KR100708822B1 - 니트로이미다졸 유도체 및 이를 함유하는 화상 진단약 - Google Patents

니트로이미다졸 유도체 및 이를 함유하는 화상 진단약 Download PDF

Info

Publication number
KR100708822B1
KR100708822B1 KR1020027002927A KR20027002927A KR100708822B1 KR 100708822 B1 KR100708822 B1 KR 100708822B1 KR 1020027002927 A KR1020027002927 A KR 1020027002927A KR 20027002927 A KR20027002927 A KR 20027002927A KR 100708822 B1 KR100708822 B1 KR 100708822B1
Authority
KR
South Korea
Prior art keywords
nitroimidazole
cancer cells
derivative
imaging
nitroimidazole derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
KR1020027002927A
Other languages
English (en)
Korean (ko)
Other versions
KR20020057955A (ko
Inventor
타카이요시히로
이도타츠오
츠지타니미치히코
Original Assignee
포라 가세이 고교 가부시키가이샤
타카이 요시히로
이도 타츠오
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 포라 가세이 고교 가부시키가이샤, 타카이 요시히로, 이도 타츠오 filed Critical 포라 가세이 고교 가부시키가이샤
Publication of KR20020057955A publication Critical patent/KR20020057955A/ko
Application granted granted Critical
Publication of KR100708822B1 publication Critical patent/KR100708822B1/ko
Assigned to 포라 파마 가부시키가이샤 reassignment 포라 파마 가부시키가이샤 권리지분의 전부이전등록 Assignors: 포라 가세이 고교 가부시키가이샤
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Hydrogenated Pyridines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pyrane Compounds (AREA)
KR1020027002927A 1999-09-13 2000-09-12 니트로이미다졸 유도체 및 이를 함유하는 화상 진단약 Expired - Lifetime KR100708822B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP25905799 1999-09-13
JPJP-P-1999-00259057 1999-09-13
JPJP-P-1999-00260315 1999-09-14
JP26031599 1999-09-14

Publications (2)

Publication Number Publication Date
KR20020057955A KR20020057955A (ko) 2002-07-12
KR100708822B1 true KR100708822B1 (ko) 2007-04-17

Family

ID=26543940

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027002927A Expired - Lifetime KR100708822B1 (ko) 1999-09-13 2000-09-12 니트로이미다졸 유도체 및 이를 함유하는 화상 진단약

Country Status (10)

Country Link
US (1) US6743925B1 (https=)
EP (1) EP1218351B1 (https=)
JP (1) JP4116793B2 (https=)
KR (1) KR100708822B1 (https=)
AT (1) ATE293607T1 (https=)
AU (1) AU6878400A (https=)
CA (1) CA2384879C (https=)
DE (1) DE60019622T2 (https=)
ES (1) ES2237447T3 (https=)
WO (1) WO2001019799A2 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2841554B1 (fr) * 2002-07-01 2008-01-18 Commissariat Energie Atomique Composes de maleimides marques, leur procede de preparation et leur utilisation pour le marquage de macromolecules
US8257680B1 (en) 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
US9017724B2 (en) 2004-02-24 2015-04-28 The General Hospital Corporation Catalytic radiofluorination
WO2008090731A1 (ja) * 2007-01-23 2008-07-31 Pola Pharma Inc. ２－ニトロイミダゾール誘導体の製造法
CA2978149C (en) 2008-03-21 2019-02-12 The General Hospital Corporation Inositol derivatives for the detection and treatment of alzheimer's disease and related disorders
JP2012532879A (ja) * 2009-07-07 2012-12-20 ノームオキシーズ，インコーポレイテッド イノシトールトリピロリン酸を使用して多剤耐性を低減する方法
US20120219500A1 (en) 2009-10-26 2012-08-30 Fujifilm Ri Pharma Co., Ltd. Diagnostic agent for infectious diseases
NL1038473C2 (en) * 2010-12-24 2012-06-27 Centre Nat Rech Scient Cancer targeting using carbonic anhydrase isoform ix inhibitors.
ES2569196T3 (es) * 2011-09-22 2016-05-09 ihon Medi-Physics Co., Ltd. Compuesto marcado con flúor radiactivo
CA2959776A1 (en) * 2014-09-25 2016-03-31 Nihon Medi-Physics Co., Ltd. Renal imaging agent

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728843A (en) * 1993-10-04 1998-03-17 Wallace Technologies (2'-nitro-1'-imidazolyl)-2,3-isopropylidene-y-tosylbutanol, a precursor to 18 F!fluoroerythronitroimidazole PET imaging agent

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0819111B2 (ja) * 1987-10-22 1996-02-28 ポーラ化成工業株式会社 ２―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤
EP0669913B1 (en) * 1992-11-19 2003-03-05 The Trustees Of The University Of Pennsylvania Detection of hypoxia

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728843A (en) * 1993-10-04 1998-03-17 Wallace Technologies (2'-nitro-1'-imidazolyl)-2,3-isopropylidene-y-tosylbutanol, a precursor to 18 F!fluoroerythronitroimidazole PET imaging agent

