BRPI0017596A2 - Método para radiomarcação de um anticorpo conjugado a um quelante com 111in para administração a um paciente - Google Patents
Método para radiomarcação de um anticorpo conjugado a um quelante com 111in para administração a um pacienteInfo
- Publication number
- BRPI0017596A2 BRPI0017596A2 BRPI0017596A BRPI0017596A2 BR PI0017596 A2 BRPI0017596 A2 BR PI0017596A2 BR PI0017596 A BRPI0017596 A BR PI0017596A BR PI0017596 A2 BRPI0017596 A2 BR PI0017596A2
- Authority
- BR
- Brazil
- Prior art keywords
- radiolabeling
- chelator
- administration
- patient
- antibody conjugated
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/534—Production of labelled immunochemicals with radioactive label
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/259,337 US20020102208A1 (en) | 1999-03-01 | 1999-03-01 | Radiolabeling kit and binding assay |
| PCT/US2000/005061 WO2000052473A2 (en) | 1999-03-01 | 2000-02-29 | Radiolabeling kit and binding assay |
| BRPI0008719-0 BRPI0008719B8 (pt) | 1999-03-01 | 2000-02-29 | Método para radiomarcação de um anticorpo conjugado a um quelante com 90y e ensaio de ligação para determinação da ligação percentual de um anticorpo radiomarcado à sua célula alvo |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0017596A2 true BRPI0017596A2 (pt) | 2011-09-27 |
| BRPI0017596B1 BRPI0017596B1 (pt) | 2015-09-01 |
| BRPI0017596B8 BRPI0017596B8 (pt) | 2023-04-25 |
Family
ID=22984524
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0008719-0 BRPI0008719B8 (pt) | 1999-03-01 | 2000-02-29 | Método para radiomarcação de um anticorpo conjugado a um quelante com 90y e ensaio de ligação para determinação da ligação percentual de um anticorpo radiomarcado à sua célula alvo |
| BRPI0017596A BRPI0017596B8 (pt) | 1999-03-01 | 2000-02-29 | método para radiomarcação de um anticorpo conjugado a um quelante com 111in para administração a um paciente |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0008719-0 BRPI0008719B8 (pt) | 1999-03-01 | 2000-02-29 | Método para radiomarcação de um anticorpo conjugado a um quelante com 90y e ensaio de ligação para determinação da ligação percentual de um anticorpo radiomarcado à sua célula alvo |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US20020102208A1 (pt) |
| EP (2) | EP2112512B1 (pt) |
| JP (1) | JP4704570B2 (pt) |
| KR (1) | KR100729247B1 (pt) |
| CN (1) | CN1235639C (pt) |
| AT (1) | ATE433108T1 (pt) |
| AU (1) | AU776747B2 (pt) |
| BG (1) | BG65690B1 (pt) |
| BR (2) | BRPI0008719B8 (pt) |
| CA (2) | CA2742153C (pt) |
| CY (2) | CY1109335T1 (pt) |
| CZ (2) | CZ306959B6 (pt) |
| DE (1) | DE60042326D1 (pt) |
| DK (2) | DK1192463T3 (pt) |
| EE (1) | EE05650B1 (pt) |
| ES (2) | ES2328100T3 (pt) |
| HK (2) | HK1045730B (pt) |
| HR (1) | HRP20010714B1 (pt) |
| HU (2) | HU230516B1 (pt) |
| IL (1) | IL145109A0 (pt) |
| ME (1) | ME00782B (pt) |
| MX (1) | MXPA01008837A (pt) |
| MY (1) | MY138674A (pt) |
| NO (2) | NO329142B1 (pt) |
| NZ (2) | NZ513788A (pt) |
| PL (1) | PL205780B1 (pt) |
| PT (2) | PT2112512E (pt) |
| RS (1) | RS51778B (pt) |
| RU (1) | RU2251110C2 (pt) |
| SI (2) | SI1192463T1 (pt) |
| SK (2) | SK287745B6 (pt) |
| TW (1) | TWI294969B (pt) |
| UA (1) | UA78484C2 (pt) |
| WO (1) | WO2000052473A2 (pt) |
| ZA (1) | ZA200106943B (pt) |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6107090A (en) | 1996-05-06 | 2000-08-22 | Cornell Research Foundation, Inc. | Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains |
| US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
| MY133346A (en) | 1999-03-01 | 2007-11-30 | Biogen Inc | Kit for radiolabeling ligands with yttrium-90 |
