TWI456196B - 檢體免疫分析檢測裝置 - Google Patents

檢體免疫分析檢測裝置 Download PDF

Info

Publication number
TWI456196B
TWI456196B TW101119292A TW101119292A TWI456196B TW I456196 B TWI456196 B TW I456196B TW 101119292 A TW101119292 A TW 101119292A TW 101119292 A TW101119292 A TW 101119292A TW I456196 B TWI456196 B TW I456196B
Authority
TW
Taiwan
Prior art keywords
chamber
disposed
magnetic
detecting device
microchannel
Prior art date
Application number
TW101119292A
Other languages
English (en)
Other versions
TW201344193A (zh
Inventor
Shaw Hwa Parng
Chih Wen Yang
Yu Yin Tsai
Yi Chau Huang
Original Assignee
Ind Tech Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ind Tech Res Inst filed Critical Ind Tech Res Inst
Priority to CN201210175548.0A priority Critical patent/CN103376312B/zh
Priority to TW101119292A priority patent/TWI456196B/zh
Priority to US13/667,341 priority patent/US8703070B1/en
Publication of TW201344193A publication Critical patent/TW201344193A/zh
Application granted granted Critical
Publication of TWI456196B publication Critical patent/TWI456196B/zh

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N35/00069—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0672—Integrated piercing tool
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0439—Rotary sample carriers, i.e. carousels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0439—Rotary sample carriers, i.e. carousels
    • G01N2035/0446—Combinations of the above
    • G01N2035/0449—Combinations of the above using centrifugal transport of liquid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/809—Multifield plates or multicontainer arrays
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
    • Y10T436/118339—Automated chemical analysis with a continuously flowing sample or carrier stream with formation of a segmented stream

Claims (17)

