DE60126297D1 - Modifizierte carbocyaninfarbstoffe und deren konjugate - Google Patents
Modifizierte carbocyaninfarbstoffe und deren konjugateInfo
- Publication number
- DE60126297D1 DE60126297D1 DE60126297T DE60126297T DE60126297D1 DE 60126297 D1 DE60126297 D1 DE 60126297D1 DE 60126297 T DE60126297 T DE 60126297T DE 60126297 T DE60126297 T DE 60126297T DE 60126297 D1 DE60126297 D1 DE 60126297D1
- Authority
- DE
- Germany
- Prior art keywords
- conjugates
- carbocyanine dyes
- dyes
- modified carbocyanine
- modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000298 carbocyanine Substances 0.000 title abstract 2
- QWYZFXLSWMXLDM-UHFFFAOYSA-M pinacyanol iodide Chemical class [I-].C1=CC2=CC=CC=C2N(CC)C1=CC=CC1=CC=C(C=CC=C2)C2=[N+]1CC QWYZFXLSWMXLDM-UHFFFAOYSA-M 0.000 title 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical group C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000021615 conjugation Effects 0.000 abstract 1
- 239000000975 dye Substances 0.000 abstract 1
- 230000003595 spectral effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C66/00—Quinone carboxylic acids
- C07C66/02—Anthraquinone carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/54—Spiro-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/13—Labelling of peptides
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/06—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups three >CH- groups, e.g. carbocyanines
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
- C09B23/083—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines five >CH- groups
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/10—The polymethine chain containing an even number of >CH- groups
- C09B23/107—The polymethine chain containing an even number of >CH- groups four >CH- groups
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N2001/302—Stain compositions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23663700P | 2000-09-29 | 2000-09-29 | |
US236637P | 2000-09-29 | ||
US27687001P | 2001-03-16 | 2001-03-16 | |
US276870P | 2001-03-16 | ||
PCT/US2001/030404 WO2002026891A1 (en) | 2000-09-29 | 2001-09-28 | Modified carbocyanine dyes and their conjugates |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60126297D1 true DE60126297D1 (de) | 2007-03-15 |
DE60126297T2 DE60126297T2 (de) | 2007-11-15 |
Family
ID=26929964
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE2001975541 Active DE01975541T9 (de) | 2000-09-29 | 2001-09-28 | Modifizierte carbocyaninfarbstoffe und deren konjugate |
DE2001626297 Expired - Fee Related DE60126297T2 (de) | 2000-09-29 | 2001-09-28 | Modifizierte carbocyaninfarbstoffe und deren konjugate |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE2001975541 Active DE01975541T9 (de) | 2000-09-29 | 2001-09-28 | Modifizierte carbocyaninfarbstoffe und deren konjugate |
Country Status (7)
Country | Link |
---|---|
US (15) | US6977305B2 (de) |
EP (2) | EP1322710B2 (de) |
AT (1) | ATE352586T2 (de) |
AU (1) | AU2001294859A1 (de) |
CA (1) | CA2423806C (de) |
DE (2) | DE01975541T9 (de) |
WO (1) | WO2002026891A1 (de) |
Families Citing this family (205)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6133445A (en) | 1997-12-17 | 2000-10-17 | Carnegie Mellon University | Rigidized trimethine cyanine dyes |
US20030030797A1 (en) * | 1999-09-24 | 2003-02-13 | Henry Palladino | Solid state fluorescence and absorption spectroscopy |
DE10046215B4 (de) * | 2000-09-19 | 2004-04-15 | Institut für Chemo- und Biosensorik Münster e.V. i.Ins. | Fluorochrome und deren Verwendung |
CA2423806C (en) * | 2000-09-29 | 2009-12-22 | Molecular Probes, Inc. | Modified carbocyanine dyes and their conjugates |
US7579463B2 (en) * | 2000-12-20 | 2009-08-25 | Life Technologies Corporation | Crown ether derivatives |
US7129346B2 (en) * | 2000-12-20 | 2006-10-31 | Molecular Probes, Inc. | Crown ether derivatives |
JP4676654B2 (ja) * | 2001-07-19 | 2011-04-27 | 富士フイルム株式会社 | 蛍光ヌクレオチド及びそれを用いた標識法 |
US20050069962A1 (en) | 2001-10-12 | 2005-03-31 | Archer Robert M | Antibody complexes and methods for immunolabeling |
US8323903B2 (en) * | 2001-10-12 | 2012-12-04 | Life Technologies Corporation | Antibody complexes and methods for immunolabeling |
US6972326B2 (en) * | 2001-12-03 | 2005-12-06 | Molecular Probes, Inc. | Labeling of immobilized proteins using dipyrrometheneboron difluoride dyes |
EP1485716A1 (de) * | 2002-03-11 | 2004-12-15 | Visen Medical, Inc. | Sonden zur erzeugung von optischen bildern |
US20040171034A1 (en) * | 2002-05-03 | 2004-09-02 | Brian Agnew | Compositions and methods for detection and isolation of phosphorylated molecules |
AU2003299466A1 (en) * | 2002-05-03 | 2004-06-07 | Molecular Probes, Inc. | Compositions and methods for detection and isolation of phosphorylated molecules |
US7445894B2 (en) * | 2002-05-03 | 2008-11-04 | Molecular Probes, Inc. | Compositions and methods for detection and isolation of phosphorylated molecules |
EP1525265B1 (de) * | 2002-05-10 | 2011-07-20 | Carnegie Mellon University | Chirale indole als zwischenprodukte und daraus hergestellte cyaninfluoreszenzfarbstoffe mit funktionellen gruppen |
US7785898B2 (en) | 2002-05-31 | 2010-08-31 | Genetic Technologies Limited | Maternal antibodies as fetal cell markers to identify and enrich fetal cells from maternal blood |
CA2491692C (en) * | 2002-07-08 | 2010-12-07 | Amersham Biosciences Uk Limited | Reagents and a method for saturation labelling of proteins |
WO2004025259A2 (en) | 2002-09-12 | 2004-03-25 | Molecular Probes, Inc. | Site-specific labeling of affinity tags in fusion proteins |
ES2527068T3 (es) | 2002-10-23 | 2015-01-19 | University Of Utah Research Foundation | Análisis de fusión de amplicones con colorantes de saturación |
