DE60037139D1 - Polyhydroxylierte aromatischen verbindungen für die behandlung von amyloidosis und alpha-synuclein fibril krankheiten - Google Patents

Polyhydroxylierte aromatischen verbindungen für die behandlung von amyloidosis und alpha-synuclein fibril krankheiten

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Publication number
DE60037139D1
DE60037139D1 DE60037139A DE60037139A DE60037139D1 DE 60037139 D1 DE60037139 D1 DE 60037139D1 DE 60037139 A DE60037139 A DE 60037139A DE 60037139 A DE60037139 A DE 60037139A DE 60037139 D1 DE60037139 D1 DE 60037139D1
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DE
Germany
Prior art keywords
treatment
amyloidosis
aromatic compounds
alpha
poly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60037139A
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English (en)
Other versions
DE60037139T2 (de
DE60037139T4 (de
Inventor
Gerardo M Castillo
Paula Y Choi
Alan D Snow
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ProteoTech Inc
Original Assignee
ProteoTech Inc
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Publication of DE60037139D1 publication Critical patent/DE60037139D1/de
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Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60037139A 1999-12-30 2000-12-28 Polyhydroxylierte aromatischen verbindungen für die behandlung von amyloidosis und alpha-synuclein fibril krankheiten Expired - Lifetime DE60037139D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17395899P 1999-12-30 1999-12-30
US09/748,748 US20010047032A1 (en) 1999-12-30 2000-12-26 Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases
PCT/US2000/035715 WO2001049281A2 (en) 1999-12-30 2000-12-28 POLYHYDROXYLATED AROMATIC COMPOUNDS FOR THE TREATMENT OF AMYLOIDOSIS AND α-SYNUCLEIN FIBRIL DISEASES

Publications (1)

Publication Number Publication Date
DE60037139D1 true DE60037139D1 (de) 2007-12-27

Family

ID=26869723

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60037139T Expired - Lifetime DE60037139T4 (de) 1999-12-30 2000-12-28 Polyhydroxylierte aromatischen verbindungen für die behandlung von amyloidosis und alpha-synuclein fibril krankheiten
DE60037139A Expired - Lifetime DE60037139D1 (de) 1999-12-30 2000-12-28 Polyhydroxylierte aromatischen verbindungen für die behandlung von amyloidosis und alpha-synuclein fibril krankheiten

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60037139T Expired - Lifetime DE60037139T4 (de) 1999-12-30 2000-12-28 Polyhydroxylierte aromatischen verbindungen für die behandlung von amyloidosis und alpha-synuclein fibril krankheiten

Country Status (10)

