HK1052647B - 用於治療cns疾病的吡咯烷乙酰胺衍生物或者其組合物 - Google Patents

用於治療cns疾病的吡咯烷乙酰胺衍生物或者其組合物

Info

Publication number
HK1052647B
HK1052647B HK03104923.1A HK03104923A HK1052647B HK 1052647 B HK1052647 B HK 1052647B HK 03104923 A HK03104923 A HK 03104923A HK 1052647 B HK1052647 B HK 1052647B
Authority
HK
Hong Kong
Prior art keywords
treatment
combination
cns disorders
derivative alone
pyrrolidineacetamide
Prior art date
Application number
HK03104923.1A
Other languages
English (en)
Other versions
HK1052647A1 (en
Inventor
Y‧蘭伯蒂
A‧馬塔格尼
H‧克裡特加德
T‧瓦傑曼斯
Original Assignee
Ucb公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb公司 filed Critical Ucb公司
Publication of HK1052647A1 publication Critical patent/HK1052647A1/xx
Publication of HK1052647B publication Critical patent/HK1052647B/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
HK03104923.1A 1999-12-01 2003-07-09 用於治療cns疾病的吡咯烷乙酰胺衍生物或者其組合物 HK1052647B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99124269 1999-12-01
EP99123803 1999-12-01
PCT/EP2000/011808 WO2001039779A1 (en) 1999-12-01 2000-11-27 A pyrrolidineacetamide derivative alone or in combination for treatment of cns disorders

Publications (2)

Publication Number Publication Date
HK1052647A1 HK1052647A1 (en) 2003-09-26
HK1052647B true HK1052647B (zh) 2010-05-20

Family

ID=26153183

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03104923.1A HK1052647B (zh) 1999-12-01 2003-07-09 用於治療cns疾病的吡咯烷乙酰胺衍生物或者其組合物

Country Status (32)

Country Link
US (2) US6903130B1 (zh)
EP (4) EP1600167A3 (zh)
JP (2) JP4249415B2 (zh)
KR (1) KR20030016205A (zh)
CN (1) CN100525761C (zh)
AR (1) AR026610A1 (zh)
AT (1) ATE361751T1 (zh)
AU (1) AU773418B2 (zh)
BG (1) BG106708A (zh)
BR (1) BR0015974A (zh)
CA (2) CA2392879C (zh)
CO (1) CO5261590A1 (zh)
CZ (1) CZ20021904A3 (zh)
DE (1) DE60034815T2 (zh)
EE (1) EE200200274A (zh)
ES (1) ES2287039T3 (zh)
HK (1) HK1052647B (zh)
HU (1) HUP0204023A3 (zh)
IL (2) IL149530A0 (zh)
IS (1) IS6377A (zh)
MX (1) MXPA02005275A (zh)
MY (1) MY127980A (zh)
NO (1) NO20022585L (zh)
NZ (1) NZ518901A (zh)
PL (1) PL357472A1 (zh)
RO (1) RO121085B1 (zh)
RU (1) RU2261093C2 (zh)
SA (1) SA01210655B1 (zh)
SK (1) SK7492002A3 (zh)
TW (1) TWI238062B (zh)
WO (1) WO2001039779A1 (zh)
YU (1) YU37602A (zh)

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Also Published As

Publication number Publication date
HK1052647A1 (en) 2003-09-26
CA2392879C (en) 2005-03-29
AR026610A1 (es) 2003-02-19
MY127980A (en) 2007-01-31
EP1600169A3 (en) 2009-09-23
EP1600167A2 (en) 2005-11-30
US20050187205A1 (en) 2005-08-25
MXPA02005275A (es) 2003-02-17
NZ518901A (en) 2004-08-27
RU2002117279A (ru) 2004-02-27
RU2261093C2 (ru) 2005-09-27
EP1600167A3 (en) 2009-09-30
SK7492002A3 (en) 2003-02-04
YU37602A (sh) 2005-07-19
HUP0204023A3 (en) 2005-03-29
CA2475026A1 (en) 2001-06-07
CO5261590A1 (es) 2003-03-31
RO121085B1 (ro) 2006-12-29
ATE361751T1 (de) 2007-06-15
IL149530A (en) 2007-07-04
CA2392879A1 (en) 2001-06-07
DE60034815D1 (de) 2007-06-21
EP1244456B1 (en) 2007-05-09
AU773418B2 (en) 2004-05-27
PL357472A1 (en) 2004-07-26
NO20022585D0 (no) 2002-05-31
IS6377A (is) 2002-05-10
CZ20021904A3 (cs) 2002-11-13
JP4249415B2 (ja) 2009-04-02
SA01210655B1 (ar) 2006-10-29
EP1600168A2 (en) 2005-11-30
HUP0204023A2 (hu) 2003-03-28
CN100525761C (zh) 2009-08-12
EE200200274A (et) 2003-06-16
IL149530A0 (en) 2002-11-10
DE60034815T2 (de) 2008-01-31
EP1244456A1 (en) 2002-10-02
NO20022585L (no) 2002-07-25
TWI238062B (en) 2005-08-21
ES2287039T3 (es) 2007-12-16
KR20030016205A (ko) 2003-02-26
JP2003515564A (ja) 2003-05-07
BG106708A (bg) 2003-02-28
BR0015974A (pt) 2002-07-23
EP1600169A2 (en) 2005-11-30
US6903130B1 (en) 2005-06-07
WO2001039779A1 (en) 2001-06-07
EP1600168A3 (en) 2009-09-23
JP2008056697A (ja) 2008-03-13
CN1402637A (zh) 2003-03-12
AU1524101A (en) 2001-06-12

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PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20131127