 Rheonix, Inc. Microfluidic pump and valve structures and fabrication methods
WO2006050499A2 (en) * 2004-11-03 2006-05-11 Third Wave Technologies, Inc. Single step detection assay
BRPI0606316A2 (pt) * 2005-01-20 2017-06-27 3M Innovative Properties Co método para formar uma película polimérica estruturada, e , artigo de processamento de amostra
GB0501590D0 (en) * 2005-01-25 2005-03-02 Ceres Power Ltd Processing of enhanced performance LSCF fuel cell cathode microstructure and a fuel cell cathode
DE602005023534D1 (de) 2005-01-25 2010-10-21 Seng Entpr Ltd Mikrofluidische vorrichtung zur untersuchung zellen
US20060252032A1 (en) * 2005-01-28 2006-11-09 Third Wave Technologies, Inc. Detection of human herpesviruses
US7507575B2 (en) 2005-04-01 2009-03-24 3M Innovative Properties Company Multiplex fluorescence detection device having removable optical modules
US7709249B2 (en) * 2005-04-01 2010-05-04 3M Innovative Properties Company Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector
EP1885839B1 (en) 2005-04-26 2018-08-08 Life Technologies Corporation Systems and methods for multiple analyte detection
AU2006249956A1 (en) 2005-05-24 2006-11-30 Angros, Lee H In situ heat induced antigen recovery and staining apparatus and method
US7323660B2 (en) 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
USD564667S1 (en) 2005-07-05 2008-03-18 3M Innovative Properties Company Rotatable sample processing disk
US7527763B2 (en) * 2005-07-05 2009-05-05 3M Innovative Properties Company Valve control system for a rotating multiplex fluorescence detection device
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
US20070009382A1 (en) * 2005-07-05 2007-01-11 William Bedingham Heating element for a rotating multiplex fluorescence detection device
US7763210B2 (en) 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
US20080014124A1 (en) * 2005-08-04 2008-01-17 Third Wave Technologies, Inc. Sample processing devices, systems and methods
US20070053800A1 (en) * 2005-09-02 2007-03-08 Applera Corporation Fluid processing device comprising sample transfer feature
US20070141555A1 (en) * 2005-10-11 2007-06-21 Mordechai Deutsch Current damper for the study of cells
WO2007044974A2 (en) * 2005-10-12 2007-04-19 The Research Foundation Of State University Of New York Absolute pcr quantification
US7482127B2 (en) * 2005-11-03 2009-01-27 Third Wave Technologies, Inc. Nucleic acid detection assays employing blocker oligonucleotides
US8288120B2 (en) * 2005-11-03 2012-10-16 Seng Enterprises Ltd. Method for studying floating, living cells
US20080181823A1 (en) * 2005-11-08 2008-07-31 Third Wave Technologies, Inc. Plate spinner systems and devices
PL1820571T3 (pl) * 2006-02-09 2009-11-30 Hoffmann La Roche Struktury 3D na bazie podłoży 2D
US7815868B1 (en) 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
US20080131875A1 (en) * 2006-06-07 2008-06-05 Third Wave Technologies, Inc. Multiplex assays
US7759062B2 (en) * 2006-06-09 2010-07-20 Third Wave Technologies, Inc. T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
EP2032257B1 (en) * 2006-06-28 2018-11-07 Anatrace Products, LLC A device and a method for promoting crystallisation
US7629124B2 (en) * 2006-06-30 2009-12-08 Canon U.S. Life Sciences, Inc. Real-time PCR in micro-channels
EP2040833A1 (en) * 2006-07-14 2009-04-01 Aviza Technology, Ltd. Microfluidic devices
JP4292279B2 (ja) * 2006-07-18 2009-07-08 ファルマ・アクセス株式会社 結晶作製器具
EP2079754B1 (en) 2006-10-04 2017-03-15 Third Wave Technologies, Inc. Snap-back primers and detectable hairpin structures
US7521189B2 (en) * 2006-10-12 2009-04-21 Fair Isaac Corporation Devices for generating detectable polymers
US7462456B2 (en) * 2006-10-12 2008-12-09 Fair Isaac Corporation Devices for generating detectable polymers
US7476505B2 (en) * 2006-10-12 2009-01-13 Fair Isaac Corporation Devices for generating detectable polymers
US7582433B2 (en) * 2006-10-12 2009-09-01 Fair Isaac Corporation Devices for generating detectable polymers
KR100846501B1 (ko) 2006-11-09 2008-07-17 삼성전자주식회사 밸브 유닛 및 이를 구비한 유체 처리 장치
US20100068099A1 (en) * 2006-11-09 2010-03-18 Gyros Patent Ab Lid
KR20090105934A (ko) * 2006-12-22 2009-10-07 쓰리엠 이노베이티브 프로퍼티즈 컴파니 향상된 샘플 처리 장치, 시스템 및 방법
