PT788356E - Metodo e composicoes para a inibicao de proteina-quinases. - Google Patents

Metodo e composicoes para a inibicao de proteina-quinases.

Info

Publication number
PT788356E
PT788356E PT95941340T PT95941340T PT788356E PT 788356 E PT788356 E PT 788356E PT 95941340 T PT95941340 T PT 95941340T PT 95941340 T PT95941340 T PT 95941340T PT 788356 E PT788356 E PT 788356E
Authority
PT
Portugal
Prior art keywords
independently represents
kinases
inhibition
protein
compositions
Prior art date
Application number
PT95941340T
Other languages
English (en)
Inventor
Neill A Giese
Nathalie Lokker
Original Assignee
Cor Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cor Therapeutics Inc filed Critical Cor Therapeutics Inc
Publication of PT788356E publication Critical patent/PT788356E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
PT95941340T 1994-10-28 1995-10-26 Metodo e composicoes para a inibicao de proteina-quinases. PT788356E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/332,597 US5795910A (en) 1994-10-28 1994-10-28 Method and compositions for inhibiting protein kinases

Publications (1)

Publication Number Publication Date
PT788356E true PT788356E (pt) 2002-06-28

Family

ID=23298937

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95941340T PT788356E (pt) 1994-10-28 1995-10-26 Metodo e composicoes para a inibicao de proteina-quinases.

Country Status (14)

Country Link
US (3) US5795910A (pt)
EP (1) EP0788356B9 (pt)
JP (1) JPH10508024A (pt)
KR (1) KR970706812A (pt)
CN (1) CN1165481A (pt)
AT (1) ATE210439T1 (pt)
AU (1) AU706621B2 (pt)
CA (1) CA2203757A1 (pt)
DE (1) DE69524628T2 (pt)
DK (1) DK0788356T3 (pt)
ES (1) ES2170172T3 (pt)
PT (1) PT788356E (pt)
TW (1) TW467743B (pt)
WO (1) WO1996013259A2 (pt)

