DE60042326D1 - Radiomarkierungssatz und bindungstest - Google Patents
Radiomarkierungssatz und bindungstestInfo
- Publication number
- DE60042326D1 DE60042326D1 DE60042326T DE60042326T DE60042326D1 DE 60042326 D1 DE60042326 D1 DE 60042326D1 DE 60042326 T DE60042326 T DE 60042326T DE 60042326 T DE60042326 T DE 60042326T DE 60042326 D1 DE60042326 D1 DE 60042326D1
- Authority
- DE
- Germany
- Prior art keywords
- radiolabeling
- kit
- radiomarking
- binding test
- kits
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000163 radioactive labelling Methods 0.000 abstract 3
- 208000003950 B-cell lymphoma Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 238000000159 protein binding assay Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/534—Production of labelled immunochemicals with radioactive label
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Steroid Compounds (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Packages (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/259,337 US20020102208A1 (en) | 1999-03-01 | 1999-03-01 | Radiolabeling kit and binding assay |
| PCT/US2000/005061 WO2000052473A2 (en) | 1999-03-01 | 2000-02-29 | Radiolabeling kit and binding assay |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60042326D1 true DE60042326D1 (de) | 2009-07-16 |
Family
ID=22984524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60042326T Expired - Lifetime DE60042326D1 (de) | 1999-03-01 | 2000-02-29 | Radiomarkierungssatz und bindungstest |
Country Status (35)
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6107090A (en) | 1996-05-06 | 2000-08-22 | Cornell Research Foundation, Inc. | Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains |
| US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
| MY133346A (en) | 1999-03-01 | 2007-11-30 | Biogen Inc | Kit for radiolabeling ligands with yttrium-90 |
| US20020102208A1 (en) * | 1999-03-01 | 2002-08-01 | Paul Chinn | Radiolabeling kit and binding assay |
| US6207858B1 (en) * | 1999-03-03 | 2001-03-27 | Idec Pharmaceuticals Corporation | Regioselective synthesis of DTPA derivatives |
| EP1918305A1 (en) | 1999-08-11 | 2008-05-07 | Biogen Idec Inc. | New clinical parameters for determining hematologic toxicity prior to radioimmunotherapy |
| WO2002028481A2 (en) | 2000-10-02 | 2002-04-11 | Chiron Corporation | Methods of therapy for b-cell malignancies using antagonist anti-cd40 antibodies |
| JP2005500018A (ja) * | 2001-04-02 | 2005-01-06 | アイデック ファーマスーティカルズ コーポレイション | GnTIIIと同時発現する組換え抗体 |
| US7514078B2 (en) | 2001-06-01 | 2009-04-07 | Cornell Research Foundation, Inc. | Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies |
| JP4619651B2 (ja) | 2001-06-01 | 2011-01-26 | コーネル・リサーチ・ファンデーション・インコーポレイテッド | 前立腺特異的膜抗原に対する修飾抗体およびその使用 |
| AU2002305767B2 (en) | 2001-09-20 | 2008-04-10 | Cornell Research Foundation, Inc. | Methods and compositions for treating and preventing skin disorders using binding agents specific for PSMA |
| DE60323677D1 (de) | 2003-01-10 | 2008-10-30 | Millennium Pharm Inc | Verfahren zur bestimmung des wiederauftretens von prostata krebs |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| ATE402947T1 (de) * | 2003-06-25 | 2008-08-15 | Peregrine Pharmaceuticals Inc | Verfahren und vorrichtung zur kontinuierlichen radioaktiven markierung von proteinen im grossen massstab |
| SI1682177T1 (sl) | 2003-11-04 | 2010-12-31 | Novartis Vaccines & Diagnostic | Uporaba antagonističnih anti-CD40 protiteles za zdravljenje kronične limfocitne levkemije |