| US20020102208A1 (en) * | 1999-03-01 | 2002-08-01 | Paul Chinn | Radiolabeling kit and binding assay |
| US6207858B1 (en) * | 1999-03-03 | 2001-03-27 | Idec Pharmaceuticals Corporation | Regioselective synthesis of DTPA derivatives |
| EP1918305A1 (en) | 1999-08-11 | 2008-05-07 | Biogen Idec Inc. | New clinical parameters for determining hematologic toxicity prior to radioimmunotherapy |
| DE60143535D1 (de) | 2000-10-02 | 2011-01-05 | Novartis Vaccines & Diagnostic | Humane antikörper gegen cd40 |
| WO2002079255A1 (en) * | 2001-04-02 | 2002-10-10 | Idec Pharmaceuticals Corporation | RECOMBINANT ANTIBODIES COEXPRESSED WITH GnTIII |
| WO2003024388A2 (en) | 2001-09-20 | 2003-03-27 | Cornell Research Foundation, Inc. | Methods and compositions for treating and preventing skin disorders using binding agents specific for psma |
| ATE408712T1 (de) | 2003-01-10 | 2008-10-15 | Millennium Pharm Inc | Verfahren zur bestimmung des wiederauftretens von prostata krebs |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| NZ543495A (en) * | 2003-06-25 | 2009-04-30 | Peregrine Pharmaceuticals Inc | Method and apparatus for continuous large-scale radiolabeling of proteins |
| ES2346978T3 (es) | 2003-11-04 | 2010-10-22 | Novartis Vaccines And Diagnostics, Inc. | Uso de anticuerpos monoclonantes anti-cd40 antagonistas para el tratamiento del mieloma multiple. |
| EP2301575A1 (en) | 2003-11-04 | 2011-03-30 | Novartis Vaccines and Diagnostics, Inc. | Methods of therapy for solid tumors expressing the CD40 cell-surface antigen |
| EP1694360B1 (en) | 2003-11-04 | 2010-08-04 | Novartis Vaccines and Diagnostics, Inc. | Use of antagonist anti-cd40 antibodies for treatment of autoimmune and inflammatory diseases and organ transplant rejection |
| EP2236172A1 (en) | 2003-11-04 | 2010-10-06 | Novartis Vaccines and Diagnostics, Inc. | Combination therapy comprising anti-CD20 and anti-CD40 antibodies for the treatment of B cell-related cancers |
| WO2005044304A2 (en) | 2003-11-04 | 2005-05-19 | Chiron Corporation | Use of antagonist anti-cd40 antibodies for treatment of chronic lymphocytic leukemia |
| JP5421590B2 (ja) | 2005-05-18 | 2014-02-19 | ノバルティス アーゲー | 自己免疫および／または炎症性成分を有する疾患の診断および治療のための方法 |
| EP2238986A3 (en) | 2005-07-08 | 2010-11-03 | Biogen Idec MA Inc. | Sp35 antibodies and uses thereof |
| EP1921982A2 (en) * | 2005-08-25 | 2008-05-21 | Koninklijke Philips Electronics N.V. | 4d image-based planning methods and apparatus for targeted therapy |
| CN101535244B (zh) | 2005-11-23 | 2014-07-23 | 文塔納医疗系统公司 | 分子缀合物 |
| EA018301B1 (ru) | 2006-04-21 | 2013-07-30 | Новартис Аг | Фармацевтические композиции, содержащие антагонистическое моноклональное антитело к cd40, и их применение |
| EP2037967B1 (en) | 2006-06-16 | 2016-12-07 | The Trustees Of The University Of Pennsylvania | Prostaglandin d2 receptor antagonists for treating androgenetic alopecia |
| US9382327B2 (en) | 2006-10-10 | 2016-07-05 | Vaccinex, Inc. | Anti-CD20 antibodies and methods of use |
| DK2089401T3 (da) * | 2006-11-10 | 2012-09-17 | Radioprotect Alphaptose Ug Haftungsbeschraenkt & Co Kg | Anvendelse af trisubstituerede glycerolforbindelser til behandling af strålingsskader |
| CZ300074B6 (cs) * | 2006-12-20 | 2009-01-21 | Azacycles S. R. O. | Inteligentní trífunkcní makrokonjugáty a farmaceutický nebo diagnostický prostredek s jejich obsahem |
| GB0700133D0 (en) | 2007-01-04 | 2007-02-14 | Humabs Llc | Human cytomegalovirus neutralising antibodies and use thereof |
| AU2008205244B2 (en) | 2007-01-09 | 2013-02-07 | Biogen Ma Inc. | Sp35 antibodies and uses thereof |
| MX2010006395A (es) * | 2007-12-21 | 2010-07-01 | Hoffmann La Roche | Formulacion de anticuerpos. |