  1. 一種檢體免疫分析檢測裝置，包含：一卡匣，係可以一參考軸為中心進行轉動，該卡匣具有至少一組檢測單元，該檢測單元包括：複數儲液室，每一該儲液室係儲放一種工作流體；複數刺針活動室，每一該刺針活動室係對應於一該儲液室，每一該刺針活動室設有一第一密封膜，該第一密封膜係用以使該刺針活動室與該儲液室形成不連通狀態；一微流道結構，係連通每一該刺針活動室；一緩衝室，係連接於該微流道結構；一檢測室，係與該緩衝室相連通，該微流道結構係用以導引該工作流體由該儲液室流至該檢測室；一廢液室，係與該檢測室相連通；一毛細導引U形槽，係連接該檢測室與該廢液室；一排氣結構，係連接於該緩衝室與該複數儲液室；一針膜裝置，其包括：一第二密封膜，係設置且覆蓋於該卡匣設有該檢測室之一面；複數刺針結構，係設置於該第二密封膜，每一該刺針結構係對應於一該刺針活動室，每一該刺針結構包括一刺針以及一可撓性結構，該可撓性結構係提供該刺針由一第一位置移動至一第二位置；以及一第一致動裝置，係用以驅動該刺針由該第一位置移動至該第二位置，且該刺針由該第一位置移動至該第 二位置時，可將該第一密封膜刺破，使該刺針活動室與該儲液室形成相連通狀態；複數磁性粒子，係設置於該檢測室內，每一該磁性粒子具有磁性吸引性，每一該磁性粒子表面具有一第一標定物；至少一第一磁性元件，係設置於該檢測室之一側，該第一磁性元件係用以對該複數磁性粒子產生磁性，將該複數磁性粒子吸引並附著於該檢測室設有該第一磁性元件之一側；以及至少一第二磁性元件，係可往復移動於一第三位置以及一第四位置之間，該第二磁性元件之磁力大於該第一磁性元件之磁力，該第二磁性元件位於該第四位置時，該第二磁性元件係位於該檢測室相對於設有該第一磁性元件之一側，且該第二磁性元件對該複數磁性粒子產生磁性，將該複數磁性粒子吸引並附著於該檢測室設有該第二磁性元件之一側。
  2. 如申請專利範圍第1項所述之檢體免疫分析檢測裝置，其中該可撓性結構係一呈圓錐形之筒狀結構，該可撓性結構沿其軸向具有相對之一第一端以及一第二端，該第一端之外徑大於該第二端之外徑，於該第二密封膜相對應於每一該刺針活動室之位置設有孔洞，該可撓性結構之該第一端係連接於該孔洞，該可撓性結構之該第二端係凸出於該第二密封膜相對於設有該卡匣之一面，該刺針具有相對二端，該刺針其中一端係連接於該可撓性結構之該第二端，該刺針之另一端係朝向該卡匣。
  3. 如申請專利範圍第2項所述之檢體免疫分析檢測裝置，其中該刺針朝向該卡匣之一端係為尖錐狀結構，於該尖錐狀結構之表面設有至少一導槽，該導槽沿著刺針之軸向延伸一長度。
  4. 如申請專利範圍第1項所述之檢體免疫分析檢測裝置，其中該第一致動裝置包括：一推桿，該推桿之一軸向端係朝向該刺針結構；以及一第一致動器，用以驅動該推桿軸向移動，使該推桿與該刺針結構相對運動。
  5. 如申請專利範圍第1項所述之檢體免疫分析檢測裝置，其更包括一載盤，該載盤係用以承載該卡匣，該載盤與該卡匣之間設有連結結構，使該載盤與該卡匣可同步轉動。
  6. 如申請專利範圍第5項所述之檢體免疫分析檢測裝置，其中該第一磁性元件係凸出設置於該載盤設有該卡匣之面，於該卡匣對應於該第一磁性元件之位置設有一第一凹槽，該第一磁性元件係嵌設於該第一凹槽中。
  7. 如申請專利範圍第5項所述之檢體免疫分析檢測裝置，其中該載盤相對應於該第二磁性元件之位置設有一貫穿孔，於該卡匣相對應於該第二磁性元件之位置設有一第二凹槽，該第二磁性元件係設置於該載盤相對於設有該卡匣之一面，該第二磁性元件位於該第四位置時，該第二磁性元件係穿設於該貫穿孔並位於該第二凹槽內。
  8. 如申請專利範圍第5項所述之檢體免疫分析檢測裝置，更包括至少一支撐架結構，該支撐架結構包括： 一基座；一檢測平台，係用以承載該載盤；複數支柱，係設置於該基座與該檢測平台之間，該複數支柱係用以支撐該檢測平台；複數導桿，係設置於該檢測平台設有該載盤之面；以及一暗室結構，係設置於該檢測平台設有該載盤之面，該暗室結構係連接於該複數導桿，該暗室結構可沿著該導桿之軸向往復移動，該暗室結構係用以覆蓋該卡匣。
  9. 如申請專利範圍第8項所述之檢體免疫分析檢測裝置，其中該支撐架結構更包括至少一固定架，於該固定架設有一第二致動器，該第二致動器係連接於該第二磁性元件，該第二致動器係用以驅動該第二磁性元件往復移動於該第三位置以及該第四位置之間。
  10. 如申請專利範圍第1項所述之檢體免疫分析檢測裝置，其中該微流道結構包括：一第一微流道，其具有一弧度，該弧度之圓心係與該參考軸偏心設置；以及複數第二微流道，每一該第二微流道係以該參考軸為中心徑向延伸，每一該第二微流道具有相對二端，每一該第二微流道之其中一端係連接該第一微流道，每一該第二微流道之另外一端係連接一該刺針活動室。
  11. 如申請專利範圍第10項所述之檢體免疫分析檢測裝置，其中該第一微流道具有相對之一第一端以及一第二端，其中一該第二微流道係設置於該第一微流道之該第一端，其中一該第二微流道係設置於該第一微流道之該 第二端，該複數第二微流道之長度係由該第一微流道之該第一端至該第一微流道之該第二端逐漸縮短，該緩衝室係設置於該第一微流道之該第一端。
  12. 如申請專利範圍第10項所述之檢體免疫分析檢測裝置，其中該微流道結構更包括一第三微流道，該第三微流道係以該參考軸為中心徑向延伸，該第三微流道之其中一端連接該緩衝室，該第三微流道之另一端連接該檢測室。
  13. 如申請專利範圍第1項所述之檢體免疫分析檢測裝置，其中該複數刺針活動室係以該參考軸為中心且環繞該參考軸設置。
  14. 如申請專利範圍第1項所述之檢體免疫分析檢測裝置，其中該檢測室靠近該第一磁性元件之一側設有一第一側壁，該檢測室靠近該第二磁性元件之一側設有一第二側壁，該第一側壁以及該第二側壁為平面。
  15. 如申請專利範圍第1項所述之檢體免疫分析檢測裝置，其中該毛細導引U形槽包括一第一弧形槽、一第二弧形槽、一第一連接槽以及一第二連接槽，該第一弧形槽、第一連接槽、第二弧形槽、第二連接槽串接構成一U形結構，該第一弧形槽之其中一端與該檢測室連接，該第二連接槽之其中一端係與該廢液室連接。
  16. 如申請專利範圍第15項所述之檢體免疫分析檢測裝置，其中該第二弧形槽具有一凸弧面，該凸弧面係朝向該參考軸，該凸弧面距離該參考軸的距離小於該緩衝室距離該參考軸的距離。
  17. 如申請專利範圍第1項所述之檢體免疫分析檢測裝置，其中該排氣結構係連接於每一該儲液室、該廢液室以及該緩衝室。
TW101119292A 2012-04-24 2012-05-30 檢體免疫分析檢測裝置 TWI456196B (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN201210175548.0A CN103376312B (zh) 2012-04-24 2012-05-30 检体免疫分析检测装置
TW101119292A TWI456196B (zh) 2012-04-24 2012-05-30 檢體免疫分析檢測裝置
US13/667,341 US8703070B1 (en) 2012-04-24 2012-11-02 Apparatus for immunoassay