AU2007336774A1 (en) 2006-12-22 2008-07-03 3M Innovative Properties Company Thermal transfer methods and structures for microfluidic systems
JP4957260B2 (ja) 2007-01-16 2012-06-20 横河電機株式会社 化学反応用カートリッジ及びその使用方法
GB2445739A (en) * 2007-01-16 2008-07-23 Lab901 Ltd Polymeric laminates containing heat seals
GB2445738A (en) * 2007-01-16 2008-07-23 Lab901 Ltd Microfluidic device
US20100062421A1 (en) * 2007-04-25 2010-03-11 Wensheng Xia Compositions, methods, and devices for isolating biological materials
ES2453379T3 (es) * 2007-04-25 2014-04-07 3M Innovative Properties Company Reactivos soportados, métodos y dispositivos
US20100129878A1 (en) * 2007-04-25 2010-05-27 Parthasarathy Ranjani V Methods for nucleic acid amplification
KR20100017126A (ko) * 2007-04-25 2010-02-16 쓰리엠 이노베이티브 프로퍼티즈 컴파니 화학적 요소 및 처리 장치 조립체
KR100885267B1 (ko) * 2007-05-09 2009-02-23 삼성전기주식회사 원심력과 관성을 이용한 시료 분석 장치
JP2008284626A (ja) * 2007-05-16 2008-11-27 Miraial Kk マイクロ流路デバイス
IL184183A0 (en) * 2007-06-25 2007-10-31 Benjamin Alspector Bi directional transfer of an aliquot of fluid between compartments
CN102007222A (zh) * 2007-08-13 2011-04-06 3M创新有限公司 用于检测耐药微生物的方法
WO2009025161A1 (ja) 2007-08-17 2009-02-26 Toppan Printing Co., Ltd. 反応場独立冶具及びそれを用いた反応チップ処理装置
US20090081768A1 (en) * 2007-09-21 2009-03-26 Applera Corporation Devices and Methods for Thermally Isolating Chambers of an Assay Card
CA2700532A1 (en) * 2007-09-28 2009-04-02 3M Innovative Properties Company Dual oligonucleotide method of nucleic acid detection
JP5523327B2 (ja) 2007-10-12 2014-06-18 レオニックス，インコーポレイテッド 統合型マイクロ流体デバイスおよび方法
US20100273162A1 (en) * 2007-10-17 2010-10-28 Sailaja Chandrapati Rapid detection of microorganisms
TWI447393B (zh) * 2007-10-26 2014-08-01 Toppan Printing Co Ltd 反應晶片及其製造方法
JP5251882B2 (ja) * 2007-10-26 2013-07-31 凸版印刷株式会社 反応チップ及び反応方法、遺伝子処理装置用温度調節機構及び遺伝子処理装置
US20100209927A1 (en) * 2007-11-06 2010-08-19 Menon Vinod P Processing device tablet
US9145540B1 (en) 2007-11-15 2015-09-29 Seng Enterprises Ltd. Device for the study of living cells
EP2237887A2 (en) 2007-12-26 2010-10-13 Seng Enterprises Ltd. Device for the study of living cells
WO2009085884A1 (en) * 2007-12-28 2009-07-09 3M Innovative Properties Company Sample processing device with optical elements
DE102007063102B4 (de) * 2007-12-28 2022-02-10 Robert Bosch Gmbh Verfahren zur Erfassung eines periodisch pulsierenden Betriebsparameters
WO2009086343A2 (en) * 2007-12-31 2009-07-09 3M Innovative Properties Company Microorganism-capturing compositions and methods
WO2009117327A2 (en) 2008-03-15 2009-09-24 Hologic, Inc. Compositions and methods for analysis of nucleic acid molecules during amplification reactions
CN102046807B (zh) * 2008-04-24 2014-11-26 3M创新有限公司 利用小波变换分析核酸扩增曲线
JP5109824B2 (ja) * 2008-06-16 2012-12-26 凸版印刷株式会社 反応チップ処理装置
JP5228797B2 (ja) * 2008-10-28 2013-07-03 藤倉化成株式会社 液体流路装置
US9283562B2 (en) 2008-06-26 2016-03-15 Fujikura Kasei Co., Ltd. Liquid channel device and production method therefor
WO2010050208A1 (ja) 2008-10-28 2010-05-06 藤倉化成株式会社 液体流路装置とその製造方法
WO2010025425A1 (en) 2008-08-29 2010-03-04 Angros Lee H Multiplexed microscope slide staining apparatus
EP2347007A2 (en) 2008-10-17 2011-07-27 3M Innovative Properties Company Biological sterilization indicator, system, and methods of using same
BRPI0918358A2 (pt) 2008-12-19 2015-12-15 3M Innovative Properties Co sistema e método para a concentração de amostras
BRPI0918357A2 (pt) 2008-12-19 2016-07-26 3M Innovative Properties Co sistema e método para processamento de amostras
US10203310B2 (en) 2009-01-26 2019-02-12 Detectachem Llc Chemical detection of substances by utilizing a sample medium impregnated with solid test chemicals
AU2009342863B2 (en) * 2009-03-23 2013-09-05 Actherm Inc. Analytical Strip and the Manufacturing Method Thereof
WO2010113959A1 (ja) 2009-03-31 2010-10-07 凸版印刷株式会社 試料分析チップ、これを用いた試料分析装置及び試料分析方法並びに試料分析チップの製造方法
USD636891S1 (en) * 2009-05-15 2011-04-26 L3 Technology Ltd. Diagnostic instrument
CN102482720B (zh) 2009-09-10 2014-10-08 3M创新有限公司 对多重核酸扩增中的光谱串扰的补偿
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
USD638550S1 (en) 2009-11-13 2011-05-24 3M Innovative Properties Company Sample processing disk cover