| PT1684869E (pt) | 2003-11-04 | 2011-09-16 | Novartis Vaccines & Diagnostic | Métodos de terapêutica para cancros relacionados com células b |
| RS53073B (sr) | 2003-11-04 | 2014-04-30 | Novartis Vaccines And Diagnostics Inc. | Upotreba antagonističkih anti-cd40 monoklonska antitela |
| DK1684805T3 (da) | 2003-11-04 | 2010-10-04 | Novartis Vaccines & Diagnostic | Anvendelse af antagonist anti-CD40-monoklonale antistoffer til behandling af multipel myeloma |
| EP2301575A1 (en) | 2003-11-04 | 2011-03-30 | Novartis Vaccines and Diagnostics, Inc. | Methods of therapy for solid tumors expressing the CD40 cell-surface antigen |
| JP5421590B2 (ja) | 2005-05-18 | 2014-02-19 | ノバルティス アーゲー | 自己免疫および/または炎症性成分を有する疾患の診断および治療のための方法 |
| WO2007008547A2 (en) | 2005-07-08 | 2007-01-18 | Biogen Idec Ma Inc. | Sp35 antibodies and uses thereof |
| WO2007023408A2 (en) * | 2005-08-25 | 2007-03-01 | Koninklijke Philips Electronics N.V. | 4d image-based planning methods and apparatus for targeted therapy |
| EP3095467B1 (en) * | 2005-11-23 | 2020-05-06 | Ventana Medical Systems, Inc. | Antibody-enzyme conjugate |
| GEP20125628B (en) | 2006-04-21 | 2012-09-10 | Novartis Ag | Pharmaceutical compositions containing antagonist anti-cd40 antibody |
| DK2037967T3 (en) | 2006-06-16 | 2017-03-13 | Univ Pennsylvania | PROSTAGLANDIN-D2 RECEPTOR ANTAGONISTS FOR TREATMENT OF ANDROGENETIC ALOPECI |
| US9382327B2 (en) | 2006-10-10 | 2016-07-05 | Vaccinex, Inc. | Anti-CD20 antibodies and methods of use |
| EP2089401B1 (en) * | 2006-11-10 | 2012-07-25 | RadioProtect Alphaptose UG (haftungsbeschränkt) & Co. KG | Use of tri-substituted glycerol compounds for the treatment of radiation injuries |
| CZ300074B6 (cs) * | 2006-12-20 | 2009-01-21 | Azacycles S. R. O. | Inteligentní trífunkcní makrokonjugáty a farmaceutický nebo diagnostický prostredek s jejich obsahem |
| GB0700133D0 (en) | 2007-01-04 | 2007-02-14 | Humabs Llc | Human cytomegalovirus neutralising antibodies and use thereof |
| NO2740744T3 (enExample) | 2007-01-09 | 2018-08-25 | ||
| NZ585516A (en) * | 2007-12-21 | 2012-07-27 | Hoffmann La Roche | Anti-cd20 antibody formulation |
| JP2011527572A (ja) | 2008-07-09 | 2011-11-04 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | Lingo抗体または断片を含む組成物 |
| JP5475774B2 (ja) | 2008-07-16 | 2014-04-16 | インスティテュート フォー リサーチ イン バイオメディシン | ヒトサイトメガロウイルス中和抗体およびその使用 |
| EP2352759B1 (en) | 2008-07-16 | 2017-11-01 | Institute for Research in Biomedicine | Human cytomegalovirus neutralizing antibodies and use thereof |
| US8871207B2 (en) | 2008-07-25 | 2014-10-28 | Humabs, LLC | Neutralizing anti-influenza A virus antibodies and uses thereof |
| CN102216327A (zh) | 2008-07-25 | 2011-10-12 | 生物医学研究所 | 中和抗甲型流感病毒抗体及其用途 |
| WO2010043977A2 (en) | 2008-10-13 | 2010-04-22 | Institute For Research In Biomedicine | Dengue virus neutralizing antibodies and uses thereof |
| JP2012514458A (ja) | 2008-12-31 | 2012-06-28 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 抗リンホトキシン抗体 |
| WO2011092593A2 (en) | 2010-01-20 | 2011-08-04 | Institute For Research In Biomedicine | Hiv-1 neutralizing antibodies and uses thereof |
| SI3117709T1 (sl) | 2010-03-12 | 2018-12-31 | Genzyme Corporation | Kombinirana terapija za zdravljenje raka dojke |
| WO2012006635A1 (en) | 2010-07-09 | 2012-01-12 | Biogen Idec Hemophilia Inc. | Processable single chain molecules and polypeptides made using same |
