EP1088229A4 - High throughput methods, systems and apparatus for performing cell based screening assays - Google Patents

High throughput methods, systems and apparatus for performing cell based screening assays

Info

Publication number
EP1088229A4
EP1088229A4 EP19990933529 EP99933529A EP1088229A4 EP 1088229 A4 EP1088229 A4 EP 1088229A4 EP 19990933529 EP19990933529 EP 19990933529 EP 99933529 A EP99933529 A EP 99933529A EP 1088229 A4 EP1088229 A4 EP 1088229A4
Authority
EP
Grant status
Application
Patent type
Prior art keywords
based
throughput
assays
methods
screening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19990933529
Other languages
German (de)
French (fr)
Other versions
EP1088229A1 (en )
Inventor
H Garrett Wada
Steven A Sundberg
Marja Liisa Alajoki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Caliper Life Sciences Inc
Original Assignee
Caliper Life Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • G01N33/56972White blood cells
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
EP19990933529 1998-06-25 1999-06-21 High throughput methods, systems and apparatus for performing cell based screening assays Withdrawn EP1088229A4 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US10451998 true 1998-06-25 1998-06-25
US104519 1998-06-25
US11737099 true 1999-01-27 1999-01-27
US117370P 1999-01-27
PCT/US1999/013918 WO1999067639A1 (en) 1998-06-25 1999-06-21 High throughput methods, systems and apparatus for performing cell based screening assays

Publications (2)

Publication Number Publication Date
EP1088229A1 true EP1088229A1 (en) 2001-04-04
EP1088229A4 true true EP1088229A4 (en) 2002-05-08

Family

ID=26801647

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19990933529 Withdrawn EP1088229A4 (en) 1998-06-25 1999-06-21 High throughput methods, systems and apparatus for performing cell based screening assays

Country Status (2)

Country Link
EP (1) EP1088229A4 (en)
WO (1) WO1999067639A1 (en)

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US7883872B2 (en) 1996-10-10 2011-02-08 Dyadic International (Usa), Inc. Construction of highly efficient cellulase compositions for enzymatic hydrolysis of cellulose
EP1117808B1 (en) 1998-10-06 2004-12-29 Mark Aaron Emalfarb Transformation system in the field of filamentous fungal hosts: in chrysosporium
US6800437B1 (en) 1999-08-06 2004-10-05 Tibotec Bvba Method of monitoring a biological system by labeling with an apo metal binding protein
US6589729B2 (en) 2000-02-04 2003-07-08 Caliper Technologies Corp. Methods, devices, and systems for monitoring time dependent reactions
WO2001057509A1 (en) * 2000-02-04 2001-08-09 Caliper Technologies Corp. Methods, devices, and systems for monitoring time dependent reactions
US6734420B2 (en) * 2000-04-06 2004-05-11 Quantum Dot Corporation Differentiable spectral bar code methods and systems
JP2003532871A (en) * 2000-04-14 2003-11-05 カリパー・テクノロジーズ・コープ. Screening assays and systems using target Pooling
US7087375B1 (en) 2000-06-23 2006-08-08 Johan Lennerstrand Method for determining the mechanism of HIV RT inhibitors
US6734401B2 (en) 2000-06-28 2004-05-11 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
US6627159B1 (en) 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
US6720187B2 (en) 2000-06-28 2004-04-13 3M Innovative Properties Company Multi-format sample processing devices
US6770434B2 (en) * 2000-12-29 2004-08-03 The Provost, Fellows And Scholars Of The College Of The Holy & Undivided Trinity Of Queen Elizabeth Near Dublin Biological assay method
WO2002083852A3 (en) * 2001-04-10 2004-02-19 Bioprocessors Corp Microfermentor device and cell based screening method
US20020189947A1 (en) * 2001-06-13 2002-12-19 Eksigent Technologies Llp Electroosmotic flow controller
US6889468B2 (en) 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
GB0215879D0 (en) * 2002-07-09 2002-08-14 Univ Cambridge Tech Monitoring of cells
US7332129B2 (en) 2003-01-09 2008-02-19 3M Innovative Properties Company Sample processing device having process chambers with bypass slots
US7763210B2 (en) 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
US7323660B2 (en) 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
US7708873B2 (en) * 2006-02-02 2010-05-04 Massachusetts Institute Of Technology Induced-charge electro-osmotic microfluidic devices
WO2008073914A3 (en) 2006-12-10 2008-10-30 Dyadic Internat Inc Expression and high-throughput screening of complex expressed dna libraries in filamentous fungi
CA2736661A1 (en) 2007-09-07 2009-03-12 Dyadic International, Inc. Novel fungal enzymes
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
EP2709761A1 (en) 2011-05-18 2014-03-26 3M Innovative Properties Company Systems and methods for volumetric metering on a sample processing device
JP2014517291A (en) 2011-05-18 2014-07-17 スリーエム イノベイティブ プロパティズ カンパニー System and method for valve operation of the sample processing device
JP6235462B2 (en) 2011-05-18 2017-11-22 スリーエム イノベイティブ プロパティズ カンパニー System and method for detecting the presence of a selected volume of the material in the sample processing device
US9423234B2 (en) 2012-11-05 2016-08-23 The Regents Of The University Of California Mechanical phenotyping of single cells: high throughput quantitative detection and sorting

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0815940A2 (en) * 1996-06-28 1998-01-07 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
WO1998000231A1 (en) * 1996-06-28 1998-01-08 Caliper Technologies Corporation High-throughput screening assay systems in microscale fluidic devices
WO1998004909A1 (en) * 1996-07-30 1998-02-05 Aclara Biosciences, Inc. Integrated microfluidic devices
WO1998038490A1 (en) * 1997-02-27 1998-09-03 Cellomics, Inc. A system for cell-based screening
WO1998045481A1 (en) * 1997-04-04 1998-10-15 Caliper Technologies Corporation Closed-loop biochemical analyzers
WO2000070353A2 (en) * 1999-05-13 2000-11-23 Caliper Technologies Corp. High throughput assay systems and methods

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US4345027A (en) * 1980-12-12 1982-08-17 The United States Of America As Represented By The United States Department Of Energy Fluorometric method of quantitative cell mutagenesis
US5164598A (en) * 1985-08-05 1992-11-17 Biotrack Capillary flow device
US5225326A (en) * 1988-08-31 1993-07-06 Research Development Foundation One step in situ hybridization assay
US5460945A (en) * 1991-05-30 1995-10-24 Center For Blood Research, Inc. Device and method for analysis of blood components and identifying inhibitors and promoters of the inflammatory response
US5637469A (en) * 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5843640A (en) * 1992-06-19 1998-12-01 Northwestern University Method of simultaneously detecting amplified nucleic acid sequences and cellular antigens in cells
US5629147A (en) * 1992-07-17 1997-05-13 Aprogenex, Inc. Enriching and identifying fetal cells in maternal blood for in situ hybridization
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
JP2000508923A (en) * 1996-04-26 2000-07-18 マサチューセッツ・インスティテュート・オブ・テクノロジー 3-hybrid screening assay
US5795726A (en) * 1996-11-12 1998-08-18 Millennium Pharmaceuticals, Inc. Methods for identifying compounds useful in treating type II diabetes
US5885470A (en) * 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
US5891720A (en) * 1997-04-17 1999-04-06 Millennium Pharmaceuticals, Inc. Isolated DNA encoding a novel human G-protein coupled receptor
CA2293254A1 (en) * 1997-06-13 1998-12-23 Maxxam Biodiscoveries Inc. Assay methods and compositions useful for measuring receptor ligand binding

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0815940A2 (en) * 1996-06-28 1998-01-07 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
WO1998000231A1 (en) * 1996-06-28 1998-01-08 Caliper Technologies Corporation High-throughput screening assay systems in microscale fluidic devices
WO1998004909A1 (en) * 1996-07-30 1998-02-05 Aclara Biosciences, Inc. Integrated microfluidic devices
WO1998038490A1 (en) * 1997-02-27 1998-09-03 Cellomics, Inc. A system for cell-based screening
WO1998045481A1 (en) * 1997-04-04 1998-10-15 Caliper Technologies Corporation Closed-loop biochemical analyzers
WO2000070353A2 (en) * 1999-05-13 2000-11-23 Caliper Technologies Corp. High throughput assay systems and methods

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CLIFF HENKE, ANNE R. KOPF-SILL: "DNA-chip technologies; Part 2: State-of-the-Art and competing technologies", IVD TECHHNOLOGY MAGAZINE, - 1 November 1998 (1998-11-01), pages 1 - 13, XP002152828 *
See also references of WO9967639A1 *

Also Published As

Publication number Publication date Type
EP1088229A1 (en) 2001-04-04 application
WO1999067639A1 (en) 1999-12-29 application

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Effective date: 20040423