DE60034815T2 - Ein pyrrolidinacetatderivat zur behandlung von chronischem oder neuropathischem schmerz - Google Patents

Ein pyrrolidinacetatderivat zur behandlung von chronischem oder neuropathischem schmerz Download PDF

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Publication number
DE60034815T2
DE60034815T2 DE60034815T DE60034815T DE60034815T2 DE 60034815 T2 DE60034815 T2 DE 60034815T2 DE 60034815 T DE60034815 T DE 60034815T DE 60034815 T DE60034815 T DE 60034815T DE 60034815 T2 DE60034815 T2 DE 60034815T2
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DE
Germany
Prior art keywords
levetiracetam
valproate
dose
der
die
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60034815T
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German (de)
English (en)
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DE60034815D1 (de
Inventor
Yves Lamberty
Alain Matagne
Henrik Klitgaard
Tony Waegemans
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UCB SA
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UCB SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
DE60034815T 1999-12-01 2000-11-27 Ein pyrrolidinacetatderivat zur behandlung von chronischem oder neuropathischem schmerz Expired - Lifetime DE60034815T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP99124269 1999-12-01
EP99123803 1999-12-01
EP99124269 1999-12-01
EP99123803 1999-12-01
PCT/EP2000/011808 WO2001039779A1 (en) 1999-12-01 2000-11-27 A pyrrolidineacetamide derivative alone or in combination for treatment of cns disorders

Publications (2)

Publication Number Publication Date
DE60034815D1 DE60034815D1 (de) 2007-06-21
DE60034815T2 true DE60034815T2 (de) 2008-01-31

Family

ID=26153183

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60034815T Expired - Lifetime DE60034815T2 (de) 1999-12-01 2000-11-27 Ein pyrrolidinacetatderivat zur behandlung von chronischem oder neuropathischem schmerz

Country Status (32)

Country Link
US (2) US6903130B1 (xx)
EP (4) EP1600167A3 (xx)
JP (2) JP4249415B2 (xx)
KR (1) KR20030016205A (xx)
CN (1) CN100525761C (xx)
AR (1) AR026610A1 (xx)
AT (1) ATE361751T1 (xx)
AU (1) AU773418B2 (xx)
BG (1) BG106708A (xx)
BR (1) BR0015974A (xx)
CA (2) CA2392879C (xx)
CO (1) CO5261590A1 (xx)
CZ (1) CZ20021904A3 (xx)
DE (1) DE60034815T2 (xx)
EE (1) EE200200274A (xx)
ES (1) ES2287039T3 (xx)
HK (1) HK1052647B (xx)
HU (1) HUP0204023A3 (xx)
IL (2) IL149530A0 (xx)
IS (1) IS6377A (xx)
MX (1) MXPA02005275A (xx)
MY (1) MY127980A (xx)
NO (1) NO20022585L (xx)
NZ (1) NZ518901A (xx)
PL (1) PL357472A1 (xx)
RO (1) RO121085B1 (xx)
RU (1) RU2261093C2 (xx)
SA (1) SA01210655B1 (xx)
SK (1) SK7492002A3 (xx)
TW (1) TWI238062B (xx)
WO (1) WO2001039779A1 (xx)
YU (1) YU37602A (xx)

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Also Published As

Publication number Publication date
HK1052647A1 (en) 2003-09-26
CA2392879C (en) 2005-03-29
AR026610A1 (es) 2003-02-19
MY127980A (en) 2007-01-31
EP1600169A3 (en) 2009-09-23
EP1600167A2 (en) 2005-11-30
US20050187205A1 (en) 2005-08-25
MXPA02005275A (es) 2003-02-17
NZ518901A (en) 2004-08-27
RU2002117279A (ru) 2004-02-27
RU2261093C2 (ru) 2005-09-27
EP1600167A3 (en) 2009-09-30
SK7492002A3 (en) 2003-02-04
YU37602A (sh) 2005-07-19
HUP0204023A3 (en) 2005-03-29
CA2475026A1 (en) 2001-06-07
CO5261590A1 (es) 2003-03-31
RO121085B1 (ro) 2006-12-29
ATE361751T1 (de) 2007-06-15
IL149530A (en) 2007-07-04
CA2392879A1 (en) 2001-06-07
DE60034815D1 (de) 2007-06-21
EP1244456B1 (en) 2007-05-09
AU773418B2 (en) 2004-05-27
PL357472A1 (en) 2004-07-26
NO20022585D0 (no) 2002-05-31
IS6377A (is) 2002-05-10
CZ20021904A3 (cs) 2002-11-13
JP4249415B2 (ja) 2009-04-02
SA01210655B1 (ar) 2006-10-29
HK1052647B (zh) 2010-05-20
EP1600168A2 (en) 2005-11-30
HUP0204023A2 (hu) 2003-03-28
CN100525761C (zh) 2009-08-12
EE200200274A (et) 2003-06-16
IL149530A0 (en) 2002-11-10
EP1244456A1 (en) 2002-10-02
NO20022585L (no) 2002-07-25
TWI238062B (en) 2005-08-21
ES2287039T3 (es) 2007-12-16
KR20030016205A (ko) 2003-02-26
JP2003515564A (ja) 2003-05-07
BG106708A (bg) 2003-02-28
BR0015974A (pt) 2002-07-23
EP1600169A2 (en) 2005-11-30
US6903130B1 (en) 2005-06-07
WO2001039779A1 (en) 2001-06-07
EP1600168A3 (en) 2009-09-23
JP2008056697A (ja) 2008-03-13
CN1402637A (zh) 2003-03-12
AU1524101A (en) 2001-06-12

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