SE501380C2 - Sätt att tillverka mikrokanal/mikrokavitetsstrukturer - Google Patents

Sätt att tillverka mikrokanal/mikrokavitetsstrukturer

Info

Publication number
SE501380C2
SE501380C2 SE9302051A SE9302051A SE501380C2 SE 501380 C2 SE501380 C2 SE 501380C2 SE 9302051 A SE9302051 A SE 9302051A SE 9302051 A SE9302051 A SE 9302051A SE 501380 C2 SE501380 C2 SE 501380C2
Authority
SE
Sweden
Prior art keywords
elements
pct
materials
solvent
microchannel
Prior art date
Application number
SE9302051A
Other languages
English (en)
Other versions
SE9302051D0 (sv
SE9302051L (sv
Inventor
Ove Oehman
Original Assignee
Pharmacia Lkb Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Lkb Biotech filed Critical Pharmacia Lkb Biotech
Priority to SE9302051A priority Critical patent/SE501380C2/sv
Publication of SE9302051D0 publication Critical patent/SE9302051D0/sv
Priority to EP94919060A priority patent/EP0738306B1/en
Priority to DE69406020T priority patent/DE69406020T2/de
Priority to PCT/SE1994/000584 priority patent/WO1994029400A1/en
Priority to US08/564,217 priority patent/US6126765A/en
Priority to JP50168695A priority patent/JP3515784B2/ja
Priority to ES94919060T priority patent/ES2109706T3/es
Publication of SE9302051L publication Critical patent/SE9302051L/sv
Publication of SE501380C2 publication Critical patent/SE501380C2/sv
Priority to US09/625,022 priority patent/US6620478B1/en
Priority to JP2003379763A priority patent/JP3688281B2/ja

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
    • B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
    • B81C1/00055—Grooves
    • B81C1/00071—Channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/48—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding
    • B29C65/4895—Solvent bonding, i.e. the surfaces of the parts to be joined being treated with solvents, swelling or softening agents, without adhesives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
    • B29C66/112—Single lapped joints
    • B29C66/1122—Single lap to lap joints, i.e. overlap joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/53—Joining single elements to tubular articles, hollow articles or bars
    • B29C66/534—Joining single elements to open ends of tubular or hollow articles or to the ends of bars
    • B29C66/5346—Joining single elements to open ends of tubular or hollow articles or to the ends of bars said single elements being substantially flat
    • B29C66/53461—Joining single elements to open ends of tubular or hollow articles or to the ends of bars said single elements being substantially flat joining substantially flat covers and/or substantially flat bottoms to open ends of container bodies
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/90—Measuring or controlling the joining process
    • B29C66/91—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux
    • B29C66/919—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux characterised by specific temperature, heat or thermal flux values or ranges
    • B29C66/9192—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux characterised by specific temperature, heat or thermal flux values or ranges in explicit relation to another variable, e.g. temperature diagrams
    • B29C66/91921—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux characterised by specific temperature, heat or thermal flux values or ranges in explicit relation to another variable, e.g. temperature diagrams in explicit relation to another temperature, e.g. to the softening temperature or softening point, to the thermal degradation temperature or to the ambient temperature
    • B29C66/91931—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux characterised by specific temperature, heat or thermal flux values or ranges in explicit relation to another variable, e.g. temperature diagrams in explicit relation to another temperature, e.g. to the softening temperature or softening point, to the thermal degradation temperature or to the ambient temperature in explicit relation to the fusion temperature or melting point of the material of one of the parts to be joined
    • B29C66/91935—Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux characterised by specific temperature, heat or thermal flux values or ranges in explicit relation to another variable, e.g. temperature diagrams in explicit relation to another temperature, e.g. to the softening temperature or softening point, to the thermal degradation temperature or to the ambient temperature in explicit relation to the fusion temperature or melting point of the material of one of the parts to be joined lower than said fusion temperature
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/12—Bonding of a preformed macromolecular material to the same or other solid material such as metal, glass, leather, e.g. using adhesives
    • C08J5/124—Bonding of a preformed macromolecular material to the same or other solid material such as metal, glass, leather, e.g. using adhesives using adhesives based on a macromolecular component
    • C08J5/125—Adhesives in organic diluents
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J5/00—Adhesive processes in general; Adhesive processes not provided for elsewhere, e.g. relating to primers
    • C09J5/06—Adhesive processes in general; Adhesive processes not provided for elsewhere, e.g. relating to primers involving heating of the applied adhesive
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/71—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/756—Microarticles, nanoarticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2203/00—Basic microelectromechanical structures
    • B81B2203/03—Static structures
    • B81B2203/0315—Cavities
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2203/00—Basic microelectromechanical structures
    • B81B2203/03—Static structures
    • B81B2203/0323—Grooves
    • B81B2203/0338—Channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C2201/00—Manufacture or treatment of microstructural devices or systems
    • B81C2201/01—Manufacture or treatment of microstructural devices or systems in or on a substrate
    • B81C2201/0174—Manufacture or treatment of microstructural devices or systems in or on a substrate for making multi-layered devices, film deposition or growing
    • B81C2201/019—Bonding or gluing multiple substrate layers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C2203/00—Forming microstructural systems
    • B81C2203/03—Bonding two components
    • B81C2203/033—Thermal bonding
    • B81C2203/036—Fusion bonding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6052—Construction of the column body
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y10T156/1002—Methods of surface bonding and/or assembly therefor with permanent bending or reshaping or surface deformation of self sustaining lamina
    • Y10T156/1039—Surface deformation only of sandwich or lamina [e.g., embossed panels]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/21—Circular sheet or circular blank
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
    • Y10T428/24479—Structurally defined web or sheet [e.g., overall dimension, etc.] including variation in thickness
    • Y10T428/24562—Interlaminar spaces