US20110117607A1 (en) * 2009-11-13 2011-05-19 3M Innovative Properties Company Annular compression systems and methods for sample processing devices
USD667561S1 (en) 2009-11-13 2012-09-18 3M Innovative Properties Company Sample processing disk cover
USD638951S1 (en) 2009-11-13 2011-05-31 3M Innovative Properties Company Sample processing disk cover
JP5505041B2 (ja) * 2010-03-31 2014-05-28 凸版印刷株式会社 生化学反応用チップ及びその製造方法
WO2011149829A1 (en) * 2010-05-27 2011-12-01 3M Innovative Properties Company Integrated systems and assemblies for sample processing
JP2013533796A (ja) * 2010-05-27 2013-08-29 スリーエム イノベイティブ プロパティズ カンパニー 試料処理のための方法及び物品
EP2431747B1 (en) 2010-09-20 2013-10-23 F. Hoffmann-La Roche AG Instrument and process for the storing and/or processing of liquid sample
EP2436446B1 (en) 2010-10-04 2016-09-21 F. Hoffmann-La Roche AG Multi-chamber plate and method for filling it with a sample fluid
FR2966368B1 (fr) * 2010-10-22 2014-02-28 Biomerieux Sa Procede pour isoler un puits a echantillon d'une carte test pour analyse et carte test obtenue
EP2637788A1 (de) * 2010-11-10 2013-09-18 Boehringer Ingelheim Microparts GmbH Vorrichtung zur filtration von blut
CA3043100C (en) 2011-03-08 2022-03-01 Universite Laval Fluidic centripetal device
USD672467S1 (en) 2011-05-18 2012-12-11 3M Innovative Properties Company Rotatable sample processing disk
CN103501908B (zh) 2011-05-18 2016-03-16 3M创新有限公司 用于样品处理装置上阀调的系统和方法
AU2012255144B2 (en) 2011-05-18 2015-01-29 Diasorin Italia S.P.A. Systems and methods for volumetric metering on a sample processing device
US9168523B2 (en) 2011-05-18 2015-10-27 3M Innovative Properties Company Systems and methods for detecting the presence of a selected volume of material in a sample processing device
JP2014518394A (ja) 2011-06-30 2014-07-28 スリーエム イノベイティブ プロパティズ カンパニー 微細構造化表面を使用して、サンプル内の目的の検体を検出するためのシステム及び方法
CN103620373B (zh) 2011-06-30 2017-07-07 3M创新有限公司 利用过滤器和微结构化表面检测样品中所关注分析物的方法
WO2013077391A1 (ja) 2011-11-25 2013-05-30 凸版印刷株式会社 試料分析チップ並びに試料分析方法及び遺伝子解析方法
BR112014020083A8 (pt) * 2012-02-16 2017-07-11 3M Innovative Properties Company Dispositivos indicadores biológicos de esterilização e métodos de uso
EP2647435B1 (de) 2012-04-05 2020-08-05 ThinXXS Microtechnology AG Anordnung aus einer flusszelle und einem temperierelement
EP2856178B1 (en) 2012-05-31 2020-07-15 The University of North Carolina at Chapel Hill Dissolution guided wetting of structured surfaces
CN102886280B (zh) * 2012-08-28 2014-06-11 博奥生物有限公司 一种微流控芯片及其应用
US9724689B2 (en) * 2012-11-20 2017-08-08 Detectachem Llc Colorimetric test system designed to control flow of simultaneously released chemicals to a target area
WO2014158628A1 (en) 2013-03-14 2014-10-02 Hologic, Inc. Compositions and methods for analysis of nucleic acid molecules
CN114471756B (zh) * 2013-11-18 2024-04-16 尹特根埃克斯有限公司 用于样本分析的卡盒和仪器
WO2015179098A1 (en) 2014-05-21 2015-11-26 Integenx Inc. Fluidic cartridge with valve mechanism
JP6722657B2 (ja) 2014-08-20 2020-07-15 スリーエム イノベイティブ プロパティズ カンパニー 試料の分割及び分析のためのデバイス及び方法
US10585518B2 (en) * 2014-10-15 2020-03-10 Microsoft Technology Licensing, Llc Display module support
CN107106983B (zh) 2014-10-22 2021-04-16 尹特根埃克斯有限公司 用于样品制备、处理和分析的系统和方法
KR102134953B1 (ko) 2015-05-29 2020-07-16 일루미나, 인코포레이티드 지정된 반응을 수행하기 위한 샘플 캐리어 및 검정 시스템
US10233491B2 (en) 2015-06-19 2019-03-19 IntegenX, Inc. Valved cartridge and system
EP3367105A4 (en) * 2015-10-23 2019-05-15 Japan Science and Technology Agency NANO FLUID DEVICE AND CHEMICAL ANALYSIS DEVICE
USD799715S1 (en) 2015-10-23 2017-10-10 Gene POC, Inc. Fluidic centripetal device
EP3393663B1 (en) 2015-12-22 2021-04-14 3M Innovative Properties Company Method of partitioning an aqueous test sample
CA3029111C (en) * 2016-07-08 2025-05-06 Macdonald, Dettwiler And Associates Inc. SYSTEM AND METHOD FOR AUTOMATED, VISION-GUIDED DISTRIBUTION OF VISCOUS FLUIDS, INTENDED FOR CALFATILLING AND SEALING OPERATIONS
CN109789411A (zh) 2016-10-07 2019-05-21 勃林格殷格翰维特梅迪卡有限公司 用于测试特别是生物样品的储物筒
CN107159329A (zh) * 2017-05-22 2017-09-15 天津微纳芯科技有限公司 一种用于样品检测的芯片及其封装方法
US10046322B1 (en) * 2018-03-22 2018-08-14 Talis Biomedical Corporation Reaction well for assay device
WO2020128956A2 (en) * 2018-12-21 2020-06-25 3M Innovative Properties Company Sterilization chemical indicator