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US6819376B1 (en) * 1996-08-06 2004-11-16 Seiko Epson Corporation Liquid crystal display device with a light-shielding portion
WO2000009113A1 (en) * 1998-08-17 2000-02-24 Trout William E Use of zeranol to modulate reproductive cycles
US20030219427A1 (en) * 1998-08-18 2003-11-27 Allen Hamish J. TPL-2/COT kinase and methods of use
AR020020A1 (es) * 1998-12-07 2002-03-27 Ecosmart Technologies Inc Composicion para el tratamiento de cancer y metodo usando moduladores de transduccion de senal y aceites esenciales de plantas naturales como sinergistas para tratamientos convencionales
JP2002533389A (ja) 1998-12-24 2002-10-08 ノーベーション ファーマシューティカルズ インコーポレーテッド ｍＲＮＡ安定性に影響する化合物およびそのための使用
SK2142002A3 (en) * 1999-08-13 2002-07-02 Scripps Research Inst Methods and compositions useful for modulation of angiogenesis using protein kinase raf and ras
GB9925958D0 (en) * 1999-11-02 1999-12-29 Bundred Nigel J Therapeutic use
US7087608B2 (en) 2000-03-03 2006-08-08 Robert Charles Atkins Use of PDGF receptor tyrosine kinase inhibitors for the treatment of diabetic nephropathy
JP2004292314A (ja) * 2000-12-14 2004-10-21 Chugai Pharmaceut Co Ltd ケラチノサイト増殖抑制剤
US6565864B2 (en) 2000-12-28 2003-05-20 Unilever Home & Personal Care Usa, A Division Of Conopco, Inc. Skin care product containing retinoids and phytoestrogens in a dual compartment package
ATE356554T1 (de) * 2001-02-09 2007-04-15 Unilever Nv Nahrungsmittel enthaltend sojaprotein und statin
WO2003041643A2 (en) * 2001-11-09 2003-05-22 Conforma Therapeutics Corporation Hsp90-inhibiting zearalanol compounds and methods of producing and using same
FR2835252B1 (fr) * 2002-01-25 2005-08-05 Seppic Sa Utilisation d'un compose inactivant la proteine kinase a dans une composition contenant un milieu cosmetiquement acceptable, pour eclaicir la peau
RU2334744C2 (ru) * 2002-03-08 2008-09-27 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Макроциклические соединения, которые могут быть использованы в качестве фармацевтических препаратов
US7915306B2 (en) * 2002-03-08 2011-03-29 Eisai Co., Ltd. Macrocyclic compounds useful as pharmaceuticals
EP1498104A4 (en) * 2002-04-17 2006-05-03 Taisho Pharmaceutical Co Ltd TONIC PRODUCT FOR HAIR GROWTH
US8853376B2 (en) 2002-11-21 2014-10-07 Archemix Llc Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
EP1608338A1 (en) * 2003-04-02 2005-12-28 Celator Technologies Inc. Pharmaceutical compositions containing active agents having a lactone group and transition metal ions
CN102813923B (zh) 2003-08-27 2015-04-01 奥普索特克公司 用于治疗眼新血管疾病的组合治疗
EP1794137A4 (en) * 2004-09-27 2009-12-02 Kosan Biosciences Inc SPECIFIC KINASE INHIBITORS
JP2009521493A (ja) * 2005-12-23 2009-06-04 アルコン，インコーポレイテッド 眼への受容体チロシンキナーゼ阻害（ＲＴＫｉ）化合物の送達のための医薬製剤
US7601852B2 (en) * 2006-05-11 2009-10-13 Kosan Biosciences Incorporated Macrocyclic kinase inhibitors
WO2008021213A1 (en) 2006-08-11 2008-02-21 Nicolas Winssinger Macrocyclic compounds useful as inhibitors of kinases and hsp90
US8642067B2 (en) 2007-04-02 2014-02-04 Allergen, Inc. Methods and compositions for intraocular administration to treat ocular conditions
KR101667960B1 (ko) 2007-07-25 2016-10-20 에자이 알앤드디 매니지먼트 가부시키가이샤 암 치료에서 이용하기 위한 멀티키나아제 억제제
EP2453234B1 (en) 2007-10-29 2014-01-15 Eisai R&D Management Co., Ltd. Methods for prognosing the ability of a zearalenone analog compound to treat cancer
RU2478630C2 (ru) 2007-12-07 2013-04-10 ЭЙСАН Ар ЭНД Ди МЕНЕДЖМЕНТ КО., ЛТД. Промежуточные соединения и способы получения зеараленоновых макролидных аналогов
US20110190237A1 (en) * 2008-01-15 2011-08-04 Nexgenix Pharmaceuticals Macrocyclic Prodrug Compounds Useful as Therapeutics
EP2400985A2 (en) 2009-02-25 2012-01-04 OSI Pharmaceuticals, LLC Combination of an either an anti-igf-1r antibody or an igf binding protein and a small molecule igf-1r kinase inhibitor
JP2012519281A (ja) 2009-02-27 2012-08-23 オーエスアイ・ファーマシューティカルズ，エルエルシー 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法
WO2010099138A2 (en) 2009-02-27 2010-09-02 Osi Pharmaceuticals, Inc. Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
US8465912B2 (en) 2009-02-27 2013-06-18 OSI Pharmaceuticals, LLC Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
CN101928700B (zh) * 2009-07-28 2012-05-02 北京恒宇视野生物科技有限公司 蛋白激酶pftk1单克隆抗体及其制备方法
US9120768B2 (en) 2010-08-20 2015-09-01 The Hospital For Sick Children Compositions and methods for treatment of cystic fibrosis and diseases associated with aberrant protein cellular processing
US9896730B2 (en) 2011-04-25 2018-02-20 OSI Pharmaceuticals, LLC Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment
WO2013152252A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
US10434085B2 (en) 2015-06-04 2019-10-08 University Of North Carolina At Greensboro Non-aromatic difluoro analogues of resorcylic acid lactones

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US3196019A (en) * 1964-04-06 1965-07-20 Purdue Research Foundation Anabolic and estrogenic compound and process of making
JPS6239558A (ja) * 1985-08-13 1987-02-20 Kanegafuchi Chem Ind Co Ltd α−シアノアクリル酸アミド誘導体
JPS6239523A (ja) * 1985-08-14 1987-02-20 Kanegafuchi Chem Ind Co Ltd 酵素阻害剤
JPS6242923A (ja) * 1985-08-19 1987-02-24 Kanegafuchi Chem Ind Co Ltd 酵素阻害剤
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US4842862A (en) * 1986-07-03 1989-06-27 International Minerals & Chemical Corp. Immunostimulating agents
GB9225396D0 (en) * 1992-12-04 1993-01-27 Sandoz Ltd Improvements in or relating to organic compounds

Also Published As

Publication number Publication date
US5728726A (en) 1998-03-17
TW467743B (en) 2001-12-11
EP0788356A2 (en) 1997-08-13
ATE210439T1 (de) 2001-12-15
US5674892A (en) 1997-10-07
US5795910A (en) 1998-08-18
MX9703113A (es) 1998-06-30
KR970706812A (ko) 1997-12-01
CA2203757A1 (en) 1996-05-09
AU706621B2 (en) 1999-06-17
CN1165481A (zh) 1997-11-19
WO1996013259A2 (en) 1996-05-09
AU4278996A (en) 1996-05-23
WO1996013259A3 (en) 1996-08-01
ES2170172T3 (es) 2002-08-01
EP0788356B1 (en) 2001-12-12
DE69524628D1 (de) 2002-01-24
DE69524628T2 (de) 2002-08-08
JPH10508024A (ja) 1998-08-04
DK0788356T3 (da) 2002-03-18
EP0788356B9 (en) 2002-10-02

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