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TW101114541 2012-04-24
TW101119292A TWI456196B (zh) 2012-04-24 2012-05-30 檢體免疫分析檢測裝置

Publications (2)

Publication Number Publication Date
TW201344193A TW201344193A (zh) 2013-11-01
TWI456196B true TWI456196B (zh) 2014-10-11

Family

ID=49990164

Family Applications (1)

Application Number Title Priority Date Filing Date
TW101119292A TWI456196B (zh) 2012-04-24 2012-05-30 檢體免疫分析檢測裝置

Country Status (2)

Country Link
US (1) US8703070B1 (zh)
TW (1) TWI456196B (zh)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6588910B2 (ja) * 2014-06-30 2019-10-09 Ｐｈｃホールディングス株式会社 試料分析用基板、試料分析装置、試料分析システムおよび試料分析システム用プログラム
JP6588909B2 (ja) * 2014-06-30 2019-10-09 Ｐｈｃホールディングス株式会社 試料分析用基板、試料分析システムおよび磁性粒子を含む液体から液体を取り除く方法
CN106662596A (zh) * 2014-06-30 2017-05-10 松下健康医疗控股株式会社 试样分析用基板和试样分析装置
US10309976B2 (en) 2014-06-30 2019-06-04 Phc Holdings Corporation Substrate for sample analysis, sample analysis device, sample analysis system, and program for sample analysis system
KR20160018200A (ko) * 2014-08-08 2016-02-17 삼성전자주식회사 미세유동장치
JP6660305B2 (ja) 2014-12-12 2020-03-11 Ｐｈｃホールディングス株式会社 試料分析用基板、試料分析装置、試料分析システムおよび試料分析システム用プログラム
CN108027280B (zh) 2015-06-26 2021-07-06 雅培实验室 用于使得反应容器在诊断分析仪中从处理轨道运动至旋转装置的反应容器运动部件
US10449539B2 (en) * 2015-08-27 2019-10-22 Rushabh Instruments, Inc. Immuno histo chemistry tissue processing system and cartridge therefor
US11262356B2 (en) * 2015-12-28 2022-03-01 Phc Holdings Corporation Specimen analysis substrate, specimen analysis device, specimen analysis system, and program for specimen analysis system
TWI588486B (zh) * 2016-04-20 2017-06-21 光寶電子（廣州）有限公司 液體分析裝置
JP6479730B2 (ja) * 2016-06-30 2019-03-06 シスメックス株式会社 化学発光測定装置
US11480525B2 (en) 2016-06-30 2022-10-25 Sysmex Corporation Chemiluminescence measurement apparatus
CN107561299B (zh) 2016-06-30 2021-08-31 希森美康株式会社 检测装置以及检测方法
JP6457451B2 (ja) * 2016-06-30 2019-01-23 シスメックス株式会社 検出装置および検出方法
JP6421159B2 (ja) * 2016-10-28 2018-11-07 シスメックス株式会社 液体封止カートリッジおよび送液方法
KR101965963B1 (ko) * 2017-08-24 2019-08-13 경희대학교 산학협력단 시료 분석용 칩, 이를 포함하는 시료 분석용 디바이스, 그리고 시료 분석용 칩에 장착되는 카트리지
CA3107550A1 (en) * 2018-08-24 2020-02-27 Zoetis Services Llc Microfluidic rotor device
CN109799336B (zh) * 2019-02-20 2023-11-03 重庆科斯迈生物科技有限公司 磁微粒化学发光免疫分析仪暗箱检测系统
EP3993908B1 (en) * 2019-07-03 2023-11-15 Siemens Healthcare Diagnostics Inc. Rotary platform for cell lysing and purification and method of use
US11534766B2 (en) 2019-09-06 2022-12-27 Rushabh Instruments, Llc Immuno histo chemistry tissue processing system
JP7445403B2 (ja) 2019-09-27 2024-03-07 シスメックス株式会社 液体封止カートリッジおよび送液方法
CN114764185B (zh) * 2021-05-10 2023-12-15 锘海生物科学仪器(上海)有限公司 一种卡槽安装方式的废液池