| AU2009269099B2 (en) | 2008-07-09 | 2016-03-10 | Biogen Ma Inc. | Compositions comprising antibodies to LINGO or fragments thereof |
| JP5475774B2 (ja) | 2008-07-16 | 2014-04-16 | インスティテュート フォー リサーチ イン バイオメディシン | ヒトサイトメガロウイルス中和抗体およびその使用 |
| SG10201608381SA (en) | 2008-07-16 | 2016-11-29 | Inst Research In Biomedicine | Human cytomegalovirus neutralizing antibodies and use thereof |
| US8871207B2 (en) | 2008-07-25 | 2014-10-28 | Humabs, LLC | Neutralizing anti-influenza A virus antibodies and uses thereof |
| NZ590890A (en) | 2008-07-25 | 2013-05-31 | Inst Research In Biomedicine | Neutralizing anti-influenza a virus antibodies and uses thereof |
| CN108610416B (zh) | 2008-10-13 | 2022-01-14 | 生物医学研究所 | 登革热病毒中和抗体及其用途 |
| CN102341411A (zh) | 2008-12-31 | 2012-02-01 | 比奥根艾迪克Ma公司 | 抗-淋巴细胞毒素抗体 |
| US20110212106A1 (en) | 2010-01-20 | 2011-09-01 | Institute For Research In Bioscience | Hiv-1 neutralizing antibodies and uses thereof |
| HUE027831T2 (en) | 2010-03-12 | 2016-11-28 | Genzyme Corp | Combination therapy for breast cancer |
| EP2591006B1 (en) | 2010-07-09 | 2019-04-24 | Bioverativ Therapeutics Inc. | Processable single chain molecules and polypeptides made using same |
| EP2601214B1 (en) | 2010-08-06 | 2017-11-01 | Genzyme Corporation | Vegf antagonist compositions and uses thereof |
| AU2011288946A1 (en) | 2010-08-13 | 2013-03-21 | Rdm Empreendimentos E Participacoes S.A. | Method and composition for reducing the color of sugar |
| PT3045183T (pt) | 2011-03-11 | 2018-11-02 | Genzyme Corp | Apelina peguilada e suas utilizações |
| HUE044089T2 (hu) | 2011-07-18 | 2019-09-30 | Inst Res Biomedicine | Neutralizáló anti-influenza A antitestek és alkalmazásaik |
| UY34317A (es) | 2011-09-12 | 2013-02-28 | Genzyme Corp | Anticuerpo antireceptor de célula T (alfa)/ß |
| US9717803B2 (en) | 2011-12-23 | 2017-08-01 | Innate Pharma | Enzymatic conjugation of polypeptides |
| EA030319B1 (ru) | 2012-03-20 | 2018-07-31 | Хумабс Биомед Са | Антитела, нейтрализующие rsv, mpv и pvm, и их применения |
| WO2013175276A1 (en) | 2012-05-23 | 2013-11-28 | Argen-X B.V | Il-6 binding molecules |
| RU2522203C2 (ru) * | 2012-06-26 | 2014-07-10 | Василий Александрович Ишутин | Способ контроля стерилизации материалов и изделий |
| EP2872894B1 (en) | 2012-07-13 | 2019-04-17 | Innate Pharma | Screening of conjugated antibodies |
| US9790268B2 (en) | 2012-09-12 | 2017-10-17 | Genzyme Corporation | Fc containing polypeptides with altered glycosylation and reduced effector function |
| US10036010B2 (en) | 2012-11-09 | 2018-07-31 | Innate Pharma | Recognition tags for TGase-mediated conjugation |
| BR112015020885A2 (pt) | 2013-03-11 | 2017-10-10 | Genzyme Corp | polipeptídeos de ligação hiperglicosilados |
| WO2014165216A1 (en) | 2013-03-12 | 2014-10-09 | The Trustees Of The University Of Pennsylvania | Diagnosing and treating cancer |
| WO2014140300A1 (en) | 2013-03-15 | 2014-09-18 | Innate Pharma | Solid phase tgase-mediated conjugation of antibodies |
| US10071169B2 (en) | 2013-06-20 | 2018-09-11 | Innate Pharma | Enzymatic conjugation of polypeptides |
| AU2014283185B2 (en) | 2013-06-21 | 2019-05-02 | Innate Pharma | Enzymatic conjugation of polypeptides |
| RU2558929C2 (ru) * | 2013-08-08 | 2015-08-10 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт кардиологии" (НИИ Кардиологии) | СПОСОБ ОПРЕДЕЛЕНИЯ СВЯЗЫВАНИЯ РАДИОФАРМПРЕПАРАТА НА ОСНОВЕ ЦИПРОФЛОКСАЦИНА, МЕЧЕННОГО 99mTc C БАКТЕРИЯМИ |
| PE20160244A1 (es) | 2013-08-13 | 2016-05-10 | Sanofi Sa | Anticuerpos contra el inhibidor del activador de plasminogeno tipo 1 (pai-1) y usos de los mismos |
| US11052177B2 (en) | 2013-09-06 | 2021-07-06 | The Trustees Of The University Of Pennsylvania | Antimicrobial polymer layers |
