DE60127846T2 - Tricyclic antitumor komponenten als farnesyl protein transferase inhibitoren - Google Patents
Tricyclic antitumor komponenten als farnesyl protein transferase inhibitoren Download PDFInfo
- Publication number
- DE60127846T2 DE60127846T2 DE60127846T DE60127846T DE60127846T2 DE 60127846 T2 DE60127846 T2 DE 60127846T2 DE 60127846 T DE60127846 T DE 60127846T DE 60127846 T DE60127846 T DE 60127846T DE 60127846 T2 DE60127846 T2 DE 60127846T2
- Authority
- DE
- Germany
- Prior art keywords
- substituted
- compound
- alkyl
- mmol
- give
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CC(*)Nc1cnc[n]1 Chemical compound CC(*)Nc1cnc[n]1 0.000 description 43
- FLHXHSKTABNPDY-UHFFFAOYSA-N CN(CC1)CCC1C1c2ccccc2C(Br)=Cc2ccccc12 Chemical compound CN(CC1)CCC1C1c2ccccc2C(Br)=Cc2ccccc12 FLHXHSKTABNPDY-UHFFFAOYSA-N 0.000 description 2
- FZVBHRRTRHNMJY-UHFFFAOYSA-N Cc1c(C)nc[n]1CCCC(c1c(C2C3CCNCC3)ccc(Cl)c1)=Cc1c2nccc1 Chemical compound Cc1c(C)nc[n]1CCCC(c1c(C2C3CCNCC3)ccc(Cl)c1)=Cc1c2nccc1 FZVBHRRTRHNMJY-UHFFFAOYSA-N 0.000 description 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N C1CCNCC1 Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 1
- HYTQIJWXBOJSLE-IGTJQSIKSA-O CC#C/C=C\C=[NH+]\OC Chemical compound CC#C/C=C\C=[NH+]\OC HYTQIJWXBOJSLE-IGTJQSIKSA-O 0.000 description 1
- LMGQEJPTROIWAP-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCC1C(c(ccc(Cl)c1)c1C(CCCC1C=NC(C)=CC1)=C1)C2=C1C#CC=C=C2)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1C(c(ccc(Cl)c1)c1C(CCCC1C=NC(C)=CC1)=C1)C2=C1C#CC=C=C2)=O LMGQEJPTROIWAP-UHFFFAOYSA-N 0.000 description 1
- ABFHRRJGVMYFFM-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCC1C1c2ccccc2C(C=C)=Cc2ccccc12)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1C1c2ccccc2C(C=C)=Cc2ccccc12)=O ABFHRRJGVMYFFM-UHFFFAOYSA-N 0.000 description 1
- WRUSGHNLOFJSCT-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCC1C1c2ncccc2C(CCC[n]2cncc2)=Cc2cc(Cl)ccc12)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1C1c2ncccc2C(CCC[n]2cncc2)=Cc2cc(Cl)ccc12)=O WRUSGHNLOFJSCT-UHFFFAOYSA-N 0.000 description 1
- BSHCLIGDTSJICO-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCC1C1c2ncccc2C=C(C(O)=O)c2cc(Cl)ccc12)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1C1c2ncccc2C=C(C(O)=O)c2cc(Cl)ccc12)=O BSHCLIGDTSJICO-UHFFFAOYSA-N 0.000 description 1
- CWKFIFUBSRMNFP-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCC1C1c2ncccc2C=C(CCC[n]2cnc(C)c2)c2cc(Cl)ccc12)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1C1c2ncccc2C=C(CCC[n]2cnc(C)c2)c2cc(Cl)ccc12)=O CWKFIFUBSRMNFP-UHFFFAOYSA-N 0.000 description 1
- AGCPTPYYYCOTOZ-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCC1C1c2ncccc2C=C(COS(C)(=O)=O)c2cc(Cl)ccc12)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1C1c2ncccc2C=C(COS(C)(=O)=O)c2cc(Cl)ccc12)=O AGCPTPYYYCOTOZ-UHFFFAOYSA-N 0.000 description 1
- GISKBRJTOXVUTD-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCN1C(c1ccccc1C(C(O)=O)=Cc1c2)c1ncc2Br)=O Chemical compound CC(C)(C)OC(N(CC1)CCN1C(c1ccccc1C(C(O)=O)=Cc1c2)c1ncc2Br)=O GISKBRJTOXVUTD-UHFFFAOYSA-N 0.000 description 1
- ZRXGTMAFNONIFJ-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCN1C(c1ccccc1C=C(C(O)=O)c1c2)c1ncc2Br)=O Chemical compound CC(C)(C)OC(N(CC1)CCN1C(c1ccccc1C=C(C(O)=O)c1c2)c1ncc2Br)=O ZRXGTMAFNONIFJ-UHFFFAOYSA-N 0.000 description 1
- GICHVHNIQFUZRI-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCN1C(c1ccccc1C=C(CO)c1c2)c1ncc2Br)=O Chemical compound CC(C)(C)OC(N(CC1)CCN1C(c1ccccc1C=C(CO)c1c2)c1ncc2Br)=O GICHVHNIQFUZRI-UHFFFAOYSA-N 0.000 description 1
- GDPDJFBLENQQRP-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCN1C1c(nccc2)c2C=C(Cc2cnc[n]2C)c2c1ccc(Cl)c2)=O Chemical compound CC(C)(C)OC(N(CC1)CCN1C1c(nccc2)c2C=C(Cc2cnc[n]2C)c2c1ccc(Cl)c2)=O GDPDJFBLENQQRP-UHFFFAOYSA-N 0.000 description 1
- MNWWNXWZHQEYKR-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCN1C1c2ncccc2C=C(CBr)c2cc(Cl)ccc12)=O Chemical compound CC(C)(C)OC(N(CC1)CCN1C1c2ncccc2C=C(CBr)c2cc(Cl)ccc12)=O MNWWNXWZHQEYKR-UHFFFAOYSA-N 0.000 description 1
- FHDGXULNXYKVCQ-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCN1C1c2ncccc2C=C(COS(C)(=O)=O)c2cc(Cl)ccc12)=O Chemical compound CC(C)(C)OC(N(CC1)CCN1C1c2ncccc2C=C(COS(C)(=O)=O)c2cc(Cl)ccc12)=O FHDGXULNXYKVCQ-UHFFFAOYSA-N 0.000 description 1
- OJCLHERKFHHUTB-VIFPVBQESA-N CC(C)(C)OC(N1C[C@@H](CO)CCC1)=O Chemical compound CC(C)(C)OC(N1C[C@@H](CO)CCC1)=O OJCLHERKFHHUTB-VIFPVBQESA-N 0.000 description 1
- DMGPVORHOIVYLQ-UHFFFAOYSA-N CC(C)NC(CCCCl)=O Chemical compound CC(C)NC(CCCCl)=O DMGPVORHOIVYLQ-UHFFFAOYSA-N 0.000 description 1
- WLSJWLBGYYDHKE-UHFFFAOYSA-N CCC(C(c1ccccc1)N(CC1)CCN1C(OC(C)(C)C)=O)=N Chemical compound CCC(C(c1ccccc1)N(CC1)CCN1C(OC(C)(C)C)=O)=N WLSJWLBGYYDHKE-UHFFFAOYSA-N 0.000 description 1
- JEQNHRNCYDIAEY-UHFFFAOYSA-N CCC(C)(CC(C)(C)C)[n]1cncc1 Chemical compound CCC(C)(CC(C)(C)C)[n]1cncc1 JEQNHRNCYDIAEY-UHFFFAOYSA-N 0.000 description 1
- PZVFQOBASICMME-UHFFFAOYSA-N CCNS(C)(=O)=O Chemical compound CCNS(C)(=O)=O PZVFQOBASICMME-UHFFFAOYSA-N 0.000 description 1
- SIPSCQWLZZEZOA-UHFFFAOYSA-N CCOC(C(c1cc(Br)cnc1C1C2CCNCC2)=Cc2c1ccc(Cl)c2)=O Chemical compound CCOC(C(c1cc(Br)cnc1C1C2CCNCC2)=Cc2c1ccc(Cl)c2)=O SIPSCQWLZZEZOA-UHFFFAOYSA-N 0.000 description 1
- IHSUFLCKRIHFGY-UHFFFAOYSA-N CCOC(CC1CCNCC1)=O Chemical compound CCOC(CC1CCNCC1)=O IHSUFLCKRIHFGY-UHFFFAOYSA-N 0.000 description 1
- NJQHZENQKNIRSY-UHFFFAOYSA-N CCc1c[nH]cn1 Chemical compound CCc1c[nH]cn1 NJQHZENQKNIRSY-UHFFFAOYSA-N 0.000 description 1
- PVOAHINGSUIXLS-UHFFFAOYSA-N CN1CCNCC1 Chemical compound CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 description 1
- UZPUVQBDELWKOP-UHFFFAOYSA-N COC(C(c1c2)=Cc3cccnc3C(C3CCNCC3)c1ccc2Cl)=O Chemical compound COC(C(c1c2)=Cc3cccnc3C(C3CCNCC3)c1ccc2Cl)=O UZPUVQBDELWKOP-UHFFFAOYSA-N 0.000 description 1
- APUJVOCZJKISSC-UHFFFAOYSA-N CS(N(CC1)CCC1C1c2ncccc2C(CCCN(CCC2)C2=O)=Cc2cc(Cl)ccc12)(=O)=O Chemical compound CS(N(CC1)CCC1C1c2ncccc2C(CCCN(CCC2)C2=O)=Cc2cc(Cl)ccc12)(=O)=O APUJVOCZJKISSC-UHFFFAOYSA-N 0.000 description 1
- YYFUPDPDJCPQAN-UHFFFAOYSA-N CS(N(CC1)CCC1C1c2ncccc2C(CI)=Cc2cc(Cl)ccc12)(=O)=O Chemical compound CS(N(CC1)CCC1C1c2ncccc2C(CI)=Cc2cc(Cl)ccc12)(=O)=O YYFUPDPDJCPQAN-UHFFFAOYSA-N 0.000 description 1
- MISIFKLJDQPYTI-UHFFFAOYSA-N Cc(c(C=C)c1)ccc1Cl Chemical compound Cc(c(C=C)c1)ccc1Cl MISIFKLJDQPYTI-UHFFFAOYSA-N 0.000 description 1
- FXDRWCPBGYJWRL-ONEGZZNKSA-N Cc1ncc[n]1C/C=C/C1=Cc2cc(Cl)ccc2C(C2CCNCC2)c2ncccc12 Chemical compound Cc1ncc[n]1C/C=C/C1=Cc2cc(Cl)ccc2C(C2CCNCC2)c2ncccc12 FXDRWCPBGYJWRL-ONEGZZNKSA-N 0.000 description 1
- YWMQUUJHWXWOKF-UHFFFAOYSA-N Cc1ncc[n]1CC(C1=C2NCC(Br)=C1)=Cc1ccccc1C2N(CC1)CCN1C(Nc(cc1)ccc1C#N)=O Chemical compound Cc1ncc[n]1CC(C1=C2NCC(Br)=C1)=Cc1ccccc1C2N(CC1)CCN1C(Nc(cc1)ccc1C#N)=O YWMQUUJHWXWOKF-UHFFFAOYSA-N 0.000 description 1
- QBZDCOANGJIRPP-UHFFFAOYSA-N Cc1ncc[n]1CC(c1cc(Br)cnc11)=Cc2cc(Cl)ccc2C1N(CC1)CCN1C(Nc(cc1)ccc1O)=O Chemical compound Cc1ncc[n]1CC(c1cc(Br)cnc11)=Cc2cc(Cl)ccc2C1N(CC1)CCN1C(Nc(cc1)ccc1O)=O QBZDCOANGJIRPP-UHFFFAOYSA-N 0.000 description 1
- DXBSRBPBKURCAB-UHFFFAOYSA-N Cc1ncc[n]1CC(c1cc(Cl)cnc11)=Cc2ccccc2C1N(CC1)CCN1C(Nc(cc1)ccc1C#N)=O Chemical compound Cc1ncc[n]1CC(c1cc(Cl)cnc11)=Cc2ccccc2C1N(CC1)CCN1C(Nc(cc1)ccc1C#N)=O DXBSRBPBKURCAB-UHFFFAOYSA-N 0.000 description 1
- GOPDSGRNPORGCE-UHFFFAOYSA-N Cc1ncc[n]1CC1=Cc2ccccc2C(C2CCNCC2)c2ccccc12 Chemical compound Cc1ncc[n]1CC1=Cc2ccccc2C(C2CCNCC2)c2ccccc12 GOPDSGRNPORGCE-UHFFFAOYSA-N 0.000 description 1
- AUELWJRRASQDKI-UHFFFAOYSA-N NC(OC1CCCCC1)=O Chemical compound NC(OC1CCCCC1)=O AUELWJRRASQDKI-UHFFFAOYSA-N 0.000 description 1
- BSKDLJZSLLXZOE-UHFFFAOYSA-N O=C(Cc1ccncc1)OCCl Chemical compound O=C(Cc1ccncc1)OCCl BSKDLJZSLLXZOE-UHFFFAOYSA-N 0.000 description 1
- YMHMOEJBUFBBCZ-UHFFFAOYSA-N O=C1c2ncccc2C(Br)=Cc2cc(Cl)ccc12 Chemical compound O=C1c2ncccc2C(Br)=Cc2cc(Cl)ccc12 YMHMOEJBUFBBCZ-UHFFFAOYSA-N 0.000 description 1
- ZQEXIXXJFSQPNA-UHFFFAOYSA-N O=Cc1c[nH]cn1 Chemical compound O=Cc1c[nH]cn1 ZQEXIXXJFSQPNA-UHFFFAOYSA-N 0.000 description 1
- ZGWLIGZALJYZHU-UHFFFAOYSA-N OC1c2ccccc2C(Br)=Cc2ccccc12 Chemical compound OC1c2ccccc2C(Br)=Cc2ccccc12 ZGWLIGZALJYZHU-UHFFFAOYSA-N 0.000 description 1
- ISFHVRIHILJZLI-UHFFFAOYSA-N OCC(c1cc(Br)cnc1C1C2CCNCC2)=Cc2c1ccc(Cl)c2 Chemical compound OCC(c1cc(Br)cnc1C1C2CCNCC2)=Cc2c1ccc(Cl)c2 ISFHVRIHILJZLI-UHFFFAOYSA-N 0.000 description 1
- VUNPWIPIOOMCPT-UHFFFAOYSA-N OCC1CNCCC1 Chemical compound OCC1CNCCC1 VUNPWIPIOOMCPT-UHFFFAOYSA-N 0.000 description 1
- VUNPWIPIOOMCPT-LURJTMIESA-N OC[C@@H]1CNCCC1 Chemical compound OC[C@@H]1CNCCC1 VUNPWIPIOOMCPT-LURJTMIESA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22918300P | 2000-08-30 | 2000-08-30 | |
| US229183P | 2000-08-30 | ||
| PCT/US2001/026792 WO2002018368A1 (en) | 2000-08-30 | 2001-08-28 | Tricyclic antitumor compounds being farnesyl protein transferase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60127846D1 DE60127846D1 (en) | 2007-05-24 |
| DE60127846T2 true DE60127846T2 (de) | 2008-03-06 |
Family
ID=22860141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60127846T Expired - Fee Related DE60127846T2 (de) | 2000-08-30 | 2001-08-28 | Tricyclic antitumor komponenten als farnesyl protein transferase inhibitoren |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US20020198216A1 (https=) |
| EP (1) | EP1313725B1 (https=) |
| JP (1) | JP2004513885A (https=) |
| KR (1) | KR20030034161A (https=) |
| CN (1) | CN100384837C (https=) |
| AR (1) | AR033680A1 (https=) |
| AT (1) | ATE359281T1 (https=) |
| AU (2) | AU2001288451C1 (https=) |
| BR (1) | BR0113675A (https=) |
| CA (1) | CA2420673A1 (https=) |
| CO (1) | CO5640109A2 (https=) |
| DE (1) | DE60127846T2 (https=) |
| EC (1) | ECSP034494A (https=) |
| ES (1) | ES2284686T3 (https=) |
| HK (1) | HK1054548B (https=) |
| HU (1) | HUP0302942A3 (https=) |
| IL (1) | IL154528A0 (https=) |
| MX (1) | MXPA03001849A (https=) |
| NO (1) | NO20030918L (https=) |
| NZ (1) | NZ524246A (https=) |
| PE (1) | PE20020486A1 (https=) |
| PL (1) | PL361103A1 (https=) |
| RU (1) | RU2293734C9 (https=) |
| SK (1) | SK2292003A3 (https=) |
| TW (1) | TWI268280B (https=) |
| WO (1) | WO2002018368A1 (https=) |
| ZA (1) | ZA200301545B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7342016B2 (en) | 2000-08-30 | 2008-03-11 | Schering Corporation | Farnesyl protein transferase inhibitors as antitumor agents |
| WO2002072085A1 (en) | 2001-03-14 | 2002-09-19 | Bristol-Myers Squibb Company | Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases |
| WO2003030908A2 (en) * | 2001-10-09 | 2003-04-17 | The University Of Cincinnati | Inhibitors of the egf receptor for the treatment of thyroid cancer |
| WO2003047697A2 (en) * | 2001-11-30 | 2003-06-12 | Schering Corporation | Use of an farsenyl protein tranferase inhibitor in combination with other antineoplastic agents for the manufacture of a medicament against cancer |
| AU2002346644A1 (en) * | 2001-12-03 | 2003-06-17 | Schering Corporation | Use of fpt inhibitors and at least two antineoplastic agents in the treatment of cancer |
| US20030195192A1 (en) * | 2002-04-05 | 2003-10-16 | Fortuna Haviv | Nicotinamides having antiangiogenic activity |
| US20040014744A1 (en) * | 2002-04-05 | 2004-01-22 | Fortuna Haviv | Substituted pyridines having antiangiogenic activity |
| WO2004094409A1 (en) | 2003-03-27 | 2004-11-04 | Lankenau Institute For Medical Research | Novel ido inhibitors and methods of use |
| CA2525987A1 (en) * | 2003-06-05 | 2005-01-06 | Charles Achkar | Methods of treating hyperproliferative cell disorders |
| CN1972712A (zh) * | 2003-06-09 | 2007-05-30 | 塞缪尔·瓦克萨尔 | 用胞外拮抗物和胞内拮抗物抑制受体酪氨酸激酶的方法 |
| ES2235611B2 (es) * | 2003-07-25 | 2006-07-16 | Universidade De Santiago De Compostela | Metodo cuantitativo para la deteccion de yesotoxinas en productos pesqueros basado en la activacion que producen en las fosfodiesterasas. |
| ES2317047T3 (es) | 2003-08-07 | 2009-04-16 | Schering Corporation | Nuevos inhibidores de la farnesil proteina transferasa como agentes antitumorales. |
| US7592466B2 (en) | 2003-10-09 | 2009-09-22 | Abbott Laboratories | Ureas having antiangiogenic activity |
| MX2007007611A (es) * | 2004-12-21 | 2007-09-04 | Schering Corp | Nuevos inhibidores de la farnesil protein-transferasa como agentes antitumorales. |
| RU2361587C1 (ru) * | 2008-02-14 | 2009-07-20 | Михаил Владимирович Кутушов | Лекарственное средство для лечения онкологических заболеваний |
| WO2010006432A1 (en) * | 2008-07-14 | 2010-01-21 | Queen's University At Kingston | Pharmaceutical compositions comprising ret inhibitors and methods for the treatment of cancer |
| US20220257540A1 (en) * | 2019-06-28 | 2022-08-18 | Anhui Ronghang Biotech Development Co., Ltd. | Compositions and methods for treatment of hepatitis b virus infection |
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| US5089496A (en) * | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
| IE68935B1 (en) * | 1990-06-22 | 1996-07-24 | Schering Corp | Bis-benzo or benzopyrido cyclohepta piperidene piperidylidene and piperazine compounds compositions and methods of use |
| US5719148A (en) * | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| PE92098A1 (es) * | 1996-07-31 | 1998-12-31 | Schering Corp | N-cianoiminas triciclicas utiles como inhibidores de transferasa de proteina farnesilo |
| US6071907A (en) * | 1996-09-13 | 2000-06-06 | Schering Corporation | Tricyclic compounds useful as FPT inhibitors |
| US5925648A (en) * | 1997-07-29 | 1999-07-20 | Schering Corporation | Tricyclic N-cyanoimines useful as inhibitors of a farnesyl-protein transferase |
| TR200101754T2 (tr) * | 1998-12-18 | 2002-05-21 | Schering Corporation | Farnezil protein transferaz inhibitörleri |
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