US11008627B2 (en) 2019-08-15 2021-05-18 Talis Biomedical Corporation Diagnostic system
US12492427B2 (en) 2020-06-18 2025-12-09 Resolve Biosciences Gmbh Multiplex method for detecting different analytes in a sample
WO2024231149A1 (en) * 2023-05-11 2024-11-14 Sefunda Ag Fluidic cartridge with an analyte detection member

Family Cites Families (166)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3555284A (en) * 1968-12-18 1971-01-12 Norman G Anderson Multistation, single channel analytical photometer and method of use
US3798459A (en) * 1972-10-06 1974-03-19 Atomic Energy Commission Compact dynamic multistation photometer utilizing disposable cuvette rotor
US3856470A (en) 1973-01-10 1974-12-24 Baxter Laboratories Inc Rotor apparatus
US3855470A (en) * 1973-01-22 1974-12-17 Aquitaine Petrole Process and apparatus for x-ray crystallography
US3795451A (en) * 1973-04-24 1974-03-05 Atomic Energy Commission Rotor for fast analyzer of rotary cuvette type
US3873217A (en) * 1973-07-24 1975-03-25 Atomic Energy Commission Simplified rotor for fast analyzer of rotary cuvette type
US3938958A (en) * 1975-03-24 1976-02-17 Corning Glass Works Fluid dispensing device
US4358979A (en) 1980-11-24 1982-11-16 Exxon Research & Engineering Co. Apparatus for cutting plastic film
US4399103A (en) * 1981-01-28 1983-08-16 Ferrara Louis T Blood dispenser device
US4390499A (en) 1981-08-13 1983-06-28 International Business Machines Corporation Chemical analysis system including a test package and rotor combination
EP0139373A1 (en) * 1983-08-26 1985-05-02 The Regents Of The University Of California Multiple immunoassay system
US4673657A (en) 1983-08-26 1987-06-16 The Regents Of The University Of California Multiple assay card and system
US4632908A (en) 1984-05-03 1986-12-30 Abbott Laboratories Heating system for rotating members
US4580898A (en) 1984-05-31 1986-04-08 Allied Corporation Analytical system
US4708931A (en) * 1984-06-01 1987-11-24 Regents Of University Of California Laminated rod having alternating detection and spacer layers for binding assays
US5214119A (en) 1986-06-20 1993-05-25 Minnesota Mining And Manufacturing Company Block copolymer, method of making the same, dimaine precursors of the same, method of making such diamines and end products comprising the block copolymer
US4806316A (en) * 1987-03-17 1989-02-21 Becton, Dickinson And Company Disposable device for use in chemical, immunochemical and microorganism analysis
FR2634892B1 (fr) 1988-07-28 1990-09-14 Guigan Jean Dispositif pour la realisation d'analyses biologiques par detection immuno-enzymatique d'anticorps ou d'antigenes dans un serum
FR2634894B1 (https=) * 1988-07-28 1990-09-14 Guigan Jean
JPH0739506B2 (ja) 1988-09-30 1995-05-01 三菱重工業株式会社 形状記憶ポリマー発泡体
JP2502132B2 (ja) 1988-09-30 1996-05-29 三菱重工業株式会社 形状記憶ポリウレタンエラストマ―成形体
US5135786A (en) 1988-10-14 1992-08-04 Mitsubishi Jukogyo Kabushiki Kaisha Shape memory Transparent body and method of using the same
JPH066342B2 (ja) 1988-10-14 1994-01-26 三菱重工業株式会社 形状記憶性フィルム及びその使用法
JPH0723572B2 (ja) 1988-10-17 1995-03-15 三菱重工業株式会社 形状記憶性ポリマーによる織布
US4851371A (en) * 1988-12-05 1989-07-25 Xerox Corporation Fabricating process for large array semiconductive devices
US6645758B1 (en) * 1989-02-03 2003-11-11 Johnson & Johnson Clinical Diagnostics, Inc. Containment cuvette for PCR and method of use
US5229297A (en) * 1989-02-03 1993-07-20 Eastman Kodak Company Containment cuvette for PCR and method of use
CA2011740A1 (en) 1989-04-07 1990-10-07 Glen Connell Microwave heatable materials
US5089233A (en) * 1989-06-12 1992-02-18 Eastman Kodak Company Processing apparatus for a chemical reaction pack
CA1329698C (en) * 1989-06-12 1994-05-24 Mark Joseph Devaney, Jr. Temperature control device
US5346672A (en) * 1989-11-17 1994-09-13 Gene Tec Corporation Devices for containing biological specimens for thermal processing
US5258163A (en) * 1990-04-14 1993-11-02 Boehringer Mannheim Gmbh Test carrier for analysis of fluids
US5219526A (en) * 1990-04-27 1993-06-15 Pb Diagnostic Systems Inc. Assay cartridge
ES2057904T3 (es) * 1990-06-15 1994-10-16 Chiron Corp Conjunto y aparato de ensayo, autonomos y completos en si mismos.