| SG11201602522VA (en) | 2013-10-02 | 2016-04-28 | Medimmune Llc | Neutralizing anti-influenza a antibodies and uses thereof |
| JP6156962B2 (ja) * | 2014-02-27 | 2017-07-05 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | エキソソームを単離するための方法および組成物 |
| EP3129067B1 (en) | 2014-03-19 | 2023-01-04 | Genzyme Corporation | Site-specific glycoengineering of targeting moieties |
| TWI694086B (zh) | 2014-03-27 | 2020-05-21 | 美商銳意公司 | 結合人類大麻素１（ｃｂ１）受體之抗體 |
| MX2017000595A (es) | 2014-07-15 | 2017-10-12 | Medimmune Llc | Anticuerpos anti-influenza b neutralizantes y usos de los mismos. |
| US20170296650A1 (en) | 2014-10-08 | 2017-10-19 | Novartis Ag | Combination of human cytomegalovirus neutralizing antibodies |
| CA2964123C (en) | 2014-10-09 | 2023-09-05 | Genzyme Corporation | Glycoengineered antibody drug conjugates |
| WO2016075546A2 (en) | 2014-11-14 | 2016-05-19 | Antonio Lanzavecchia | Antibodies that neutralize ebola virus and uses thereof |
| BR112017010298B1 (pt) | 2014-11-18 | 2023-10-31 | Humabs Biomed Sa | Anticorpos que neutralizam de modo potente vírus da raiva e outros lissavírus, usos dos mesmos, molécula de ácido nucleico, vetor, célula isolada, composição farmacêutica, e kit de partes |
| US10442854B2 (en) | 2015-06-01 | 2019-10-15 | Medimmune, Llc | Neutralizing anti-influenza binding molecules and uses thereof |
| KR20180031019A (ko) | 2015-07-30 | 2018-03-27 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | Ｐｇｄ２에 의한 모발 성장 억제에 대한 민감성의 검출을 위한 인간 ｄｐ―２ 유전자의 단일 뉴클레오티드 다형성 대립유전자 |
| WO2017040708A1 (en) | 2015-08-31 | 2017-03-09 | Fruition Marketing, Llc | Consumer usable device with redeemable member |
| JP7020687B2 (ja) | 2015-09-15 | 2022-02-16 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | Ｔ細胞受容体（ｔｃｒ）結合抗体及びその使用 |
| MX2018003982A (es) | 2015-09-30 | 2019-01-31 | Bird Rock Bio Inc | Anticuerpos que se unen al receptor cannabinoide 1 (cb1) humano. |
| WO2017059878A1 (en) | 2015-10-07 | 2017-04-13 | Humabs Biomed Sa | Antibodies that potently neutralize hepatitis b virus and uses thereof |
| AU2017207330C1 (en) | 2016-01-13 | 2022-06-09 | Medimmune, Llc | Method of treating influenza A |
| WO2018010789A1 (en) | 2016-07-13 | 2018-01-18 | Humabs Biomed Sa | Novel antibodies specifically binding to zika virus epitopes and uses thereof |
| WO2018193063A2 (en) | 2017-04-19 | 2018-10-25 | Institute For Research In Biomedicine | Novel malaria vaccines and antibodies binding to plasmodium sporozoites |
| AU2018261947A1 (en) | 2017-05-05 | 2019-11-07 | Vaccinex, Inc. | Human anti-semaphorin 4D antibody |
| CN111032089A (zh) | 2017-07-19 | 2020-04-17 | 霍夫曼技术公司 | 用于治疗应激相关障碍的组合物 |
| WO2019042555A1 (en) | 2017-08-31 | 2019-03-07 | Humabs Biomed Sa | MULTISPECIFIC ANTIBODIES SPECIFICALLY BINDING TO ZIKA VIRUS EPITOPES AND USES THEREOF |
| CN109550061A (zh) * | 2017-09-26 | 2019-04-02 | 南京江原安迪科正电子研究发展有限公司 | 一种用于放射性核素标记抗体的试剂盒及应用 |
| RU2700584C1 (ru) * | 2018-12-13 | 2019-09-18 | Общество С Ограниченной Ответственностью "Апто-Фарм" | Способ оценки сродства олигонуклеотида |
| LT3898668T (lt) | 2018-12-19 | 2023-11-10 | Humabs Biomed Sa | Antikūnai, neutralizuojantys hepatito b virusą ir jų panaudojimas |
| MX2022002231A (es) | 2019-08-29 | 2022-03-22 | Vir Biotechnology Inc | Composiciones de anticuerpos y metodos para tratar la infeccion por el virus de la hepatitis b. |
| CN115515643A (zh) | 2020-02-28 | 2022-12-23 | 建新公司 | 用于优化的药物缀合的经修饰的结合多肽 |
| AU2021286476A1 (en) | 2020-06-11 | 2023-02-02 | Vaccinex, Inc. | Use of CXCL13 binding molecules to promote peripheral nerve regeneration |
| US20240092872A1 (en) | 2021-01-26 | 2024-03-21 | Vir Biotechnology, Inc. | Compositions and methods for treating hepatitis b virus infection |
| WO2024068944A1 (en) | 2022-09-30 | 2024-04-04 | Sanofi | Anti-cd28 antibodies |
| WO2024089609A1 (en) | 2022-10-25 | 2024-05-02 | Ablynx N.V. | Glycoengineered fc variant polypeptides with enhanced effector function |
Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3994966A (en) * | 1972-09-28 | 1976-11-30 | The Board Of Trustees Of The Leland Stanford Junior University | Chelating agents |
| US4043998A (en) * | 1974-10-09 | 1977-08-23 | The Board Of Trustees Of The Leland Stanford Junior University | 1-(P-benzenediazonium)-ethylenediamine tetraacetic acid |
| US4315851A (en) * | 1978-12-29 | 1982-02-16 | Kureha Kagaku Kogyo Kabushiki Kaisha | Pharmaceutical composition having antitumor activity |
| US4460561A (en) * | 1980-03-03 | 1984-07-17 | Goldenberg M David | Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers |
| US4361544A (en) * | 1980-03-03 | 1982-11-30 | Goldenberg Milton David | Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers |
| US4331647A (en) * | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
| US4460559A (en) * | 1980-03-03 | 1984-07-17 | Goldenberg Milton David | Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers |
| US4444744A (en) * | 1980-03-03 | 1984-04-24 | Goldenberg Milton David | Tumor localization and therapy with labeled antibodies to cell surface antigens |
| US4348376A (en) * | 1980-03-03 | 1982-09-07 | Goldenberg Milton David | Tumor localization and therapy with labeled anti-CEA antibody |
| US4622420A (en) * | 1980-03-18 | 1986-11-11 | The Regents Of The University Of California | Chelating agents and method |
| US4472509A (en) * | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
| US4454106A (en) * | 1982-06-07 | 1984-06-12 | Gansow Otto A | Use of metal chelate conjugated monoclonal antibodies |
| JPS5982222U (ja) * | 1982-11-26 | 1984-06-02 | 松井 三郎 | 眼鏡 |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4707352A (en) * | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group |
| US4636380A (en) | 1984-04-23 | 1987-01-13 | Wong Dennis W | Novel physiologic chemical method of labeling protein substances with the radionuclides of indium |
| US4634586A (en) * | 1984-05-21 | 1987-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | Reagent and method for radioimaging leukocytes |
| US4722892A (en) * | 1984-08-31 | 1988-02-02 | Meares Claude F | Monoclonal antibodies against metal chelates |
| US4824986A (en) * | 1985-04-26 | 1989-04-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Metal chelate protein conjugate |
| US4735210A (en) * | 1985-07-05 | 1988-04-05 | Immunomedics, Inc. | Lymphographic and organ imaging method and kit |
| US5101827A (en) * | 1985-07-05 | 1992-04-07 | Immunomedics, Inc. | Lymphographic and organ imaging method and kit |
| US4926869A (en) * | 1986-01-16 | 1990-05-22 | The General Hospital Corporation | Method for the diagnosis and treatment of inflammation |
| DK172629B1 (da) * | 1986-02-14 | 1999-03-22 | Nihon Mediphysics Co Ltd | Reaktive højmolekylære forbindelser med mindst én fri aminogruppe, højmolekylære forbindelser kombineret med et fysiologisk |
| EP0529645B1 (en) * | 1986-09-05 | 1996-10-23 | GANSOW, Otto A. | Process for the preparation of backbone polysubstituted chelates |
| US5246692A (en) * | 1986-09-05 | 1993-09-21 | The United States Of America As Represented By The Secretary Of Health And Human Services | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
| US4831175A (en) * | 1986-09-05 | 1989-05-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
| US5099069A (en) | 1986-09-05 | 1992-03-24 | Gansow Otto A | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