US7005518B2 (en) * | 2002-10-25 | 2006-02-28 | Li-Cor, Inc. | Phthalocyanine dyes |
ES2311736T3 (es) * | 2003-01-24 | 2009-02-16 | Bayer Schering Pharma Aktiengesellschaft | Tintes hidrofilicos de cianina tiol reactivo y conjugados de los mismos con biomoleculas para el diagnostico por fluorescencia. |
AU2004217872B2 (en) | 2003-03-05 | 2010-03-25 | Genetic Technologies Limited | Identification of fetal DNA and fetal cell markers in maternal plasma or serum |
US7217649B2 (en) * | 2003-03-14 | 2007-05-15 | Lam Research Corporation | System and method for stress free conductor removal |
US7172907B2 (en) * | 2003-03-21 | 2007-02-06 | Ge Healthcare Bio-Sciences Corp. | Cyanine dye labelling reagents with meso-substitution |
CA2528843A1 (en) | 2003-05-20 | 2005-02-24 | Investigen, Inc. | System for detecting polynucleotides |
US7727969B2 (en) | 2003-06-06 | 2010-06-01 | Massachusetts Institute Of Technology | Controlled release nanoparticle having bound oligonucleotide for targeted delivery |
US7727752B2 (en) | 2003-07-29 | 2010-06-01 | Life Technologies Corporation | Kinase and phosphatase assays |
US7271265B2 (en) | 2003-08-11 | 2007-09-18 | Invitrogen Corporation | Cyanine compounds and their application as quenching compounds |
US7754496B2 (en) * | 2003-08-16 | 2010-07-13 | Bayer Schering Pharma Aktiengesellschaft | Determination of free fractions |
WO2005050206A2 (en) | 2003-09-17 | 2005-06-02 | Molecular Probes, Inc. | Competitive immunoassay |
US20050095174A1 (en) * | 2003-10-31 | 2005-05-05 | Wolf David E. | Semipermeable sensors for detecting analyte |
CN100577742C (zh) | 2003-10-31 | 2010-01-06 | 阿默森生物科学英国有限公司 | 花青染料标记试剂 |
US20050214807A1 (en) * | 2003-11-19 | 2005-09-29 | Iain Johnson | Environmental sensitive fluorogenic compounds and their application for singlet oxygen and protein detection |
WO2005051967A2 (en) * | 2003-11-19 | 2005-06-09 | Allelogic Biosciences Corp. | Oligonucleotides labeled with a plurality of fluorophores |
US7776529B2 (en) | 2003-12-05 | 2010-08-17 | Life Technologies Corporation | Methine-substituted cyanine dye compounds |
EP1720944B1 (de) | 2003-12-05 | 2013-07-17 | Life Technologies Corporation | Cyanin farbstoffverbindungen |
EP1711504A2 (de) | 2004-01-21 | 2006-10-18 | Molecular Probes Inc. | Derivate von cephalosporin und clavulansäure zum nachweis von beta-lactamase in einer probe |
US7387887B2 (en) | 2004-04-20 | 2008-06-17 | University Of Utah Research Foundation | Nucleic acid melting analysis with saturation dyes |
US9657347B2 (en) | 2004-04-20 | 2017-05-23 | University of Utah Research Foundation and BioFire Defense, LLC | Nucleic acid melting analysis with saturation dyes |
US8961407B2 (en) | 2004-07-21 | 2015-02-24 | Covidien Lp | Surgical port assembly |
WO2006023231A2 (en) | 2004-07-27 | 2006-03-02 | Molecular Probes, Inc. | Fluorescent metal ion indicators with large stokes shift |
US7524672B2 (en) * | 2004-09-22 | 2009-04-28 | Sandia Corporation | Microfluidic microarray systems and methods thereof |
US7592139B2 (en) | 2004-09-24 | 2009-09-22 | Sandia National Laboratories | High temperature flow-through device for rapid solubilization and analysis |
US8685711B2 (en) | 2004-09-28 | 2014-04-01 | Singulex, Inc. | Methods and compositions for highly sensitive detection of molecules |
EP1805500A4 (de) * | 2004-09-28 | 2008-05-07 | Singulex Inc | System und verfahren zur spektroskopischen analyse einzelner partikel |
US9040305B2 (en) * | 2004-09-28 | 2015-05-26 | Singulex, Inc. | Method of analysis for determining a specific protein in blood samples using fluorescence spectrometry |
US7572640B2 (en) * | 2004-09-28 | 2009-08-11 | Singulex, Inc. | Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties |
WO2006035207A2 (en) * | 2004-09-30 | 2006-04-06 | Ge Healthcare Uk Limited | Fluorescent nucleotide analogues |
WO2006047452A2 (en) * | 2004-10-25 | 2006-05-04 | Anaspec, Inc. | Reactive 1,3’-crosslinked carbocyanines and their bioconjugates |
CA2599709A1 (en) * | 2005-03-09 | 2006-09-21 | Cepheid | Polar dyes |
US7456281B2 (en) | 2005-04-20 | 2008-11-25 | Idaho Technology, Inc. | Nucleic acid melting analysis with saturation dyes |
JP2008538382A (ja) * | 2005-04-22 | 2008-10-23 | ジーイー・ヘルスケア・ユーケイ・リミテッド | 反応性蛍光標識試薬としての水溶性フルオロ置換シアニン色素 |
JP5306811B2 (ja) | 2005-05-11 | 2013-10-02 | ライフ テクノロジーズ コーポレーション | 2本鎖dnaへの高い選択性を有する蛍光化学物質及びそれらの使用 |
US7737281B2 (en) * | 2005-05-24 | 2010-06-15 | Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. | Purine based fluorescent dyes |
US7569695B2 (en) * | 2005-05-24 | 2009-08-04 | Enzo Life Sciences, Inc. | Dyes for the detection or quantification of desirable target molecules |
US8227621B2 (en) * | 2005-06-30 | 2012-07-24 | Li-Cor, Inc. | Cyanine dyes and methods of use |
FR2889700B1 (fr) * | 2005-08-11 | 2012-11-23 | Synthinnove Lab | Marqueurs, leur procede de fabrication et leurs applications |
US20070134685A1 (en) * | 2005-09-06 | 2007-06-14 | Invitrogen Corporation | Control of chemical modification |
EP1934607B1 (de) | 2005-10-13 | 2013-08-28 | Fundação D. Anna Sommer Champalimaud E Dr. Carlos Montez Champalimaud | Multiplex in situ immunochemische analyse |
DE102006029454A1 (de) * | 2005-12-05 | 2007-06-06 | Dyomics Gmbh | Hydrophile Marker auf Basis von diasteromeren |
DK1792949T3 (da) * | 2005-12-05 | 2010-12-06 | Dyomics Gmbh | Hydrofil markør på basis af diastereoisomere cyaniner |
US7521577B2 (en) | 2006-01-12 | 2009-04-21 | Molecular Probes, Inc. | Heavy metal binding compounds and their method of use |
US20070196860A1 (en) * | 2006-01-18 | 2007-08-23 | Invitrogen Corporation | Methods for Measuring Real Time Kinase Activity |
