PT788356E - Metodo e composicoes para a inibicao de proteina-quinases. - Google Patents
Metodo e composicoes para a inibicao de proteina-quinases.Info
- Publication number
- PT788356E PT788356E PT95941340T PT95941340T PT788356E PT 788356 E PT788356 E PT 788356E PT 95941340 T PT95941340 T PT 95941340T PT 95941340 T PT95941340 T PT 95941340T PT 788356 E PT788356 E PT 788356E
- Authority
- PT
- Portugal
- Prior art keywords
- independently represents
- kinases
- inhibition
- protein
- compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/332,597 US5795910A (en) | 1994-10-28 | 1994-10-28 | Method and compositions for inhibiting protein kinases |
Publications (1)
Publication Number | Publication Date |
---|---|
PT788356E true PT788356E (pt) | 2002-06-28 |
Family
ID=23298937
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT95941340T PT788356E (pt) | 1994-10-28 | 1995-10-26 | Metodo e composicoes para a inibicao de proteina-quinases. |
Country Status (14)
Country | Link |
---|---|
US (3) | US5795910A (pt) |
EP (1) | EP0788356B9 (pt) |
JP (1) | JPH10508024A (pt) |
KR (1) | KR970706812A (pt) |
CN (1) | CN1165481A (pt) |
AT (1) | ATE210439T1 (pt) |
AU (1) | AU706621B2 (pt) |
CA (1) | CA2203757A1 (pt) |
DE (1) | DE69524628T2 (pt) |
DK (1) | DK0788356T3 (pt) |
ES (1) | ES2170172T3 (pt) |
PT (1) | PT788356E (pt) |
TW (1) | TW467743B (pt) |
WO (1) | WO1996013259A2 (pt) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6699843B2 (en) * | 1995-06-07 | 2004-03-02 | Gilead Sciences, Inc. | Method for treatment of tumors using nucleic acid ligands to PDGF |
US6819376B1 (en) * | 1996-08-06 | 2004-11-16 | Seiko Epson Corporation | Liquid crystal display device with a light-shielding portion |
WO2000009113A1 (en) * | 1998-08-17 | 2000-02-24 | Trout William E | Use of zeranol to modulate reproductive cycles |
US20030219427A1 (en) * | 1998-08-18 | 2003-11-27 | Allen Hamish J. | TPL-2/COT kinase and methods of use |
AR020020A1 (es) * | 1998-12-07 | 2002-03-27 | Ecosmart Technologies Inc | Composicion para el tratamiento de cancer y metodo usando moduladores de transduccion de senal y aceites esenciales de plantas naturales como sinergistas para tratamientos convencionales |
JP2002533389A (ja) | 1998-12-24 | 2002-10-08 | ノーベーション ファーマシューティカルズ インコーポレーテッド | mRNA安定性に影響する化合物およびそのための使用 |
SK2142002A3 (en) * | 1999-08-13 | 2002-07-02 | Scripps Research Inst | Methods and compositions useful for modulation of angiogenesis using protein kinase raf and ras |
GB9925958D0 (en) * | 1999-11-02 | 1999-12-29 | Bundred Nigel J | Therapeutic use |
US7087608B2 (en) | 2000-03-03 | 2006-08-08 | Robert Charles Atkins | Use of PDGF receptor tyrosine kinase inhibitors for the treatment of diabetic nephropathy |
JP2004292314A (ja) * | 2000-12-14 | 2004-10-21 | Chugai Pharmaceut Co Ltd | ケラチノサイト増殖抑制剤 |
US6565864B2 (en) | 2000-12-28 | 2003-05-20 | Unilever Home & Personal Care Usa, A Division Of Conopco, Inc. | Skin care product containing retinoids and phytoestrogens in a dual compartment package |
ATE356554T1 (de) * | 2001-02-09 | 2007-04-15 | Unilever Nv | Nahrungsmittel enthaltend sojaprotein und statin |
