DE60102161T2 - Cumarin-derivate mit comt hemmender wirkung - Google Patents

Cumarin-derivate mit comt hemmender wirkung Download PDF

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Publication number
DE60102161T2
DE60102161T2 DE60102161T DE60102161T DE60102161T2 DE 60102161 T2 DE60102161 T2 DE 60102161T2 DE 60102161 T DE60102161 T DE 60102161T DE 60102161 T DE60102161 T DE 60102161T DE 60102161 T2 DE60102161 T2 DE 60102161T2
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DE
Germany
Prior art keywords
alkyl
halogen
cooh
oder
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60102161T
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German (de)
English (en)
Other versions
DE60102161D1 (de
Inventor
Jarmo Pystynen
Martti Ovaska
Jukka Vidgren
Timo Lotta
Marjo Yliperttula-Ikonen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Oyj
Original Assignee
Orion Oyj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Oyj filed Critical Orion Oyj
Publication of DE60102161D1 publication Critical patent/DE60102161D1/de
Application granted granted Critical
Publication of DE60102161T2 publication Critical patent/DE60102161T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
DE60102161T 2000-07-03 2001-06-28 Cumarin-derivate mit comt hemmender wirkung Expired - Lifetime DE60102161T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI20001593A FI20001593A (fi) 2000-07-03 2000-07-03 Comt-entsyymiõ inhiboivaa aktiivisuutta omaavia kumariinijohdannaisia
FI20001593 2000-07-03
PCT/FI2001/000613 WO2002002548A1 (en) 2000-07-03 2001-06-28 Coumarin derivatives with comt inhibiting activity

Publications (2)

Publication Number Publication Date
DE60102161D1 DE60102161D1 (de) 2004-04-01
DE60102161T2 true DE60102161T2 (de) 2004-09-16

Family

ID=8558717

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60102161T Expired - Lifetime DE60102161T2 (de) 2000-07-03 2001-06-28 Cumarin-derivate mit comt hemmender wirkung

Country Status (27)

Country Link
US (1) US6951870B2 (ja)
EP (1) EP1301503B1 (ja)
JP (1) JP4851051B2 (ja)
KR (1) KR20030040225A (ja)
CN (1) CN1199963C (ja)
AT (1) ATE260268T1 (ja)
AU (2) AU2001272597B9 (ja)
BG (1) BG107513A (ja)
BR (1) BR0111969A (ja)
CA (1) CA2414787C (ja)
DE (1) DE60102161T2 (ja)
DK (1) DK1301503T3 (ja)
EE (1) EE200300008A (ja)
ES (1) ES2215919T3 (ja)
FI (1) FI20001593A (ja)
HU (1) HUP0301706A3 (ja)
IL (2) IL153352A0 (ja)
MX (1) MXPA02012657A (ja)
NO (1) NO328699B1 (ja)
NZ (1) NZ523121A (ja)
PL (1) PL359068A1 (ja)
PT (1) PT1301503E (ja)
RU (1) RU2282627C2 (ja)
SK (1) SK18452002A3 (ja)
TR (1) TR200400802T4 (ja)
WO (1) WO2002002548A1 (ja)
ZA (1) ZA200210161B (ja)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPR846401A0 (en) * 2001-10-25 2001-11-15 Novogen Research Pty Ltd 6-Hydroxy isoflavones, derivatives and medicaments involving same
AU2003265737B2 (en) * 2002-10-02 2008-10-16 Novogen Research Pty Ltd Combination chemotherapy compositions and methods
AU2002951833A0 (en) * 2002-10-02 2002-10-24 Novogen Research Pty Ltd Compositions and therapeutic methods invloving platinum complexes
CN1506359A (zh) * 2002-12-05 2004-06-23 �й�ҽѧ��ѧԺҩ���о��� 新的香豆素酰胺衍生物及其制法和其药物组合物与用途
US8080675B2 (en) 2004-09-21 2011-12-20 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
US7601855B2 (en) 2004-09-21 2009-10-13 Novogen Research Pty Ltd Substituted chroman derivatives, medicaments and use in therapy
MY148644A (en) * 2005-07-18 2013-05-15 Orion Corp New pharmaceutical compounds
EP1917245A1 (de) 2005-08-21 2008-05-07 Abbott GmbH & Co. KG Heterocyclische verbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren
WO2007124617A1 (fr) * 2006-04-28 2007-11-08 Institute Of Mataria Medica, Chinese Academy Of Medical Sciences Dérivés de coumarine, leurs procédés de préparation, compositions pharmaceutiques et utilisations
ES2343347B2 (es) * 2009-01-27 2011-12-07 Universidade De Santiago De Compostela Uso de derivados de 3-fenilcumarinas 6-sustituidas y preparacion de nuevos derivados.
EP2635121B1 (en) 2010-11-01 2020-01-08 MEI Pharma, Inc. Isoflavonoid compounds and methods for the treatment of cancer
TWI638802B (zh) 2012-05-24 2018-10-21 芬蘭商奧利安公司 兒茶酚ｏ－甲基轉移酶活性抑制化合物
HUE054998T2 (hu) 2015-02-02 2021-10-28 Mei Pharma Inc Kombinációs terápiák emlõrák kezelésében való alkalmazásra
US11008282B2 (en) * 2015-12-18 2021-05-18 Caprotec Bioanalytics Gmbh Bicyclic-compounds for use as a medicament, in particular for treatment of parkinson's disease
CN107868069A (zh) * 2017-10-31 2018-04-03 山东新华制药股份有限公司 7‑羟基‑8‑甲基‑6‑硝基‑2‑氧‑2h‑苯并吡喃‑3‑羧酸的制备工艺