| US9441029B2 (en) | 2010-08-06 | 2016-09-13 | Genzyme Corporation | VEGF antagonist compositions and uses thereof |
| US9587285B2 (en) | 2010-08-13 | 2017-03-07 | José Raimundo Filho | Method and composition for reducing the color of sugar |
| EP3045183B1 (en) | 2011-03-11 | 2018-07-04 | Genzyme Corporation | Pegylated apelin and uses thereof |
| EP3418300B1 (en) | 2011-07-18 | 2020-10-28 | Institute for Research in Biomedicine | Neutralizing anti-influenza a virus antibodies and uses thereof |
| UY34317A (es) | 2011-09-12 | 2013-02-28 | Genzyme Corp | Anticuerpo antireceptor de célula T (alfa)/ß |
| WO2013092998A1 (en) | 2011-12-23 | 2013-06-27 | Innate Pharma | Enzymatic conjugation of antibodies |
| NZ630920A (en) | 2012-03-20 | 2017-01-27 | Humabs Biomed Sa | Antibodies that neutralize rsv, mpv and pvm and uses thereof |
| WO2013175276A1 (en) | 2012-05-23 | 2013-11-28 | Argen-X B.V | Il-6 binding molecules |
| RU2522203C2 (ru) * | 2012-06-26 | 2014-07-10 | Василий Александрович Ишутин | Способ контроля стерилизации материалов и изделий |
| WO2014009426A2 (en) * | 2012-07-13 | 2014-01-16 | Innate Pharma | Screening of conjugated antibodies |
| US9790268B2 (en) | 2012-09-12 | 2017-10-17 | Genzyme Corporation | Fc containing polypeptides with altered glycosylation and reduced effector function |
| WO2014072482A1 (en) | 2012-11-09 | 2014-05-15 | Innate Pharma | Recognition tags for tgase-mediated conjugation |
| KR102420934B1 (ko) | 2013-03-11 | 2022-07-15 | 젠자임 코포레이션 | 과글리코실화된 결합 폴리펩티드 |
| WO2014165216A1 (en) | 2013-03-12 | 2014-10-09 | The Trustees Of The University Of Pennsylvania | Diagnosing and treating cancer |
| WO2014140300A1 (en) | 2013-03-15 | 2014-09-18 | Innate Pharma | Solid phase tgase-mediated conjugation of antibodies |
| WO2014202773A1 (en) | 2013-06-20 | 2014-12-24 | Innate Pharma | Enzymatic conjugation of polypeptides |
| KR20160042871A (ko) | 2013-06-21 | 2016-04-20 | 이나뜨 파르마, 에스.아. | 폴리펩티드의 효소적 콘쥬게이션 |
| RU2558929C2 (ru) * | 2013-08-08 | 2015-08-10 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт кардиологии" (НИИ Кардиологии) | СПОСОБ ОПРЕДЕЛЕНИЯ СВЯЗЫВАНИЯ РАДИОФАРМПРЕПАРАТА НА ОСНОВЕ ЦИПРОФЛОКСАЦИНА, МЕЧЕННОГО 99mTc C БАКТЕРИЯМИ |
| US9845363B2 (en) | 2013-08-13 | 2017-12-19 | Sanofi | Antibodies to plasminogen activator inhibitor-1 (PAI-1) and uses thereof |
| US11052177B2 (en) | 2013-09-06 | 2021-07-06 | The Trustees Of The University Of Pennsylvania | Antimicrobial polymer layers |
| SG10202103140XA (en) | 2013-10-02 | 2021-05-28 | Medimmune Llc | Neutralizing anti-influenza a antibodies and uses thereof |
| CA2940823C (en) | 2014-02-27 | 2017-03-28 | Board Of Regents, The University Of Texas System | Methods and compositions for isolating exosomes |
| EP4640239A2 (en) | 2014-03-19 | 2025-10-29 | Genzyme Corporation | Site-specific glycoengineering of targeting moieties |
| JP6598844B2 (ja) | 2014-03-27 | 2019-10-30 | バード・ロック・バイオ・インコーポレイテッド | ヒトカンナビノイド1(cb1)受容体に結合する抗体 |
| RU2739952C2 (ru) | 2014-07-15 | 2020-12-30 | МЕДИММЬЮН, ЭлЭлСи | Нейтрализующие антитела к вирусу гриппа b и пути их применения |
| US12214038B2 (en) | 2014-07-22 | 2025-02-04 | The Trustees Of The University Of Pennsylvania | Compositions and methods for cancer immunotherapy |
| US20170296650A1 (en) | 2014-10-08 | 2017-10-19 | Novartis Ag | Combination of human cytomegalovirus neutralizing antibodies |
| PL3204425T3 (pl) | 2014-10-09 | 2021-03-08 | Genzyme Corporation | Glikomodyfikowane koniugaty przeciwciał z lekami |