WO2003041643A2 (en) * | 2001-11-09 | 2003-05-22 | Conforma Therapeutics Corporation | Hsp90-inhibiting zearalanol compounds and methods of producing and using same |
FR2835252B1 (fr) * | 2002-01-25 | 2005-08-05 | Seppic Sa | Utilisation d'un compose inactivant la proteine kinase a dans une composition contenant un milieu cosmetiquement acceptable, pour eclaicir la peau |
RU2334744C2 (ru) * | 2002-03-08 | 2008-09-27 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Макроциклические соединения, которые могут быть использованы в качестве фармацевтических препаратов |
US7915306B2 (en) * | 2002-03-08 | 2011-03-29 | Eisai Co., Ltd. | Macrocyclic compounds useful as pharmaceuticals |
EP1498104A4 (en) * | 2002-04-17 | 2006-05-03 | Taisho Pharmaceutical Co Ltd | TONIC PRODUCT FOR HAIR GROWTH |
US8853376B2 (en) | 2002-11-21 | 2014-10-07 | Archemix Llc | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
EP1608338A1 (en) * | 2003-04-02 | 2005-12-28 | Celator Technologies Inc. | Pharmaceutical compositions containing active agents having a lactone group and transition metal ions |
CN102813923B (zh) | 2003-08-27 | 2015-04-01 | 奥普索特克公司 | 用于治疗眼新血管疾病的组合治疗 |
EP1794137A4 (en) * | 2004-09-27 | 2009-12-02 | Kosan Biosciences Inc | SPECIFIC KINASE INHIBITORS |
JP2009521493A (ja) * | 2005-12-23 | 2009-06-04 | アルコン,インコーポレイテッド | 眼への受容体チロシンキナーゼ阻害(RTKi)化合物の送達のための医薬製剤 |
US7601852B2 (en) * | 2006-05-11 | 2009-10-13 | Kosan Biosciences Incorporated | Macrocyclic kinase inhibitors |
WO2008021213A1 (en) | 2006-08-11 | 2008-02-21 | Nicolas Winssinger | Macrocyclic compounds useful as inhibitors of kinases and hsp90 |
US8642067B2 (en) | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
KR101667960B1 (ko) | 2007-07-25 | 2016-10-20 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 암 치료에서 이용하기 위한 멀티키나아제 억제제 |
EP2453234B1 (en) | 2007-10-29 | 2014-01-15 | Eisai R&D Management Co., Ltd. | Methods for prognosing the ability of a zearalenone analog compound to treat cancer |
RU2478630C2 (ru) | 2007-12-07 | 2013-04-10 | ЭЙСАН Ар ЭНД Ди МЕНЕДЖМЕНТ КО., ЛТД. | Промежуточные соединения и способы получения зеараленоновых макролидных аналогов |
US20110190237A1 (en) * | 2008-01-15 | 2011-08-04 | Nexgenix Pharmaceuticals | Macrocyclic Prodrug Compounds Useful as Therapeutics |
EP2400985A2 (en) | 2009-02-25 | 2012-01-04 | OSI Pharmaceuticals, LLC | Combination of an either an anti-igf-1r antibody or an igf binding protein and a small molecule igf-1r kinase inhibitor |
JP2012519281A (ja) | 2009-02-27 | 2012-08-23 | オーエスアイ・ファーマシューティカルズ,エルエルシー | 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法 |
WO2010099138A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
US8465912B2 (en) | 2009-02-27 | 2013-06-18 | OSI Pharmaceuticals, LLC | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
CN101928700B (zh) * | 2009-07-28 | 2012-05-02 | 北京恒宇视野生物科技有限公司 | 蛋白激酶pftk1单克隆抗体及其制备方法 |
US9120768B2 (en) | 2010-08-20 | 2015-09-01 | The Hospital For Sick Children | Compositions and methods for treatment of cystic fibrosis and diseases associated with aberrant protein cellular processing |
