TR200400802T4 - COMT inhibe edici etkiye sahip kumarin türevleri - Google Patents

COMT inhibe edici etkiye sahip kumarin türevleri

Info

Publication number
TR200400802T4
TR200400802T4 TR2004/00802T TR200400802T TR200400802T4 TR 200400802 T4 TR200400802 T4 TR 200400802T4 TR 2004/00802 T TR2004/00802 T TR 2004/00802T TR 200400802 T TR200400802 T TR 200400802T TR 200400802 T4 TR200400802 T4 TR 200400802T4
Authority
TR
Turkey
Prior art keywords
inhibitory effect
coumarin derivatives
comt inhibitory
comt
ortho
Prior art date
Application number
TR2004/00802T
Other languages
English (en)
Inventor
Pystynen Jarmo
Ovaska Martti
Vidgren Jukka
Lotta Timo
Yliperttula-Ikonen Marjo
Original Assignee
Orion Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corporation filed Critical Orion Corporation
Publication of TR200400802T4 publication Critical patent/TR200400802T4/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Fenil kisminda bulunan iki OH- ikame edicinin, bir digerine göre orto olan bir konumda bulundugu ve R1'in, hidroksi gruplarindan birine göre orto konumunda bulundugu; ve X, R1-R6'nin, istemlemlerde tanimlandigi gibi oldugu formül (I') bilesikleri, COMT enzimini inhibe edici bir etki sergilediklerinden, COMT inhibitörleri olarak faydalidirlar.
TR2004/00802T 2000-07-03 2001-06-28 COMT inhibe edici etkiye sahip kumarin türevleri TR200400802T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI20001593A FI20001593A (fi) 2000-07-03 2000-07-03 Comt-entsyymiõ inhiboivaa aktiivisuutta omaavia kumariinijohdannaisia

Publications (1)

Publication Number Publication Date
TR200400802T4 true TR200400802T4 (tr) 2004-07-21

Family

ID=8558717

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2004/00802T TR200400802T4 (tr) 2000-07-03 2001-06-28 COMT inhibe edici etkiye sahip kumarin türevleri

Country Status (27)

Country Link
US (1) US6951870B2 (tr)
EP (1) EP1301503B1 (tr)
JP (1) JP4851051B2 (tr)
KR (1) KR20030040225A (tr)
CN (1) CN1199963C (tr)
AT (1) ATE260268T1 (tr)
AU (2) AU2001272597B9 (tr)
BG (1) BG107513A (tr)
BR (1) BR0111969A (tr)
CA (1) CA2414787C (tr)
DE (1) DE60102161T2 (tr)
DK (1) DK1301503T3 (tr)
EE (1) EE200300008A (tr)
ES (1) ES2215919T3 (tr)
FI (1) FI20001593A (tr)
HU (1) HUP0301706A3 (tr)
IL (2) IL153352A0 (tr)
MX (1) MXPA02012657A (tr)
NO (1) NO328699B1 (tr)
NZ (1) NZ523121A (tr)
PL (1) PL359068A1 (tr)
PT (1) PT1301503E (tr)
RU (1) RU2282627C2 (tr)
SK (1) SK18452002A3 (tr)
TR (1) TR200400802T4 (tr)
WO (1) WO2002002548A1 (tr)
ZA (1) ZA200210161B (tr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPR846401A0 (en) * 2001-10-25 2001-11-15 Novogen Research Pty Ltd 6-Hydroxy isoflavones, derivatives and medicaments involving same
AU2002951833A0 (en) * 2002-10-02 2002-10-24 Novogen Research Pty Ltd Compositions and therapeutic methods invloving platinum complexes
AU2003265737B2 (en) * 2002-10-02 2008-10-16 Novogen Research Pty Ltd Combination chemotherapy compositions and methods
CN1506359A (zh) * 2002-12-05 2004-06-23 �й�ҽѧ��ѧԺҩ���о��� 新的香豆素酰胺衍生物及其制法和其药物组合物与用途
NZ553834A (en) 2004-09-21 2010-03-26 Novogen Res Pty Ltd 7-hydroxy-3,4-diphenyl-chroman and chromene derivatives
US8080675B2 (en) 2004-09-21 2011-12-20 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
MY148644A (en) * 2005-07-18 2013-05-15 Orion Corp New pharmaceutical compounds
EP1917245A1 (de) 2005-08-21 2008-05-07 Abbott GmbH & Co. KG Heterocyclische verbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren
WO2007124617A1 (fr) * 2006-04-28 2007-11-08 Institute Of Mataria Medica, Chinese Academy Of Medical Sciences Dérivés de coumarine, leurs procédés de préparation, compositions pharmaceutiques et utilisations
ES2343347B2 (es) * 2009-01-27 2011-12-07 Universidade De Santiago De Compostela Uso de derivados de 3-fenilcumarinas 6-sustituidas y preparacion de nuevos derivados.
WO2012061413A2 (en) 2010-11-01 2012-05-10 Marshall Edwards, Inc. Isoflavonoid compositions and methods for the treatment of cancer
TWI638802B (zh) 2012-05-24 2018-10-21 芬蘭商奧利安公司 兒茶酚ｏ－甲基轉移酶活性抑制化合物
MX2017010002A (es) 2015-02-02 2018-02-09 Mei Pharma Inc Terapias de combinacion.
JP7007292B2 (ja) * 2015-12-18 2022-02-10 ケスター、ヒューバート 薬剤としての使用のため、特にパーキンソン病の治療のための新規二環式化合物
CN107868069A (zh) * 2017-10-31 2018-04-03 山东新华制药股份有限公司 7‑羟基‑8‑甲基‑6‑硝基‑2‑氧‑2h‑苯并吡喃‑3‑羧酸的制备工艺

