ATE366745T1 - Mutant er-alpha und nachweissysteme für transaktivierung - Google Patents
Mutant er-alpha und nachweissysteme für transaktivierungInfo
- Publication number
- ATE366745T1 ATE366745T1 AT00981647T AT00981647T ATE366745T1 AT E366745 T1 ATE366745 T1 AT E366745T1 AT 00981647 T AT00981647 T AT 00981647T AT 00981647 T AT00981647 T AT 00981647T AT E366745 T1 ATE366745 T1 AT E366745T1
- Authority
- AT
- Austria
- Prior art keywords
- eralpha
- mutant
- test
- transactivation
- diagnosing
- Prior art date
Links
- 230000023603 positive regulation of transcription initiation, DNA-dependent Effects 0.000 title abstract 3
- 238000001514 detection method Methods 0.000 title 1
- 102000007594 Estrogen Receptor alpha Human genes 0.000 abstract 10
- 108010007005 Estrogen Receptor alpha Proteins 0.000 abstract 10
- 238000000034 method Methods 0.000 abstract 7
- 102000040430 polynucleotide Human genes 0.000 abstract 3
- 108091033319 polynucleotide Proteins 0.000 abstract 3
- 239000002157 polynucleotide Substances 0.000 abstract 3
- 108700008625 Reporter Genes Proteins 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 238000012216 screening Methods 0.000 abstract 2
- 239000000592 Artificial Cell Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 230000001076 estrogenic effect Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 230000002103 transcriptional effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Mushroom Cultivation (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP34802299 | 1999-12-07 | ||
| JP37066799 | 1999-12-27 | ||
| JP2000207011 | 2000-07-07 | ||
| JP2000220508 | 2000-07-21 | ||
| JP2000234053 | 2000-08-02 | ||
| JP2000235460 | 2000-08-03 | ||
| JP2000235463 | 2000-08-03 | ||
| JP2000235461 | 2000-08-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE366745T1 true ATE366745T1 (de) | 2007-08-15 |
Family
ID=27573667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00981647T ATE366745T1 (de) | 1999-12-07 | 2000-12-01 | Mutant er-alpha und nachweissysteme für transaktivierung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7582476B2 (https=) |
| EP (1) | EP1237925B1 (https=) |
| JP (1) | JP4742483B2 (https=) |
| AT (1) | ATE366745T1 (https=) |
| AU (1) | AU782142B2 (https=) |
| CA (1) | CA2393045A1 (https=) |
| DE (1) | DE60035522T2 (https=) |
| WO (1) | WO2001042307A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002057283A1 (en) * | 2001-01-19 | 2002-07-25 | Baylor College Of Medecine | Methods and compositions in breast cancer diagnosis and therapeutics |
| JPWO2004005497A1 (ja) * | 2002-07-02 | 2005-11-04 | アステラス製薬株式会社 | インスリン抵抗性改善薬スクリーニング方法 |
| US7927840B2 (en) * | 2006-09-11 | 2011-04-19 | Gen Probe Incorporated | Method for detecting West Nile Virus nucleic acids in the 3′ non-coding region |
| US7115374B2 (en) * | 2002-10-16 | 2006-10-03 | Gen-Probe Incorporated | Compositions and methods for detecting West Nile virus |
| AU2003280793A1 (en) * | 2002-11-15 | 2004-06-15 | Sumitomo Chemical Company, Limited | MUTANT ESTROGEN RECEPTOR-Alpha AND GENE THEREOF |
| EP1680447A2 (en) * | 2003-10-24 | 2006-07-19 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Orthogonal gene switches |
| FR2863275B1 (fr) * | 2003-12-09 | 2007-08-10 | Biomerieux Sa | Procede pour le diagnostic/pronostic du cancer du sein |
| EP1711606A2 (en) | 2004-01-20 | 2006-10-18 | Isis Pharmaceuticals, Inc. | Modulation of glucocorticoid receptor expression |
| JP2006153656A (ja) * | 2004-11-29 | 2006-06-15 | Olympus Corp | 反応カプセル、反応カプセルを使用した検査方法およびシステム |
| AU2012328680A1 (en) | 2011-10-25 | 2014-05-01 | Ionis Pharmaceuticals, Inc. | Antisense modulation of GCCR expression |
| EA031077B1 (ru) | 2013-06-19 | 2018-11-30 | Серагон Фармасьютикалз, Инк. | Модулятор рецептора эстрогена и его применения |
| CA2915534A1 (en) | 2013-06-19 | 2014-12-24 | Seragon Pharmaceuticals, Inc. | Azetidine estrogen receptor modulators and uses thereof |
| SG11201607339VA (en) | 2014-03-13 | 2016-10-28 | Hoffmann La Roche | Methods and compositions for modulating estrogen receptor mutants |
| US10053451B2 (en) | 2015-05-26 | 2018-08-21 | Genentech, Inc. | Heterocyclic estrogen receptor modulators and uses thereof |
| US10179676B1 (en) | 2017-07-26 | 2019-01-15 | William Hagan Taylor | Dispenser with self-closing cap |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63502397A (ja) * | 1986-02-20 | 1988-09-14 | カロビオ エービー | ステロイドレセプタ−タンパクの真核細胞における発現 |