US9896730B2 (en) | 2011-04-25 | 2018-02-20 | OSI Pharmaceuticals, LLC | Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment |
WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
US10434085B2 (en) | 2015-06-04 | 2019-10-08 | University Of North Carolina At Greensboro | Non-aromatic difluoro analogues of resorcylic acid lactones |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3196019A (en) * | 1964-04-06 | 1965-07-20 | Purdue Research Foundation | Anabolic and estrogenic compound and process of making |
JPS6239558A (ja) * | 1985-08-13 | 1987-02-20 | Kanegafuchi Chem Ind Co Ltd | α−シアノアクリル酸アミド誘導体 |
JPS6239523A (ja) * | 1985-08-14 | 1987-02-20 | Kanegafuchi Chem Ind Co Ltd | 酵素阻害剤 |
JPS6242923A (ja) * | 1985-08-19 | 1987-02-24 | Kanegafuchi Chem Ind Co Ltd | 酵素阻害剤 |
JPS6242925A (ja) * | 1985-08-20 | 1987-02-24 | Kanegafuchi Chem Ind Co Ltd | 酵素阻害剤 |
US4842862A (en) * | 1986-07-03 | 1989-06-27 | International Minerals & Chemical Corp. | Immunostimulating agents |
GB9225396D0 (en) * | 1992-12-04 | 1993-01-27 | Sandoz Ltd | Improvements in or relating to organic compounds |
-
1994
- 1994-10-28 US US08/332,597 patent/US5795910A/en not_active Expired - Fee Related
-
1995
- 1995-06-05 US US08/463,773 patent/US5674892A/en not_active Expired - Lifetime
- 1995-06-05 US US08/462,475 patent/US5728726A/en not_active Expired - Fee Related
- 1995-10-26 EP EP95941340A patent/EP0788356B9/en not_active Expired - Lifetime
- 1995-10-26 WO PCT/US1995/013882 patent/WO1996013259A2/en not_active Application Discontinuation
- 1995-10-26 PT PT95941340T patent/PT788356E/pt unknown
- 1995-10-26 AT AT95941340T patent/ATE210439T1/de not_active IP Right Cessation
- 1995-10-26 ES ES95941340T patent/ES2170172T3/es not_active Expired - Lifetime
- 1995-10-26 KR KR1019970702786A patent/KR970706812A/ko not_active Application Discontinuation
- 1995-10-26 DK DK95941340T patent/DK0788356T3/da active
- 1995-10-26 AU AU42789/96A patent/AU706621B2/en not_active Ceased
- 1995-10-26 DE DE69524628T patent/DE69524628T2/de not_active Expired - Fee Related
- 1995-10-26 CN CN95195945A patent/CN1165481A/zh active Pending
- 1995-10-26 JP JP8514745A patent/JPH10508024A/ja not_active Ceased
- 1995-10-26 CA CA002203757A patent/CA2203757A1/en not_active Abandoned
- 1995-10-27 TW TW084111358A patent/TW467743B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US5728726A (en) | 1998-03-17 |
TW467743B (en) | 2001-12-11 |
EP0788356A2 (en) | 1997-08-13 |
ATE210439T1 (de) | 2001-12-15 |
US5674892A (en) | 1997-10-07 |
US5795910A (en) | 1998-08-18 |
MX9703113A (es) | 1998-06-30 |
KR970706812A (ko) | 1997-12-01 |
CA2203757A1 (en) | 1996-05-09 |
AU706621B2 (en) | 1999-06-17 |
CN1165481A (zh) | 1997-11-19 |
WO1996013259A2 (en) | 1996-05-09 |
AU4278996A (en) | 1996-05-23 |
WO1996013259A3 (en) | 1996-08-01 |
ES2170172T3 (es) | 2002-08-01 |
EP0788356B1 (en) | 2001-12-12 |
DE69524628D1 (de) | 2002-01-24 |
DE69524628T2 (de) | 2002-08-08 |
JPH10508024A (ja) | 1998-08-04 |
DK0788356T3 (da) | 2002-03-18 |
EP0788356B9 (en) | 2002-10-02 |
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