| US5034223A (en) * | 1986-10-09 | 1991-07-23 | Neorx Corporation | Methods for improved targeting of antibody, antibody fragments, hormones and other targeting agents, and conjugates thereof |
| US4921690A (en) * | 1986-12-29 | 1990-05-01 | City Of Hope | Method of enhancing the biodistribution of antibody for localization in lesions |
| IL85035A0 (en) * | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| US5130118A (en) | 1987-11-06 | 1992-07-14 | Abbott Laboratories | Methods and materials for the preparation of metal labelled antibody solutions |
| AU619218B2 (en) | 1987-11-06 | 1992-01-23 | Abbott Laboratories | Methods and materials for the preparation of metal labelled antibody solutions |
| US5217704A (en) | 1987-11-06 | 1993-06-08 | Abbott Laboratories | Methods and materials for the preparation of metal labelled antibody solutions |
| US4978745A (en) | 1987-11-23 | 1990-12-18 | Centocor, Inc. | Immunoreactive heterochain antibodies |
| US4861579A (en) * | 1988-03-17 | 1989-08-29 | American Cyanamid Company | Suppression of B-lymphocytes in mammals by administration of anti-B-lymphocyte antibodies |
| US4975369A (en) | 1988-04-21 | 1990-12-04 | Eli Lilly And Company | Recombinant and chimeric KS1/4 antibodies directed against a human adenocarcinoma antigen |
| AU630362B2 (en) * | 1988-05-25 | 1992-10-29 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Macrocyclic chelates & methods of use thereof |
| US4923985A (en) * | 1988-05-25 | 1990-05-08 | The United States Of America As Represented By The Department Of Health & Human Services | Process for synthesizing macrocyclic chelates |
| US5059518A (en) * | 1988-10-20 | 1991-10-22 | Coulter Corporation | Stabilized lyophilized mammalian cells and method of making same |
| CA2010511A1 (en) | 1989-03-01 | 1990-09-01 | Roberto L. Ceriani | Method of enhancing cancer therapy by administration of unsaturated fatty acids |
| US5376356A (en) * | 1989-03-14 | 1994-12-27 | Neorx Corporation | Imaging tissue sites of inflammation |
| US5162115A (en) * | 1989-05-09 | 1992-11-10 | Pietronigro Dennis D | Antineoplastic solution and method for treating neoplasms |
| US5460785A (en) | 1989-08-09 | 1995-10-24 | Rhomed Incorporated | Direct labeling of antibodies and other protein with metal ions |
| US5124471A (en) * | 1990-03-26 | 1992-06-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Bifunctional dtpa-type ligand |
| US5219556A (en) * | 1990-07-09 | 1993-06-15 | Mallinckrodt Medical, Inc. | Stabilized therapeutic radiopharmaceutical complexes |
| US5009069A (en) * | 1990-08-24 | 1991-04-23 | Molini Alberto E | Method of recovering energy from ocean water |
| GB9022543D0 (en) * | 1990-10-17 | 1990-11-28 | Wellcome Found | Antibody production |
| JPH06501705A (ja) | 1990-11-05 | 1994-02-24 | ブリストル−マイアーズ スクイブ カンパニー | 抗−腫瘍抗体及び生物学的活性剤の組合せによる相乗治療 |
| US5208008A (en) * | 1990-11-14 | 1993-05-04 | University Of Pittsburgh | Regioselective chemical modification of monoclonal antibodies |
| CA2075928A1 (en) * | 1991-01-11 | 1992-07-12 | Roger W. Hackett | Method of detecting circulating antibody types using dried or lyophilized cells or cell-like material |
| US5403573A (en) * | 1992-04-23 | 1995-04-04 | The Curators Of The University Of Missouri | Radiolabeled protein composition and method for radiation synovectomy |
| US5541287A (en) | 1992-06-09 | 1996-07-30 | Neorx Corporation | Pretargeting methods and compounds |
| US5716596A (en) | 1992-06-23 | 1998-02-10 | Diatide, Inc. | Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses |
| US5620675A (en) | 1992-06-23 | 1997-04-15 | Diatech, Inc. | Radioactive peptides |