| WO2016075546A2 (en) | 2014-11-14 | 2016-05-19 | Antonio Lanzavecchia | Antibodies that neutralize ebola virus and uses thereof |
| EP3220947B1 (en) | 2014-11-18 | 2020-10-28 | Humabs Biomed S.A. | Antibodies that potently neutralize rabies virus and other lyssaviruses and uses thereof |
| MX389708B (es) | 2015-06-01 | 2025-03-20 | Medimmune Llc | Neutralizacion de moleculas de union anti-influenza y usos de las mismas. |
| US12201625B2 (en) | 2015-07-30 | 2025-01-21 | The Trustees Of The University Of Pennsylvania | Single nucleotide polymorphic alleles of human DP-2 gene for detection of susceptibility to hair growth inhibition by PGD2 |
| WO2017040708A1 (en) | 2015-08-31 | 2017-03-09 | Fruition Marketing, Llc | Consumer usable device with redeemable member |
| KR20180042449A (ko) | 2015-09-15 | 2018-04-25 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | T 세포 수용체(tcr) 결합 항체 및 이의 용도 |
| JP2019502651A (ja) | 2015-09-30 | 2019-01-31 | バード・ロック・バイオ・インコーポレイテッドBird Rock Bio, Inc. | ヒトカンナビノイド1(cb1)受容体に結合する抗体 |
| WO2017059878A1 (en) | 2015-10-07 | 2017-04-13 | Humabs Biomed Sa | Antibodies that potently neutralize hepatitis b virus and uses thereof |
| SG11201805001UA (en) | 2016-01-13 | 2018-07-30 | Medimmune Llc | Method of treating influenza a |
| WO2018010789A1 (en) | 2016-07-13 | 2018-01-18 | Humabs Biomed Sa | Novel antibodies specifically binding to zika virus epitopes and uses thereof |
| IL269904B2 (en) | 2017-04-19 | 2025-10-01 | Inst Res Biomedicine | Plasmodium sporozoite NPDP peptides as a vaccine and target for novel malaria vaccines and antibody binding |
| CN110636858B (zh) | 2017-05-05 | 2024-03-19 | 瓦西尼斯公司 | 人抗脑信号蛋白4d抗体 |
| EP3655036B1 (en) | 2017-07-19 | 2024-09-04 | Hoffman Technologies, LLC | Compositions for treating stress-related disorders |
| WO2019042555A1 (en) | 2017-08-31 | 2019-03-07 | Humabs Biomed Sa | MULTISPECIFIC ANTIBODIES SPECIFICALLY BINDING TO ZIKA VIRUS EPITOPES AND USES THEREOF |
| CN109550061A (zh) * | 2017-09-26 | 2019-04-02 | 南京江原安迪科正电子研究发展有限公司 | 一种用于放射性核素标记抗体的试剂盒及应用 |
| RU2700584C1 (ru) * | 2018-12-13 | 2019-09-18 | Общество С Ограниченной Ответственностью "Апто-Фарм" | Способ оценки сродства олигонуклеотида |
| US12304946B2 (en) | 2018-12-19 | 2025-05-20 | Humabs Biomed Sa | Antibodies that neutralize hepatitis B virus and uses thereof |
| EP3947458A1 (en) | 2019-04-03 | 2022-02-09 | Genzyme Corporation | Anti-alpha beta tcr binding polypeptides with reduced fragmentation |
| NZ785788A (en) | 2019-08-29 | 2025-09-26 | Vir Biotechnology Inc | Antibody compositions and methods for treating hepatitis b virus infection |
| CA3169521A1 (en) | 2020-02-28 | 2021-09-02 | Marie-Priscille Brun | Modified binding polypeptides for optimized drug conjugation |
| CN116782930A (zh) | 2020-06-11 | 2023-09-19 | 瓦西尼斯公司 | Cxcl13结合分子促进周围神经再生的用途 |
| US20240092872A1 (en) | 2021-01-26 | 2024-03-21 | Vir Biotechnology, Inc. | Compositions and methods for treating hepatitis b virus infection |
| TW202430561A (zh) | 2022-09-30 | 2024-08-01 | 法商賽諾菲公司 | 抗cd28抗體 |
| KR20250094703A (ko) | 2022-10-25 | 2025-06-25 | 아블린쓰 엔.브이. | 향상된 효과기 기능을 갖는 당조작된 Fc 변이체 폴리펩타이드 |
| US12195546B2 (en) | 2022-12-19 | 2025-01-14 | Sanofi | CD28/OX40 bispecific antibodies |
Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3994966A (en) * | 1972-09-28 | 1976-11-30 | The Board Of Trustees Of The Leland Stanford Junior University | Chelating agents |