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5035393A (ja) * 1973-08-01 1975-04-04
US3973608A (en) 1973-08-01 1976-08-10 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Microbial production of certain isoflavones
US5236952A (en) * 1986-03-11 1993-08-17 Hoffmann-La Roche Inc. Catechol derivatives
US5283352A (en) * 1986-11-28 1994-02-01 Orion-Yhtyma Oy Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same
GB8816519D0 (en) 1987-07-23 1988-08-17 Ici Plc Antibiotic compounds
HUT63843A (en) 1992-02-13 1993-10-28 Biosignal Kutato Fejlesztoe Kf Process for producing new kumarin derivatives and their analogs inhibiting mammal cell proliferation and tumour growth, as well as pharmaceutical comkpositions comprising such compounds
JP3166094B2 (ja) * 1993-09-08 2001-05-14 森永乳業株式会社 クマリン誘導体及びそれらの用途
JPH0892157A (ja) 1994-05-02 1996-04-09 F Hoffmann La Roche Ag プルプロガリン誘導体
GB9626472D0 (en) 1996-12-20 1997-02-05 Aperia Anita C New use of comt inhibitors

Also Published As

Publication number Publication date
EE200300008A (et) 2004-08-16
IL153352A (en) 2009-05-04
NO328699B1 (no) 2010-04-26
BG107513A (bg) 2003-06-30
JP2004502684A (ja) 2004-01-29
MXPA02012657A (es) 2003-05-14
KR20030040225A (ko) 2003-05-22
WO2002002548A1 (en) 2002-01-10
FI20001593A0 (fi) 2000-07-03
PT1301503E (pt) 2004-06-30
NZ523121A (en) 2004-08-27
RU2282627C2 (ru) 2006-08-27
HUP0301706A2 (hu) 2003-09-29
EP1301503B1 (en) 2004-02-25
ATE260268T1 (de) 2004-03-15
US20030186975A1 (en) 2003-10-02
ZA200210161B (en) 2004-03-15
DE60102161D1 (de) 2004-04-01
PL359068A1 (en) 2004-08-23
AU2001272597B9 (en) 2005-08-11
AU7259701A (en) 2002-01-14
US20040110750A9 (en) 2004-06-10
US6951870B2 (en) 2005-10-04
HUP0301706A3 (en) 2005-12-28
CA2414787A1 (en) 2002-01-10
JP4851051B2 (ja) 2012-01-11
IL153352A0 (en) 2003-07-06
EP1301503A1 (en) 2003-04-16
CN1199963C (zh) 2005-05-04
SK18452002A3 (sk) 2004-04-06
CA2414787C (en) 2010-12-14
TR200400802T4 (tr) 2004-07-21
NO20026095D0 (no) 2002-12-18
AU2001272597B2 (en) 2005-07-21
DK1301503T3 (da) 2004-06-28
NO20026095L (no) 2003-03-03
BR0111969A (pt) 2003-07-01
FI20001593A (fi) 2002-01-04
ES2215919T3 (es) 2004-10-16
CN1440399A (zh) 2003-09-03

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