PE20020486A1 - Compuestos triciclicos como inhibidores de la farnesil proteino transferasa - Google Patents

Compuestos triciclicos como inhibidores de la farnesil proteino transferasa

Info

Publication number
PE20020486A1
PE20020486A1 PE2001000865A PE2001000865A PE20020486A1 PE 20020486 A1 PE20020486 A1 PE 20020486A1 PE 2001000865 A PE2001000865 A PE 2001000865A PE 2001000865 A PE2001000865 A PE 2001000865A PE 20020486 A1 PE20020486 A1 PE 20020486A1
Authority
PE
Peru
Prior art keywords
united
compounds
link
farnesil
tricyclic compounds
Prior art date
Application number
PE2001000865A
Other languages
English (en)
Inventor
Carmen S Alvarez
Hugh Y Zhu
W Robert Bishop
Alan B Cooper
Jagdish A Desai
Ronald J Doll
Viyyoor Moopil Girijavallabhan
Timothy Guzi
Chia-Yu Huang
Ray A James
Kartik M Keertikar
Ge Li
Keith P Minor
F George Njoroge
Patrick A Pinto
Dinanath F Rane
Bama Santhanam
Bancha Vibulbhan
James J-S Wang
John J Baldwin
Original Assignee
Schering Corp
Pharmacopeia Drug Discovery
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp, Pharmacopeia Drug Discovery filed Critical Schering Corp
Publication of PE20020486A1 publication Critical patent/PE20020486A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A COMPUESTOS TRICICLICOS DE FORMULA I DONDE UNO DE a, b, c, d ES N, N+O-; EL RESTO SON C SUSTITUIDOS CON R1 O R2; SI X Y C11 ESTAN UNIDOS POR ENLACE SIMPLE, X ES N, CH; SI ENTRE X Y C11 ESTAN UNIDOS POR DOBLE ENLACE X ES C; SI C5 Y C6 ESTA UNIDOS POR ENLACE DOBLE A Y B NO SON H; SI C5 Y C6 ESTAN UNIDOS POR ENLACE SIMPLE UNO DE A Y B ES H, O A Y B SON R9, R9C0R9, (CH2)pC(R9)-OR9a, ENTRE OTROS; p ES 0-4; R1 Y R2 SON H, HALO, CF3, OR10, S(O)tR15, ENTRE OTROS; t ES 0-2; R3 Y R4 SON H, R1, R2; R5, R6, R7, SON H, CF3, COR10, ALQUILO, ARILO, ENTRE OTROS; R9 ES HETEROARILO, ARILALCOXI, HETEROCICLOALCOXI, ENTRE OTROS; R9a ARILO, ARILALQUILO. R10 ES H, ALQUILO, ARILO, ARILALQUILO; R15 ES ALQUILO, ARILO. LOS COMPUESTOS SE PUEDEN UTILIZAR CON QUIMIOTERAPICOS O RADIACION COMO MOSTAZA DE URACILO, CLORMETINA, CICLOFOSFAMIDA, IFOSFAMIDA, PIPOBROMAN, COLCHICINA, PACLITAXEL, EPOLTIONA, GEMCITABINA, ENTRE OTROS. LOS COMPUESTOS INHIBEN A CELULAS QUE EXPRESAN ONCOGEN DE RAS ACTIVADO POR INHIBICION DE LA FARNESIL TRANSFERASA Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE CANCER DE PULMON, PANCREATICO, COLON, LEUCEMIA MIELOIDE, FOLICULAR TIROIDEO, VEJIGA GLIOMA
PE2001000865A 2000-08-30 2001-08-28 Compuestos triciclicos como inhibidores de la farnesil proteino transferasa PE20020486A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22918300P 2000-08-30 2000-08-30

Publications (1)

Publication Number Publication Date
PE20020486A1 true PE20020486A1 (es) 2002-06-14

Family

ID=22860141

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000865A PE20020486A1 (es) 2000-08-30 2001-08-28 Compuestos triciclicos como inhibidores de la farnesil proteino transferasa

Country Status (27)

