RS20050561A - HYDROPHILIC, THIOL-REACTIVE CYANINE DYES AND CONjUGATES THEREOF WITH BIOMOLECULES FOR FLUORESCENCE DIAGNOSIS - Google Patents

HYDROPHILIC, THIOL-REACTIVE CYANINE DYES AND CONjUGATES THEREOF WITH BIOMOLECULES FOR FLUORESCENCE DIAGNOSIS

Info

Publication number
RS20050561A
RS20050561A YUP-2005/0561A YUP20050561A RS20050561A RS 20050561 A RS20050561 A RS 20050561A YU P20050561 A YUP20050561 A YU P20050561A RS 20050561 A RS20050561 A RS 20050561A
Authority
RS
Serbia
Prior art keywords
biomolecules
conjugates
thiol
hydrophilic
dyes
Prior art date
Application number
YUP-2005/0561A
Other languages
Serbian (sr)
Inventor
Kai Licha
Christin Perlitz
Original Assignee
Schering Ag.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag., filed Critical Schering Ag.,
Priority claimed from PCT/EP2003/012735 external-priority patent/WO2004065491A1/en
Publication of RS20050561A publication Critical patent/RS20050561A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0066—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

This invention relates to new fluorescence dyes from the class of cyanine dyes, especially indotricarbocyanines with an absorption and fluorescence maximum in the spectral range of 700 to 900 nm, a thiol-specific reactive group, and three, preferably four, sulfonate groups, to an increase of water solubility as well as the production of dyes. This invention also relates to the conjugates of these dyes with biomolecules and uses thereof.
YUP-2005/0561A 2003-01-24 2003-11-14 HYDROPHILIC, THIOL-REACTIVE CYANINE DYES AND CONjUGATES THEREOF WITH BIOMOLECULES FOR FLUORESCENCE DIAGNOSIS RS20050561A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE2003102787 DE10302787A1 (en) 2003-01-24 2003-01-24 New indotricarbocyanine dyes are conjugated to biomolecules, used in fluorescence diagnosis of e.g. tumors
US44319703P 2003-01-29 2003-01-29
PCT/EP2003/012735 WO2004065491A1 (en) 2003-01-24 2003-11-14 Hydrophilic, thiol-reactive cyanine dyes and conjugates thereof with biomolecules for fluorescence diagnosis

Publications (1)

Publication Number Publication Date
RS20050561A true RS20050561A (en) 2007-09-21

Family

ID=32694952

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-2005/0561A RS20050561A (en) 2003-01-24 2003-11-14 HYDROPHILIC, THIOL-REACTIVE CYANINE DYES AND CONjUGATES THEREOF WITH BIOMOLECULES FOR FLUORESCENCE DIAGNOSIS

Country Status (6)

Country Link
CN (1) CN1742057A (en)
DE (1) DE10302787A1 (en)
NO (1) NO20053919L (en)
RS (1) RS20050561A (en)
UA (1) UA82684C2 (en)
ZA (1) ZA200506759B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8367842B2 (en) * 2009-07-16 2013-02-05 Beckman Coulter, Inc. Fluorescent dyes and uses thereof
EP3001197A1 (en) * 2014-09-23 2016-03-30 Universität Heidelberg Fluorescent protein stains
CN107488657A (en) * 2017-08-15 2017-12-19 苏州泽科生物科技有限公司 Reactive dye coupling mark, detection and the method for purification of nucleic acid
US10968386B2 (en) 2018-01-09 2021-04-06 Shenzhen University Pentamethine cyanine dye and preparation method therefor
CN108192376A (en) * 2018-01-09 2018-06-22 深圳大学 A kind of Cyanine dyestuff and preparation method
CN108727245B (en) * 2018-07-02 2021-09-28 广州中医药大学(广州中医药研究院) Salicylic acid compound and preparation method and application thereof
CN110201189B (en) * 2019-06-03 2021-12-07 沈阳药科大学 Albumin-binding near-infrared fluorescent dye-maleimide conjugate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6225050B1 (en) * 1986-04-18 2001-05-01 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US6002503A (en) * 1997-10-23 1999-12-14 Ciena Corporation Optical add/drop multiplexer
US6217848B1 (en) * 1999-05-20 2001-04-17 Mallinckrodt Inc. Cyanine and indocyanine dye bioconjugates for biomedical applications
US6180085B1 (en) * 2000-01-18 2001-01-30 Mallinckrodt Inc. Dyes

Also Published As

Publication number Publication date
DE10302787A1 (en) 2004-08-12
ZA200506759B (en) 2007-01-31
NO20053919L (en) 2005-10-24
UA82684C2 (en) 2008-05-12
CN1742057A (en) 2006-03-01
NO20053919D0 (en) 2005-08-23

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