Country Link
US (4) US20010047032A1 (de)
EP (1) EP1244435B9 (de)
JP (2) JP4370072B2 (de)
AT (1) ATE378043T1 (de)
AU (1) AU2612101A (de)
CA (2) CA2686468C (de)
DE (2) DE60037139T4 (de)
DK (1) DK1244435T5 (de)
ES (1) ES2295078T3 (de)
WO (1) WO2001049281A2 (de)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010047032A1 (en) * 1999-12-30 2001-11-29 Castillo Gerardo M. Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases
GB2348371B (en) * 2000-03-14 2001-04-04 Soares Da Silva Patricio Compositions comprising blockers of L-DOPA renal cell transfer for the treatment of Parkinson's disease
JP4633897B2 (ja) * 2000-08-17 2011-02-16 長瀬産業株式会社 神経突起伸長剤
US20070208087A1 (en) 2001-11-02 2007-09-06 Sanders Virginia J Compounds, compositions and methods for the treatment of inflammatory diseases
WO2002054083A2 (en) * 2001-01-03 2002-07-11 Ortho-Mcneil Pharmaceutical, Inc. Alpha synuclein aggregation assays
DK1372682T3 (da) * 2001-03-15 2012-08-20 Proteotech Inc Catechiner til behandling af fibrillogenese ved alzheimers sygdom, parkinsons sygdom, systemisk AA amyloidose og andre amyloide forstyrrelser
PL205635B1 (pl) * 2001-04-09 2010-05-31 Inst Farmaceutyczny Nowe pochodne genisteiny i zawierające je środki farmaceutyczne
AUPR957001A0 (en) * 2001-12-19 2002-01-24 Novogen Research Pty Ltd Isoflavone conjugates, derivatives thereof and therapeutic methods involving same
US20040260076A1 (en) * 2002-10-11 2004-12-23 Castillo Gerardo M. Isolation, purification and synthesis of procyanidin B2 and uses thereof
JP2003252766A (ja) * 2002-02-28 2003-09-10 Sanei Gen Ffi Inc シアニジン３−グルコシドを有効成分とする抗肥満及び／又は抗糖尿病剤
US6964784B2 (en) * 2002-03-07 2005-11-15 Optigenex, Inc. Method of preparation and composition of a water soluble extract of the bioactive component of the plant species uncaria for enhancing immune, anti-inflammatory, anti-tumor and dna repair processes of warm blooded animals
US20050220753A1 (en) * 2002-03-22 2005-10-06 Beijing Jiankai Technology Co., Ltd Hydrophilic polymers-flavoids conjugates and pharmaceutical compositions comprising them
US20030229136A1 (en) 2002-04-18 2003-12-11 Nurulain Zaveri Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents
SI2527315T1 (sl) * 2002-05-31 2014-06-30 Proteotech Inc., Spojine, sestavki in metode za zdravljenje amiloidnih bolezni in sinukleinopatij, kot so Alzheimerjeva bolezen, diabetes tipa 2 in Parkinsonova bolezen
US7491699B2 (en) 2002-12-09 2009-02-17 Ramot At Tel Aviv University Ltd. Peptide nanostructures and methods of generating and using the same
WO2004060791A1 (en) 2003-01-07 2004-07-22 Ramot At Tel Aviv University Ltd. Peptide nanostructures encapsulating a foreign material and method of manufacturing same
WO2004096240A1 (en) * 2003-05-02 2004-11-11 Medpalett Pharmaceuticals As Anthocyanins useful for the treatment of diabetes, cardiovascular disorders and to lower the risk of adverse effects of hormone replacement therapy
US20060105036A1 (en) 2003-05-12 2006-05-18 Stephen Peroutka Threo-dops controlled release formulation
US8158149B2 (en) * 2004-05-12 2012-04-17 Chelsea Therapeutics, Inc. Threo-DOPS controlled release formulation
MXPA05013692A (es) * 2003-06-23 2006-03-13 Neurochem Int Ltd Metodos para tratar trastornos por acumulacion de proteina.
WO2005025561A1 (en) * 2003-09-04 2005-03-24 Synergia Pharma, Inc. Compositions and methods for orthostatic intolerance
