BR0111969A - Derivados da cumarina com atividade inibidora da comt - Google Patents

Derivados da cumarina com atividade inibidora da comt

Info

Publication number
BR0111969A
BR0111969A BR0111969-9A BR0111969A BR0111969A BR 0111969 A BR0111969 A BR 0111969A BR 0111969 A BR0111969 A BR 0111969A BR 0111969 A BR0111969 A BR 0111969A
Authority
BR
Brazil
Prior art keywords
inhibitory activity
comt
coumarin derivatives
comt inhibitory
ortho position
Prior art date
Application number
BR0111969-9A
Other languages
English (en)
Original Assignee
Orion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corp filed Critical Orion Corp
Publication of BR0111969A publication Critical patent/BR0111969A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans

Abstract

"DERIVADOS DA CUMARINA COM ATIVIDADE INIBIDORA DA COMT". Trata-se de um composto de fórmula (I') onde os dois substituintes OH- na metade fenila estão na posição orto entre si e R~ 1~ em uma posição orto em relação aos grupos hidroxila; e X, R~ 1~ a R~ 6~ estão conforme definidos nas reivindicações, exibindo atividade inibitória da enzima COMT para que sejam úteis como inibidores da COMT.
BR0111969-9A 2000-07-03 2001-06-28 Derivados da cumarina com atividade inibidora da comt BR0111969A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20001593A FI20001593A (fi) 2000-07-03 2000-07-03 Comt-entsyymiõ inhiboivaa aktiivisuutta omaavia kumariinijohdannaisia
PCT/FI2001/000613 WO2002002548A1 (en) 2000-07-03 2001-06-28 Coumarin derivatives with comt inhibiting activity

Publications (1)

Publication Number Publication Date
BR0111969A true BR0111969A (pt) 2003-07-01

Family

ID=8558717

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0111969-9A BR0111969A (pt) 2000-07-03 2001-06-28 Derivados da cumarina com atividade inibidora da comt

Country Status (27)

Country Link
US (1) US6951870B2 (pt)
EP (1) EP1301503B1 (pt)
JP (1) JP4851051B2 (pt)
KR (1) KR20030040225A (pt)
CN (1) CN1199963C (pt)
AT (1) ATE260268T1 (pt)
AU (2) AU2001272597B9 (pt)
BG (1) BG107513A (pt)
BR (1) BR0111969A (pt)
CA (1) CA2414787C (pt)
DE (1) DE60102161T2 (pt)
DK (1) DK1301503T3 (pt)
EE (1) EE200300008A (pt)
ES (1) ES2215919T3 (pt)
FI (1) FI20001593A (pt)
HU (1) HUP0301706A3 (pt)
IL (2) IL153352A0 (pt)
MX (1) MXPA02012657A (pt)
NO (1) NO328699B1 (pt)
NZ (1) NZ523121A (pt)
PL (1) PL359068A1 (pt)
PT (1) PT1301503E (pt)
RU (1) RU2282627C2 (pt)
SK (1) SK18452002A3 (pt)
TR (1) TR200400802T4 (pt)
WO (1) WO2002002548A1 (pt)
ZA (1) ZA200210161B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPR846401A0 (en) * 2001-10-25 2001-11-15 Novogen Research Pty Ltd 6-Hydroxy isoflavones, derivatives and medicaments involving same
AU2003265737B2 (en) * 2002-10-02 2008-10-16 Novogen Research Pty Ltd Combination chemotherapy compositions and methods
AU2002951833A0 (en) 2002-10-02 2002-10-24 Novogen Research Pty Ltd Compositions and therapeutic methods invloving platinum complexes
CN1506359A (zh) * 2002-12-05 2004-06-23 �й�ҽѧ��ѧԺҩ���о��� 新的香豆素酰胺衍生物及其制法和其药物组合物与用途
US8080675B2 (en) 2004-09-21 2011-12-20 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
EP2407462B1 (en) 2004-09-21 2014-07-30 Marshall Edwards, Inc. Substituted chroman derivatives, medicaments and use in therapy
MY148644A (en) 2005-07-18 2013-05-15 Orion Corp New pharmaceutical compounds
US8686002B2 (en) 2005-08-21 2014-04-01 AbbVie Deutschland GmbH & Co. KG Heterocyclic compounds and their use as binding partners for 5-HT5 receptors
WO2007124617A1 (fr) * 2006-04-28 2007-11-08 Institute Of Mataria Medica, Chinese Academy Of Medical Sciences Dérivés de coumarine, leurs procédés de préparation, compositions pharmaceutiques et utilisations
ES2343347B2 (es) * 2009-01-27 2011-12-07 Universidade De Santiago De Compostela Uso de derivados de 3-fenilcumarinas 6-sustituidas y preparacion de nuevos derivados.
CA2816322A1 (en) 2010-11-01 2012-05-10 Marshall Edwards, Inc. Isoflavonoid compositions and methods for the treatment of cancer
TWI638802B (zh) 2012-05-24 2018-10-21 芬蘭商奧利安公司 兒茶酚ｏ－甲基轉移酶活性抑制化合物
CA2974123C (en) 2015-02-02 2023-08-01 Mei Pharma, Inc. Combination of benzopyran derivative and glycolytic inhibitors for cancer therapy
CA3007458A1 (en) 2015-12-18 2017-06-22 Hubert Koester Bicyclic-compounds for use as a medicament, in particular for trea tment of parkinson's disease
CN107868069A (zh) * 2017-10-31 2018-04-03 山东新华制药股份有限公司 7‑羟基‑8‑甲基‑6‑硝基‑2‑氧‑2h‑苯并吡喃‑3‑羧酸的制备工艺

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5035393A (pt) * 1973-08-01 1975-04-04
US3973608A (en) 1973-08-01 1976-08-10 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Microbial production of certain isoflavones
US5236952A (en) * 1986-03-11 1993-08-17 Hoffmann-La Roche Inc. Catechol derivatives
US5283352A (en) * 1986-11-28 1994-02-01 Orion-Yhtyma Oy Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same
GB8816519D0 (en) 1987-07-23 1988-08-17 Ici Plc Antibiotic compounds
HUT63843A (en) 1992-02-13 1993-10-28 Biosignal Kutato Fejlesztoe Kf Process for producing new kumarin derivatives and their analogs inhibiting mammal cell proliferation and tumour growth, as well as pharmaceutical comkpositions comprising such compounds
JP3166094B2 (ja) * 1993-09-08 2001-05-14 森永乳業株式会社 クマリン誘導体及びそれらの用途
JPH0892157A (ja) 1994-05-02 1996-04-09 F Hoffmann La Roche Ag プルプロガリン誘導体
GB9626472D0 (en) 1996-12-20 1997-02-05 Aperia Anita C New use of comt inhibitors

Also Published As

Publication number Publication date
CN1199963C (zh) 2005-05-04
IL153352A (en) 2009-05-04
ES2215919T3 (es) 2004-10-16
CA2414787A1 (en) 2002-01-10
DE60102161T2 (de) 2004-09-16
DK1301503T3 (da) 2004-06-28
EP1301503B1 (en) 2004-02-25
WO2002002548A1 (en) 2002-01-10
CA2414787C (en) 2010-12-14
JP4851051B2 (ja) 2012-01-11
EE200300008A (et) 2004-08-16
BG107513A (bg) 2003-06-30
FI20001593A (fi) 2002-01-04
AU7259701A (en) 2002-01-14
IL153352A0 (en) 2003-07-06
EP1301503A1 (en) 2003-04-16
US20030186975A1 (en) 2003-10-02
MXPA02012657A (es) 2003-05-14
NO20026095D0 (no) 2002-12-18
ATE260268T1 (de) 2004-03-15
PT1301503E (pt) 2004-06-30
NO328699B1 (no) 2010-04-26
NZ523121A (en) 2004-08-27
AU2001272597B2 (en) 2005-07-21
HUP0301706A2 (hu) 2003-09-29
AU2001272597B9 (en) 2005-08-11
JP2004502684A (ja) 2004-01-29
KR20030040225A (ko) 2003-05-22
TR200400802T4 (tr) 2004-07-21
US20040110750A9 (en) 2004-06-10
DE60102161D1 (de) 2004-04-01
US6951870B2 (en) 2005-10-04
FI20001593A0 (fi) 2000-07-03
CN1440399A (zh) 2003-09-03
PL359068A1 (en) 2004-08-23
ZA200210161B (en) 2004-03-15
RU2282627C2 (ru) 2006-08-27
SK18452002A3 (sk) 2004-04-06
HUP0301706A3 (en) 2005-12-28
NO20026095L (no) 2003-03-03

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A E 8A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2016 DE 25/08/2009.