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5061381A (en) * 1990-06-04 1991-10-29 Abaxis, Inc. Apparatus and method for separating cells from biological fluids
JP2005270747A (ja) * 2004-03-24 2005-10-06 Hitachi Industries Co Ltd マイクロ流体装置
TW201107038A (en) * 2009-08-25 2011-03-01 Ind Tech Res Inst Analytical system, analytical method and flow-path structure
CN102170971A (zh) * 2008-10-06 2011-08-31 皇家飞利浦电子股份有限公司 微流体装置

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5160702A (en) 1989-01-17 1992-11-03 Molecular Devices Corporation Analyzer with improved rotor structure
US5173193A (en) 1991-04-01 1992-12-22 Schembri Carol T Centrifugal rotor having flow partition
US5186844A (en) 1991-04-01 1993-02-16 Abaxis, Inc. Apparatus and method for continuous centrifugal blood cell separation
US5413732A (en) 1991-08-19 1995-05-09 Abaxis, Inc. Reagent compositions for analytical testing
US5304348A (en) 1992-02-11 1994-04-19 Abaxis, Inc. Reagent container for analytical rotor
AU4047493A (en) 1992-04-02 1993-11-08 Abaxis, Inc. Analytical rotor with dye mixing chamber
US5275016A (en) 1992-04-24 1994-01-04 Abaxis, Inc. Cryogenic apparatus
US5478750A (en) 1993-03-31 1995-12-26 Abaxis, Inc. Methods for photometric analysis
SE501380C2 (sv) 1993-06-15 1995-01-30 Pharmacia Lkb Biotech Sätt att tillverka mikrokanal/mikrokavitetsstrukturer
US5591643A (en) 1993-09-01 1997-01-07 Abaxis, Inc. Simplified inlet channels
US5409665A (en) 1993-09-01 1995-04-25 Abaxis, Inc. Simultaneous cuvette filling with means to isolate cuvettes
US5590052A (en) 1994-04-14 1996-12-31 Abaxis, Inc. Error checking in blood analyzer
GB9808836D0 (en) 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
DE69911802T2 (de) 1998-10-14 2004-07-29 Gyros Ab Form und verfahren zu deren herstellung
US7261859B2 (en) 1998-12-30 2007-08-28 Gyros Ab Microanalysis device
KR20020021810A (ko) 1999-08-11 2002-03-22 야마모토 카즈모토 분석용 카트리지 및 송액 제어 장치
SE9903011D0 (sv) 1999-08-26 1999-08-26 Aamic Ab Sätt att framställa en plastprodukt och ett härför utnyttjat plastproduktformande arrangemang
US6878255B1 (en) 1999-11-05 2005-04-12 Arrowhead Center, Inc. Microfluidic devices with thick-film electrochemical detection
US6884395B2 (en) 2000-05-12 2005-04-26 Gyros Ab Integrated microfluidic disc
SE0000300D0 (sv) 2000-01-30 2000-01-30 Amersham Pharm Biotech Ab Microfluidic assembly, covering method for the manufacture of the assembly and the use of the assembly
AU2002219979A1 (en) 2000-12-01 2002-06-11 Burstein Technologies, Inc. Apparatus and methods for separating components of particulate suspension
US7429354B2 (en) 2001-03-19 2008-09-30 Gyros Patent Ab Structural units that define fluidic functions
US6818415B2 (en) 2001-06-22 2004-11-16 Abaxis, Inc. Sodium activation of amylase
SE0104077D0 (sv) 2001-10-21 2001-12-05 Gyros Ab A method and instrumentation for micro dispensation of droplets
SE0103109D0 (sv) 2001-09-17 2001-09-17 Gyros Microlabs Ab Detector arrangement with rotary drive in an instrument for analysis of microscale liquid sample volumes
SE0103108D0 (sv) 2001-09-17 2001-09-17 Gyros Microlabs Ab Rotary drive in an instrument for analysis of microscale liquid sample volumes