| US4043998A (en) * | 1974-10-09 | 1977-08-23 | The Board Of Trustees Of The Leland Stanford Junior University | 1-(P-benzenediazonium)-ethylenediamine tetraacetic acid |
| US4315851A (en) * | 1978-12-29 | 1982-02-16 | Kureha Kagaku Kogyo Kabushiki Kaisha | Pharmaceutical composition having antitumor activity |
| US4361544A (en) * | 1980-03-03 | 1982-11-30 | Goldenberg Milton David | Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers |
| US4460559A (en) * | 1980-03-03 | 1984-07-17 | Goldenberg Milton David | Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers |
| US4444744A (en) * | 1980-03-03 | 1984-04-24 | Goldenberg Milton David | Tumor localization and therapy with labeled antibodies to cell surface antigens |
| US4348376A (en) * | 1980-03-03 | 1982-09-07 | Goldenberg Milton David | Tumor localization and therapy with labeled anti-CEA antibody |
| US4331647A (en) * | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
| US4460561A (en) * | 1980-03-03 | 1984-07-17 | Goldenberg M David | Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers |
| US4622420A (en) * | 1980-03-18 | 1986-11-11 | The Regents Of The University Of California | Chelating agents and method |
| US4472509A (en) * | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
| US4454106A (en) * | 1982-06-07 | 1984-06-12 | Gansow Otto A | Use of metal chelate conjugated monoclonal antibodies |
| JPS5982222U (ja) * | 1982-11-26 | 1984-06-02 | 松井 三郎 | 眼鏡 |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4707352A (en) | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group |
| US4636380A (en) | 1984-04-23 | 1987-01-13 | Wong Dennis W | Novel physiologic chemical method of labeling protein substances with the radionuclides of indium |
| US4634586A (en) * | 1984-05-21 | 1987-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | Reagent and method for radioimaging leukocytes |
| US4722892A (en) * | 1984-08-31 | 1988-02-02 | Meares Claude F | Monoclonal antibodies against metal chelates |
| US4824986A (en) * | 1985-04-26 | 1989-04-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Metal chelate protein conjugate |
| US4735210A (en) * | 1985-07-05 | 1988-04-05 | Immunomedics, Inc. | Lymphographic and organ imaging method and kit |
| US5101827A (en) * | 1985-07-05 | 1992-04-07 | Immunomedics, Inc. | Lymphographic and organ imaging method and kit |
| US4926869A (en) * | 1986-01-16 | 1990-05-22 | The General Hospital Corporation | Method for the diagnosis and treatment of inflammation |
| DK172629B1 (da) * | 1986-02-14 | 1999-03-22 | Nihon Mediphysics Co Ltd | Reaktive højmolekylære forbindelser med mindst én fri aminogruppe, højmolekylære forbindelser kombineret med et fysiologisk |
| US4831175A (en) * | 1986-09-05 | 1989-05-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
| US5246692A (en) * | 1986-09-05 | 1993-09-21 | The United States Of America As Represented By The Secretary Of Health And Human Services | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
| EP0529645B1 (en) * | 1986-09-05 | 1996-10-23 | GANSOW, Otto A. | Process for the preparation of backbone polysubstituted chelates |
| US5099069A (en) | 1986-09-05 | 1992-03-24 | Gansow Otto A | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
| US5034223A (en) * | 1986-10-09 | 1991-07-23 | Neorx Corporation | Methods for improved targeting of antibody, antibody fragments, hormones and other targeting agents, and conjugates thereof |