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Nuclear Medicine and Biology, 26(4), 371-376, 1999*

Also Published As

Publication number Publication date
DE60019622T2 (de) 2006-03-02
WO2001019799A3 (en) 2002-05-10
ES2237447T3 (es) 2005-08-01
WO2001019799A2 (en) 2001-03-22
JP4116793B2 (ja) 2008-07-09
AU6878400A (en) 2001-04-17
ATE293607T1 (de) 2005-05-15
CA2384879C (en) 2010-11-30
EP1218351B1 (en) 2005-04-20
US6743925B1 (en) 2004-06-01
JP2003509413A (ja) 2003-03-11
DE60019622D1 (de) 2005-05-25
KR20020057955A (ko) 2002-07-12
CA2384879A1 (en) 2001-03-22
EP1218351A2 (en) 2002-07-03

Similar Documents

Publication Publication Date Title
KR102008635B1 (ko) 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템
KR100708822B1 (ko) 니트로이미다졸 유도체 및 이를 함유하는 화상 진단약
TWI893724B (zh) 丹磺醯胺修飾的psma靶向化合物及其製備方法和應用
JP7036802B2 (ja) Ｐｅｔ放射性トレーサとしての［１８ｆ］で標識された乳酸誘導体
JP5085824B2 (ja) 低酸素の検出のために有用な化合物の製造
US6252087B1 (en) Nitroaromatic compounds for the detection of hypoxia
US8476449B2 (en) Radioactive iodine labeled organic compound or salt thereof
EP2712631A1 (en) Radiopharmaceutical products for diagnosis and therapy of renal carcinoma
US9056136B2 (en) Weakly basic 2-nitroimidazoles for the non-invasive detection of tissue hypoxia
KR102518936B1 (ko) 베타-아드레날린성 수용체에 특이적인 pet용 추적자
US6855828B1 (en) Detection of hypoxia
KR101519006B1 (ko) 신규한 벤즈아마이드 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 피부암 진단용 약학적 조성물
US20240383871A1 (en) Compound useful for pet-imaging of bruton’s tyrosine kinase
CN110382513A (zh) 用于衰老的PET成像的放射性标记的β-半乳糖苷酶底物
US20050026974A1 (en) Detection of hypoxia
US20230263915A1 (en) Radiolabeled compounds
JP2021536495A (ja) 多環式芳香族アミンの第四級アンモニウム塩の放射標識化合物、陽電子放射断層撮影の診断方法における放射標識化合物の使用、及び多環式芳香族アミンの第四級アンモニウム塩の放射標識化合物を含有する医薬組成物
HK40030015B (en) Compositions, methods and systems for the synthesis and use of imaging agents
HK1203941A1 (en) Compositions, methods, and systems for the synthesis and use of imaging agents
CN108066776A (zh) 快速成像的坏死心肌显像剂及其制备方法和应用
CN107207499A (zh) 经放射性碘标记的吡啶并[1,2‑a]苯并咪唑衍生物化合物
HK1240579A1 (en) Radioactive iodine labeled pyrido[1,2-a]benzoimidazole derivative compound
HK1203941B (en) Compositions, methods, and systems for the synthesis and use of imaging agents
HK1182933A (en) Compositions, methods and systems for the synthesis and use of imaging agents

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20020305

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20050803

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20060926

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20070223

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20070411

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20070412

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
PR1001 Payment of annual fee

Payment date: 20100331

Start annual number: 4

End annual number: 4

PR1001 Payment of annual fee

Payment date: 20110406

Start annual number: 5

End annual number: 5

PR1001 Payment of annual fee

Payment date: 20120403

Start annual number: 6

End annual number: 6

FPAY Annual fee payment

Payment date: 20130312

Year of fee payment: 7

PR1001 Payment of annual fee

Payment date: 20130312

Start annual number: 7

End annual number: 7

FPAY Annual fee payment

Payment date: 20140313

Year of fee payment: 8

PR1001 Payment of annual fee

Payment date: 20140313

Start annual number: 8

End annual number: 8

FPAY Annual fee payment

Payment date: 20150316

Year of fee payment: 9

PR1001 Payment of annual fee

Payment date: 20150316

Start annual number: 9

End annual number: 9

FPAY Annual fee payment

Payment date: 20160314

Year of fee payment: 10

PR1001 Payment of annual fee

Payment date: 20160314

Start annual number: 10

End annual number: 10

FPAY Annual fee payment

Payment date: 20170317

Year of fee payment: 11

PR1001 Payment of annual fee

Payment date: 20170317

Start annual number: 11

End annual number: 11

PR1001 Payment of annual fee

Payment date: 20180315

Start annual number: 12

End annual number: 12

PR1001 Payment of annual fee

Payment date: 20190315

Start annual number: 13

End annual number: 13

PR1001 Payment of annual fee

Payment date: 20200317

Start annual number: 14

End annual number: 14

PC1801 Expiration of term