| EP0752248B1 (en) * | 1992-11-13 | 2000-09-27 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| US5650134A (en) | 1993-01-12 | 1997-07-22 | Novartis Ag (Formerly Sandoz Ltd.) | Peptides |
| US5595721A (en) * | 1993-09-16 | 1997-01-21 | Coulter Pharmaceutical, Inc. | Radioimmunotherapy of lymphoma using anti-CD20 |
| IL113610A0 (en) * | 1994-06-03 | 1995-08-31 | Immunomedics Inc | A method of radiolabeling a protein, radiolabeled proteins prepared thereby and diagnostic kits containing the same |
| US5686578A (en) | 1994-08-05 | 1997-11-11 | Immunomedics, Inc. | Polyspecific immunoconjugates and antibody composites for targeting the multidrug resistant phenotype |
| US5874540A (en) | 1994-10-05 | 1999-02-23 | Immunomedics, Inc. | CDR-grafted type III anti-CEA humanized mouse monoclonal antibodies |
| US5728369A (en) | 1994-10-05 | 1998-03-17 | Immunomedics, Inc. | Radioactive phosphorus labeling of proteins for targeted radiotherapy |
| US5942210A (en) | 1994-11-15 | 1999-08-24 | Cytogen Corporation | Methods for lyoprotecting a macromolecule using tricine |
| US5830431A (en) | 1995-06-07 | 1998-11-03 | Mallinckrodt Medical, Inc. | Radiolabeled peptide compositions for site-specific targeting |
| US5961955A (en) * | 1997-06-03 | 1999-10-05 | Coulter Pharmaceutical, Inc. | Radioprotectant for peptides labeled with radioisotope |
| MY133346A (en) * | 1999-03-01 | 2007-11-30 | Biogen Inc | Kit for radiolabeling ligands with yttrium-90 |
| US20020102208A1 (en) * | 1999-03-01 | 2002-08-01 | Paul Chinn | Radiolabeling kit and binding assay |
-
1999
- 1999-03-01 US US09/259,337 patent/US20020102208A1/en not_active Abandoned
-
2000
- 2000-02-28 MY MYPI20000754A patent/MY138674A/en unknown
- 2000-02-29 DK DK00913645T patent/DK1192463T3/da active
- 2000-02-29 EP EP09158514.1A patent/EP2112512B1/en not_active Expired - Lifetime
- 2000-02-29 BR BRPI0008719-0 patent/BRPI0008719B8/pt not_active IP Right Cessation
- 2000-02-29 DK DK09158514.1T patent/DK2112512T3/en active
- 2000-02-29 CN CNB008057397A patent/CN1235639C/zh not_active Expired - Lifetime
- 2000-02-29 SK SK1216-2001A patent/SK287745B6/sk not_active IP Right Cessation
- 2000-02-29 MX MXPA01008837A patent/MXPA01008837A/es active IP Right Grant
- 2000-02-29 CA CA2742153A patent/CA2742153C/en not_active Expired - Lifetime
- 2000-02-29 CZ CZ2010-746A patent/CZ306959B6/cs not_active IP Right Cessation
- 2000-02-29 AT AT00913645T patent/ATE433108T1/de active
- 2000-02-29 SI SI200031036T patent/SI1192463T1/sl unknown
- 2000-02-29 RU RU2001126400/15A patent/RU2251110C2/ru active
- 2000-02-29 BR BRPI0017596A patent/BRPI0017596B8/pt not_active IP Right Cessation
- 2000-02-29 NZ NZ513788A patent/NZ513788A/xx not_active IP Right Cessation
- 2000-02-29 UA UA2001096636A patent/UA78484C2/uk unknown
- 2000-02-29 DE DE60042326T patent/DE60042326D1/de not_active Expired - Lifetime
- 2000-02-29 HU HU1300275A patent/HU230516B1/hu unknown
- 2000-02-29 PT PT91585141T patent/PT2112512E/pt unknown
- 2000-02-29 ME MEP-2009-21A patent/ME00782B/me unknown
- 2000-02-29 CZ CZ20013126A patent/CZ303262B6/cs not_active IP Right Cessation
- 2000-02-29 NZ NZ530868A patent/NZ530868A/en not_active IP Right Cessation
- 2000-02-29 CA CA2362119A patent/CA2362119C/en not_active Expired - Lifetime
- 2000-02-29 HU HU0202522A patent/HU229627B1/hu unknown
- 2000-02-29 PT PT00913645T patent/PT1192463E/pt unknown
- 2000-02-29 JP JP2000602634A patent/JP4704570B2/ja not_active Expired - Lifetime
- 2000-02-29 ES ES00913645T patent/ES2328100T3/es not_active Expired - Lifetime
- 2000-02-29 SI SI200031085T patent/SI2112512T1/sl unknown
- 2000-02-29 PL PL352531A patent/PL205780B1/pl unknown
- 2000-02-29 WO PCT/US2000/005061 patent/WO2000052473A2/en active Application Filing
- 2000-02-29 SK SK91-2010A patent/SK288096B6/sk not_active IP Right Cessation
- 2000-02-29 IL IL14510900A patent/IL145109A0/xx not_active IP Right Cessation
- 2000-02-29 AU AU35052/00A patent/AU776747B2/en not_active Expired
- 2000-02-29 RS YU61601A patent/RS51778B/sr unknown
- 2000-02-29 EP EP00913645A patent/EP1192463B1/en not_active Expired - Lifetime
- 2000-02-29 EE EEP200100465A patent/EE05650B1/xx unknown
- 2000-02-29 KR KR1020017011093A patent/KR100729247B1/ko active IP Right Grant
- 2000-02-29 ES ES09158514.1T patent/ES2526723T3/es not_active Expired - Lifetime
- 2000-03-01 TW TW089103582A patent/TWI294969B/zh not_active IP Right Cessation
-
2001
- 2001-08-22 ZA ZA200106943A patent/ZA200106943B/xx unknown
- 2001-08-31 NO NO20014245A patent/NO329142B1/no not_active IP Right Cessation
- 2001-09-27 BG BG105957A patent/BG65690B1/bg unknown
- 2001-10-01 HR HR20010714A patent/HRP20010714B1/xx not_active IP Right Cessation
-
2002
- 2002-10-03 HK HK02107258.0A patent/HK1045730B/zh not_active IP Right Cessation
-
2005
- 2005-01-12 US US11/033,439 patent/US7608241B2/en not_active Expired - Fee Related
-
2009
- 2009-09-01 CY CY20091100912T patent/CY1109335T1/el unknown
- 2009-11-12 HK HK09110560.0A patent/HK1131208A1/xx not_active IP Right Cessation
-
2010
- 2010-05-18 NO NO20100717A patent/NO330705B1/no not_active IP Right Cessation
-
2015
- 2015-02-16 CY CY20151100160T patent/CY1116265T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0017596A2 (pt) | Método para radiomarcação de um anticorpo conjugado a um quelante com 111in para administração a um paciente | |
| CY1123400T1 (el) | Ανθρωπινα anti-il-23 αντισωματα, συνθεσεις, μεθοδοι και χρησεις | |
| BRPI9912227B8 (pt) | método para diagnóstico precoce in vitro de carcinomas e de seus estágios iniciais e kit para realização do método. | |
| CR20150350A (es) | Proceso para preparar conjugados de anticuerpo y maytansinoide | |
| BRPI0210579B8 (pt) | anticorpo e composição farmacêutica | |
| DE69937899D1 (de) | Antikörper-serumprotein hybride | |
| BR0315161A (pt) | Anticorpo isolado, polinicleotìdeo isolado, vetor, célula hospedeira, método de produzir um anticorpo, e, composição | |
| DE60041592D1 (de) | Testverfahren für verbindungen die frühzeitige tra | |
| EA202092087A1 (ru) | Анализы для выявления нейродегенеративных заболеваний | |
| WO2003016464A3 (en) | Cancer specific oligosaccharide sequences and use thereof | |
| ATE277352T1 (de) | Einetenascin-c isoform als marker für neoplasmen | |
| AU5352901A (en) | Method for quantification of akt protein expression | |
| AR029540A1 (es) | COMPOSICIONES Y METODOS PARA EL DIAGNoSTICO Y LA TERAPIA DE CA NCER DE PULMoN | |
| BR0108609A (pt) | Anticorpo com especificidade pelo câncer de cólon | |
| WO2001073031A3 (en) | Compositions and methods for the therapy and diagnosis of ovarian cancer | |
| ATE414904T1 (de) | Verfahren zum testen des oxidiertes-ldl-beta-2- glycoprotein-i-komplexes in vivo | |
| 이종권 et al. | Evaluation of neutral red uptake and alamar blue assays using hacat cell as a screening test for skin irritancy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] |
Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI. |
|
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 01/09/2015, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 29/02/00, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: REF. RPI 2330 DE 01/09/2015 QUANTO AO PRAZO DE VALIDADE. (PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 29/02/00, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO ) |
|
| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 29/02/2020 |