CA2540407A1 (en) * 2003-09-25 2005-03-31 Tel Aviv University Future Technology Development L.P. Compositions and methods using same for treating amyloid-associated diseases
CA2543404A1 (en) * 2003-10-24 2005-05-06 Meiji Seika Kaisha, Ltd. Novel inhibitor of the formation of advanced glycation end product and aldose reductase inhibitor
EP1744761A4 (de) 2004-04-28 2010-01-13 Molecules For Health Inc Verfahren zur behandlung oder prävention von restenose und anderen proliferativen gefässstörungen
CN100496470C (zh) * 2004-07-19 2009-06-10 中国科学院上海生命科学研究院 多酚及其氧化物的应用
US8568637B2 (en) 2004-08-02 2013-10-29 Ramot At Tel-Aviv University Ltd. Method of forming a fiber made of peptide nanostructures
WO2006017763A2 (en) * 2004-08-04 2006-02-16 Aspira Biosystems, Inc. Capture and removal of biomolecules from body fluids using partial molecular imprints
US9216161B2 (en) 2004-08-13 2015-12-22 Healthpartners Research Foundation Methods of treating Huntington's disease comprising administering metal chelators to the upper one-third of the nasal cavity
US7618615B2 (en) 2004-08-13 2009-11-17 Healthpartners Research Foundation Methods for providing neuroprotection for the animal central nervous system against neurodegeneration caused by ischemia
US20070122509A1 (en) * 2004-12-02 2007-05-31 Molecular Research Center, Inc. Antioxidant dietary supplement compositions and methods for maintaining healthy skin
US9579298B2 (en) 2004-12-02 2017-02-28 Piotr Chomczynski Antioxidant dietary supplement compositions and methods for maintaining healthy skin
KR100673595B1 (ko) 2005-03-07 2007-01-24 영남대학교 산학협력단 푸스틴을 포함하는 퇴행성 신경질환 예방 또는 치료용 조성물
ATE452632T1 (de) * 2005-04-07 2010-01-15 Astrum Therapeutics Pty Ltd Verbindungen zur behandlung von amyloidose und verhinderung des tods von beta-zellen bei diabetes mellitus typ 2
CN101180319B (zh) * 2005-05-20 2012-06-27 新加坡科技研究局 醛结合的类黄酮制剂
RU2420513C2 (ru) * 2005-07-21 2011-06-10 Релайанс Лайф Сайенсиз Пвт Лтд Соединения для лечения заболеваний, опосредованных липазой
JP2009504682A (ja) * 2005-08-11 2009-02-05 ザ スクリプス リサーチ インスティテュート トランスサイレチンアミロイドーシスのゲニステインによる阻害
US20100310587A1 (en) * 2005-08-29 2010-12-09 Academia Sinica Immunomodulatory compositions
WO2007043048A2 (en) 2005-10-11 2007-04-19 Ramot At Tel Aviv University Ltd. Self-assembled fmoc-ff hydrogels
ES2277567B1 (es) * 2005-12-30 2008-06-01 Universidad Del Pais Vasco Compuestos con propiedades neuroprotectoras.
US9155792B2 (en) * 2006-02-13 2015-10-13 Trustees Of Boston University RecA inhibitors with antibiotic activity, compositions and methods of use
WO2007118226A2 (en) 2006-04-07 2007-10-18 Sunten Phytotech Co., Ltd. Anthracenedione compounds
WO2007132784A1 (ja) * 2006-05-15 2007-11-22 Niigata University アントラキノン誘導体を有効成分として含有する抗精神病薬、認知異常の治療薬
CN101091706B (zh) * 2006-06-23 2011-05-04 和泓生物技术（上海）有限公司 多巴胺转运蛋白激动剂及其用途
ATE548034T1 (de) * 2006-06-28 2012-03-15 Chelsea Therapeutics Inc Pharmazeutische zusammensetzungen mit droxidopa
US20080033038A1 (en) * 2006-07-07 2008-02-07 Shytle R D Compositions of polyphenols and methods of use
WO2008011538A2 (en) * 2006-07-19 2008-01-24 The Salk Institute For Biological Studies Methods of using flavonoids to enhance memory
WO2008019292A2 (en) * 2006-08-04 2008-02-14 Trustees Of Boston University Compositions and methods for potentiating antibiotic activity
US8802638B1 (en) * 2007-01-25 2014-08-12 University Of South Florida Flavonoid treatment of glycogen synthase kinase-based disease
US8778986B1 (en) * 2007-01-25 2014-07-15 University Of South Florida Treatment of glycogen synthase kinase-based disease
EP2117306A4 (de) * 2007-02-14 2010-02-10 Mars Inc Neurogene verbindungen
CN101244074A (zh) * 2007-02-16 2008-08-20 首都医科大学宣武医院 淫羊藿黄酮及其有效成分在制备促进神经细胞增殖和分化作用药物中的用途
WO2008109517A1 (en) * 2007-03-02 2008-09-12 University Of South Florida Neurodegenerative disease treatment using jak/stat inhibition
WO2008112562A1 (en) * 2007-03-09 2008-09-18 Chelsea Therapeutics, Inc. Droxidopa and pharmaceutical composition thereof for the treatment of fibromyalgia
EP2514417A3 (de) * 2007-05-07 2013-01-30 Chelsea Therapeutics, Inc. Droxidopa und pharmazeutische Zusammensetzung davon, zur Behandlung von Stimmungsstörungen, Schlafstörungen oder Aufmerksamkeitsdefizit-Störungen
US9707274B2 (en) 2007-06-08 2017-07-18 Healthpartners Research & Education Methods for preventing and treating post-traumatic stress disorder (PTSD)
US20110111014A1 (en) * 2007-06-26 2011-05-12 Parkinson's Institute Methods and compositions for treatment of neurological disorders
EP2030615A3 (de) * 2007-08-13 2009-12-02 ELFORD, Howard L. Ribonukleotidreduktase-Inhibitoren zur Verwendung für die Behandlung oder Vorbeugung von Nervenentzündung- oder Autoimmunerkrankungen
US8597640B2 (en) * 2007-10-31 2013-12-03 University Of Massachusetts Lowell Over-the-counter vitamin/nutriceutical formulation that provides neuroprotection and maintains or improves cognitive performance in alzheimer's disease and normal aging
US20090176718A1 (en) * 2007-10-31 2009-07-09 David Ribnicky Berry Preparations For Treatment Of Diabetes And Metabolic Syndrome
GB0821994D0 (en) * 2008-12-02 2009-01-07 Ge Healthcare Ltd In viva imaging method
HUE028729T2 (en) 2009-03-09 2017-01-30 Ramot At Tel-Aviv Univ Ltd Compositions for the prevention and treatment of neurodegenerative diseases
US9072730B2 (en) * 2009-05-14 2015-07-07 The Board Of Trustees Of The Leland Stanford Junior University Method of improving cognitive functions in individuals with down syndrome and/or alzheimer's disease
CA2789484C (en) 2010-03-08 2019-10-22 Sloan-Kettering Institute For Cancer Research Cdc7 kinase inhibitors and uses thereof
CN101780098A (zh) * 2010-03-13 2010-07-21 青岛大学 迷迭香酸-杨梅黄酮药物配方及其在治疗帕金森病中的应用
KR20110111594A (ko) * 2010-04-05 2011-10-12 서울대학교산학협력단 알파-시뉴클레인 유래 곱슬 아밀로이드 섬유의 제조방법, 이를 이용한 하이드로젤의 제조 방법 및 그 이용 방법
KR101723635B1 (ko) * 2010-09-28 2017-04-05 서울대학교 산학협력단 전도성 바이오-나노 융합 사슬 및 이의 제조방법
US9872850B2 (en) 2010-12-23 2018-01-23 Amazentis Sa Compositions and methods for improving mitochondrial function and treating neurodegenerative diseases and cognitive disorders
WO2012118935A1 (en) * 2011-03-03 2012-09-07 Proteotech Inc Compounds for the treatment of neurodegenerative diseases
CN102690244A (zh) * 2011-03-22 2012-09-26 中国科学院上海生命科学研究院 调节α-突触核蛋白积聚的物质及其制药用途
JP5880913B2 (ja) 2011-05-17 2016-03-09 三郎 佐古田 パーキンソン病の体幹症状（姿勢反射異常）の治療剤
JP2013053133A (ja) * 2011-08-10 2013-03-21 Taisho Pharmaceutical Co Ltd 認知機能障害の予防及び／または治療用組成物
JP6126531B2 (ja) * 2011-10-03 2017-05-10 国立研究開発法人国立長寿医療研究センター タウ凝集阻害剤
KR101301253B1 (ko) * 2011-12-09 2013-08-28 한국원자력연구원 방사선을 이용한 크로메논 유도체의 제조방법
WO2013142370A1 (en) * 2012-03-19 2013-09-26 Varghese John APP SPECIFIC BACE INHIBITORS (ASBIs) AND USES THEREOF
CN102743367A (zh) * 2012-05-31 2012-10-24 兰州理工大学 路路通鞣质单体的用途
CN102940712B (zh) * 2012-12-07 2014-03-19 辽宁大学 枳实在制备抗朊病毒药物中的应用
WO2014127191A1 (en) * 2013-02-15 2014-08-21 The Regents Of The University Of Michigan Compositions and methods relating to hindering dot1l recruitment by mll-fusion proteins
CU20130027A7 (es) 2013-02-28 2014-10-30 Ct De Neurociencias De Cuba Chaperoninas químicas como nuevos moduladores moleculares de la beta agregación proteica presente en las enfermedades conformacionales
US10279012B2 (en) 2013-03-11 2019-05-07 Healthpartners Research & Education Methods of treating and preventing social communication disorder in patients by intranasal administration of insulin
EP2962687B1 (de) 2013-04-02 2019-06-05 The Doshisha Tau-aggregationshemmer
BR102013022567B1 (pt) * 2013-09-03 2021-09-21 Uniao Brasileira De Educacão E Assistência Uso de 6-hidroxi-2-piridonas e seus derivados na preparação de uma composição farmacêutica que atue pela inibição da enzima uridina fosforilase humana
US10314911B2 (en) 2014-04-08 2019-06-11 Healthpartners Research & Education Methods for protecting and treating traumatic brain injury, concussion and brain inflammation with intranasal insulin
EP3237066B1 (de) * 2014-12-23 2020-10-21 Sloan-Kettering Institute for Cancer Research Polymorph von granaticin b
CN104546825A (zh) * 2014-12-30 2015-04-29 上海中医药大学 高良姜素的医药用途
KR101636733B1 (ko) * 2015-02-24 2016-07-07 인제대학교 산학협력단 에키노크롬 a를 유효성분으로 함유하는 운동능력 증진용 건강식품 및 이를 이용한 운동능력 증진방법
KR101818084B1 (ko) * 2015-04-14 2018-01-15 대구가톨릭대학교산학협력단 석송강 추출물 또는 이로부터 분리된 화합물을 포함하는 알츠하이머병의 예방 또는 치료용 조성물-ⅱ
WO2017096049A1 (en) 2015-12-03 2017-06-08 The University Of North Carolina At Pembroke Materials for cathepsin b enhancement and methods of use
BR112018012343A2 (pt) 2015-12-17 2018-12-04 Massachusetts Inst Technology composições de benzofenonas poli-hidroxiladas e métodos de tratamento de distúrbios neurodegenerativos
KR102441381B1 (ko) * 2016-07-18 2022-09-07 (주)아모레퍼시픽 3-O-갈로일-3,3',5,5',7-펜타하이드록시플라반(3-O-galloyl-3,3',5,5',7- pentahydroxyflavan)을 포함하는 인지 기능 개선용 조성물
US11969408B2 (en) 2017-03-08 2024-04-30 Amazentis Sa Method for improving mitophagy in subjects
CA3097521C (en) 2017-05-15 2023-10-17 Axial Biotherapeutics, Inc. Inhibitors of microbially induced amyloid
CN107349199A (zh) * 2017-07-18 2017-11-17 华北制药集团新药研究开发有限责任公司 榴菌素类化合物的医药用途
KR102098780B1 (ko) * 2017-09-27 2020-05-26 농업회사법인 대제한약 주식회사 블랙쵸크베리 추출물을 포함하는 뇌질환 예방 또는 치료용 약학 조성물
CN107823295A (zh) * 2017-11-28 2018-03-23 江西中医药大学 栀子花在制备改善睡眠障碍或改善记忆力减退或通便或提高免疫力药物或保健食品中应用
KR20200106988A (ko) * 2018-04-13 2020-09-15 주식회사 그랜메드 알츠하이머 병의 병원성 인자로서 그래닌의 확인과, 그래닌의 응집 억제와 알츠하이머 병을 치료하기 위한 조성물 및 방법
GB2596491B (en) * 2018-12-18 2022-06-29 Sang Hee Kim Composition for preventing or treating attention deficit hyperactivity disorder, comprising galla rhois extract and fraxin as active ingredients
KR102246444B1 (ko) * 2018-12-18 2021-04-29 김상희 오배자 추출물 및 프락신을 유효성분으로 포함하는 인지력 개선 및 치매 예방 또는 치료용 조성물
BR112021014774A2 (pt) * 2019-02-08 2021-09-28 Industrial Técnica Pecuaria, S.A. Composição antioxidante compreendendo quercetagetina e ácido gálico
CN110548023A (zh) * 2019-09-19 2019-12-10 天津科技大学 胭脂虫红酸在制备抑制β-淀粉样蛋白聚集中的用途
CN111096972B (zh) * 2020-02-25 2023-07-14 成都医学院 一种预防和/或治疗阿尔茨海默症的药物组合物

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3729563A (en) * 1970-12-08 1973-04-24 Ciba Geigy Corp Method of treating movement disorders
US3833732A (en) * 1973-05-24 1974-09-03 Miles Lab Method of treating inflammation utilizing alkyl esters of gallic acid
US5283352A (en) * 1986-11-28 1994-02-01 Orion-Yhtyma Oy Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same
JP2587842B2 (ja) * 1987-12-09 1997-03-05 株式会社ニチレイ 神経疾患治療・予防剤
GB2264707A (en) * 1991-06-18 1993-09-08 Roger Michael Marchbanks Acridine derivatives for treating alzheimer's disease
US5958883A (en) * 1992-09-23 1999-09-28 Board Of Regents Of The University Of Washington Office Of Technology Animal models of human amyloidoses
US5643562A (en) * 1993-03-29 1997-07-01 Queen's University Of Kingston Method for treating amyloidosis
US6251928B1 (en) * 1994-03-16 2001-06-26 Eli Lilly And Company Treatment of alzheimer's disease employing inhibitors of cathepsin D
US5464619A (en) * 1994-06-03 1995-11-07 The Procter & Gamble Company Beverage compositions containing green tea solids, electrolytes and carbohydrates to provide improved cellular hydration and drinkability
GB9416007D0 (en) * 1994-08-08 1994-09-28 Erba Carlo Spa Anthracyclinone derivatives
US5972956A (en) * 1995-11-02 1999-10-26 Warner-Lambert Company Inhibition of amyloidosis by 9-acridinones
IL120269A0 (en) * 1996-02-28 1997-06-10 Pfizer 1,1,2-triphenylbut-1-ene derivatives for treating Alzheimer's disease
EP0937137A4 (de) * 1996-06-06 2002-10-23 Univ Washington Perlecan exprimierende transgene tiere und verfahren zur identifikation von verbindungen zur behandlung der amyloidose
AU4236297A (en) * 1996-08-26 1998-03-19 University Of Washington Therapeutic and diagnostic applications of perlecan domain splice variants
FR2753098B1 (fr) * 1996-09-06 1998-11-27 Sod Conseils Rech Applic Composition pharmaceutique comprenant au moins un inhibiteur de no synthase et au moins un piegeur des formes reactives de l'oxygene
WO1998015179A1 (en) * 1996-10-08 1998-04-16 University Of Washington Therapeutic and diagnostic applications of laminin and laminin-derived protein fragments
US6933280B2 (en) * 1996-10-08 2005-08-23 Gerardo Castillo Peptides for the treatment of Alzheimer's disease and other beta-amyloid protein fibrillogenesis disorders
CA2219605C (en) * 1996-10-31 2002-02-05 Deepa Ashok Khambe Method of stimulating gastrointestinal motility with ellagic acid
US5746441A (en) * 1996-12-02 1998-05-05 Rockwell Heavy Vehicle Suspension Systems, Inc. Center beam suspension system
US5733926A (en) * 1996-12-13 1998-03-31 Gorbach; Sherwood L. Isoflavonoids for treatment and prevention of alzheimer dementia and reduced cognitive functions
KR100543151B1 (ko) * 1997-01-16 2006-01-20 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 산화방지제와의 상승적인 상호작용을 통해 폴리시클릭 페놀계화합물의 세포 보호 효과를 증강시키는 조성물
ES2285772T3 (es) * 1997-05-15 2007-11-16 University Of Washington Composicion y metodos para tratar la enfermedad de alzheimer y otras amiloidosis.
US6264994B1 (en) * 1997-05-15 2001-07-24 University Of Washington Compositions for treating alzheimer's disease and other amyloidoses
US20030017998A1 (en) * 1997-05-16 2003-01-23 Snow Alan D. Proanthocyanidins for the treatment of amyloid and alpha-synuclein diseases
US6346280B1 (en) * 1997-05-15 2002-02-12 University Of Washington Composition and methods for inhibiting the formation of brain amyloid deposits
US5869469A (en) * 1997-08-18 1999-02-09 Queen's University At Kingston Phosphonocarboxylate compounds for treating amyloidosis
ES2200366T3 (es) * 1997-08-28 2004-03-01 University Of Washington Composiciones de sacaridos para el tratamiento de la enfermedad de alzheimer y otras amiloidoisis.
US5952374A (en) * 1997-09-29 1999-09-14 Protein Technologies International, Inc. Method for inhibiting the development of Alzheimer's disease and related dementias- and for preserving cognitive function
JP4537577B2 (ja) * 1998-03-13 2010-09-01 ユニバーシティ・オブ・ワシントン アルツハイマー病及びプリオン病の治療に関する抗プラーク療法を特定するコンゴ好染性マルタ十字形アミロイドプラークのｉｎｖｉｔｒｏにおける形成
US5981168A (en) * 1998-05-15 1999-11-09 The University Of British Columbia Method and composition for modulating amyloidosis
KR20000019716A (ko) * 1998-09-15 2000-04-15 박호군 바이오플라보노이드 화합물을 포함하는 혈당 강하용 조성물
UA75569C2 (en) * 1998-12-01 2006-05-15 Reddys Lab Ltd Dr Pharmaceutical composition of thiadiazolidinedione and method for its manufacture
US20010047032A1 (en) * 1999-12-30 2001-11-29 Castillo Gerardo M. Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases
CA2427661C (en) * 2000-11-03 2013-05-28 Proteotech, Inc. Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from uncaria tomentosa and related plants

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EP1244435B9 (de) 2009-05-06
US20110065657A1 (en) 2011-03-17
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AU2612101A (en) 2001-07-16
US20010047032A1 (en) 2001-11-29
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EP1244435B1 (de) 2007-11-14
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US20040152760A1 (en) 2004-08-05
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US20070191330A1 (en) 2007-08-16
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ATE378043T1 (de) 2007-11-15

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