WO2007087582A1 (en) | 2006-01-24 | 2007-08-02 | Invitrogen Corporation | Device and methods for quantifying analytes |
WO2007090126A2 (en) * | 2006-01-30 | 2007-08-09 | Invitrogen Corporation | Compositions and methods for detecting and quantifying toxic substances in disease states |
EP3438131B1 (de) | 2006-02-10 | 2022-03-16 | Life Technologies Corporation | Modifizierung von oligosacchariden und etikettierung von proteinen |
US8114636B2 (en) | 2006-02-10 | 2012-02-14 | Life Technologies Corporation | Labeling and detection of nucleic acids |
US8562802B1 (en) | 2006-02-13 | 2013-10-22 | Life Technologies Corporation | Transilluminator base and scanner for imaging fluorescent gels, charging devices and portable electrophoresis systems |
EP2010677A4 (de) * | 2006-02-24 | 2010-04-14 | Investigen Inc | Verfahren und zusammensetzungen zum nachweis von polynukleotiden |
SG171598A1 (en) | 2006-03-23 | 2011-06-29 | Absorber Ab | Blood group antigens of different types for diagnostic and therapeutic applications |
JP4958461B2 (ja) * | 2006-03-30 | 2012-06-20 | 富士フイルム株式会社 | 近赤外吸収色素含有硬化性組成物 |
JP5391691B2 (ja) | 2006-03-31 | 2014-01-15 | 和光純薬工業株式会社 | ピラゾール系シアニン色素 |
JP5308328B2 (ja) | 2006-04-04 | 2013-10-09 | シングレックス,インコーポレイテッド | トロポニンの分析のための高感度のシステムおよび方法 |
EP3156799B1 (de) | 2006-04-04 | 2024-01-24 | Novilux, LLC | Analysator und verfahren zur hochempfindlichen detektion von analyten |
US7838250B1 (en) | 2006-04-04 | 2010-11-23 | Singulex, Inc. | Highly sensitive system and methods for analysis of troponin |
US20070281363A1 (en) * | 2006-04-13 | 2007-12-06 | Ewald Terpetschnig | Luminescent compounds |
CA2649535A1 (en) | 2006-04-20 | 2007-11-01 | Becton, Dickinson And Company | Thermostable proteins and methods of making and using thereof |
US20080076188A1 (en) * | 2006-06-19 | 2008-03-27 | Patsenker Leonid D | Luminescent compounds |
DK2074211T3 (da) | 2006-09-06 | 2013-06-17 | Medical Res Council | DNA polymeraser til inkorporation af farvestof-mærkede nukleotid-analoger |
GB0619626D0 (en) * | 2006-10-05 | 2006-11-15 | Ge Healthcare Uk Ltd | Fluoro-substituted benzoxazole polymethine dyes |
EP2064290B1 (de) | 2006-10-27 | 2013-10-09 | Life Technologies Corporation | Fluorgene ph-sensitive farbstoffe und ihre verwendung |
US7888506B2 (en) * | 2007-01-26 | 2011-02-15 | Duquesne University Of The Holy Spirit | Composition, synthesis, and use of a new class of fluorophores |
US8586743B2 (en) | 2007-01-30 | 2013-11-19 | Life Technologies Corporation | Labeling reagents and methods of their use |
WO2008094637A2 (en) | 2007-01-30 | 2008-08-07 | Seta Biomedicals. Llc | Luminescent compounds |
ATE553221T1 (de) | 2007-01-31 | 2012-04-15 | Wako Pure Chem Ind Ltd | Verfahren zum nachweis von amplifikation oder deletion in einem genomischen dna-fragment |
ES2670852T3 (es) | 2007-02-09 | 2018-06-01 | Visen Medical, Inc. | Colorantes con policiclo y uso de los mismos |
WO2008103702A2 (en) | 2007-02-23 | 2008-08-28 | Investigen, Inc. | Methods and compositions for rapid light-activated isolation and detection of analytes |
US20100119764A1 (en) * | 2007-02-28 | 2010-05-13 | Mitsubishi Kagaku Media Co., Ltd. | Cyanine dye and optical recording medium |
FR2913424B1 (fr) | 2007-03-09 | 2009-07-24 | Cis Bio Internat Sa | Derives de cyanine, conjuges fluorescents les contenant et leur utilisation |
WO2008127139A1 (fr) | 2007-04-11 | 2008-10-23 | Institut Molekulyarnoi Biologii Im. V.A. Engeldardta Rossiiskoi Akademii Nauk | Colorants d'indocyanine fluorescents et leurs dérivés destinés à l'analyse de macromolécules biologiques |
US8513451B2 (en) * | 2007-05-30 | 2013-08-20 | Hee Chol Kang | Fluorescent phospholipase A2 indicators |
WO2009029550A2 (en) * | 2007-08-24 | 2009-03-05 | Singulex, Inc. | Highly sensitive system and methods for analysis of prostate specific antigen (psa) |
CN101946171B (zh) * | 2007-12-14 | 2014-03-12 | 拜奥蒂乌姆股份有限公司 | 荧光化合物 |
CN103543094B (zh) | 2007-12-19 | 2017-06-09 | 神谷来克斯公司 | 单分子检测用扫描分析器和使用方法 |
EP2269064B1 (de) * | 2008-03-27 | 2016-11-30 | Promega Corporation | Proteinetikettierung mit cyanbenzothiazol-konjugaten |
CN102119223A (zh) | 2008-05-16 | 2011-07-06 | 生命技术公司 | 用于测量细胞增殖的双标记法 |
US7951959B2 (en) | 2008-09-17 | 2011-05-31 | Thermo Fisher Scientific (Milwaukee) LLC | Hydrophilic labels for biomolecules |
CN102272106A (zh) * | 2008-11-07 | 2011-12-07 | 通用医疗公司 | 用于体内和体外成像的单官能羰花青染料 |
EP2373349A1 (de) * | 2008-11-20 | 2011-10-12 | GE Healthcare AS | Färbemittel-konjugat-bildgebungsmittel |
JP5500875B2 (ja) | 2009-01-30 | 2014-05-21 | キヤノン株式会社 | 新規化合物、該新規化合物を用いたプローブ及び該新規化合物もしくは該プローブを用いた蛍光イメージング用造影剤 |
AU2010236189B2 (en) * | 2009-04-17 | 2015-01-29 | Li-Cor, Inc. | Fluorescent imaging with substituted cyanine dyes |
SG175282A1 (en) | 2009-04-21 | 2011-11-28 | Genetic Technologies Ltd | Methods for obtaining fetal genetic material |
US20110021908A1 (en) * | 2009-05-27 | 2011-01-27 | Lumicell Diagnostics, Inc. | Methods and systems for spatially identifying abnormal cells |
US9155471B2 (en) | 2009-05-27 | 2015-10-13 | Lumicell, Inc'. | Methods and systems for spatially identifying abnormal cells |
AU2010259022B2 (en) | 2009-06-08 | 2016-05-12 | Singulex, Inc. | Highly sensitive biomarker panels |
WO2011026085A2 (en) | 2009-08-31 | 2011-03-03 | Promega Corporation | Reactive cyanine compounds |
US8652441B2 (en) * | 2009-10-05 | 2014-02-18 | Canon Kabushiki Kaisha | Contrast agent for photoacoustic imaging and photoacoustic imaging method |
US8658434B2 (en) * | 2009-10-28 | 2014-02-25 | Biotium, Inc. | Fluorescent pyrene compounds |
US9579402B2 (en) * | 2009-12-04 | 2017-02-28 | Biotium, Inc. | Heterocycle-substituted xanthene dyes |
US8974651B2 (en) | 2010-04-17 | 2015-03-10 | C.C. Imex | Illuminator for visualization of fluorophores |
JP2013525820A (ja) | 2010-05-06 | 2013-06-20 | シングレクス、インコーポレイテッド | 関節リウマチの発症に関するリスクを診断し、病期分類し、予測し、治療レスポンダーを同定するための方法 |
WO2012001063A1 (en) * | 2010-06-29 | 2012-01-05 | Ge Healthcare As | Dye compositions and dye syntheses |
GB201010878D0 (en) * | 2010-06-29 | 2010-08-11 | Ge Healthcare As | Dye compositiion and dye syntheses |
US8623324B2 (en) | 2010-07-21 | 2014-01-07 | Aat Bioquest Inc. | Luminescent dyes with a water-soluble intramolecular bridge and their biological conjugates |
WO2012022734A2 (en) | 2010-08-16 | 2012-02-23 | Medimmune Limited | Anti-icam-1 antibodies and methods of use |
WO2012054784A1 (en) | 2010-10-20 | 2012-04-26 | Li-Cor, Inc. | Fluorescent imaging with substituted cyanine dyes |
WO2012061403A1 (en) * | 2010-11-02 | 2012-05-10 | Life Technologies Corporation | Modified hydrocyanine dyes for the detection of reactive oxygen species |
US9314304B2 (en) | 2010-12-08 | 2016-04-19 | Lumicell, Inc. | Methods and system for image guided cell ablation with microscopic resolution |
EP3029027B1 (de) | 2010-12-21 | 2018-06-27 | Pierce Biotechnology, Inc. | Fluoreszierende verbindungen |
US8889884B1 (en) | 2011-07-14 | 2014-11-18 | Pierce Biotechnology, Inc. | Phosphine derivatives of fluorescent compounds |
US9249307B2 (en) | 2011-08-16 | 2016-02-02 | Pierce Biotechnology, Inc. | Benzocyanine compounds |
AU2012309824A1 (en) | 2011-09-12 | 2013-04-18 | Abbvie Biotherapeutics Inc. | Artificial NK cells and uses thereof |
WO2013041117A1 (en) | 2011-09-23 | 2013-03-28 | Illumina Cambrigde Ltd. | Dyes for labelling molecular ligands |
CZ304094B6 (cs) * | 2011-12-01 | 2013-10-16 | Vysoká skola chemicko-technologická v Praze | Vyuzití polymethiniových solí jako mitochondriálních sond |
NL2008241C2 (en) * | 2012-02-06 | 2013-08-08 | Hq Medical Netherlands B V | Cell death probe. |
US9751868B2 (en) | 2012-02-28 | 2017-09-05 | Pierce Biotechnology, Inc. | Benzocyanine compounds |
CN104395306B (zh) | 2012-03-02 | 2019-04-23 | 皮尔斯生物科技有限公司 | 作为生物分子的标记染料的吲哚衍生物 |
WO2013148498A1 (en) | 2012-03-27 | 2013-10-03 | Ventana Medical Systems, Inc. | Signaling conjugates and methods of use |
JP2015521293A (ja) | 2012-05-31 | 2015-07-27 | ザ・ユニバーシテイ・オブ・ノース・カロライナ・アト・チャペル・ヒル | 溶解に誘導される構造化表面の湿潤 |
WO2014035712A1 (en) | 2012-08-28 | 2014-03-06 | Pierce Biotechnology, Inc. | Benzopyrylium compounds |
AU2013334635B2 (en) * | 2012-10-24 | 2018-12-06 | Becton, Dickinson And Company | Hydroxamate substituted azaindoline-cyanine dyes and bioconjugates of the same |
WO2014066733A2 (en) | 2012-10-25 | 2014-05-01 | Life Technologies Corporation | Methods and compositions for enzyme-mediated site-specific radiolabeling of glycoproteins |
US20160010145A1 (en) * | 2012-12-07 | 2016-01-14 | Life Technologies Corporation | Detection of rna with substituted unsymmetrical cyanine dyes |
ES2620427T3 (es) | 2013-03-08 | 2017-06-28 | Illumina Cambridge Limited | Compuestos rodamina y su uso como marcadores fluorescentes |
EP2964612B1 (de) | 2013-03-08 | 2017-02-01 | Illumina Cambridge Limited | Polymethinverbindungen und deren verwendung als fluoreszierende markierungen |
US10813554B2 (en) | 2013-03-14 | 2020-10-27 | Lumicell, Inc. | Medical imaging device and methods of use |
CN105339436B (zh) | 2013-03-15 | 2018-05-25 | 文森医学公司 | 4,4-二取代环己基桥连七甲川花菁染料及其应用 |
AU2014228504C1 (en) | 2013-03-15 | 2019-10-03 | Visen Medical, Inc. | Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection |
EP2970675A2 (de) * | 2013-03-15 | 2016-01-20 | Life Technologies Corporation | Verfahren für farbstoffauswahl zur bestimmung der proteinschmelztemperatur |
WO2015050959A1 (en) | 2013-10-01 | 2015-04-09 | Yale University | Anti-kit antibodies and methods of use thereof |
PL3052192T3 (pl) | 2013-10-02 | 2021-04-06 | Medimmune, Llc | Przeciwciała neutralizujące przeciwko grypie A i ich zastosowania |
US10542918B2 (en) | 2013-10-23 | 2020-01-28 | Verily Life Sciences Llc | Modulation of a response signal to distinguish between analyte and background signals |
US9504405B2 (en) | 2013-10-23 | 2016-11-29 | Verily Life Sciences Llc | Spatial modulation of magnetic particles in vasculature by external magnetic field |
US9835587B2 (en) | 2014-04-01 | 2017-12-05 | C.C. Imex | Electrophoresis running tank assembly |
GB201408077D0 (en) | 2014-05-07 | 2014-06-18 | Illumina Cambridge Ltd | Polymethine compounds and their use as fluorescent labels |
EP2944326B1 (de) * | 2014-05-16 | 2018-11-21 | Cyanagen Srl | Tricarbocyanin-cyclodextrin-konjugate und deren verwendung zur diagnose von nierenkrankheiten |
US10357510B2 (en) * | 2014-08-07 | 2019-07-23 | The Regents Of The University Of Michigan | Metal nanoclusters and uses thereof |
UA109751C2 (uk) | 2014-09-26 | 2015-09-25 | Спосіб визначення гідрогелю в біологічних тканинах | |
US10539566B2 (en) | 2014-12-08 | 2020-01-21 | Berg Llc | Use of markers including filamin A in the diagnosis and treatment of prostate cancer |
US9861710B1 (en) | 2015-01-16 | 2018-01-09 | Verily Life Sciences Llc | Composite particles, methods, and in vivo diagnostic system |
JP6552236B2 (ja) * | 2015-03-23 | 2019-07-31 | キヤノン株式会社 | 近赤外色素結合トランスフェリン、前記近赤外色素結合トランスフェリンを有する光音響イメージング用造影剤 |
US10028659B2 (en) | 2015-03-26 | 2018-07-24 | Verily Life Sciences Llc | Aptamer-based sensors, implantable devices and detection system |
GB201508858D0 (en) | 2015-05-22 | 2015-07-01 | Illumina Cambridge Ltd | Polymethine compounds with long stokes shifts and their use as fluorescent labels |
US9670318B2 (en) | 2015-05-28 | 2017-06-06 | Miltenyi Biotec Gmbh | Bright fluorochromes based on multimerization of fluorescent dyes |
EP3098269B1 (de) | 2015-05-28 | 2022-04-06 | Miltenyi Biotec B.V. & Co. KG | Auf der multimerisierung von fluoreszenzfarbstoffen auf verzweigten polyethergerüsten basierende helle fluorchrome |