| US4921690A (en) * | 1986-12-29 | 1990-05-01 | City Of Hope | Method of enhancing the biodistribution of antibody for localization in lesions |
| IL85035A0 (en) * | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| US5217704A (en) | 1987-11-06 | 1993-06-08 | Abbott Laboratories | Methods and materials for the preparation of metal labelled antibody solutions |
| AU619218B2 (en) | 1987-11-06 | 1992-01-23 | Abbott Laboratories | Methods and materials for the preparation of metal labelled antibody solutions |
| US5130118A (en) | 1987-11-06 | 1992-07-14 | Abbott Laboratories | Methods and materials for the preparation of metal labelled antibody solutions |
| US4978745A (en) | 1987-11-23 | 1990-12-18 | Centocor, Inc. | Immunoreactive heterochain antibodies |
| US4861579A (en) * | 1988-03-17 | 1989-08-29 | American Cyanamid Company | Suppression of B-lymphocytes in mammals by administration of anti-B-lymphocyte antibodies |
| US4975369A (en) | 1988-04-21 | 1990-12-04 | Eli Lilly And Company | Recombinant and chimeric KS1/4 antibodies directed against a human adenocarcinoma antigen |
| ATE134999T1 (de) * | 1988-05-25 | 1996-03-15 | Us Commerce | Makrocyclische chelate und verwendungsverfahren |
| US4923985A (en) * | 1988-05-25 | 1990-05-08 | The United States Of America As Represented By The Department Of Health & Human Services | Process for synthesizing macrocyclic chelates |
| US5059518A (en) * | 1988-10-20 | 1991-10-22 | Coulter Corporation | Stabilized lyophilized mammalian cells and method of making same |
| CA2010511A1 (en) | 1989-03-01 | 1990-09-01 | Roberto L. Ceriani | Method of enhancing cancer therapy by administration of unsaturated fatty acids |
| US5376356A (en) * | 1989-03-14 | 1994-12-27 | Neorx Corporation | Imaging tissue sites of inflammation |
| US5162115A (en) * | 1989-05-09 | 1992-11-10 | Pietronigro Dennis D | Antineoplastic solution and method for treating neoplasms |
| US5460785A (en) | 1989-08-09 | 1995-10-24 | Rhomed Incorporated | Direct labeling of antibodies and other protein with metal ions |
| US5124471A (en) * | 1990-03-26 | 1992-06-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Bifunctional dtpa-type ligand |
| US5219556A (en) * | 1990-07-09 | 1993-06-15 | Mallinckrodt Medical, Inc. | Stabilized therapeutic radiopharmaceutical complexes |
| US5009069A (en) * | 1990-08-24 | 1991-04-23 | Molini Alberto E | Method of recovering energy from ocean water |
| GB9022543D0 (en) * | 1990-10-17 | 1990-11-28 | Wellcome Found | Antibody production |
| JPH06501705A (ja) | 1990-11-05 | 1994-02-24 | ブリストル−マイアーズ スクイブ カンパニー | 抗−腫瘍抗体及び生物学的活性剤の組合せによる相乗治療 |
| US5208008A (en) * | 1990-11-14 | 1993-05-04 | University Of Pittsburgh | Regioselective chemical modification of monoclonal antibodies |
| EP0522134A1 (en) * | 1991-01-11 | 1993-01-13 | COBE Laboratories, Inc. | Method of detecting circulating antibody types using dried or lyophilized cells or cell-like material |
| US5403573A (en) * | 1992-04-23 | 1995-04-04 | The Curators Of The University Of Missouri | Radiolabeled protein composition and method for radiation synovectomy |
| US5541287A (en) | 1992-06-09 | 1996-07-30 | Neorx Corporation | Pretargeting methods and compounds |
| US5620675A (en) | 1992-06-23 | 1997-04-15 | Diatech, Inc. | Radioactive peptides |
| US5716596A (en) | 1992-06-23 | 1998-02-10 | Diatide, Inc. | Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses |
| US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| ES2091684T3 (es) * | 1992-11-13 | 1996-11-01 | Idec Pharma Corp | Aplicacion terapeutica de anticuerpos quimericos y radiomarcados contra el antigeno de diferenciacion restringida de los linfocitos b humanos para el tratamiento del linfoma de las celulas b. |
| US5650134A (en) | 1993-01-12 | 1997-07-22 | Novartis Ag (Formerly Sandoz Ltd.) | Peptides |
| US5595721A (en) * | 1993-09-16 | 1997-01-21 | Coulter Pharmaceutical, Inc. | Radioimmunotherapy of lymphoma using anti-CD20 |
| IL113610A0 (en) * | 1994-06-03 | 1995-08-31 | Immunomedics Inc | A method of radiolabeling a protein, radiolabeled proteins prepared thereby and diagnostic kits containing the same |
| US5686578A (en) | 1994-08-05 | 1997-11-11 | Immunomedics, Inc. | Polyspecific immunoconjugates and antibody composites for targeting the multidrug resistant phenotype |
| US5728369A (en) * | 1994-10-05 | 1998-03-17 | Immunomedics, Inc. | Radioactive phosphorus labeling of proteins for targeted radiotherapy |
| US5874540A (en) | 1994-10-05 | 1999-02-23 | Immunomedics, Inc. | CDR-grafted type III anti-CEA humanized mouse monoclonal antibodies |
| US5942210A (en) | 1994-11-15 | 1999-08-24 | Cytogen Corporation | Methods for lyoprotecting a macromolecule using tricine |
| US5830431A (en) | 1995-06-07 | 1998-11-03 | Mallinckrodt Medical, Inc. | Radiolabeled peptide compositions for site-specific targeting |
| US5961955A (en) * | 1997-06-03 | 1999-10-05 | Coulter Pharmaceutical, Inc. | Radioprotectant for peptides labeled with radioisotope |
| MY133346A (en) * | 1999-03-01 | 2007-11-30 | Biogen Inc | Kit for radiolabeling ligands with yttrium-90 |
| US20020102208A1 (en) * | 1999-03-01 | 2002-08-01 | Paul Chinn | Radiolabeling kit and binding assay |
-
1999
- 1999-03-01 US US09/259,337 patent/US20020102208A1/en not_active Abandoned
-
2000
- 2000-02-28 MY MYPI20000754A patent/MY138674A/en unknown
- 2000-02-29 HK HK02107258.0A patent/HK1045730B/zh not_active IP Right Cessation
- 2000-02-29 HU HU1300275A patent/HU230516B1/hu unknown
- 2000-02-29 SI SI200031036T patent/SI1192463T1/sl unknown
- 2000-02-29 EP EP00913645A patent/EP1192463B1/en not_active Expired - Lifetime
- 2000-02-29 KR KR1020017011093A patent/KR100729247B1/ko not_active Expired - Lifetime
- 2000-02-29 WO PCT/US2000/005061 patent/WO2000052473A2/en not_active Ceased
- 2000-02-29 ES ES09158514.1T patent/ES2526723T3/es not_active Expired - Lifetime
- 2000-02-29 PT PT00913645T patent/PT1192463E/pt unknown
- 2000-02-29 DK DK00913645T patent/DK1192463T3/da active
- 2000-02-29 MX MXPA01008837A patent/MXPA01008837A/es active IP Right Grant
- 2000-02-29 DE DE60042326T patent/DE60042326D1/de not_active Expired - Lifetime
- 2000-02-29 SK SK1216-2001A patent/SK287745B6/sk not_active IP Right Cessation
- 2000-02-29 BR BRPI0017596A patent/BRPI0017596B8/pt not_active IP Right Cessation
- 2000-02-29 RS YU61601A patent/RS51778B/sr unknown
- 2000-02-29 PL PL352531A patent/PL205780B1/pl unknown
- 2000-02-29 ME MEP-2009-21A patent/ME00782B/me unknown
- 2000-02-29 BR BRPI0008719 patent/BRPI0008719B8/pt not_active IP Right Cessation
- 2000-02-29 HR HR20010714A patent/HRP20010714B1/xx not_active IP Right Cessation
- 2000-02-29 HU HU0202522A patent/HU229627B1/hu unknown
- 2000-02-29 CZ CZ2010-746A patent/CZ306959B6/cs not_active IP Right Cessation
- 2000-02-29 ES ES00913645T patent/ES2328100T3/es not_active Expired - Lifetime
- 2000-02-29 PT PT91585141T patent/PT2112512E/pt unknown