US7189368B2 (en) 2001-09-17 2007-03-13 Gyros Patent Ab Functional unit enabling controlled flow in a microfluidic device
US7238255B2 (en) 2001-12-31 2007-07-03 Gyros Patent Ab Microfluidic device and its manufacture
US7177767B2 (en) 2002-10-18 2007-02-13 Abaxis, Inc. Systems and methods for the detection of short and long samples
US20050221281A1 (en) * 2003-01-08 2005-10-06 Ho Winston Z Self-contained microfluidic biochip and apparatus
SE0300823D0 (sv) 2003-03-23 2003-03-23 Gyros Ab Preloaded Microscale Devices
TW594007B (en) 2003-08-15 2004-06-21 Prec Instr Dev Ct Nat Biochemical detection device and method of magnetic fluid bead control combining digital fluid and electromagnetic field
US7273590B2 (en) 2004-04-29 2007-09-25 Industrial Technology Research Institute gravity-driven apparatus and method for control of microfluidic devices
EP1987362A2 (de) 2006-02-10 2008-11-05 Boehringer Ingelheim microParts GmbH Vorrichtung und verfahren zur behandlung oder aufreinigung von probenmaterial, insbesondere von nukleinsäuren
JP2009530606A (ja) 2006-03-13 2009-08-27 ギロス パテント アーべー 増強型磁気粒子ステアリング
TWI296713B (en) 2006-08-02 2008-05-11 Ind Tech Res Inst Magnetic beads-based sample separating device
US7951333B2 (en) 2006-09-05 2011-05-31 Samsung Electronics Co., Ltd. Centrifugal force-based microfluidic device for protein detection and microfluidic system including the same
KR101343034B1 (ko) 2006-09-05 2013-12-18 삼성전자 주식회사 원심력 기반의 단백질 검출용 미세유동 장치 및 이를포함하는 미세유동 시스템
KR100851980B1 (ko) 2006-09-05 2008-08-12 삼성전자주식회사 열 활성 유닛을 구비한 원심력 기반의 미세유동 장치, 이를포함하는 미세유동 시스템 및 상기 미세유동 시스템의구동방법
KR100846501B1 (ko) 2006-11-09 2008-07-17 삼성전자주식회사 밸브 유닛 및 이를 구비한 유체 처리 장치
KR101228112B1 (ko) 2006-12-06 2013-01-31 삼성전자주식회사 원심력과 펌프를 이용해 유체의 이동을 제어하는 미세유동장치 및 이를 포함하는 미세유동 시스템
KR101305976B1 (ko) 2007-02-12 2013-09-12 삼성전자주식회사 연속희석을 위한 원심력 기반의 미세유동장치 및 이를포함하는 미세유동시스템
KR20080084049A (ko) 2007-03-14 2008-09-19 삼성전자주식회사 펌프 유닛 및 이를 구비한 원심력 기반의 미세유동 시스템
KR100858091B1 (ko) 2007-04-24 2008-09-10 삼성전자주식회사 시료 분배 구조를 갖는 원심력 기반의 미세유동장치 및이를 포함하는 미세유동시스템
KR101258434B1 (ko) 2007-05-03 2013-05-02 삼성전자주식회사 미세유동 시스템 및,이의 제조방법
KR101228308B1 (ko) 2007-05-23 2013-01-31 삼성전자주식회사 미세유동 칩을 이용한 디스크형 미세유동장치 및 생체물질마이크로어레이 칩을 이용한 디스크형 미세유동장치
KR101335727B1 (ko) 2007-08-22 2013-12-04 삼성전자주식회사 원심력 기반의 혈액 검사용 디스크형 미세유동장치
KR101563687B1 (ko) 2008-09-02 2015-11-09 삼성전자주식회사 표적 분자 분리를 위한 미세유동 카트리지, 분리장치, 및 이를 이용한 표적 분자 분리 방법
US20100068735A1 (en) 2008-09-12 2010-03-18 Samsung Electronics Co., Ltd. Microfluidic device including unit for evaluating capture material and method of evaluating capture material
WO2010038952A2 (en) 2008-10-01 2010-04-08 Samsung Electronics Co., Ltd., Centrifugal-based microfluid apparatus, method of fabricationg the same, and method of testing samples using the microfluidic apparatus
EP2253958B1 (en) * 2009-05-18 2013-04-17 F. Hoffmann-La Roche AG Centrifugal force based microfluidic system and method for the automated analysis of samples
US20110085950A1 (en) 2009-10-08 2011-04-14 Samsung Electronics Co., Ltd. Centrifugal force based microfluidic system and bio cartridge for the microfluidic system
KR20110056168A (ko) 2009-11-20 2011-05-26 삼성전자주식회사 미세유동장치, 광조사장치 및 이를 포함하는 미세유동시스템과 그 구동방법