GB201516987D0 (en) | 2015-09-25 | 2015-11-11 | Illumina Cambridge Ltd | Polymethine compounds and their use as fluorescent labels |
CA3007997A1 (en) | 2015-12-10 | 2017-06-15 | City Of Hope | Cell penetrating cyanine-coupled antibodies |
US9862682B2 (en) | 2016-01-08 | 2018-01-09 | BroadPharm | Functionalized pegylated cyanine compounds, pharmaceutical compositions, and methods of use thereof |
BR112018071026B1 (pt) | 2016-04-15 | 2023-04-11 | Beckman Coulter, Inc | Polímero fluorescente solúvel em água e método para detectar um analito de uma amostra |
WO2017181176A1 (en) | 2016-04-15 | 2017-10-19 | Lcahn School Of Medicine At Mount Sinai | Tissue profiling using multiplexed immunohistochemical consecutive staining |
US10294204B2 (en) * | 2016-04-27 | 2019-05-21 | Bioacts Co., Ltd. | Fluorescence compounds and preparation method thereof |
KR101944912B1 (ko) * | 2016-04-27 | 2019-02-07 | (주)바이오액츠 | 형광 화합물 및 이의 제조방법 |
US9796854B1 (en) | 2016-07-07 | 2017-10-24 | Intuitive Surgical Operations, Inc. | Method of synthesizing near IR, closed chain sulfo-cyanine dyes |
US20210108253A1 (en) | 2017-03-30 | 2021-04-15 | Life Technologies Corporation | Quantification of ngs dna by adapter sequence |
GB201711219D0 (en) | 2017-07-12 | 2017-08-23 | Illumina Cambridge Ltd | Short pendant arm linkers for nucleotides in sequencing applications |
CN107290198B (zh) * | 2017-07-25 | 2019-07-16 | 中国科学院微生物研究所 | 一种利用pip对生物材料染色的方法 |
US11091646B2 (en) | 2017-08-14 | 2021-08-17 | Seta Biomedicals, Llc | Luminescent squaraine rotaxane compounds |
GB201716931D0 (en) | 2017-10-16 | 2017-11-29 | Illumina Cambridge Ltd | New fluorescent compounds and their use as biomarkers |
WO2019204432A2 (en) * | 2018-04-17 | 2019-10-24 | Cornell University | Fluorine-18 labeled compositions and their use in imaging of biological tissue |
CN108752406A (zh) * | 2018-05-29 | 2018-11-06 | 苏州百源基因技术有限公司 | 一种荧光标记的核苷酸及其制备方法和用途 |
US11408840B2 (en) | 2018-06-28 | 2022-08-09 | Just-Evotec Biologics, Inc. | High throughput interrogation of physiochemical properties of a protein |
BR102019025989A2 (pt) | 2018-12-14 | 2020-06-23 | Beckman Coulter, Inc. | Modificação de corantes poliméricos e aplicações |
WO2020178165A1 (en) | 2019-03-01 | 2020-09-10 | Illumina Cambridge Limited | Tertiary amine substituted coumarin compounds and their uses as fluorescent labels |
JP2022522553A (ja) | 2019-03-01 | 2022-04-20 | イルミナ ケンブリッジ リミテッド | 環外アミン置換クマリン化合物およびそれらの蛍光標識としての使用 |
NL2023327B1 (en) | 2019-03-01 | 2020-09-17 | Illumina Inc | Multiplexed fluorescent detection of analytes |
WO2020178231A1 (en) | 2019-03-01 | 2020-09-10 | Illumina, Inc. | Multiplexed fluorescent detection of analytes |
EP3963099A1 (de) | 2019-04-30 | 2022-03-09 | Larimar Therapeutics, Inc. | Frataxin-sensitive marker zur bestimmung der wirksamkeit einer frataxin ersatztherapie |
US20230021681A1 (en) * | 2019-11-11 | 2023-01-26 | The Trustees Of Dartmouth College | Composition and method for in vivo assay of opioid receptors |
CN113736285A (zh) * | 2020-03-18 | 2021-12-03 | 宝天生物科技(上海)有限公司 | 紫外光激发荧光染料及其应用 |
EP4140999A4 (de) * | 2020-04-24 | 2023-11-29 | FUJIFILM Corporation | Verbindung und markiertes biomaterial damit |
JP2023533721A (ja) | 2020-07-02 | 2023-08-04 | ライフ テクノロジーズ コーポレーション | トリヌクレオチドキャップ類似体、それらの調製、及び使用 |
WO2022020723A1 (en) | 2020-07-23 | 2022-01-27 | Life Technologies Corporation | Energy transfer dye conjugates for use in biological assays |
EP4185858A2 (de) | 2020-07-23 | 2023-05-31 | Life Technologies Corporation | Zusammensetzungen, systeme und verfahren zur biologischen analyse unter verwendung von farbstoffen |
US20220033900A1 (en) | 2020-07-28 | 2022-02-03 | Illumina Cambridge Limited | Substituted coumarin dyes and uses as fluorescent labels |
CN116134044A (zh) | 2020-07-30 | 2023-05-16 | 富士胶片株式会社 | 化合物及使用了该化合物的标记生物物质 |
WO2022047359A1 (en) | 2020-08-31 | 2022-03-03 | Berg Llc | Protein biomarkers for pancreatic cancer |
EP4288776A1 (de) | 2021-02-05 | 2023-12-13 | Beckman Coulter, Inc. | Zusammensetzungen und verfahren zur verhinderung von nichtspezifischen wechselwirkungen zwischen polymerfarbstoff-antikörper-konjugaten |
EP4320443A1 (de) | 2021-04-06 | 2024-02-14 | BPGbio, Inc. | Proteinmarker zur prognose der brustkrebsprogression |
US20230059578A1 (en) | 2021-04-06 | 2023-02-23 | Berg Llc | Protein markers for estrogen receptor (er)-positive-like and estrogen receptor (er)-negative-like breast cancer |
WO2022216841A1 (en) | 2021-04-06 | 2022-10-13 | Berg Llc | Protein markers for estrogen receptor (er)-positive luminal a(la)-like and luminal b1 (lb1)-like breast cancer |
WO2022265043A1 (ja) | 2021-06-18 | 2022-12-22 | 富士フイルム株式会社 | 化合物及びこれを用いた標識生体物質 |
CN117529529A (zh) * | 2021-07-21 | 2024-02-06 | 生命技术公司 | 氮杂吲哚花菁染料、用途和制备方法 |
CN117897454A (zh) | 2021-07-21 | 2024-04-16 | 生命技术公司 | 二苯并呫吨猝灭剂、用途和制备方法 |
WO2023022187A1 (ja) | 2021-08-18 | 2023-02-23 | 富士フイルム株式会社 | 蛍光性化合物及びこれを用いた蛍光標識生体物質 |
WO2023032995A1 (ja) | 2021-08-31 | 2023-03-09 | 富士フイルム株式会社 | 化合物及びこれを用いた標識生体物質 |
WO2023032994A1 (ja) | 2021-08-31 | 2023-03-09 | 富士フイルム株式会社 | 化合物及びこれを用いた標識生体物質 |
WO2023032996A1 (ja) | 2021-08-31 | 2023-03-09 | 富士フイルム株式会社 | 化合物及びこれを用いた標識生体物質 |
WO2023056460A1 (en) | 2021-09-30 | 2023-04-06 | Beckman Coulter, Inc. | Water-soluble tetrahydropyrene based fluorescent polymers |
WO2023086103A1 (en) | 2021-11-12 | 2023-05-19 | Beckman Coulter, Inc. | Novel formulation for drying of polymer dye conjugated antibodies |
KR102414574B1 (ko) * | 2022-02-27 | 2022-06-30 | (주)바이오액츠 | 생체물질을 검출하기 위한 형광 화합물 및 이의 제조방법 |
WO2023196937A1 (en) | 2022-04-06 | 2023-10-12 | Larimar Therapeutics, Inc. | Frataxin-sensitive markers for monitoring frataxin replacement therapy |
WO2023240201A1 (en) | 2022-06-08 | 2023-12-14 | Larimar Therapeutics, Inc. | Frataxin-sensitive markers for monitoring progression and treatment of leigh syndrome |
WO2024007016A2 (en) | 2022-07-01 | 2024-01-04 | Beckman Coulter, Inc. | Novel fluorescent dyes and polymers from dihydrophenanthrene derivatives |
WO2024044327A1 (en) | 2022-08-26 | 2024-02-29 | Beckman Coulter, Inc. | Dhnt monomers and polymer dyes with modified photophysical properties |
CN115772390B (zh) * | 2022-12-02 | 2023-09-08 | 湖北龙海化工有限公司 | 一种钻井液用低荧光封堵防塌沥青 |
Family Cites Families (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB870753A (en) | 1957-07-04 | 1961-06-21 | Ilford Ltd | Improvements in or relating to methine dyes |
US2993791A (en) | 1957-10-31 | 1961-07-25 | Gen Aniline & Film Corp | Color couplers containing long chain alkylaminoisophthalicester groups |
US3723419A (en) | 1967-05-17 | 1973-03-27 | Eastman Kodak Co | Preparation of formylmethylene compounds and corresponding photographic dyestuffs |
US3864644A (en) | 1971-03-22 | 1975-02-04 | Eastman Kodak Co | Dye lasers including rigidized carbocyanine dyes |
US4011086A (en) | 1975-10-14 | 1977-03-08 | Eastman Kodak Company | Photographic emulsions and elements containing rigidized carbocyanine dyes |
US4273862A (en) | 1977-06-11 | 1981-06-16 | Mitsubishi Paper Mills, Ltd. | Direct-positive silver halide photographic sensitive materials |
US4711955A (en) | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
US5171534A (en) | 1984-01-16 | 1992-12-15 | California Institute Of Technology | Automated DNA sequencing technique |
US5366603A (en) | 1984-03-29 | 1994-11-22 | Li-Cor, Inc. | Sequencing near infrared and infrared fluorescence labeled DNA for detecting useing laser diodes |
US6086737A (en) | 1984-03-29 | 2000-07-11 | Li-Cor, Inc. | Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor |
JPS62123454A (ja) † | 1985-08-08 | 1987-06-04 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
US5569587A (en) | 1986-04-18 | 1996-10-29 | Carnegie Mellon University | Method for labeling and detecting materials employing luminescent arysulfonate cyanine dyes |
US6225050B1 (en) * | 1986-04-18 | 2001-05-01 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
US5268486A (en) * | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
US6048982A (en) * | 1986-04-18 | 2000-04-11 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
US5627027A (en) * | 1986-04-18 | 1997-05-06 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
CA1340806C (en) | 1986-07-02 | 1999-11-02 | James Merrill Prober | Method, system and reagents for dna sequencing |
US5047519A (en) | 1986-07-02 | 1991-09-10 | E. I. Du Pont De Nemours And Company | Alkynylamino-nucleotides |
US5049673A (en) | 1987-10-30 | 1991-09-17 | The Regents Of The University Of California | Fluorescent indicator dyes for calcium working at long wavelengths |
JPH0672706B2 (ja) | 1988-05-31 | 1994-09-14 | 清水建設株式会社 | 香り供給方法および香り供給装置 |
US4997928A (en) | 1988-09-15 | 1991-03-05 | E. I. Du Pont De Nemours And Company | Fluorescent reagents for the preparation of 5'-tagged oligonucleotides |
US5196306A (en) | 1989-03-29 | 1993-03-23 | E. I. Du Pont De Nemours And Company | Method for the detection or quantitation of an analyte using an analyte dependent enzyme activation system |
US5137810A (en) | 1989-04-26 | 1992-08-11 | The University Of North Carolina | Method of determining the gram sign of bacteria |
US4981977A (en) | 1989-06-09 | 1991-01-01 | Carnegie-Mellon University | Intermediate for and fluorescent cyanine dyes containing carboxylic acid groups |
JPH0614984Y2 (ja) | 1989-11-29 | 1994-04-20 | 西川化成株式会社 | 樹脂成形体への部品取付構造 |
US5405975A (en) | 1993-03-29 | 1995-04-11 | Molecular Probes, Inc. | Fluorescent ion-selective diaryldiaza crown ether conjugates |
US5648270A (en) | 1995-02-06 | 1997-07-15 | Molecular Probes, Inc. | Methods of sensing with fluorescent conjugates of metal-chelating nitrogen heterocycles |
US5453517A (en) | 1992-02-25 | 1995-09-26 | Molecular Probes, Inc. | Reactive derivatives of bapta used to make ion-selective chelators |
US5567588A (en) | 1990-06-11 | 1996-10-22 | University Research Corporation | Systematic evolution of ligands by exponential enrichment: Solution SELEX |
FR2664760B1 (fr) * | 1990-07-13 | 1996-09-27 | Sgs Thomson Microelectronics | Dispositif de protection contre des surtensions et sa realisation monolithique. |
NL9001639A (nl) | 1990-07-19 | 1992-02-17 | Amc Amsterdam | Pt-houdende verbinding, werkwijze voor de bereiding ervan, alsmede toepassing van dergelijke verbindingen. |
US5714327A (en) | 1990-07-19 | 1998-02-03 | Kreatech Diagnostics | Platinum-containing compounds, methods for their preparation and applications thereof |
US5208148A (en) | 1990-12-07 | 1993-05-04 | Molecular Probes, Inc. | Lipophilic fluorescent glycosidase substrates |
YU187991A (sh) | 1990-12-11 | 1994-09-09 | Hoechst Aktiengesellschaft | 3-(2)-amino-ali tiol-modifikovani, s fluorescentnom bojom vezani nukleozidi, nukleotidi i oligonukleotidi, postupak za njihovo dobijanje i njihova upotreba |
JPH08168B2 (ja) | 1991-02-12 | 1996-01-10 | マルチネツ ムジカ デー.フェルナンド | 工作機械用ろ過装置 |
JP3084454B2 (ja) * | 1991-04-23 | 2000-09-04 | コニカ株式会社 | ハロゲン化銀写真感光材料 |
US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
SE9200917D0 (sv) * | 1991-08-20 | 1992-03-25 | Pharmacia Biosensor Ab | Assay method |
US5831098A (en) | 1992-03-16 | 1998-11-03 | Minnesota Mining And Manufacturing Company | 2-methyl-4,4a-dihydro-3H-carbazolium salts and dyes derived therefrom |
JPH05313304A (ja) † | 1992-05-11 | 1993-11-26 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
JPH0614984A (ja) | 1992-07-01 | 1994-01-25 | Yamatake Honeywell Co Ltd | 香り発生装置 |
DE69324494T2 (de) | 1992-09-03 | 1999-09-23 | Perkin Elmer Corp | 4,7-dichlorofluoroszein-farbestoffe als molekulare sonden |
US5808044A (en) | 1993-01-22 | 1998-09-15 | Pharmacia Biotech Inc. | Indocarbocyanine and benzindocarbocyanine phosphoramidites |
US5556959A (en) † | 1993-01-22 | 1996-09-17 | Pharmacia P-L Biochemicals Inc. | Indocarbocyanine-linked phosphoramidites |
US5436134A (en) | 1993-04-13 | 1995-07-25 | Molecular Probes, Inc. | Cyclic-substituted unsymmetrical cyanine dyes |
US5496700A (en) * | 1993-08-06 | 1996-03-05 | The United States Of America As Represented By The Secretary Of The Navy | Optical immunoassay for microbial analytes using non-specific dyes |
US5516911A (en) | 1993-12-30 | 1996-05-14 | The United States Of America As Represented By The Department Of Health And Human Services | Fluorescent intracellular calcium indicators |
US5453505A (en) | 1994-06-30 | 1995-09-26 | Biometric Imaging, Inc. | N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels |
US5487502A (en) | 1994-07-25 | 1996-01-30 | Liao; Ming-Kang | Decorative means for emitting odor and generating sound |
EP0703494B1 (de) * | 1994-09-22 | 2002-05-08 | Fuji Photo Film Co., Ltd. | Infrarot absorbierenden Farbstoff photographisches Silberhalogenidmaterial |
US5547588A (en) * | 1994-10-25 | 1996-08-20 | Gas Research Institute | Enhanced ettringite formation for the treatment of hazardous liquid waste |
US6150510A (en) | 1995-11-06 | 2000-11-21 | Aventis Pharma Deutschland Gmbh | Modified oligonucleotides, their preparation and their use |
DE4445065A1 (de) † | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
US6127134A (en) | 1995-04-20 | 2000-10-03 | Carnegie Mellon University | Difference gel electrophoresis using matched multiple dyes |
US5684142A (en) | 1995-06-07 | 1997-11-04 | Oncor, Inc. | Modified nucleotides for nucleic acid labeling |
US6008373A (en) | 1995-06-07 | 1999-12-28 | Carnegie Mellon University | Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer |
JP3292007B2 (ja) * | 1995-11-09 | 2002-06-17 | 松下電器産業株式会社 | 色素標識タンパク質複合体及びその作製方法 |
US6004536A (en) | 1995-11-14 | 1999-12-21 | Molecular Probes, Inc. | Lipophilic cyanine dyes with enchanced aqueous solubilty |
US5668268A (en) | 1995-11-27 | 1997-09-16 | Hybridon, Inc. | Passivated polymer supports for nucleic acid synthesis |
US6165734A (en) * | 1995-12-12 | 2000-12-26 | Applied Spectral Imaging Ltd. | In-situ method of analyzing cells |
US5714386A (en) | 1996-01-11 | 1998-02-03 | Board Of Trustees Of The Leland Stanford Junior University | Cy7-allophycocyanin conjugates for use in multiplex fluorescence detection assays |
US5922618A (en) * | 1996-03-04 | 1999-07-13 | Matsushita Electric Industrial Co., Ltd. | Dye-labeled antibody conjugate and preparation method thereof |
DE69706417T2 (de) | 1996-04-19 | 2002-06-27 | Amersham Pharm Biotech Uk Ltd | Quadratfarbstoffe und deren verwendung in einem fluorescenzsequenzierungsverfahren |
US6245499B1 (en) * | 1996-04-30 | 2001-06-12 | Fuji Photo Film Co., Ltd. | Photothermographic material |
JP3537267B2 (ja) * | 1996-06-06 | 2004-06-14 | 松下電器産業株式会社 | 設備運用方法 |
US5688966A (en) | 1996-07-26 | 1997-11-18 | E. I. Du Pont De Nemours And Company | Compounds and method for synthesizing sulfoindocyanine dyes |
US6303758B1 (en) * | 1996-11-08 | 2001-10-16 | Matsushita Electric Industrial Co., Ltd. | Dye-labeled and polymerized antibody and method for preparing the same |
US6303759B1 (en) * | 1996-11-08 | 2001-10-16 | Matsushita Electric Industrial Co., Ltd. | Dye-labeled and polymerized antibody and method for preparing the same |
US6027709A (en) | 1997-01-10 | 2000-02-22 | Li-Cor Inc. | Fluorescent cyanine dyes |
US5877310A (en) | 1997-04-25 | 1999-03-02 | Carnegie Mellon University | Glycoconjugated fluorescent labeling reagents |
WO1998048838A1 (en) † | 1997-04-29 | 1998-11-05 | Nycomed Imaging As | Compounds |
US5986086A (en) | 1997-06-20 | 1999-11-16 | Amersham Pharmacia Biotech Inc. | Non-sulfonated cyanine dyes for labeling nucleosides and nucleotides |
US6133445A (en) | 1997-12-17 | 2000-10-17 | Carnegie Mellon University | Rigidized trimethine cyanine dyes |
US6538129B1 (en) * | 1999-04-07 | 2003-03-25 | Ewald A. Terpetschnig | Luminescent compounds |
WO1999051702A1 (en) | 1998-04-08 | 1999-10-14 | Terpetschnig Ewald A | Luminescent compounds |
US7250517B2 (en) * | 1998-04-08 | 2007-07-31 | Ewald A. Terpetschnig | Luminescent compounds |
US6002003A (en) | 1998-04-14 | 1999-12-14 | Beckman Instruments, Inc. | Cyanine dye activating group with improved coupling selectivity |
GB9812596D0 (en) | 1998-06-11 | 1998-08-12 | Amersham Pharm Biotech Uk Ltd | Energy transfer assay method |
US6114350A (en) | 1999-04-19 | 2000-09-05 | Nen Life Science Products, Inc. | Cyanine dyes and synthesis methods thereof |
US6664047B1 (en) | 1999-04-30 | 2003-12-16 | Molecular Probes, Inc. | Aza-benzazolium containing cyanine dyes |
AU5728400A (en) * | 1999-06-09 | 2000-12-28 | Amersham Pharmacia Biotech Uk Limited | Ph sensitive cyanine dyes as reactive fluorescent reagents |
ES2329572T3 (es) | 1999-07-02 | 2009-11-27 | Visen Medical, Inc. | Nuevos marcadores fluorescentes de cianina que contienen un grupo enlazador sulfamido. |
WO2001002374A1 (en) | 1999-07-06 | 2001-01-11 | Surromed, Inc. | Bridged fluorescent dyes, their preparation and their use in assays |
DE19937024A1 (de) * | 1999-08-05 | 2001-02-08 | Bayer Ag | Verwendung von Acylsulfonamido substituierten Polymethin-Farbstoffen als Fluoreszenz-Farbstoffe und/oder Marker |
EP1219626B1 (de) | 1999-09-20 | 2005-06-01 | Fuji Photo Film Co., Ltd. | Verbindungen zur floureszenz-kennzeichnung |
