DE60035522T2 - Mutant er-alpha und nachweissysteme für transaktivierung - Google Patents

Mutant er-alpha und nachweissysteme für transaktivierung Download PDF

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Publication number
DE60035522T2
DE60035522T2 DE60035522T DE60035522T DE60035522T2 DE 60035522 T2 DE60035522 T2 DE 60035522T2 DE 60035522 T DE60035522 T DE 60035522T DE 60035522 T DE60035522 T DE 60035522T DE 60035522 T2 DE60035522 T2 DE 60035522T2
Authority
DE
Germany
Prior art keywords
erα
seq
relative position
reporter gene
mutant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60035522T
Other languages
German (de)
English (en)
Other versions
DE60035522D1 (de
Inventor
Koichi Takarazuka-shi SAITO
Norihisa Nara-shi OHE
Hideo Ibaraki-shi SATOH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Application granted granted Critical
Publication of DE60035522D1 publication Critical patent/DE60035522D1/de
Publication of DE60035522T2 publication Critical patent/DE60035522T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Mushroom Cultivation (AREA)
DE60035522T 1999-12-07 2000-12-01 Mutant er-alpha und nachweissysteme für transaktivierung Expired - Lifetime DE60035522T2 (de)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
JP34802299 1999-12-07
JP34802299 1999-12-07
JP37066799 1999-12-27
JP37066799 1999-12-27
JP2000207011 2000-07-07
JP2000207011 2000-07-07
JP2000220508 2000-07-21
JP2000220508 2000-07-21
JP2000234053 2000-08-02
JP2000234053 2000-08-02
JP2000235463 2000-08-03
JP2000235460 2000-08-03
JP2000235461 2000-08-03
JP2000235461 2000-08-03
JP2000235463 2000-08-03
JP2000235460 2000-08-03
PCT/JP2000/008553 WO2001042307A1 (en) 1999-12-07 2000-12-01 MUTANT ERα AND TEST SYSTEMS FOR TRANSACTIVATION

Publications (2)

Publication Number Publication Date
DE60035522D1 DE60035522D1 (de) 2007-08-23
DE60035522T2 true DE60035522T2 (de) 2008-03-20

Family

ID=27573667

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60035522T Expired - Lifetime DE60035522T2 (de) 1999-12-07 2000-12-01 Mutant er-alpha und nachweissysteme für transaktivierung

Country Status (8)

Country Link
US (1) US7582476B2 (https=)
EP (1) EP1237925B1 (https=)
JP (1) JP4742483B2 (https=)
AT (1) ATE366745T1 (https=)
AU (1) AU782142B2 (https=)
CA (1) CA2393045A1 (https=)
DE (1) DE60035522T2 (https=)
WO (1) WO2001042307A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002057283A1 (en) * 2001-01-19 2002-07-25 Baylor College Of Medecine Methods and compositions in breast cancer diagnosis and therapeutics
JPWO2004005497A1 (ja) * 2002-07-02 2005-11-04 アステラス製薬株式会社 インスリン抵抗性改善薬スクリーニング方法
US7927840B2 (en) * 2006-09-11 2011-04-19 Gen Probe Incorporated Method for detecting West Nile Virus nucleic acids in the 3′ non-coding region
US7115374B2 (en) * 2002-10-16 2006-10-03 Gen-Probe Incorporated Compositions and methods for detecting West Nile virus
AU2003280793A1 (en) * 2002-11-15 2004-06-15 Sumitomo Chemical Company, Limited MUTANT ESTROGEN RECEPTOR-Alpha AND GENE THEREOF
EP1680447A2 (en) * 2003-10-24 2006-07-19 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Orthogonal gene switches
FR2863275B1 (fr) * 2003-12-09 2007-08-10 Biomerieux Sa Procede pour le diagnostic/pronostic du cancer du sein
EP1711606A2 (en) 2004-01-20 2006-10-18 Isis Pharmaceuticals, Inc. Modulation of glucocorticoid receptor expression
JP2006153656A (ja) * 2004-11-29 2006-06-15 Olympus Corp 反応カプセル、反応カプセルを使用した検査方法およびシステム
AU2012328680A1 (en) 2011-10-25 2014-05-01 Ionis Pharmaceuticals, Inc. Antisense modulation of GCCR expression
EA031077B1 (ru) 2013-06-19 2018-11-30 Серагон Фармасьютикалз, Инк. Модулятор рецептора эстрогена и его применения
CA2915534A1 (en) 2013-06-19 2014-12-24 Seragon Pharmaceuticals, Inc. Azetidine estrogen receptor modulators and uses thereof
SG11201607339VA (en) 2014-03-13 2016-10-28 Hoffmann La Roche Methods and compositions for modulating estrogen receptor mutants
US10053451B2 (en) 2015-05-26 2018-08-21 Genentech, Inc. Heterocyclic estrogen receptor modulators and uses thereof
US10179676B1 (en) 2017-07-26 2019-01-15 William Hagan Taylor Dispenser with self-closing cap

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63502397A (ja) * 1986-02-20 1988-09-14 カロビオ　エービー ステロイドレセプタ−タンパクの真核細胞における発現
FR2634495B1 (fr) * 1988-07-01 1990-10-26 Chambon Pierre Procede de preparation d'une proteine par des levures utilisant un systeme inductible, vecteurs et souches transformees correspondantes
JPH06510363A (ja) * 1990-10-29 1994-11-17 ディカルブ　プラント　ジェネティクス 磁気性粒子を使用する生物学的材料の単離

Also Published As

Publication number Publication date
US7582476B2 (en) 2009-09-01
US20030207380A1 (en) 2003-11-06
DE60035522D1 (de) 2007-08-23
WO2001042307A1 (en) 2001-06-14
CA2393045A1 (en) 2001-06-14
JP4742483B2 (ja) 2011-08-10
EP1237925A1 (en) 2002-09-11
AU782142B2 (en) 2005-07-07
JP2003516137A (ja) 2003-05-13
EP1237925B1 (en) 2007-07-11
AU1886801A (en) 2001-06-18
ATE366745T1 (de) 2007-08-15

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