| FR2634495B1 (fr) * | 1988-07-01 | 1990-10-26 | Chambon Pierre | Procede de preparation d'une proteine par des levures utilisant un systeme inductible, vecteurs et souches transformees correspondantes |
| JPH06510363A (ja) * | 1990-10-29 | 1994-11-17 | ディカルブ プラント ジェネティクス | 磁気性粒子を使用する生物学的材料の単離 |
-
2000
- 2000-12-01 CA CA002393045A patent/CA2393045A1/en not_active Abandoned
- 2000-12-01 AT AT00981647T patent/ATE366745T1/de not_active IP Right Cessation
- 2000-12-01 JP JP2001543602A patent/JP4742483B2/ja not_active Expired - Fee Related
- 2000-12-01 WO PCT/JP2000/008553 patent/WO2001042307A1/en not_active Ceased
- 2000-12-01 US US10/148,835 patent/US7582476B2/en not_active Expired - Fee Related
- 2000-12-01 EP EP00981647A patent/EP1237925B1/en not_active Expired - Lifetime
- 2000-12-01 AU AU18868/01A patent/AU782142B2/en not_active Ceased
- 2000-12-01 DE DE60035522T patent/DE60035522T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US7582476B2 (en) | 2009-09-01 |
| DE60035522T2 (de) | 2008-03-20 |
| US20030207380A1 (en) | 2003-11-06 |
| DE60035522D1 (de) | 2007-08-23 |
| WO2001042307A1 (en) | 2001-06-14 |
| CA2393045A1 (en) | 2001-06-14 |
| JP4742483B2 (ja) | 2011-08-10 |
| EP1237925A1 (en) | 2002-09-11 |
| AU782142B2 (en) | 2005-07-07 |
| JP2003516137A (ja) | 2003-05-13 |
| EP1237925B1 (en) | 2007-07-11 |
| AU1886801A (en) | 2001-06-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE366745T1 (de) | Mutant er-alpha und nachweissysteme für transaktivierung | |
| Joensuu et al. | Follow-up strategies for patients with gastrointestinal stromal tumour treated with or without adjuvant imatinib after surgery | |
| Ladeira et al. | Human biomonitoring: An overview on biomarkers and their application in occupational and environmental health | |
| ATE205884T1 (de) | Assays und vorrichtungen zum nachweis von extrahepatischer biliäreratresie | |
| GB2383043A (en) | Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human brain | |
| PL325914A1 (en) | Testing apparatus, application thereof, analysing system, method of making such apparatus and method of performing tests by means of such apparatus | |
| DE59405710D1 (de) | Mittel zur rauchsimulation für streulichtrauchmelder, verfahren zum abgleich von deren rauchempfindlichkeit und verwendung des mittels | |
| DE60233574D1 (de) | Verfahren und zusammensetzungen zum nachweis des aktivierungszustands multipler proteine in einzelzellen | |
| ATE515575T1 (de) | Verfahren und sonden für den nachweis von krebs | |
| Marshall et al. | Importance of minimal residual disease testing during the second year of therapy for children with acute lymphoblastic leukemia | |
| GB2336684A (en) | Predicting logarithmic reduction values | |
| WO2005052592A3 (en) | Methods for diagnosis, stratification, and monitoring of alzheimer’s disease | |
| ATE419390T1 (de) | Verfahren zur diagnose von bauchspeicheldrüsenkrebs | |
| PT1171873E (pt) | Aparelho e metodo para detectar emocoes na voz humana | |
| RU2003106971A (ru) | Способ оценки качества тестирующей полоски, устройство и считываемый компьютером носитель | |
| DE60023905D1 (de) | Optisches system analyse für zellen | |
| DK1520039T3 (da) | Mitokondrisk polymorfi, forbundet til en prædisposition til udvikling af uhensigtsmæssig ardannelse og fibrose | |
| DE69929785D1 (de) | Verfahren zur Diagnose, Erkennung, und Einstufung von Dickdarmkrebs | |
| DE69841164D1 (de) | Sphingosin-1-phosphat-lyase polypeptide, polynukleotide und modulierende mitteln, und verfahren zu deren verwendung | |
| WO2002098280A3 (en) | Method for detecting infectious agents using computer controlled automated image analysis | |
| DE69721551D1 (de) | Proteom-analyse zum charakterisieren von auf- und abgeregelten proteinen in biologischen proben | |
| DE69528703D1 (de) | VERFAHREN, REAGENZIEN UND TESTSATZ ZUR DIAGNOSE UND GEZIELTE SIEBTESTUNG FÜR p53 MÜTATIONEN | |
| WO2004021008A3 (en) | Methods for detecting breast and ovarian cancer | |
| WO2004058051A3 (en) | Androgen-regulated genes and uses for diagnosis, prognosis and treatment of prostate neoplastic conditions | |
| MXPA01006914A (es) | Metodos para identificar combinaciones de entidades como terapeuticas. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |