CO4900071A1 - Derivados de pirido [4´, 3´:4,5] tieno (2,3- d) pirimidina sustituidos en posicion 3 - Google Patents
Derivados de pirido [4´, 3´:4,5] tieno (2,3- d) pirimidina sustituidos en posicion 3Info
- Publication number
- CO4900071A1 CO4900071A1 CO97052337A CO97052337A CO4900071A1 CO 4900071 A1 CO4900071 A1 CO 4900071A1 CO 97052337 A CO97052337 A CO 97052337A CO 97052337 A CO97052337 A CO 97052337A CO 4900071 A1 CO4900071 A1 CO 4900071A1
- Authority
- CO
- Colombia
- Prior art keywords
- atom
- substituted
- hydroxy
- methyl
- residue
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Derivados de 3,4,5,6,7,8- hexahidro-pirido [4´,3,:4,5]tieno [2,3,d] pirimidina sustituidos en posición 3 de la fórmula I, CARACTERIZADOS porquedonde R1 es un átomo de O, un grupo C1 -C4 -alquilo, un grupo acetil o un grupo benzol, un residuo C1 -C4 - fenilalquilo, pudiendo estar sustituido el aromático por grupos halógeno, C1 -C4 -alquilo, trifluorometilo, hidroxi, C1 -C4 -alcoxi, amino, ciano o nitro, un residuo C2 -C3 -naftilalquilo, un residuo C2 -C3 - fenilalcanon o un residuo C2 fenilcarbamoilalquilo, pudiendo estar sustituidos los grupos fenilo por halógeno; R2 es fenilo mono-di- o trisustituido por átomo de halógeno, grupos C1 -C4 -alquilo, trifluorometilo, hidroxi, C1 -C4 -alcoxi, amino, mono-metilamino, dimetilamino, ciano o nitro, por grupos piridilo, pirimidinilo o pirazinilo, que en caso necesario puede estar anillado con un núcleo benzol que puede estar mono-o disustituido con átomos de halógeno, grupos C1 -C4 -alquilo, trifluorometilo, hidroxi, C1 -C4 -alcoxi, amino, ciano o nitro y que en caso necesario puede contener un átomo de nitrógeno o con un anillo de 5 o 6 miembros que puede contener 1-2 átomos de oxígeno, o que puede estar sustituido con un grupo fenilo, C1 -C4 -alquilo o C1 -C4 -alcoxi, pudiendo estar sustituido el residuo fenilo con halógeno, un grupo metilo, trifluorometilo o metoxi, A es NH o un átomo de O, B es hidrógeno o metilo, C es H, metilo o hidroxi, X es un átomo de N, Y es CH2 , CH2 - CH2 - CH2 , CH2 - CH2 o CH2 - CH,Z es un átomo de N, un átomo de C o CH, pudiendo ser la unión entre Y y Z también una unión doble, y n es el número 2, 3 ó 4. y sus sales fisiológicamente apropiados. A es NH o un átomo de O, B es hidrógeno o metilo, C es H, metilo o hidroxi, X es un átomo de N, Y es CH2 , CH2 - CH2 - CH2 , CH2 - CH2 o CH2 - CH, Z es un átomo de N, un átomo de C o CH, pudiendo ser la unión entre Y y Z también una unión doble, y n es el número 2, 3 ó 4. y sus sales fisiológicamente apropiados.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19636769A DE19636769A1 (de) | 1996-09-10 | 1996-09-10 | 3-Substituierte Pyrido [4',3':4,5]thieno[2,3-d]pyrimidin-Derivate, ihre Herstellung und Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4900071A1 true CO4900071A1 (es) | 2000-03-27 |
Family
ID=7805168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO97052337A CO4900071A1 (es) | 1996-09-10 | 1997-09-09 | Derivados de pirido [4´, 3´:4,5] tieno (2,3- d) pirimidina sustituidos en posicion 3 |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6222034B1 (es) |
| EP (1) | EP0927184B1 (es) |
| JP (1) | JP2001500138A (es) |
| KR (1) | KR20000035987A (es) |
| CN (2) | CN1230962A (es) |
| AR (1) | AR009572A1 (es) |
| AT (1) | ATE252587T1 (es) |
| AU (1) | AU736678B2 (es) |
| BG (1) | BG63602B1 (es) |
| BR (1) | BR9711724A (es) |
| CA (1) | CA2265509A1 (es) |
| CO (1) | CO4900071A1 (es) |
| CZ (1) | CZ288896B6 (es) |
| DE (2) | DE19636769A1 (es) |
| DK (1) | DK0927184T3 (es) |
| ES (1) | ES2210570T3 (es) |
| HK (1) | HK1043593A1 (es) |
| HR (1) | HRP970484A2 (es) |
| HU (1) | HUP9904107A3 (es) |
| ID (1) | ID18260A (es) |
| IL (1) | IL128142A0 (es) |
| NO (1) | NO991132D0 (es) |
| NZ (1) | NZ334350A (es) |
| PL (1) | PL332144A1 (es) |
| PT (1) | PT927184E (es) |
| RU (1) | RU2198888C2 (es) |
| SK (1) | SK283039B6 (es) |
| TR (1) | TR199900503T2 (es) |
| TW (1) | TW480264B (es) |
| UA (1) | UA54449C2 (es) |
| WO (1) | WO1998011110A1 (es) |
| ZA (1) | ZA978081B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19724980A1 (de) * | 1997-06-13 | 1998-12-17 | Basf Ag | 3-Substituierte 3,4-Dihydro-thieno[2,3-d]pyrimidin-Derivate, ihre Herstellung und Verwendung |
| DE19724979A1 (de) * | 1997-06-13 | 1998-12-17 | Basf Ag | 3-substituierte Pyrido [3,4,5]thieno[2,3-d]pyrimidin-Derivate, ihre Herstellung und Verwendung |
| DE19734444A1 (de) * | 1997-08-08 | 1999-02-11 | Basf Ag | 3-Substituierte 3,4,5,7-Tetrahydro-pyrrolo(3',4':4,5) thieno (2,3-d) pyrimidin-Derivate, ihre Herstellung und Verwendung |
| DE19900545A1 (de) * | 1999-01-11 | 2000-07-13 | Basf Ag | Verwendung von Pyrimidinderivaten zur Prophylaxe und Therapie der zerebralen Ischämie |
| DE19900673A1 (de) | 1999-01-11 | 2000-07-13 | Basf Ag | Verwendung von Bindungspartnern für 5-HT5-Rezeptoren zur Behandlung neurodegenerativer und neuropsychiatrischer Störungen |
| FR2791980B1 (fr) * | 1999-04-09 | 2001-07-06 | Sod Conseils Rech Applic | Pyrido-thieno-diazepines, leur procede de preparation, et les compositions pharmaceutiques les contenant |
| DE10031389A1 (de) * | 2000-07-03 | 2002-01-17 | Knoll Ag | Pyrimidinderivate und ihre Verwendung zur Prophylaxe und Therapie der zerebralen Ischämie |
| DE10031390A1 (de) * | 2000-07-03 | 2002-01-17 | Knoll Ag | Pyrimidinderivate und ihre Verwendung zur Prophylaxe und Therapie der zerebralen Ischämie |
| ES2291329T3 (es) * | 2000-07-18 | 2008-03-01 | Dainippon Sumitomo Pharma Co., Ltd. | Inhibidores de la recaptacion de serotonina. |
| DE10259382A1 (de) * | 2002-12-18 | 2004-07-01 | Abbott Gmbh & Co. Kg | 3-Substituierte 3,4-Dihydro-thieno[2,3-d]pyrimidin-4-on-Derivate, ihre Herstellung und Verwendung |
| US7612078B2 (en) * | 2003-03-31 | 2009-11-03 | Epix Delaware, Inc. | Piperidinylamino-thieno[2,3-D] pyrimidine compounds |
| CA2517833A1 (en) * | 2003-03-31 | 2004-10-21 | Predix Pharmaceuticals Holdings, Inc. | New piperidinylamino-thieno[2,3-d] pyrimidine compounds |
| US20050222175A1 (en) * | 2004-03-31 | 2005-10-06 | Dhanoa Dale S | New piperidinylamino-thieno[2,3-D] pyrimidine compounds |
| US20050165025A1 (en) * | 2004-01-22 | 2005-07-28 | Recordati Ireland Ltd. | Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists |
| US7488736B2 (en) * | 2004-05-17 | 2009-02-10 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
| US7407966B2 (en) * | 2004-10-07 | 2008-08-05 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
| US7576211B2 (en) * | 2004-09-30 | 2009-08-18 | Epix Delaware, Inc. | Synthesis of thienopyridinone compounds and related intermediates |
| US7598265B2 (en) * | 2004-09-30 | 2009-10-06 | Epix Delaware, Inc. | Compositions and methods for treating CNS disorders |
| US8114894B2 (en) * | 2008-12-03 | 2012-02-14 | Nanotherapeutics, Inc. | Bicyclic compounds and methods of making and using same |