DE19957320A1 (de) * | 1999-11-29 | 2001-05-31 | Febit Ferrarius Biotech Gmbh | Dynamische Sequenzierung durch Hybridisierung |
US6977306B2 (en) * | 2000-05-02 | 2005-12-20 | Sumitomo Chemical Company, Limited | Citalopram hydrobromide crystal and method for crystallization thereof |
US6342326B1 (en) * | 2000-05-10 | 2002-01-29 | Beckman Coulter, Inc. | Synthesis and use of acyl fluorides of cyanine dyes |
DE10046215B4 (de) | 2000-09-19 | 2004-04-15 | Institut für Chemo- und Biosensorik Münster e.V. i.Ins. | Fluorochrome und deren Verwendung |
AU9301901A (en) | 2000-09-27 | 2002-04-08 | Lexicon Genetics Inc | Novel human ion-exchanger proteins and polynucleotides encoding the same |
CA2423806C (en) | 2000-09-29 | 2009-12-22 | Molecular Probes, Inc. | Modified carbocyanine dyes and their conjugates |
EP1209205A1 (de) * | 2000-11-28 | 2002-05-29 | Innosense S.r.l. | Verbesserte Verfahren und Methode zur Herstellung von asymmetrischen monofunktionalisierten Indocyaninmarkern sowie erhaltene Verbindungen |
US6962992B2 (en) | 2000-12-20 | 2005-11-08 | Molecullar Probes, Inc. | Crown ether derivatives |
US6972326B2 (en) | 2001-12-03 | 2005-12-06 | Molecular Probes, Inc. | Labeling of immobilized proteins using dipyrrometheneboron difluoride dyes |
EP1525265B1 (de) | 2002-05-10 | 2011-07-20 | Carnegie Mellon University | Chirale indole als zwischenprodukte und daraus hergestellte cyaninfluoreszenzfarbstoffe mit funktionellen gruppen |
JP2006524991A (ja) | 2003-05-08 | 2006-11-09 | エクサイト セラピーズ インコーポレーティッド | 抗原特異的t細胞の作製および単離の方法 |
CN101946171B (zh) * | 2007-12-14 | 2014-03-12 | 拜奥蒂乌姆股份有限公司 | 荧光化合物 |
-
2001
- 2001-09-28 CA CA 2423806 patent/CA2423806C/en not_active Expired - Lifetime
- 2001-09-28 WO PCT/US2001/030404 patent/WO2002026891A1/en active IP Right Grant
- 2001-09-28 DE DE2001975541 patent/DE01975541T9/de active Active
- 2001-09-28 AU AU2001294859A patent/AU2001294859A1/en not_active Abandoned
- 2001-09-28 AT AT01975541T patent/ATE352586T2/de active
- 2001-09-28 EP EP01975541.2A patent/EP1322710B2/de not_active Expired - Lifetime
- 2001-09-28 DE DE2001626297 patent/DE60126297T2/de not_active Expired - Fee Related
- 2001-09-28 EP EP20100183563 patent/EP2325263B1/de not_active Expired - Lifetime
- 2001-09-29 US US09/968,401 patent/US6977305B2/en not_active Expired - Lifetime
- 2001-10-01 US US09/969,853 patent/US6974873B2/en not_active Expired - Lifetime
-
2005
- 2005-06-10 US US11/150,596 patent/US7566790B2/en not_active Expired - Lifetime
- 2005-12-20 US US11/313,890 patent/US7790893B2/en not_active Expired - Lifetime
-
2007
- 2007-02-14 US US11/675,037 patent/US7820824B2/en not_active Expired - Lifetime
- 2007-02-14 US US11/675,033 patent/US7671214B2/en not_active Expired - Lifetime
- 2007-02-14 US US11/675,030 patent/US20070178511A1/en not_active Abandoned
-
2008
- 2008-05-29 US US12/129,671 patent/US7927830B2/en not_active Expired - Fee Related
- 2008-05-29 US US12/129,641 patent/US8614302B2/en not_active Expired - Lifetime
-
2010
- 2010-10-18 US US12/906,304 patent/US8252932B2/en not_active Expired - Lifetime
-
2012
- 2012-07-24 US US13/556,643 patent/US8569506B2/en not_active Expired - Lifetime
-
2013
- 2013-09-18 US US14/030,835 patent/US9018396B2/en not_active Expired - Fee Related
-
2015
- 2015-03-13 US US14/656,992 patent/US20150247785A1/en not_active Abandoned
- 2015-04-15 US US14/687,584 patent/US9423323B2/en not_active Expired - Lifetime
-
2016
- 2016-08-16 US US15/237,853 patent/US20160356681A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60126297D1 (de) | Modifizierte carbocyaninfarbstoffe und deren konjugate | |
WO2006047452A3 (en) | Reactive 1,3’-crosslinked carbocyanines and their bioconjugates | |
CY1124278T1 (el) | Βελτιωμενοι κυτταροτοξικοι παραγοντες οι οποιοι περιεχουν νεα μεϋτανσινοειδη | |
BR0318028A (pt) | Corantes hidrofìlicos de cianina reativos a tiol e conjugados dos mesmos com biomoléculas para diagnóstico por fluorescência | |
ATE275553T1 (de) | Isothiazole derivate verwendbar als antikrebsmittel | |
DK1594542T3 (da) | Anti-CD70 antistof-lægemiddelkonjugater og deres anvendelse ved behandling af cancer | |
WO2002094325A3 (en) | Cytotoxic cd44 antibody immunoconjugates | |
ATE315066T1 (de) | Cyaninfarbstoffe | |
RU2002108928A (ru) | Окса- и тиазолпроизводные в качестве антидиабетических агентов и агентов против ожирения | |
ATE296105T1 (de) | Iminbildende polysaccharide, deren herstellung und verwendung als zusatzmittel und immunstimulierende mittel | |
EA200101177A1 (ru) | Производные индола в качестве антагонистов прогестерона | |
CY1109593T1 (el) | Παραγωγα 12,13-κυκλοπροπανο εποθιλονης | |
DE60004172D1 (de) | Gcsf konjugate | |
DE60208355D1 (de) | 2-amino-propanol derivate | |
DE60003863D1 (de) | Dioxocyclopentylhydroxamsäure | |
ATE304866T1 (de) | Chelatorkonjugate mit verbesserten eigenschaften | |
EP1801165A3 (de) | Modifizierte Carbozyanin-Farbstoffe und ihre Konjugate | |
HN1997000098A (es) | Ccompuesto de indol 2, 3 sustituido como agentes antiinflamatorios y analgesicos. | |
PT810220E (pt) | Derivados de arilacrilamida como agonistas ou antigonistas de 5ht1 | |
BRPI0409376A (pt) | derivados de indeno como agentes farmacêuticos | |
TR200200125T2 (tr) | Yeni aminotiyazol türevleri, bunların hazırlanması ve bunları içeren farmasötik kompozisyonlar. | |
PT1107793E (pt) | Conjugados de dextrano-leptina, composicoes farmaceuticas e processos relacionados | |
ATE269315T1 (de) | C10 taxan derivate und pharmazeutische zusammensetzungen | |
ATE312842T1 (de) | Reduziertes cortisolkonjugat | |
PT937708E (pt) | Derivados de sulfonamidas |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent | ||
8339 | Ceased/non-payment of the annual fee |