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5061381A (en) * 1990-06-04 1991-10-29 Abaxis, Inc. Apparatus and method for separating cells from biological fluids
JP2005270747A (ja) * 2004-03-24 2005-10-06 Hitachi Industries Co Ltd マイクロ流体装置
CN102170971A (zh) * 2008-10-06 2011-08-31 皇家飞利浦电子股份有限公司 微流体装置
TW201107038A (en) * 2009-08-25 2011-03-01 Ind Tech Res Inst Analytical system, analytical method and flow-path structure

Also Published As

Publication number Publication date
US8703070B1 (en) 2014-04-22
TW201344193A (zh) 2013-11-01

Similar Documents

Publication Publication Date Title
TWI456196B (zh) 檢體免疫分析檢測裝置
US11097271B2 (en) Actuated microfluidic structures for directed flow in a microfluidic device and methods of use thereof
ES2829224T3 (es) Cartucho para distribuir un líquido
ES2649559T3 (es) Método y aparato para realizar ensayos
ES2870529T3 (es) Aparato que usa un agente anti-adsorción para facilitar la mezcla y el análisis de muestras
ES2908883T3 (es) Métodos para el análisis de muestras
US20170001194A1 (en) Microfluidic device, system, and method
WO2015113047A3 (en) Discontinuous fluidic systems for point-of-care analyte measurement
US9975117B2 (en) Apparatus and method for controlling droplet
Oskooei et al. Bubble gate for in-plane flow control
JPWO2017069256A1 (ja) ナノ流体デバイス及び化学分析装置
US10907748B2 (en) Flow path switching valve and manufacturing method therefor
US8777179B2 (en) Drive mechanism for the movement of an object along an axis of motion and micro-valve
TWI513508B (zh) 微流體檢測裝置
US8079278B2 (en) End effector for nano manufacturing
JP2009270716A (ja) 空気圧式直線グリッパー
JP7217228B2 (ja) 磁石アセンブリとその移動駆動部との間に非物理的なカップリングを有する磁気分離装置
JP2010044006A (ja) マイクロ分注装置
TWI457566B (zh) 檢測裝置
WO2017213129A1 (ja) 流体デバイス
KR102075037B1 (ko) 유체 제어 장치 및 유체 제어 방법
TWI696834B (zh) 微流體檢測單元及流體檢測方法
US20230294093A1 (en) Digital microfluidics cartridge device and system
JP2010210345A (ja) 検査治具
TWI320879B (en) Fluid manipulation method and system, fluid device, and actuation device