Country Link
US (1) US20020198216A1 (es)
EP (1) EP1313725B1 (es)
JP (1) JP2004513885A (es)
KR (1) KR20030034161A (es)
CN (1) CN100384837C (es)
AR (1) AR033680A1 (es)
AT (1) ATE359281T1 (es)
AU (2) AU2001288451C1 (es)
BR (1) BR0113675A (es)
CA (1) CA2420673A1 (es)
CO (1) CO5640109A2 (es)
DE (1) DE60127846T2 (es)
EC (1) ECSP034494A (es)
ES (1) ES2284686T3 (es)
HK (1) HK1054548B (es)
HU (1) HUP0302942A3 (es)
IL (1) IL154528A0 (es)
MX (1) MXPA03001849A (es)
NO (1) NO20030918L (es)
NZ (1) NZ524246A (es)
PE (1) PE20020486A1 (es)
PL (1) PL361103A1 (es)
RU (1) RU2293734C9 (es)
SK (1) SK2292003A3 (es)
TW (1) TWI268280B (es)
WO (1) WO2002018368A1 (es)
ZA (1) ZA200301545B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
BRPI0207961B8 (pt) 2001-03-14 2021-05-25 Bristol Myers Squibb Co uso de análogos de epotilona e capecitabina para fabricar medicamento para tratar tumores cancerosos sólidos e kit compreendendo os referidos compostos.
US20040191254A1 (en) * 2001-10-09 2004-09-30 Fagin James Alexander Method of treatment of thyroid cancer
AU2002352941A1 (en) * 2001-11-30 2003-06-17 Schering Corporation Use of an farsenyl protein tranferase inhibitor in combination with other antineoplastic agents for the manufacture of a medicament against cancer
AU2002346644A1 (en) * 2001-12-03 2003-06-17 Schering Corporation Use of fpt inhibitors and at least two antineoplastic agents in the treatment of cancer
US20030195192A1 (en) * 2002-04-05 2003-10-16 Fortuna Haviv Nicotinamides having antiangiogenic activity
US20040014744A1 (en) * 2002-04-05 2004-01-22 Fortuna Haviv Substituted pyridines having antiangiogenic activity
WO2004093871A1 (en) 2003-03-27 2004-11-04 Lankenau Institute For Medical Research Novel methods for the treatment of cancer
EP1628631A2 (en) * 2003-06-05 2006-03-01 Achkar, Charles C. Methods of treating hyperproliferative cell disorders
CA2528961A1 (en) * 2003-06-09 2005-01-06 Samuel Waksal Methods of inhibiting receptor tyrosine kinases with an extracellular antagonist and an intracellular antagonist
DE602004018332D1 (de) 2003-08-07 2009-01-22 Schering Corp Neue farnesylproteintransferaseinhibitoren als antitumormittel
US7592466B2 (en) 2003-10-09 2009-09-22 Abbott Laboratories Ureas having antiangiogenic activity
AU2005319182A1 (en) * 2004-12-21 2006-06-29 Schering Corporation Novel farnesyl protein transferase inhibitors as antitumor agents
CA2730190A1 (en) 2008-07-14 2010-01-21 Queen's University At Kingston Pharmaceutical compositions comprising ret inhibitors and methods for the treatment of cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
PE92098A1 (es) * 1996-07-31 1998-12-31 Schering Corp N-cianoiminas triciclicas utiles como inhibidores de transferasa de proteina farnesilo
US6071907A (en) * 1996-09-13 2000-06-06 Schering Corporation Tricyclic compounds useful as FPT inhibitors
US5925648A (en) * 1997-07-29 1999-07-20 Schering Corporation Tricyclic N-cyanoimines useful as inhibitors of a farnesyl-protein transferase
AU2347900A (en) * 1998-12-18 2000-07-12 Schering Corporation Farnesyl protein transferase inhibitors

Also Published As

Publication number Publication date
JP2004513885A (ja) 2004-05-13
NZ524246A (en) 2004-11-26
EP1313725A1 (en) 2003-05-28
AU8845101A (en) 2002-03-13
AU2001288451B2 (en) 2007-05-24
SK2292003A3 (en) 2003-08-05
CO5640109A2 (es) 2006-05-31
DE60127846T2 (de) 2008-03-06
AU2001288451C1 (en) 2008-03-06
KR20030034161A (ko) 2003-05-01
ECSP034494A (es) 2003-04-25
HK1054548B (zh) 2007-10-18
ES2284686T3 (es) 2007-11-16
NO20030918D0 (no) 2003-02-27
AR033680A1 (es) 2004-01-07
DE60127846D1 (en) 2007-05-24
US20020198216A1 (en) 2002-12-26
CN1471524A (zh) 2004-01-28
RU2293734C2 (ru) 2007-02-20
WO2002018368A1 (en) 2002-03-07
HK1054548A1 (en) 2003-12-05
HUP0302942A3 (en) 2007-02-28
CA2420673A1 (en) 2002-03-07
EP1313725B1 (en) 2007-04-11
NO20030918L (no) 2003-04-29
PL361103A1 (en) 2004-09-20
TWI268280B (en) 2006-12-11
BR0113675A (pt) 2003-06-24
ATE359281T1 (de) 2007-05-15
HUP0302942A2 (hu) 2003-12-29
ZA200301545B (en) 2004-06-22
RU2293734C9 (ru) 2007-10-10
IL154528A0 (en) 2003-09-17
CN100384837C (zh) 2008-04-30
MXPA03001849A (es) 2003-06-04

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