Description

501 380 10 15 20 25 30 35 lets smälttemperatur. Efter avdrivning av lösningsmedlet för man ihop de båda ytorna, t.ex. genom valsning, varefter man värmer det hela till en temperatur som smälter det mel- lanliggande (företrädesvis termoplastiska) materialet men inte ytmaterialet för att åstadkomma hopfogning av de båda materialytorna.
Det påförda lösningsskiktet skall givetvis ha en mycket liten tjocklek i förhållande till kanalernas resp. mikrokaviteternas bredd och djup, vilka t.ex. kan ligga i storleksordningen 50 till 100 pm.
Lämpligtvis är, när ett termoplastiskt material an- vänds för de båda materialytorna, detta termoplastiska ma- terial nàrbesläktat med det termoplastmaterial som står för sammanbindningen av kanal/kavitetsstrukturen. Som exempel på en lämplig termoplasttyp för föreliggande ändamål kan nämnas fluorelastomerer.
Lämpliga kombinationer av yt/bindningsmaterial och lösningsmedel för att utföra uppfinningen torde enkelt kunna tas fram av fackmannen pá området med ledning av fö- religgande beskrivning.
Utförandet av uppfinningsförfarandet åskådliggörs schematiskt i de bifogade ritningarna, där Fig. 1A till lC visar olika delsteg vid tillverkningen en mikroflödesstruk- tur, och Fig. 2 är ett tvärsnitt av den färdiga produkten.
I Fig. 1A visas en skiva 1 försedd med ett öppet ka- nalsystem (ej visat) avsedd att tillsammans med en likadan skiva 2 utan kanalsystem mellan sig avgränsa ett mikroka- nalsystem. För hopfogning av de båda skivorna, som företrä- desvis är av termoplastiskt material, t.ex. en fluorelasto- mer, spinner man först ut ett tunt skikt 3 av ett företrä- desvis närbesläktat termoplastiskt material, t.ex. en modi- fierad fluorelastomer med lägre smältpunkt, på båda skiv- ytorna. Därefter bakas lösningsmedlet ut under förhöjd tem- 135 °C) , 1B. De bá- da på så sätt behandlade skivorna valsas sedan samman, så- peratur (t.ex. såsom illustreras i Fig. som antyds i Fig. lC, och tillåts bondas samman under någon tid, t.ex. 5 minuter. Den färdiga mikrokanalstrukturen vi- sas i Fig. 2. Som framgår av den senare avgränsar de båda 10 15 20 25 30 35 501 389 skivorna 1, 2, som hålls samman av materialskiktet 3, ett kanalsystem 4 mellan sig.
Det följande specifika utföringsexemplet, som beskri- ver framställning av en mikrokanalstruktur, belyser uppfin- ningsförfarandet ytterligare.
EXEMPEL En polymerstruktur med slutna raka kanaler med en höjd av 50 um, en bredd av 250 um och en längd av ca 80 mm till- verkades som följer.
En kiselform med en mot den önskade kanalgeometrin svarande ytreliefstruktur tillverkades på i och för sig känt sätt. Således oxiderades först ytan hos en kiselplatta vid ca 1100 °C för bildning av ett ca 8000 Å tjockt oxid- skikt. Efter tvättning, dehydratisering i ugn och primning med hexametylsilan påspanns ett fotoresistskikt, som stabi- liserades genom bakning i ugn. En mask överensstämmande med det önskade kanalmönstret placerades sedan på plattytan, och de ej täckta partierna exponerades för ljus. De expone- rade fotoresistpartierna avlägsnades därefter med framkall- ningslösning för friläggning av oxidskiktet, och kvarva- rande fotoresist hårdbakades. Den frilagda oxiden etsades sedan med fluorvätesyra/ammoniumfluorid för exponering av kislet (varvid plattans baksida skyddades med resistent tejp), varefter fotoresistmasken avlägsnades med aceton. De oxidfria kiselytorna etsades därefter med kaliumhydroxid- lösning under tillräcklig tid för att åstadkomma det önska- de etsdjupet. Den resulterande ytan uppvisade det önskade kanalmönstret.
Den erhållna kiselformen pressades sedan mot en 2 mm tjock film av Hostaflon TFB 7100 (brytningsindex ca 1,36) vid ca 160 °C och 20 kp/cm2. fluorelastomer såld av Hoechst AG, Tyskland). Den erhållna (Hostaflon är en termoplastisk kanalstrukturen bondades mot ett basskikt i form av en plan skiva av samma material genom att ett tunt lager av Hosta- flon TFB X-7200 (med lägre smälttemperatur än Hostaflon TFB 7100) upplöst i propylmetylketon spanns ut på basskiktet och kanalstrukturen, vilka därefter fick torka vid 130 °C i 10 minuter. Kanalstrukturen valsades sedan omedelbart sam- 501 380 man med basskiktet, och den erhållna sandwichen bakades i ca 140 °C i lO minuter. Den på detta satt tillverkade poly- merstrukturen uppvisade intakta slutna kanaler.
Uppfinningen är givetvis inte begränsad till den ovan beskrivna och i ritningarna speciellt visade utföringsfor- men, utan många modifieringar och ändringar kan göras inom ramen för den allmänna uppfinningstanken sådan den anges i de efterföljande patentkraven.

Claims (5)

10 15 20 25 30 501 380 PATENTKRAV
1. Sätt att bilda en mikrokanal- och/eller mikrokavitets- struktur genom sammanbindning av två element (1, 2) av ett första material med plana ytor mot varandra, varvid den ena eller båda ytorna uppvisar öppna kanaler och/eller kavite- ter, kännetecknat av att man för nämnda sammanbindning på den ena eller båda elementytorna (1, 2) applicerar ett tunt skikt (3) av en lösning av ett material med förmåga att smälta samman med och som har lägre smältpunkt än materia- let hos de båda elementen (1, 2) i ett lösningsmedel som väsentligen inte löser elementmaterialet, avlägsnar lös- ningsmedlet, för ihop de båda elementen (1, 2) och värmer till en temperatur där det lösta materialet men inte det elementmaterialet fås att smälta.
2. Sätt enligt patentkravet 1, kännetecknat av att det lösta materialet (3) är termoplastiskt.
3. Sätt enligt patentkravet 2, kännetecknat av att mate- rialet i de båda elementen (1, 2) är termoplastiskt.
4. Sätt enligt patentkravet 3, kännetecknat av att mate- rialet i de båda elementen (1, 2) och det lösta materialet (3) är av väsentligen samma typ.
5. Sätt enligt patentkravet 4, kännetecknat av att mate- rialet í de båda elementen (1, 2) och det lösta materialet (3) är fluorelastomerer.
SE9302051A 1993-06-15 1993-06-15 Sätt att tillverka mikrokanal/mikrokavitetsstrukturer SE501380C2 (sv)

Priority Applications (9)

Application Number Priority Date Filing Date Title
SE9302051A SE501380C2 (sv) 1993-06-15 1993-06-15 Sätt att tillverka mikrokanal/mikrokavitetsstrukturer
ES94919060T ES2109706T3 (es) 1993-06-15 1994-06-14 Metodo para producir estructuras de microcanales/microcavidades.
US08/564,217 US6126765A (en) 1993-06-15 1994-06-14 Method of producing microchannel/microcavity structures
DE69406020T DE69406020T2 (de) 1993-06-15 1994-06-14 Verfahren zur herstellung von strukturen mit mikrokanälen/mikrohohlräumen
PCT/SE1994/000584 WO1994029400A1 (en) 1993-06-15 1994-06-14 Method of producing microchannel/microcavity structures
EP94919060A EP0738306B1 (en) 1993-06-15 1994-06-14 Method of producing microchannel/microcavity structures
JP50168695A JP3515784B2 (ja) 1993-06-15 1994-06-14 マイクロチャンネル／マイクロキャビティ構造体を製造する方法
US09/625,022 US6620478B1 (en) 1993-06-15 2000-07-25 Circular disk containing microchannel/microcavity structures
JP2003379763A JP3688281B2 (ja) 1993-06-15 2003-11-10 マイクロチャンネル／マイクロキャビティ構造体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9302051A SE501380C2 (sv) 1993-06-15 1993-06-15 Sätt att tillverka mikrokanal/mikrokavitetsstrukturer

Publications (3)

Publication Number Publication Date
SE9302051D0 SE9302051D0 (sv) 1993-06-15
SE9302051L SE9302051L (sv) 1994-12-16
SE501380C2 true SE501380C2 (sv) 1995-01-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
SE9302051A SE501380C2 (sv) 1993-06-15 1993-06-15 Sätt att tillverka mikrokanal/mikrokavitetsstrukturer

Country Status (7)

Country Link
US (2) US6126765A (sv)
EP (1) EP0738306B1 (sv)
JP (2) JP3515784B2 (sv)
DE (1) DE69406020T2 (sv)
ES (1) ES2109706T3 (sv)
SE (1) SE501380C2 (sv)
WO (1) WO1994029400A1 (sv)

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US6054034A (en) * 1990-02-28 2000-04-25 Aclara Biosciences, Inc. Acrylic microchannels and their use in electrophoretic applications
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ES2109706T3 (es) 1998-01-16
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US6126765A (en) 2000-10-03
DE69406020T2 (de) 1998-02-26
US6620478B1 (en) 2003-09-16
WO1994029400A1 (en) 1994-12-22
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DE69406020D1 (de) 1997-11-06
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