US5154888A (en) * 1990-10-25 1992-10-13 Eastman Kodak Company Automatic sealing closure means for closing off a passage in a flexible cuvette
US5248479A (en) * 1990-11-16 1993-09-28 Abbott Laboratories Agglutination reaction device having geometrically modified chambers
US5516581A (en) * 1990-12-20 1996-05-14 Minnesota Mining And Manufacturing Company Removable adhesive tape
AU656556B2 (en) 1991-03-13 1995-02-09 Minnesota Mining And Manufacturing Company Radio frequency induction heatable compositions
US5256376A (en) 1991-09-12 1993-10-26 Medical Laboratory Automation, Inc. Agglutination detection apparatus
US5278377A (en) 1991-11-27 1994-01-11 Minnesota Mining And Manufacturing Company Electromagnetic radiation susceptor material employing ferromagnetic amorphous alloy particles
US5254479A (en) * 1991-12-19 1993-10-19 Eastman Kodak Company Methods for preventing air injection into a detection chamber supplied with injected liquid
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5744366A (en) * 1992-05-01 1998-04-28 Trustees Of The University Of Pennsylvania Mesoscale devices and methods for analysis of motile cells
US5290518A (en) * 1992-08-17 1994-03-01 Eastman Kodak Company Flexible extraction device with burstable sidewall
US5453246A (en) * 1992-09-18 1995-09-26 Mitsubishi Yuka Bio-Clinical Laboratories, Inc. Dispensing apparatus
US5422271A (en) * 1992-11-20 1995-06-06 Eastman Kodak Company Nucleic acid material amplification and detection without washing
US5288463A (en) * 1992-10-23 1994-02-22 Eastman Kodak Company Positive flow control in an unvented container
DE69329424T2 (de) 1992-11-06 2001-04-19 Biolog, Inc. Testvorrichtung für flüssig- und suspensionsproben
US5425917A (en) * 1992-11-09 1995-06-20 Schmid; Peter Apparatus for attaching a labeled probe and/or antibody to macromolecules
WO1994026414A1 (en) 1993-05-17 1994-11-24 Syntex (U.S.A.) Inc. Reaction container for specific binding assays and method for its use
SE501380C2 (sv) 1993-06-15 1995-01-30 Pharmacia Lkb Biotech Sätt att tillverka mikrokanal/mikrokavitetsstrukturer
JPH0715998A (ja) * 1993-06-21 1995-01-17 Alex Denshi Kogyo Kk 誘導電動機用制御装置
JPH0727686A (ja) 1993-07-14 1995-01-31 Shimahisa Yakuhin Kk 破砕分散用器具
DE4444269A1 (de) * 1993-12-20 1995-06-22 Ryobi Co Feuchtevolumen-Steuerungsvorrichtung für eine Offsetpresse
ES2120174T3 (es) 1994-01-11 1998-10-16 Abbott Lab Aparato y procedimiento de ciclado termico de dosificados de acidos nucleicos.
US5639428A (en) 1994-07-19 1997-06-17 Becton Dickinson And Company Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay
US6001229A (en) * 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
DE69533554T2 (de) 1994-11-10 2005-01-27 Orchid Biosciences, Inc. Flüssigkeitsverteilungssystem
CN1098772C (zh) 1995-03-29 2003-01-15 美国3M公司 吸收电磁波的复合材料
WO1996035458A2 (en) 1995-04-25 1996-11-14 Minnesota Mining And Manufacturing Company Tackified polydiorganosiloxane polyurea segmented copolymers and a process for making same
WO1996034028A1 (en) 1995-04-25 1996-10-31 Minnesota Mining And Manufacturing Company Tackified polydiorganosiloxane oligourea segmented copolymers and a process for making same
CN1181764A (zh) 1995-04-25 1998-05-13 美国3M公司 聚二有机硅氧烷聚脲嵌段共聚物及其制备方法
WO1996041864A1 (en) 1995-06-13 1996-12-27 The Regents Of The University Of California Diode laser heated micro-reaction chamber with sample detection means
US5849208A (en) * 1995-09-07 1998-12-15 Microfab Technoologies, Inc. Making apparatus for conducting biochemical analyses
US6048734A (en) * 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US20010055812A1 (en) 1995-12-05 2001-12-27 Alec Mian Devices and method for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
AU702403B2 (en) 1995-12-05 1999-02-18 Gamera Bioscience Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
US6004512A (en) 1995-12-08 1999-12-21 Mj Research Sample cartridge slide block
US6068751A (en) * 1995-12-18 2000-05-30 Neukermans; Armand P. Microfluidic valve and integrated microfluidic system
US5833923A (en) * 1995-12-22 1998-11-10 Universal Healthwatch, Inc. Sampling-assay interface system
US5721123A (en) 1996-01-05 1998-02-24 Microfab Technology, Inc. Methods and apparatus for direct heating of biological material
US5863502A (en) 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
US6825047B1 (en) 1996-04-03 2004-11-30 Applera Corporation Device and method for multiple analyte detection
US6399023B1 (en) * 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
US5863801A (en) * 1996-06-14 1999-01-26 Sarnoff Corporation Automated nucleic acid isolation
CN1173776C (zh) * 1996-06-28 2004-11-03 卡钳技术有限公司 在微规模流体性设备里的高通过量的筛选分析系统
US6143248A (en) 1996-08-12 2000-11-07 Gamera Bioscience Corp. Capillary microvalve
US5804141A (en) * 1996-10-15 1998-09-08 Chianese; David Reagent strip slide treating apparatus
DE19749011A1 (de) * 1996-11-19 1998-05-20 Lang Volker Mikroventil
CA2276251A1 (en) * 1996-11-20 1998-05-28 The Regents Of The University Of Michigan Microfabricated isothermal nucleic acid amplification devices and methods
US5811296A (en) * 1996-12-20 1998-09-22 Johnson & Johnson Clinical Diagnostics, Inc. Blocked compartments in a PCR reaction vessel
CN1249816A (zh) 1997-02-28 2000-04-05 伯斯坦恩实验室股份有限公司 盘片中的实验室
AUPO652997A0 (en) 1997-04-30 1997-05-29 Kindconi Pty Limited Temperature cycling device and method
WO1998053311A2 (en) 1997-05-23 1998-11-26 Gamera Bioscience Corporation Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
EP0882982A1 (en) * 1997-06-04 1998-12-09 Vrije Universiteit Brussel Method for separating a fluid substance and device therefor
US6300138B1 (en) 1997-08-01 2001-10-09 Qualigen, Inc. Methods for conducting tests
US6375871B1 (en) * 1998-06-18 2002-04-23 3M Innovative Properties Company Methods of manufacturing microfluidic articles
US6426230B1 (en) * 1997-08-01 2002-07-30 Qualigen, Inc. Disposable diagnostic device and method
US5876675A (en) * 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
EP1004015B1 (en) 1997-08-15 2004-01-02 Alexion Pharmaceuticals, Inc. Apparatus for performing assays at reaction sites
EP1003973B1 (fr) * 1997-08-20 2003-04-16 Westonbridge International Limited Micropompe comprenant un organe de controle d'entree permettant son auto-amorcage
DE19745373A1 (de) * 1997-10-14 1999-04-15 Bayer Ag Optisches Meßsystem zur Erfassung von Lumineszenz- oder Fluoreszenzsignalen
US6013513A (en) 1997-10-30 2000-01-11 Motorola, Inc. Molecular detection apparatus
US6007914A (en) 1997-12-01 1999-12-28 3M Innovative Properties Company Fibers of polydiorganosiloxane polyurea copolymers
US6030513A (en) * 1997-12-05 2000-02-29 Applied Materials, Inc. Full face mask for capacitance-voltage measurements
GB9804483D0 (en) 1998-03-02 1998-04-29 Central Research Lab Ltd Apparatus for and method of controlling the rate of flow of fluid along a pathway
EP1062042B1 (de) * 1998-03-11 2003-05-28 Steag MicroParts GmbH Probenträger
GB9808836D0 (en) 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
GB9809943D0 (en) 1998-05-08 1998-07-08 Amersham Pharm Biotech Ab Microfluidic device
CA2320296A1 (en) * 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge
US6830729B1 (en) * 1998-05-18 2004-12-14 University Of Washington Sample analysis instrument
US7105354B1 (en) * 1998-06-12 2006-09-12 Asahi Kasei Kabushiki Kaisha Analyzer
EP1088229A4 (en) 1998-06-25 2002-05-08 Caliper Techn Corp HIGH THROUGHPUT METHODS, SYSTEMS AND APPARATUS FOR CELL SCREENING TEST
US6375901B1 (en) * 1998-06-29 2002-04-23 Agilent Technologies, Inc. Chemico-mechanical microvalve and devices comprising the same
EP1097378A2 (en) 1998-07-21 2001-05-09 Burstein Laboratories Inc. Optical disc-based assay devices and methods
CA2345151A1 (en) 1998-09-22 2000-03-30 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
DE19848515A1 (de) * 1998-10-21 2000-04-27 November Ag Molekulare Medizin Vorrichtung zur Durchführung biochemischer und mikrobiologischer Reaktionen
US6159368A (en) * 1998-10-29 2000-12-12 The Perkin-Elmer Corporation Multi-well microfiltration apparatus
GB9828785D0 (en) 1998-12-30 1999-02-17 Amersham Pharm Biotech Ab Sequencing systems
ATE556149T1 (de) 1999-02-23 2012-05-15 Caliper Life Sciences Inc Manipulation von mikropartikeln in mikrofluidischen systemen
US6937330B2 (en) 1999-04-23 2005-08-30 Ppd Biomarker Discovery Sciences, Llc Disposable optical cuvette cartridge with low fluorescence material
EP1177267A1 (en) 1999-05-05 2002-02-06 3M Innovative Properties Company Silicone adhesives, articles, and methods
WO2000069560A1 (en) 1999-05-14 2000-11-23 Gamera Bioscience Corporation A centripetally-motivated microfluidics system for performing in vitro hybridization and amplification of nucleic acids
JP2004529312A (ja) 1999-06-18 2004-09-24 ガメラ バイオサイエンス コーポレイション 小型化均一アッセイ用のデバイスおよび方法
JP3623479B2 (ja) 1999-06-22 2005-02-23 テカン トレーディング アーゲー 小型化されたインビトロ増幅アッセイを行うための装置および方法
US7601270B1 (en) * 1999-06-28 2009-10-13 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6899137B2 (en) * 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6929030B2 (en) 1999-06-28 2005-08-16 California Institute Of Technology Microfabricated elastomeric valve and pump systems
WO2001007892A1 (en) 1999-07-27 2001-02-01 Esperion Therapeutics, Inc. Method and device for measurement of cholesterol efflux
KR20020021810A (ko) * 1999-08-11 2002-03-22 야마모토 카즈모토 분석용 카트리지 및 송액 제어 장치
US6770441B2 (en) * 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
US6431212B1 (en) * 2000-05-24 2002-08-13 Jon W. Hayenga Valve for use in microfluidic structures
US6494433B2 (en) 2000-06-06 2002-12-17 The Regents Of The University Of Michigan Thermally activated polymer device
US6734401B2 (en) * 2000-06-28 2004-05-11 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
US6627159B1 (en) * 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
US20020031836A1 (en) * 2000-09-11 2002-03-14 Feldstein Mark J. Fluidics system
US6508988B1 (en) * 2000-10-03 2003-01-21 California Institute Of Technology Combinatorial synthesis system
US6623860B2 (en) * 2000-10-10 2003-09-23 Aclara Biosciences, Inc. Multilevel flow structures
AU2002213400A1 (en) * 2000-10-18 2002-04-29 Research Foundation Of State University Of New York Microvalve
AU2002248149A1 (en) * 2000-11-16 2002-08-12 Fluidigm Corporation Microfluidic devices for introducing and dispensing fluids from microfluidic systems
EP1350029B1 (en) 2001-01-08 2014-09-10 President and Fellows of Harvard College Valves and pumps for microfluidic systems and method for making microfluidic systems
US20020100714A1 (en) * 2001-01-31 2002-08-01 Sau Lan Tang Staats Microfluidic devices
WO2003015923A1 (en) 2001-08-20 2003-02-27 Biomicro Systems, Inc. Fluid mixing in low aspect ratio chambers
US6750039B1 (en) * 2001-03-21 2004-06-15 Boston Probes, Inc. Filtration apparatus and method for the separation of microscopic entities from a fluid
WO2002081934A2 (en) 2001-04-03 2002-10-17 Micronics, Inc. Pneumatic valve interface for use in microfluidic structures
US6457236B1 (en) 2001-06-05 2002-10-01 Agilent Technologies, Inc. Apparatus and method for restricting fluid flow in a planar manifold
US7318912B2 (en) 2001-06-07 2008-01-15 Nanostream, Inc. Microfluidic systems and methods for combining discrete fluid volumes
US7022290B2 (en) * 2001-06-19 2006-04-04 Rutgers, The State University System structure for in situ x-ray study of electrochemical cell component performance
US6729599B2 (en) 2001-06-26 2004-05-04 Tini Alloy Company Liquid microvalve
US6514750B2 (en) * 2001-07-03 2003-02-04 Pe Corporation (Ny) PCR sample handling device
KR100421359B1 (ko) 2001-07-24 2004-03-06 엘지전자 주식회사 탄성 재질의 기판 내에서 유체를 이송하는 방법 및 이를위한 장치
US7056475B2 (en) * 2002-01-30 2006-06-06 Agilent Technologies, Inc. Fluidically isolated pumping and metered fluid delivery system and methods
US20030148537A1 (en) * 2002-02-06 2003-08-07 Franck Bellon Mask for depositing and distributing reagents on an analytical support
US7048893B2 (en) * 2002-02-06 2006-05-23 Sebia Mask for depositing and distributing reagents on an analytical support
US7125523B2 (en) 2002-04-29 2006-10-24 Agilent Technologies, Inc. Holders for arrays
US6998271B2 (en) 2002-06-03 2006-02-14 The Hong Kong Polytechnic University Luminescent sensory material for organic-halogen compounds, and methods and apparatus utilizing such
US6886610B2 (en) 2002-06-05 2005-05-03 Techelan Liquid dispenser
AU2003245006A1 (en) * 2002-07-24 2004-02-09 Koninklijke Philips Electronics N.V. Game board and game element with detecting means
CA2492538A1 (en) 2002-07-26 2004-02-05 Applera Corporation Valve assembly for microfluidic devices, and method for opening and closing same
US7041258B2 (en) 2002-07-26 2006-05-09 Applera Corporation Micro-channel design features that facilitate centripetal fluid transfer
US7198759B2 (en) * 2002-07-26 2007-04-03 Applera Corporation Microfluidic devices, methods, and systems
CA2493700A1 (en) 2002-07-26 2004-02-05 Applera Corporation Micro-channel design features that facilitate centripetal fluid transfer
US7214348B2 (en) * 2002-07-26 2007-05-08 Applera Corporation Microfluidic size-exclusion devices, systems, and methods
US7135147B2 (en) * 2002-07-26 2006-11-14 Applera Corporation Closing blade for deformable valve in a microfluidic device and method
US7201881B2 (en) * 2002-07-26 2007-04-10 Applera Corporation Actuator for deformable valves in a microfluidic device, and method
EP1525053A1 (en) 2002-07-26 2005-04-27 Applera Corporation Device and method for purification of nucleic acids
WO2004011132A2 (en) 2002-07-26 2004-02-05 Applera Corporation Closing blade for deformable valve in a microfluidic device, and method
US7452712B2 (en) 2002-07-30 2008-11-18 Applied Biosystems Inc. Sample block apparatus and method of maintaining a microcard on a sample block
US20040071605A1 (en) * 2002-10-10 2004-04-15 Coonan Everett W. Slide-based high-throughput microplate device
US7028168B2 (en) * 2002-12-05 2006-04-11 Hewlett-Packard Development Company, L.P. System and method for performing matrix operations
US7507376B2 (en) * 2002-12-19 2009-03-24 3M Innovative Properties Company Integrated sample processing devices
US20050232818A1 (en) * 2003-09-19 2005-10-20 Donald Sandell Single sheet seal applicator and cartridge
US7056473B2 (en) * 2004-04-29 2006-06-06 Response Biomedical Corp. Method and apparatus of quantitative assays
EP1885839B1 (en) * 2005-04-26 2018-08-08 Life Technologies Corporation Systems and methods for multiple analyte detection

Also Published As

Publication number Publication date
CA2412220C (en) 2009-09-29
US7026168B2 (en) 2006-04-11
US7678334B2 (en) 2010-03-16
CA2411518A1 (en) 2002-01-03
US6627159B1 (en) 2003-09-30
CA2412220A1 (en) 2002-01-03
EP1296765B2 (en) 2013-10-30
US20060189000A1 (en) 2006-08-24
CA2680285A1 (en) 2002-01-03
JP2004516127A (ja) 2004-06-03
JP4927296B2 (ja) 2012-05-09
US7855083B2 (en) 2010-12-21
ATE417667T1 (de) 2009-01-15
EP1296765A2 (en) 2003-04-02
US6814935B2 (en) 2004-11-09
WO2002001180A2 (en) 2002-01-03
WO2002001180A3 (en) 2002-06-27
JP4938198B2 (ja) 2012-05-23
EP1296765B1 (en) 2008-12-17
AU2001273055B2 (en) 2006-05-11
US20050031494A1 (en) 2005-02-10
WO2002001181A2 (en) 2002-01-03
EP2316573A1 (en) 2011-05-04
AU6874501A (en) 2002-01-08
EP2316573B1 (en) 2012-12-19
AU2001268745B2 (en) 2006-04-27
EP1295101B1 (en) 2013-12-18
US20020064885A1 (en) 2002-05-30
WO2002001181A3 (en) 2003-01-03
US7595200B2 (en) 2009-09-29
EP2008718A1 (en) 2008-12-31
AU7305501A (en) 2002-01-08
US8435462B2 (en) 2013-05-07
EP1295101A2 (en) 2003-03-26
US20060269451A1 (en) 2006-11-30
US20060188396A1 (en) 2006-08-24
EP2008718B1 (en) 2016-07-20
US20060228811A1 (en) 2006-10-12
JP2004502164A (ja) 2004-01-22
US7445752B2 (en) 2008-11-04
US20020048533A1 (en) 2002-04-25

Similar Documents

Publication Publication Date Title
ATE417667T1 (de) Vorrichtungen zur probenverarbeitung
AU6380001A (en) Porous ferro- or ferrimagnetic glass particles for isolating molecules
IL142947A0 (en) Methods for transforming plants to express bacillus thuringiensis delta-endotoxins
AU8149398A (en) Method for sample injection in microchannel device
ATE544776T1 (de) Chimäre dna-bindeproteine
WO2003036265A8 (en) Assay systems with adjustable fluid communication
AU8580501A (en) Method for carrying out a saliva analysis
DE69939820D1 (de) Internalisierende erbb2 antikörper
NO972455L (no) Cytokin betegnet LERK-7
MXPA03002572A (es) Secuencias de nucleotidos que intervienen en la fertilidad de los machos y metodo de su uso.
NO20004950L (no) Bom for fluidoverföring, med koaksiale fluidkanaler
TR199900113A3 (tr) Esnek hücreli malzeme, birlesimi ve hazirlanmasi için usul.
AU2001239279A1 (en) Device and method for performing syntheses, analyses or transport processes
DE69733313D1 (de) Mehrträgerübertragung, kompatibel zum existierenden GSM-System
WO2002037944A3 (en) Multiplexed cell analysis system
DE69921897D1 (de) Abschaltgerät für unter Druck stehende Flüssigkeitshandhabungs-Anlage
FI962095L (fi) Menetelmä ja kantaja isomaltuloosin tuottamiseksi immobilisoiduilla mikro-organismeilla
GB9911972D0 (en) Module for concentrating pathogenic protozoa and concentration method using the same
AU2001288106A1 (en) Diamond electrode for measuring glucose concentration, and measuring method and apparatus employing the same
WO1999039009A8 (en) Processes for isolating, amplifying and characterizing dna
DE59201078D1 (de) Halteeinrichtung für Rohrleitungen, insbesondere für solche in Kraftwerken.
BR9813914B1 (pt) mÉtodo e aparelho para concentraÇço e pesquisa de espÉcimes microbiolàgicos.
ITBO980673A0 (it) Portasatelliti monoblocco per riduttore epicicloidale .
WO2004034012A3 (en) Coded particles for multiplexed analysis of biological samples
PT1127133E (pt) Polipeptido que proporciona permeabilidade celular

Legal Events

Date Code Title Description
8363 Opposition against the patent