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3973608A (en) 1973-08-01 1976-08-10 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Microbial production of certain isoflavones
JPS5035393A (tr) * 1973-08-01 1975-04-04
US5236952A (en) * 1986-03-11 1993-08-17 Hoffmann-La Roche Inc. Catechol derivatives
US5283352A (en) * 1986-11-28 1994-02-01 Orion-Yhtyma Oy Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same
GB8816519D0 (en) 1987-07-23 1988-08-17 Ici Plc Antibiotic compounds
HUT63843A (en) 1992-02-13 1993-10-28 Biosignal Kutato Fejlesztoe Kf Process for producing new kumarin derivatives and their analogs inhibiting mammal cell proliferation and tumour growth, as well as pharmaceutical comkpositions comprising such compounds
JP3166094B2 (ja) * 1993-09-08 2001-05-14 森永乳業株式会社 クマリン誘導体及びそれらの用途
JPH0892157A (ja) 1994-05-02 1996-04-09 F Hoffmann La Roche Ag プルプロガリン誘導体
GB9626472D0 (en) 1996-12-20 1997-02-05 Aperia Anita C New use of comt inhibitors

Also Published As

Publication number Publication date
EP1301503A1 (en) 2003-04-16
ES2215919T3 (es) 2004-10-16
US20030186975A1 (en) 2003-10-02
RU2282627C2 (ru) 2006-08-27
EP1301503B1 (en) 2004-02-25
JP4851051B2 (ja) 2012-01-11
WO2002002548A1 (en) 2002-01-10
BR0111969A (pt) 2003-07-01
HUP0301706A3 (en) 2005-12-28
AU7259701A (en) 2002-01-14
PT1301503E (pt) 2004-06-30
SK18452002A3 (sk) 2004-04-06
DE60102161D1 (de) 2004-04-01
PL359068A1 (en) 2004-08-23
AU2001272597B2 (en) 2005-07-21
BG107513A (bg) 2003-06-30
DE60102161T2 (de) 2004-09-16
EE200300008A (et) 2004-08-16
KR20030040225A (ko) 2003-05-22
FI20001593A0 (fi) 2000-07-03
NO20026095D0 (no) 2002-12-18
CN1440399A (zh) 2003-09-03
US20040110750A9 (en) 2004-06-10
IL153352A (en) 2009-05-04
JP2004502684A (ja) 2004-01-29
NZ523121A (en) 2004-08-27
HUP0301706A2 (hu) 2003-09-29
ATE260268T1 (de) 2004-03-15
FI20001593A (fi) 2002-01-04
NO20026095L (no) 2003-03-03
CN1199963C (zh) 2005-05-04
DK1301503T3 (da) 2004-06-28
NO328699B1 (no) 2010-04-26
CA2414787C (en) 2010-12-14
ZA200210161B (en) 2004-03-15
US6951870B2 (en) 2005-10-04
AU2001272597B9 (en) 2005-08-11
IL153352A0 (en) 2003-07-06
CA2414787A1 (en) 2002-01-10
MXPA02012657A (es) 2003-05-14

Similar Documents

Publication Publication Date Title
TR200400802T4 (tr) COMT inhibe edici etkiye sahip kumarin türevleri
DK1070056T3 (da) Phthalazinon-PDE III/IV-inhibitorer
BG106242A (en) Metalloprotease inhibitors
BR0108396A (pt) Derivados de pirimidina-4-0na como inibidores de ldl-pla(2)
NO992617D0 (no) Sulfinsyrederivater, deres fremstilling og anvendelse
YU40997A (sh) Novi oksadiazoli, postupci za njihovo pripremanje
TR200202806T2 (tr) 4-Triflorometilsulfinilpirazol türevi hazırlama süreci
EA200200301A1 (ru) ЗАМЕЩЕННЫЕ α-ГИДРОКСИКИСЛОТЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ИНГИБИРОВАНИЯ КЛЕТОЧНОЙ ГИБЕЛИ НА КЛЕТОЧНОМ ИЛИ ТКАНЕВОМ УРОВНЕ, СПОСОБ ЛЕЧЕНИЯ ИЛИ ОБЛЕГЧЕНИЯ СОСТОЯНИЯ ПРИ ГИБЕЛИ КЛЕТОК У ЖИВОТНОГО, СПОСОБ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ РАЗЛИЧНЫХ БОЛЕЗНЕЙ
PT920426E (pt) Novos derivados de tiazole com efeito inibidor de fosfodiesterase
DK1066291T3 (da) Svampedræbende 6-(2-halogen-4-alkoxyphenyl)-triazolopyrimidiner
ATE258930T1 (de) Dihydrobenzifurane
AP2002002554A0 (en) Ox (ADI) azolyl-hydroxamic acids useful as procollagen C- proteinase inhibitors.
DE60023025D1 (de) 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p39-kinase-inhibitoren
DK1377574T3 (da) 6-phenylbenzonaphtyridiner
DE69714056T2 (de) Cytostatische hydroxamsäurederivate
ATE374189T1 (de) Phthalazinon-derivate als pde 4 hemmer
WO2001085760A8 (en) Thrombin inhibitors
TR200102984T2 (tr) Madraftalazin trevlerinin ”n iltihaplandìrìcì sitokinlerin engelleyicileri olarak kullanìmì
AU2001223692A1 (en) Benzoic acid esters, and liquid-crystalline medium
HK1039451B (zh) 包含胰島素敏化劑的藥物組合物
AU758194C (en) Novel benzimidazoles and benzoxazoles
ATE301667T1 (de) Anthracyclinglykosid-14-sulfon säurederivate mit antitumorwirkung
DK1490391T3 (da) 11beta-langkædet substituerede 19-nor-17alfa-pregna-1,3,5(10)-trien-17beta-oler med en 21,2alfa-lactonring