- 2000-02-29 CZ CZ20013126A patent/CZ303262B6/cs not_active IP Right Cessation
- 2000-02-29 AU AU35052/00A patent/AU776747B2/en not_active Expired
- 2000-02-29 CA CA2362119A patent/CA2362119C/en not_active Expired - Lifetime
- 2000-02-29 NZ NZ513788A patent/NZ513788A/xx not_active IP Right Cessation
- 2000-02-29 IL IL14510900A patent/IL145109A0/xx not_active IP Right Cessation
- 2000-02-29 CN CNB008057397A patent/CN1235639C/zh not_active Expired - Lifetime
- 2000-02-29 EP EP09158514.1A patent/EP2112512B1/en not_active Expired - Lifetime
- 2000-02-29 UA UA2001096636A patent/UA78484C2/uk unknown
- 2000-02-29 DK DK09158514.1T patent/DK2112512T3/en active
- 2000-02-29 JP JP2000602634A patent/JP4704570B2/ja not_active Expired - Lifetime
- 2000-02-29 CA CA2742153A patent/CA2742153C/en not_active Expired - Lifetime
- 2000-02-29 EE EEP200100465A patent/EE05650B1/xx unknown
- 2000-02-29 AT AT00913645T patent/ATE433108T1/de active
- 2000-02-29 SK SK91-2010A patent/SK288096B6/sk not_active IP Right Cessation
- 2000-02-29 RU RU2001126400/15A patent/RU2251110C2/ru active
- 2000-02-29 NZ NZ530868A patent/NZ530868A/en not_active IP Right Cessation
- 2000-02-29 SI SI200031085T patent/SI2112512T1/sl unknown
- 2000-03-01 TW TW089103582A patent/TWI294969B/zh not_active IP Right Cessation
-
2001
- 2001-08-22 ZA ZA200106943A patent/ZA200106943B/xx unknown
- 2001-08-31 NO NO20014245A patent/NO329142B1/no not_active IP Right Cessation
- 2001-09-27 BG BG105957A patent/BG65690B1/bg unknown
-
2005
- 2005-01-12 US US11/033,439 patent/US7608241B2/en not_active Expired - Fee Related
-
2009
- 2009-09-01 CY CY20091100912T patent/CY1109335T1/el unknown
-
2010
- 2010-05-18 NO NO20100717A patent/NO330705B1/no not_active IP Right Cessation
-
2015
- 2015-02-16 CY CY20151100160T patent/CY1116265T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60042326D1 (de) | Radiomarkierungssatz und bindungstest | |
| IL182500A0 (en) | Cop1 molecules and uses thereof | |
| BRPI9912227B1 (pt) | método para diagnóstico precoce in vitro de carcinomas e de seus estágios iniciais e kit para realização do método. | |
| ATE490466T1 (de) | Als interne funktionskontrolle in tests zum nachweis von seltenen zellen verwendete markierte zellen | |
| ATE425266T1 (de) | Aptamer-nanopartikelkonjugate und verwendungsverfahren zur detektion von zielanalyten | |
| NO20005694L (no) | Spesifikke bindingsmolekyler for scintigrafi, konjugater som inneholder disse og terapeutiske fremgangsmåter for behandling av angiogenese | |
| EP1687283A4 (en) | FOR THE DETERMINATION OF FK506 PROCEDURE AND COMPOSITION | |
| ATE423220T1 (de) | Testverfahren für verbindungen die frühzeitige translations beendigung und nonsense rns decay hemmen | |
| DE60014064D1 (de) | Einetenascin-c isoform als marker für neoplasmen | |
| ATE408832T1 (de) | Verfahren zum nachweis von blutzell-antigenen und gegen diese gerichtete antikörper | |
| ATE208040T1 (de) | Immunoassay-reagenzien, testsätze und verfahren | |
| ATE482396T1 (de) | Blockierter enzymsondenkomplex | |
| ATE432364T1 (de) | Sonden zum nachweis von tumorzellen | |
| DE69928213D1 (de) | Verfahren zum bestimmen humaner thymidylatsynthase und versuchskit | |
| FR2841988B1 (fr) | Methode de diagnostic serologique comprenant un controle positif de l'introduction d'un serum humain a tester | |
| ATE308555T1 (de) | Tumorsuppressormoleküle und nutzungsverfahren |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |