PT788356E - Metodo e composicoes para a inibicao de proteina-quinases. - Google Patents
Metodo e composicoes para a inibicao de proteina-quinases.Info
- Publication number
- PT788356E PT788356E PT95941340T PT95941340T PT788356E PT 788356 E PT788356 E PT 788356E PT 95941340 T PT95941340 T PT 95941340T PT 95941340 T PT95941340 T PT 95941340T PT 788356 E PT788356 E PT 788356E
- Authority
- PT
- Portugal
- Prior art keywords
- independently represents
- kinases
- inhibition
- protein
- compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/332,597 US5795910A (en) | 1994-10-28 | 1994-10-28 | Method and compositions for inhibiting protein kinases |
Publications (1)
Publication Number | Publication Date |
---|---|
PT788356E true PT788356E (pt) | 2002-06-28 |
Family
ID=23298937
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT95941340T PT788356E (pt) | 1994-10-28 | 1995-10-26 | Metodo e composicoes para a inibicao de proteina-quinases. |
Country Status (14)
Country | Link |
---|---|
US (3) | US5795910A (pt) |
EP (1) | EP0788356B9 (pt) |
JP (1) | JPH10508024A (pt) |
KR (1) | KR970706812A (pt) |
CN (1) | CN1165481A (pt) |
AT (1) | ATE210439T1 (pt) |
AU (1) | AU706621B2 (pt) |
CA (1) | CA2203757A1 (pt) |
DE (1) | DE69524628T2 (pt) |
DK (1) | DK0788356T3 (pt) |
ES (1) | ES2170172T3 (pt) |
PT (1) | PT788356E (pt) |
TW (1) | TW467743B (pt) |
WO (1) | WO1996013259A2 (pt) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6699843B2 (en) * | 1995-06-07 | 2004-03-02 | Gilead Sciences, Inc. | Method for treatment of tumors using nucleic acid ligands to PDGF |
CN1146747C (zh) * | 1996-08-06 | 2004-04-21 | 精工爱普生株式会社 | 液晶显示装置和使用液晶显示装置的电子仪器 |
US6087352A (en) * | 1998-08-17 | 2000-07-11 | Trout; William E. | Use of Zeranol to modulate reproductive cycles |
US20030219427A1 (en) * | 1998-08-18 | 2003-11-27 | Allen Hamish J. | TPL-2/COT kinase and methods of use |
WO2000033857A1 (en) * | 1998-12-07 | 2000-06-15 | Ecosmart Technologies, Inc. | Cancer treatment composition and method using natural plant essential oils |
CA2356622A1 (en) | 1998-12-24 | 2000-07-06 | Novation Pharmaceuticals Inc. | Compounds which affect mrna stability and uses therefor |
CA2380966A1 (en) * | 1999-08-13 | 2001-02-22 | The Scripps Research Institute | Methods and compositions useful for modulation of angiogenesis using tyrosine kinase raf and ras |
GB9925958D0 (en) * | 1999-11-02 | 1999-12-29 | Bundred Nigel J | Therapeutic use |
US7087608B2 (en) * | 2000-03-03 | 2006-08-08 | Robert Charles Atkins | Use of PDGF receptor tyrosine kinase inhibitors for the treatment of diabetic nephropathy |
JP2004292314A (ja) * | 2000-12-14 | 2004-10-21 | Chugai Pharmaceut Co Ltd | ケラチノサイト増殖抑制剤 |
US6565864B2 (en) | 2000-12-28 | 2003-05-20 | Unilever Home & Personal Care Usa, A Division Of Conopco, Inc. | Skin care product containing retinoids and phytoestrogens in a dual compartment package |
DE60218822T2 (de) * | 2001-02-09 | 2007-07-12 | Unilever N.V. | Nahrungsmittel enthaltend sojaprotein und statin |
WO2003041643A2 (en) * | 2001-11-09 | 2003-05-22 | Conforma Therapeutics Corporation | Hsp90-inhibiting zearalanol compounds and methods of producing and using same |
FR2835252B1 (fr) * | 2002-01-25 | 2005-08-05 | Seppic Sa | Utilisation d'un compose inactivant la proteine kinase a dans une composition contenant un milieu cosmetiquement acceptable, pour eclaicir la peau |
US7915306B2 (en) * | 2002-03-08 | 2011-03-29 | Eisai Co., Ltd. | Macrocyclic compounds useful as pharmaceuticals |
AU2003224672B2 (en) * | 2002-03-08 | 2010-02-04 | Eisai R&D Management Co., Ltd. | Macrocyclic compounds useful as pharmaceuticals |
RU2312863C2 (ru) * | 2002-04-17 | 2007-12-20 | Тайсо Фармасьютикал Ко., Лтд. | Тоник для роста волос |
US8853376B2 (en) | 2002-11-21 | 2014-10-07 | Archemix Llc | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
CA2527130A1 (en) * | 2003-04-02 | 2004-10-14 | Paul Tardi | Pharmaceutical compositions containing active agents having a lactone group and transition metal ions |
KR101501870B1 (ko) | 2003-08-27 | 2015-03-12 | 옵쏘테크 코포레이션 | 안구의 혈관신생성 장애를 치료하기 위한 조합 치료법 |
US20060079494A1 (en) * | 2004-09-27 | 2006-04-13 | Santi Daniel V | Specific kinase inhibitors |
US20070149593A1 (en) * | 2005-12-23 | 2007-06-28 | Alcon, Inc. | PHARMACEUTICAL FORMULATION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE |
US7601852B2 (en) * | 2006-05-11 | 2009-10-13 | Kosan Biosciences Incorporated | Macrocyclic kinase inhibitors |
JP5465006B2 (ja) | 2006-08-11 | 2014-04-09 | ユニベルシテ・ドウ・ストラスブール | キナーゼおよびhsp90の阻害剤として有用な大環状化合物 |
US8642067B2 (en) | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
US8609640B2 (en) * | 2007-07-25 | 2013-12-17 | Eisai, Inc. | Multikinase inhibitors for use in the treatment of cancer |
AU2008318690B2 (en) | 2007-10-29 | 2015-08-13 | Eisai R & D Management Co., Ltd. | Methods for prognosing the ability of a zearalenone analog compound to treat cancer |
WO2009075818A1 (en) | 2007-12-07 | 2009-06-18 | Eisai R & D Management Co., Ltd. | Intermediates and methods for making zearalenone macrolide analogs |
US20110190237A1 (en) * | 2008-01-15 | 2011-08-04 | Nexgenix Pharmaceuticals | Macrocyclic Prodrug Compounds Useful as Therapeutics |
US20120189641A1 (en) | 2009-02-25 | 2012-07-26 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
US8465912B2 (en) | 2009-02-27 | 2013-06-18 | OSI Pharmaceuticals, LLC | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
WO2010099363A1 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
WO2010099138A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
CN101928700B (zh) * | 2009-07-28 | 2012-05-02 | 北京恒宇视野生物科技有限公司 | 蛋白激酶pftk1单克隆抗体及其制备方法 |
CA2808866A1 (en) | 2010-08-20 | 2012-02-23 | The Hospital For Sick Children | Compositions and methods for treatment of cystic fibrosis and diseases associated with aberrant protein cellular processing |
WO2012149014A1 (en) | 2011-04-25 | 2012-11-01 | OSI Pharmaceuticals, LLC | Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment |
WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
US10434085B2 (en) | 2015-06-04 | 2019-10-08 | University Of North Carolina At Greensboro | Non-aromatic difluoro analogues of resorcylic acid lactones |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3196019A (en) * | 1964-04-06 | 1965-07-20 | Purdue Research Foundation | Anabolic and estrogenic compound and process of making |
JPS6239558A (ja) * | 1985-08-13 | 1987-02-20 | Kanegafuchi Chem Ind Co Ltd | α−シアノアクリル酸アミド誘導体 |
JPS6239523A (ja) * | 1985-08-14 | 1987-02-20 | Kanegafuchi Chem Ind Co Ltd | 酵素阻害剤 |
JPS6242923A (ja) * | 1985-08-19 | 1987-02-24 | Kanegafuchi Chem Ind Co Ltd | 酵素阻害剤 |
JPS6242925A (ja) * | 1985-08-20 | 1987-02-24 | Kanegafuchi Chem Ind Co Ltd | 酵素阻害剤 |
US4842862A (en) * | 1986-07-03 | 1989-06-27 | International Minerals & Chemical Corp. | Immunostimulating agents |
GB9225396D0 (en) * | 1992-12-04 | 1993-01-27 | Sandoz Ltd | Improvements in or relating to organic compounds |
-
1994
- 1994-10-28 US US08/332,597 patent/US5795910A/en not_active Expired - Fee Related
-
1995
- 1995-06-05 US US08/462,475 patent/US5728726A/en not_active Expired - Fee Related
- 1995-06-05 US US08/463,773 patent/US5674892A/en not_active Expired - Lifetime
- 1995-10-26 CN CN95195945A patent/CN1165481A/zh active Pending
- 1995-10-26 AT AT95941340T patent/ATE210439T1/de not_active IP Right Cessation
- 1995-10-26 WO PCT/US1995/013882 patent/WO1996013259A2/en not_active Application Discontinuation
- 1995-10-26 PT PT95941340T patent/PT788356E/pt unknown
- 1995-10-26 AU AU42789/96A patent/AU706621B2/en not_active Ceased
- 1995-10-26 EP EP95941340A patent/EP0788356B9/en not_active Expired - Lifetime
- 1995-10-26 DK DK95941340T patent/DK0788356T3/da active
- 1995-10-26 DE DE69524628T patent/DE69524628T2/de not_active Expired - Fee Related
- 1995-10-26 ES ES95941340T patent/ES2170172T3/es not_active Expired - Lifetime
- 1995-10-26 KR KR1019970702786A patent/KR970706812A/ko not_active Application Discontinuation
- 1995-10-26 JP JP8514745A patent/JPH10508024A/ja not_active Ceased
- 1995-10-26 CA CA002203757A patent/CA2203757A1/en not_active Abandoned
- 1995-10-27 TW TW084111358A patent/TW467743B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR970706812A (ko) | 1997-12-01 |
DE69524628D1 (de) | 2002-01-24 |
CA2203757A1 (en) | 1996-05-09 |
DK0788356T3 (da) | 2002-03-18 |
EP0788356B1 (en) | 2001-12-12 |
ES2170172T3 (es) | 2002-08-01 |
WO1996013259A2 (en) | 1996-05-09 |
ATE210439T1 (de) | 2001-12-15 |
AU4278996A (en) | 1996-05-23 |
AU706621B2 (en) | 1999-06-17 |
US5674892A (en) | 1997-10-07 |
US5795910A (en) | 1998-08-18 |
US5728726A (en) | 1998-03-17 |
EP0788356B9 (en) | 2002-10-02 |
JPH10508024A (ja) | 1998-08-04 |
TW467743B (en) | 2001-12-11 |
EP0788356A2 (en) | 1997-08-13 |
CN1165481A (zh) | 1997-11-19 |
WO1996013259A3 (en) | 1996-08-01 |
MX9703113A (es) | 1998-06-30 |
DE69524628T2 (de) | 2002-08-08 |
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