| CN103003284B (zh) * | 2010-04-14 | 2016-01-20 | 拜耳知识产权有限责任公司 | 制备二噻烯-四甲酰亚胺的方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE272086C (es) * | ||||
| DE272079C (es) * | ||||
| DE272088C (es) * | ||||
| DE1937459A1 (de) * | 1968-08-02 | 1970-02-05 | Ciba Geigy | Neue Pyrimidinderivate und Verfahren zu ihrer Herstellung |
| US3823151A (en) * | 1968-08-02 | 1974-07-09 | Ciba Geigy Corp | 4,5,6,7-tetrahydrothieno(2,3-d)pyridines |
| JPS60146891A (ja) * | 1984-01-05 | 1985-08-02 | Mitsubishi Chem Ind Ltd | 〔２，３−ｄ〕チエノピリミジン誘導体およびその塩 |
| EP0257102B1 (en) * | 1986-02-24 | 1997-11-19 | Mitsui Petrochemical Industries, Ltd. | Agents for treating neurophathy |
| US5001130A (en) * | 1988-02-18 | 1991-03-19 | Bristol-Myers Company | Psychotropic heterobicycloalkylpiperazine derivatives |
| US4835157A (en) | 1988-03-15 | 1989-05-30 | Ortho Pharmaceutical Corporation | Thieno- and furopyrimidine-2,4-dione piperidine derivatives as serotonin antagonists and alpha adrenergic blocking agents |
-
1996
- 1996-09-10 DE DE19636769A patent/DE19636769A1/de not_active Withdrawn
-
1997
- 1997-08-22 US US09/254,449 patent/US6222034B1/en not_active Expired - Lifetime
- 1997-08-22 EP EP97940118A patent/EP0927184B1/de not_active Expired - Lifetime
- 1997-08-22 IL IL12814297A patent/IL128142A0/xx unknown
- 1997-08-22 JP JP10513191A patent/JP2001500138A/ja active Pending
- 1997-08-22 NZ NZ334350A patent/NZ334350A/xx unknown
- 1997-08-22 TR TR1999/00503T patent/TR199900503T2/xx unknown
- 1997-08-22 PL PL97332144A patent/PL332144A1/xx unknown
- 1997-08-22 BR BR9711724A patent/BR9711724A/pt not_active Application Discontinuation
- 1997-08-22 CN CN97197765A patent/CN1230962A/zh active Pending
- 1997-08-22 DK DK97940118T patent/DK0927184T3/da active
- 1997-08-22 KR KR1019997001939A patent/KR20000035987A/ko not_active Application Discontinuation
- 1997-08-22 SK SK230-99A patent/SK283039B6/sk unknown
- 1997-08-22 WO PCT/EP1997/004593 patent/WO1998011110A1/de not_active Application Discontinuation
- 1997-08-22 ES ES97940118T patent/ES2210570T3/es not_active Expired - Lifetime
- 1997-08-22 HU HU9904107A patent/HUP9904107A3/hu unknown
- 1997-08-22 DE DE59710902T patent/DE59710902D1/de not_active Expired - Fee Related
- 1997-08-22 RU RU99106781/04A patent/RU2198888C2/ru not_active IP Right Cessation
- 1997-08-22 UA UA99042039A patent/UA54449C2/uk unknown
- 1997-08-22 AU AU42071/97A patent/AU736678B2/en not_active Ceased
- 1997-08-22 CA CA002265509A patent/CA2265509A1/en not_active Abandoned
- 1997-08-22 AT AT97940118T patent/ATE252587T1/de not_active IP Right Cessation
- 1997-08-22 CZ CZ1999759A patent/CZ288896B6/cs not_active IP Right Cessation
- 1997-08-22 PT PT97940118T patent/PT927184E/pt unknown
- 1997-09-02 TW TW086112642A patent/TW480264B/zh not_active IP Right Cessation
- 1997-09-09 AR ARP970104118A patent/AR009572A1/es unknown
- 1997-09-09 ZA ZA978081A patent/ZA978081B/xx unknown
- 1997-09-09 CO CO97052337A patent/CO4900071A1/es unknown
- 1997-09-10 ID IDP973146A patent/ID18260A/id unknown
- 1997-09-10 HR HR19636769.7A patent/HRP970484A2/xx not_active Application Discontinuation
-
1999
- 1999-01-27 BG BG103122A patent/BG63602B1/bg unknown
- 1999-03-09 NO NO991132A patent/NO991132D0/no not_active Application Discontinuation
-
2001
- 2001-05-18 CN CN01116979A patent/CN1332168A/zh active Pending
-
2002
- 2002-07-17 HK HK02105304.8A patent/HK1043593A1/zh unknown
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