NO20030918L - Trisykliske antitumorforbindelser som er farnesylproteintransferaseinhibitorer - Google Patents

Trisykliske antitumorforbindelser som er farnesylproteintransferaseinhibitorer

Info

Publication number
NO20030918L
NO20030918L NO20030918A NO20030918A NO20030918L NO 20030918 L NO20030918 L NO 20030918L NO 20030918 A NO20030918 A NO 20030918A NO 20030918 A NO20030918 A NO 20030918A NO 20030918 L NO20030918 L NO 20030918L
Authority
NO
Norway
Prior art keywords
protein transferase
transferase inhibitors
farnesyl protein
antitumor compounds
tricyclic
Prior art date
Application number
NO20030918A
Other languages
English (en)
Other versions
NO20030918D0 (no
Inventor
F George Njoroge
Bancha Vibulbhan
Alan Bruce Cooper
Timothy Guzi
Dinanath F Rane
Keith P Minor
Ronald J Doll
Viyyoor Moopil Girijavallabhan
Bama Santhanam
Patrick A Pinto
Hugh Y Zhu
Kartik M Keertikar
Carmen S Alvarez
Walter Robert Bishop
James J S Wang
Jagdish A Desai
John J Baldwin
Ge Li
Chia-Yu Huang
Ray A James
Original Assignee
Pharmacopeia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacopeia Inc filed Critical Pharmacopeia Inc
Publication of NO20030918D0 publication Critical patent/NO20030918D0/no
Publication of NO20030918L publication Critical patent/NO20030918L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20030918A 2000-08-30 2003-02-27 Trisykliske antitumorforbindelser som er farnesylproteintransferaseinhibitorer NO20030918L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22918300P 2000-08-30 2000-08-30
PCT/US2001/026792 WO2002018368A1 (en) 2000-08-30 2001-08-28 Tricyclic antitumor compounds being farnesyl protein transferase inhibitors

Publications (2)

Publication Number Publication Date
NO20030918D0 NO20030918D0 (no) 2003-02-27
NO20030918L true NO20030918L (no) 2003-04-29

Family

ID=22860141

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20030918A NO20030918L (no) 2000-08-30 2003-02-27 Trisykliske antitumorforbindelser som er farnesylproteintransferaseinhibitorer

Country Status (27)

Country Link
US (1) US20020198216A1 (no)
EP (1) EP1313725B1 (no)
JP (1) JP2004513885A (no)
KR (1) KR20030034161A (no)
CN (1) CN100384837C (no)
AR (1) AR033680A1 (no)
AT (1) ATE359281T1 (no)
AU (2) AU8845101A (no)
BR (1) BR0113675A (no)
CA (1) CA2420673A1 (no)
CO (1) CO5640109A2 (no)
DE (1) DE60127846T2 (no)
EC (1) ECSP034494A (no)
ES (1) ES2284686T3 (no)
HK (1) HK1054548B (no)
HU (1) HUP0302942A3 (no)
IL (1) IL154528A0 (no)
MX (1) MXPA03001849A (no)
NO (1) NO20030918L (no)
NZ (1) NZ524246A (no)
PE (1) PE20020486A1 (no)
PL (1) PL361103A1 (no)
RU (1) RU2293734C9 (no)
SK (1) SK2292003A3 (no)
TW (1) TWI268280B (no)
WO (1) WO2002018368A1 (no)
ZA (1) ZA200301545B (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
EE05417B1 (et) * 2001-03-14 2011-06-15 Bristol-Myers Squibb Company Epotilooni analoogide ja kemoterapeutikumide kombinatsiooni kasutamine teraapias
US20040191254A1 (en) * 2001-10-09 2004-09-30 Fagin James Alexander Method of treatment of thyroid cancer
NZ532562A (en) * 2001-11-30 2007-02-23 Schering Corp Use of an FPT inhibitor in combination with other antineoplastic agents for the manufacture of a medicament to be used in the treatment of cancer
US20040006087A1 (en) * 2001-12-03 2004-01-08 Schering Corporation Method of treating cancer using FPT inhibitors and antineoplastic agents
US20030195192A1 (en) * 2002-04-05 2003-10-16 Fortuna Haviv Nicotinamides having antiangiogenic activity
US20040014744A1 (en) * 2002-04-05 2004-01-22 Fortuna Haviv Substituted pyridines having antiangiogenic activity
EP2260846B1 (en) 2003-03-27 2018-11-28 Lankenau Institute for Medical Research Novel methods for the treatment of cancer
WO2005000230A2 (en) * 2003-06-05 2005-01-06 Charles Achkar Methods of treating hyperproliferative cell disorders
JP2007500248A (ja) * 2003-06-09 2007-01-11 ワクサル，サムエル 細胞外アンタゴニストおよび細胞内アンタゴニストによる受容体チロシンキナーゼの抑制方法
TW200510384A (en) * 2003-08-07 2005-03-16 Schering Corp Novel farnesyl protein transferase inhibitors as antitumor agents
US7592466B2 (en) 2003-10-09 2009-09-22 Abbott Laboratories Ureas having antiangiogenic activity
CA2591705A1 (en) * 2004-12-21 2006-06-29 Schering Corporation Novel farnesyl protein transferase inhibitors as antitumor agents
EP2313091A4 (en) * 2008-07-14 2012-04-04 Univ Kingston PHARMACEUTICAL COMPOSITIONS WITH RET-HEMMERN AND METHOD FOR THE TREATMENT OF CANCER
CN114025751A (zh) * 2019-06-28 2022-02-08 安徽荣航生物科技发展有限责任公司 用于治疗乙型肝炎病毒感染的组合物和方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
PE92098A1 (es) * 1996-07-31 1998-12-31 Schering Corp N-cianoiminas triciclicas utiles como inhibidores de transferasa de proteina farnesilo
US6071907A (en) * 1996-09-13 2000-06-06 Schering Corporation Tricyclic compounds useful as FPT inhibitors
US5925648A (en) * 1997-07-29 1999-07-20 Schering Corporation Tricyclic N-cyanoimines useful as inhibitors of a farnesyl-protein transferase
ES2237963T3 (es) * 1998-12-18 2005-08-01 Schering Corporation Inhibidores de farnesil proteina transferasa.

Also Published As

Publication number Publication date
US20020198216A1 (en) 2002-12-26
BR0113675A (pt) 2003-06-24
CN100384837C (zh) 2008-04-30
ZA200301545B (en) 2004-06-22
CO5640109A2 (es) 2006-05-31
AU2001288451B2 (en) 2007-05-24
KR20030034161A (ko) 2003-05-01
RU2293734C2 (ru) 2007-02-20
HUP0302942A3 (en) 2007-02-28
DE60127846D1 (en) 2007-05-24
HK1054548A1 (en) 2003-12-05
CA2420673A1 (en) 2002-03-07
ES2284686T3 (es) 2007-11-16
NZ524246A (en) 2004-11-26
CN1471524A (zh) 2004-01-28
DE60127846T2 (de) 2008-03-06
AU2001288451C1 (en) 2008-03-06
HK1054548B (zh) 2007-10-18
AU8845101A (en) 2002-03-13
IL154528A0 (en) 2003-09-17
EP1313725A1 (en) 2003-05-28
EP1313725B1 (en) 2007-04-11
AR033680A1 (es) 2004-01-07
PE20020486A1 (es) 2002-06-14
MXPA03001849A (es) 2003-06-04
WO2002018368A1 (en) 2002-03-07
SK2292003A3 (en) 2003-08-05
PL361103A1 (en) 2004-09-20
JP2004513885A (ja) 2004-05-13
RU2293734C9 (ru) 2007-10-10
TWI268280B (en) 2006-12-11
ECSP034494A (es) 2003-04-25
NO20030918D0 (no) 2003-02-27
ATE359281T1 (de) 2007-05-15
HUP0302942A2 (hu) 2003-12-29

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