DE60019622T2 - Nitroimidazolderivate und diese enthaltende diagnostische bilderzeugungsmittel - Google Patents

Nitroimidazolderivate und diese enthaltende diagnostische bilderzeugungsmittel Download PDF

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Publication number
DE60019622T2
DE60019622T2 DE60019622T DE60019622T DE60019622T2 DE 60019622 T2 DE60019622 T2 DE 60019622T2 DE 60019622 T DE60019622 T DE 60019622T DE 60019622 T DE60019622 T DE 60019622T DE 60019622 T2 DE60019622 T2 DE 60019622T2
Authority
DE
Germany
Prior art keywords
derivative
nitroimidazole
compound
cancer cells
diagnostic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60019622T
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German (de)
English (en)
Other versions
DE60019622D1 (de
Inventor
Yoshihiro Sendai-shi TAKAI
Tatsuo Sendai-shi IDO
Michihiko Yokosuka-shi TSUJITANI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ido Tatsuo Sendhi Miyagi Jp
TAKAI, YOSHIHIRO, SANDAI, MYAGI, JP
Pola Pharma Inc
Original Assignee
Ido Tatsuo Sendhi
Pola Chemical Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ido Tatsuo Sendhi, Pola Chemical Industries Inc filed Critical Ido Tatsuo Sendhi
Application granted granted Critical
Publication of DE60019622D1 publication Critical patent/DE60019622D1/de
Publication of DE60019622T2 publication Critical patent/DE60019622T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Hydrogenated Pyridines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pyrane Compounds (AREA)
DE60019622T 1999-09-13 2000-09-12 Nitroimidazolderivate und diese enthaltende diagnostische bilderzeugungsmittel Expired - Lifetime DE60019622T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP25905799 1999-09-13
JP25905799 1999-09-13
JP26031599 1999-09-14
JP26031599 1999-09-14
PCT/JP2000/006226 WO2001019799A2 (en) 1999-09-13 2000-09-12 Nitroimidazole derivative and diagnostic imaging agent containing the same

Publications (2)

Publication Number Publication Date
DE60019622D1 DE60019622D1 (de) 2005-05-25
DE60019622T2 true DE60019622T2 (de) 2006-03-02

Family

ID=26543940

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60019622T Expired - Lifetime DE60019622T2 (de) 1999-09-13 2000-09-12 Nitroimidazolderivate und diese enthaltende diagnostische bilderzeugungsmittel

Country Status (10)

Country Link
US (1) US6743925B1 (https=)
EP (1) EP1218351B1 (https=)
JP (1) JP4116793B2 (https=)
KR (1) KR100708822B1 (https=)
AT (1) ATE293607T1 (https=)
AU (1) AU6878400A (https=)
CA (1) CA2384879C (https=)
DE (1) DE60019622T2 (https=)
ES (1) ES2237447T3 (https=)
WO (1) WO2001019799A2 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2841554B1 (fr) * 2002-07-01 2008-01-18 Commissariat Energie Atomique Composes de maleimides marques, leur procede de preparation et leur utilisation pour le marquage de macromolecules
US8257680B1 (en) 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
US9017724B2 (en) 2004-02-24 2015-04-28 The General Hospital Corporation Catalytic radiofluorination
WO2008090731A1 (ja) * 2007-01-23 2008-07-31 Pola Pharma Inc. ２－ニトロイミダゾール誘導体の製造法
CA2978149C (en) 2008-03-21 2019-02-12 The General Hospital Corporation Inositol derivatives for the detection and treatment of alzheimer's disease and related disorders
JP2012532879A (ja) * 2009-07-07 2012-12-20 ノームオキシーズ，インコーポレイテッド イノシトールトリピロリン酸を使用して多剤耐性を低減する方法
US20120219500A1 (en) 2009-10-26 2012-08-30 Fujifilm Ri Pharma Co., Ltd. Diagnostic agent for infectious diseases
NL1038473C2 (en) * 2010-12-24 2012-06-27 Centre Nat Rech Scient Cancer targeting using carbonic anhydrase isoform ix inhibitors.
ES2569196T3 (es) * 2011-09-22 2016-05-09 ihon Medi-Physics Co., Ltd. Compuesto marcado con flúor radiactivo
CA2959776A1 (en) * 2014-09-25 2016-03-31 Nihon Medi-Physics Co., Ltd. Renal imaging agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0819111B2 (ja) * 1987-10-22 1996-02-28 ポーラ化成工業株式会社 ２―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤
EP0669913B1 (en) * 1992-11-19 2003-03-05 The Trustees Of The University Of Pennsylvania Detection of hypoxia
WO1995009844A1 (en) 1993-10-04 1995-04-13 Board Of Regents, The University Of Texas System Rapid synthesis and use of 18f-fluoromisonidazole and analogs

Also Published As

Publication number Publication date
WO2001019799A3 (en) 2002-05-10
ES2237447T3 (es) 2005-08-01
WO2001019799A2 (en) 2001-03-22
JP4116793B2 (ja) 2008-07-09
AU6878400A (en) 2001-04-17
ATE293607T1 (de) 2005-05-15
CA2384879C (en) 2010-11-30
EP1218351B1 (en) 2005-04-20
US6743925B1 (en) 2004-06-01
JP2003509413A (ja) 2003-03-11
DE60019622D1 (de) 2005-05-25
KR20020057955A (ko) 2002-07-12
KR100708822B1 (ko) 2007-04-17
CA2384879A1 (en) 2001-03-22
EP1218351A2 (en) 2002-07-03

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: IDO, TATSUO, SENDHI, MIYAGI, JP

Owner name: POLA PHARMA INC., TOKYO, JP

Owner name: TAKAI, YOSHIHIRO, SANDAI, MYAGI, JP